d8b6cc7303b3cd6c9209972fab052448 329527.pdf feaa9a07ea38a275d43b49fc58b8e821f8301fe3 329527.pdf 9e5591ef6ec4c9ad33ee40123b6372ae0e7a5c6f4dfad8be0bbd26c6e1ecc179 329527.pdf Title: High‐frequency oscillations >250 Hz in people with Down syndrome and associated Alzheimer's disease dementia Subject: Keywords: Author: Creator: LaTeX with hyperref package Producer: Acrobat Distiller 10.0.0 (Windows) CreationDate: Wed Jul 2 08:40:07 2025 CEST ModDate: Wed Jul 2 08:40:44 2025 CEST Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 19 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 5664147 bytes Optimized: yes PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- GPNCHD+STIXMath-Italic Type 1C WinAnsi yes yes no 603 0 GPNCHE+Lato-Italic Type 1C WinAnsi yes yes no 606 0 GPNBKF+Lato-Regular Type 1C WinAnsi yes 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syndrome and associated Alzheimer’s disease dementia Destination: chapter..1 Children: Item: Title: Abstract Destination: section*.2 Item: Title: 1 | BACKGROUND Destination: section..1.1 Item: Title: 2 | METHODS Destination: section..1.2 Children: Item: Title: 2.1 | Study design and participants Destination: subsection..1.2.1 Item: Title: 2.2 | Wideband polysomnography recording Destination: subsection..1.2.2 Item: Title: 2.3 | Analyses of sleep Destination: subsection..1.2.3 Item: Title: 2.4 | HFO detection and analysis Destination: subsection..1.2.4 Item: Title: 2.5 | Assessment of epileptiform activity Destination: subsection..1.2.5 Item: Title: 2.6 | Laterality and asymmetry analyses Destination: subsection..1.2.6 Item: Title: 2.7 | Statistical analyses Destination: subsection..1.2.7 Item: Title: 3 | RESULTS Destination: section..1.3 Children: Item: Title: 3.1 | Demographics and clinical characteristics Destination: subsection..1.3.1 Item: Title: 3.2 | HFOs in asymptomatic individuals with DS Destination: subsection..1.3.2 Item: Title: 3.3 | HFOs in prodromal AD dementia Destination: subsection..1.3.3 Item: Title: 3.4 | HFOs in AD dementia cases Destination: subsection..1.3.4 Item: Title: 3.5 | Quantification of event rates and the effect of age Destination: subsection..1.3.5 Item: Title: 3.6 | Hemispheric asymmetry and regional distribution differences in asymptomatic and symptomatic individuals Destination: subsection..1.3.6 Item: Title: 3.7 | Influence of epileptiform activity Destination: subsection..1.3.7 Item: Title: 4 | DISCUSSION Destination: section..1.4 Item: Title: ACKNOWLEDGMENTS Destination: section*.4 Item: Title: CONFLICT OF INTEREST STATEMENT Destination: section*.6 Item: Title: ORCID Destination: section*.8 Item: Title: REFERENCES Destination: section*.10 Item: Title: SUPPORTING INFORMATION Destination: section*.12 Info: Title: High‐frequency oscillations >250 Hz in people with Down syndrome and associated Alzheimer's disease dementia 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