5440ee7064bc71c80e93fb8481c9d26f 329534.pdf 25e1ec8c7a978e8ffd0298cf01baa12574b63dd7 329534.pdf 80cf41fad59a96da24df31642e621d4fe96597c4d3352f5bea276c705557f91c 329534.pdf Creator: PTC Arbortext Layout Developer 12.3.6865/W-x64 Producer: PDFlib+PDI 10.0.2p2 (C++/Win64); modified using iTextSharp.LGPLv2.Core 3.7.4.0 CreationDate: Fri Nov 28 20:58:54 2025 CET ModDate: Tue Jul 14 12:13:22 2026 CEST Custom Metadata: yes Metadata Stream: yes Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 7 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 1411170 bytes Optimized: no PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- TPITUP+Avenir-Black Type 1C Custom yes yes yes 33 0 FDDQZJ+MyriadPro-Bold Type 1C Custom yes yes yes 34 0 IGAXGH+MyriadPro-Regular Type 1C Custom yes yes yes 35 0 MinionMathSymbols Type 1 Builtin yes no yes 36 0 QWSANS+MyriadPro-BoldIt Type 1C Custom yes yes yes 37 0 HJCPLA+MinionPro-Regular Type 1C Custom yes yes yes 38 0 Courier Type 1 WinAnsi no no no 1 0 GIWCCI+MyriadPro-It Type 1C Custom yes yes yes 56 0 IMTVZV+MinionMath-Regular Type 1C Custom yes yes yes 57 0 SHXTEI+MinionPro-It Type 1C Custom yes yes yes 58 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2026-07-15 04:24:44 CEST RepresentationInformation: 329534.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2026-07-14 12:19:16 CEST Size: 1411170 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Tagged PDF PDFMetadata: Objects: 1070 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: true NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Language: en Outlines: Item: Title: ADOLESBIO-HS: A Real-World Multicenter Case Series on the Effectiveness and Safety of Adalimumab in Adolescents with Modera ... Destination: titlink1 Children: Item: Title: Introduction Destination: flink1 Item: Title: Methods Destination: flink2 Children: Item: Title: Study Design and Assessments Destination: slink1 Item: Title: Statistical Analysis Destination: slink2 Item: Title: Results Destination: flink3 Children: Item: Title: Effectiveness Destination: slink3 Item: Title: Safety Destination: slink4 Item: Title: Discussion Destination: flink4 Item: Title: Statement of Ethics Destination: flink5 Item: Title: Conflict of Interest Statement Destination: flink6 Item: Title: Funding Sources Destination: flink7 Item: Title: Author Contributions Destination: flink8 Item: Title: Data Availability Statement Destination: flink9 Item: Title: References Destination: rlink1 Info: Creator: PTC Arbortext Layout Developer 12.3.6865/W-x64 Producer: PDFlib+PDI 10.0.2p2 (C++/Win64); modified using iTextSharp.LGPLv2.Core 3.7.4.0 CreationDate: Fri Nov 28 21:28:54 CET 2025 ModDate: Tue Jul 14 12:13:22 CEST 2026 ID: 0x5b8a553001835036200ff2f84e541a7b, 0x7097404cd19ddce6ff5e521ffbcbae82 Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: TPITUP+Avenir-Black FontSubset: true FirstChar: 1 LastChar: 10 FontDescriptor: FontName: TPITUP+Avenir-Black Flags: Nonsymbolic, ForceBold FontBBox: -161, -240, 1135, 953 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: Courier Encoding: WinAnsiEncoding Font: BaseFont: FDDQZJ+MyriadPro-Bold FontSubset: true FirstChar: 1 LastChar: 43 FontDescriptor: FontName: FDDQZJ+MyriadPro-Bold Flags: Nonsymbolic, ForceBold FontBBox: -163, -250, 1256, 989 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: IGAXGH+MyriadPro-Regular FontSubset: true FirstChar: 1 LastChar: 79 FontDescriptor: FontName: IGAXGH+MyriadPro-Regular Flags: Nonsymbolic FontBBox: -157, -250, 1126, 952 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MinionMathSymbols FirstChar: 1 LastChar: 149 FontDescriptor: FontName: MinionMathSymbols Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile: true ToUnicode: true Font: BaseFont: QWSANS+MyriadPro-BoldIt FontSubset: true FirstChar: 1 LastChar: 17 FontDescriptor: FontName: QWSANS+MyriadPro-BoldIt Flags: Nonsymbolic, Italic, ForceBold FontBBox: -201, -250, 1225, 987 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: HJCPLA+MinionPro-Regular FontSubset: true FirstChar: 1 LastChar: 93 FontDescriptor: FontName: HJCPLA+MinionPro-Regular Flags: Nonsymbolic FontBBox: -290, -360, 1684, 989 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: GIWCCI+MyriadPro-It FontSubset: true FirstChar: 1 LastChar: 23 FontDescriptor: FontName: GIWCCI+MyriadPro-It Flags: Nonsymbolic, Italic FontBBox: -185, -250, 1090, 953 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: IMTVZV+MinionMath-Regular FontSubset: true FirstChar: 1 LastChar: 4 FontDescriptor: FontName: IMTVZV+MinionMath-Regular Flags: Nonsymbolic FontBBox: -1196, -2876, 2350, 3473 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: SHXTEI+MinionPro-It FontSubset: true FirstChar: 1 LastChar: 23 FontDescriptor: FontName: SHXTEI+MinionPro-It Flags: Nonsymbolic, Italic FontBBox: -201, -360, 1684, 919 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true XMP: 1900-01-00T00:00:470062792+05:30 PTC Arbortext Layout Developer 12.3.6865/W-x64 2026-07-14T10:13:22+00:00 2026-07-14T10:13:22+00:00 1 application/pdf DRM546647_ADOLESBIO-HS: A Real-World Multicenter Case Series on the Effectiveness and Safety of Adalimumab in Adolescents with Moderate-to-Severe Hidradenitis Suppurativa PDF/UA Universal Accessibility Schema http://www.aiim.org/pdfua/ns/id/ pdfuaid part Integer internal Indicates, which part of ISO 14289 standard is followed Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 43, 723, 130, 737 Flags: Print Annotation: Subtype: Link Rect: 234, 698, 306, 706 Flags: Print Annotation: Subtype: Link Rect: 43, 60, 98, 67 Flags: Print Annotation: Subtype: Link Rect: 43, 51, 105, 58 Flags: Print Annotation: Subtype: Link Rect: 274, 29, 291, 34 Flags: Print Annotation: Subtype: Link Rect: 130, 22, 224, 28 Flags: Print Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 47, 533, 52, 544 Flags: Print Destination: 29 Annotation: Subtype: Link Rect: 82, 508, 87, 519 Flags: Print Destination: 29 Annotation: Subtype: Link Rect: 94, 508, 99, 519 Flags: Print Destination: 29 Annotation: Subtype: Link Rect: 166, 496, 171, 507 Flags: Print Destination: 29 Annotation: Subtype: Link Rect: 176, 496, 181, 507 Flags: Print Destination: 29 Annotation: Subtype: Link Rect: 182, 483, 187, 494 Flags: Print Destination: 29 Annotation: Subtype: Link Rect: 97, 446, 102, 457 Flags: Print Destination: 29 Annotation: Subtype: Link Rect: 143, 421, 148, 432 Flags: Print Destination: 29 Annotation: Subtype: Link Rect: 189, 371, 194, 382 Flags: Print Destination: 29 Annotation: Subtype: Link Rect: 190, 346, 200, 357 Flags: Print Destination: 29 Annotation: Subtype: Link Rect: 108, 259, 118, 270 Flags: Print Destination: 29 Annotation: Subtype: Link Rect: 519, 682, 530, 693 Flags: Print Destination: 29 Annotation: Subtype: Link Rect: 535, 682, 545, 693 Flags: Print Destination: 29 Annotation: Subtype: Link Rect: 361, 495, 371, 506 Flags: Print Destination: 29 Annotation: Subtype: Link Rect: 493, 321, 503, 332 Flags: Print Destination: 29 Annotation: Subtype: Link Rect: 510, 321, 521, 332 Flags: Print Destination: 29 Annotation: Subtype: Link Rect: 444, 271, 454, 282 Flags: Print Destination: 30 Annotation: Subtype: Link Rect: 439, 246, 450, 257 Flags: Print Destination: 30 Annotation: Subtype: Link Rect: 432, 97, 442, 108 Flags: Print Destination: 30 Page: Sequence: 3 Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 255, 395, 289, 406 Flags: Print Destination: 26 Annotation: Subtype: Link Rect: 157, 321, 183, 332 Flags: Print Destination: 27 Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 175, 682, 186, 693 Flags: Print Destination: 30 Annotation: Subtype: Link Rect: 208, 657, 213, 668 Flags: Print Destination: 29 Annotation: Subtype: Link Rect: 280, 395, 285, 406 Flags: Print Destination: 29 Annotation: Subtype: Link Rect: 123, 333, 133, 344 Flags: Print Destination: 30 Annotation: Subtype: Link Rect: 114, 196, 124, 207 Flags: Print Destination: 29 Annotation: Subtype: Link Rect: 520, 682, 531, 693 Flags: Print Destination: 29 Annotation: Subtype: Link Rect: 411, 657, 421, 668 Flags: Print Destination: 30 Annotation: Subtype: Link Rect: 357, 632, 362, 643 Flags: Print Destination: 29 Annotation: Subtype: Link Rect: 474, 607, 479, 618 Flags: Print Destination: 29 Annotation: Subtype: Link Rect: 487, 607, 497, 618 Flags: Print Destination: 29 Annotation: Subtype: Link Rect: 389, 582, 400, 593 Flags: Print Destination: 30 Annotation: Subtype: Link Rect: 307, 520, 317, 531 Flags: Print Destination: 30 Annotation: Subtype: Link Rect: 323, 520, 334, 531 Flags: Print Destination: 30 Annotation: Subtype: Link Rect: 431, 507, 441, 518 Flags: Print Destination: 30 Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 106, 345, 205, 353 Flags: Print Annotation: Subtype: Link Rect: 57, 336, 96, 344 Flags: Print Annotation: Subtype: Link Rect: 180, 241, 205, 249 Flags: Print Annotation: Subtype: Link Rect: 57, 232, 170, 240 Flags: Print Annotation: Subtype: Link Rect: 179, 194, 205, 202 Flags: Print Annotation: Subtype: Link Rect: 57, 184, 147, 193 Flags: Print Annotation: Subtype: Link Rect: 134, 137, 205, 145 Flags: Print Annotation: Subtype: Link Rect: 57, 128, 164, 136 Flags: Print Annotation: Subtype: Link Rect: 259, 364, 370, 372 Flags: Print Annotation: Subtype: Link Rect: 230, 317, 358, 325 Flags: Print Annotation: Subtype: Link Rect: 288, 279, 378, 287 Flags: Print Annotation: Subtype: Link Rect: 354, 222, 378, 230 Flags: Print Annotation: Subtype: Link Rect: 230, 213, 348, 221 Flags: Print Annotation: Subtype: Link Rect: 327, 184, 378, 193 Flags: Print Annotation: Subtype: Link Rect: 230, 175, 317, 183 Flags: Print Annotation: Subtype: Link Rect: 318, 128, 378, 136 Flags: Print Annotation: Subtype: Link Rect: 230, 118, 283, 126 Flags: Print Annotation: Subtype: Link Rect: 527, 393, 551, 401 Flags: Print Annotation: Subtype: Link Rect: 404, 383, 537, 391 Flags: Print Annotation: Subtype: Link Rect: 526, 364, 551, 372 Flags: Print Annotation: Subtype: Link Rect: 404, 355, 552, 363 Flags: Print Annotation: Subtype: Link Rect: 404, 345, 462, 353 Flags: Print Annotation: Subtype: Link Rect: 455, 260, 551, 268 Flags: Print Annotation: Subtype: Link Rect: 404, 251, 424, 259 Flags: Print Annotation: Subtype: Link Rect: 527, 184, 551, 193 Flags: Print Annotation: Subtype: Link Rect: 404, 175, 525, 183 Flags: Print Annotation: Subtype: Link Rect: 404, 99, 531, 107 Flags: Print Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 168, 665, 205, 673 Flags: Print Annotation: Subtype: Link Rect: 57, 656, 131, 664 Flags: Print Annotation: Subtype: Link Rect: 57, 561, 203, 569 Flags: Print Annotation: Subtype: Link Rect: 126, 533, 205, 541 Flags: Print Annotation: Subtype: Link Rect: 57, 523, 142, 531 Flags: Print Annotation: Subtype: Link Rect: 297, 665, 378, 673 Flags: Print Annotation: Subtype: Link Rect: 230, 656, 283, 664 Flags: Print Annotation: Subtype: Link Rect: 230, 627, 378, 635 Flags: Print Annotation: Subtype: Link Rect: 230, 618, 358, 626 Flags: Print Annotation: Subtype: Link Rect: 230, 561, 336, 569 Flags: Print Annotation: Subtype: Link Rect: 404, 703, 541, 711 Flags: Print Annotation: Subtype: Link Rect: 404, 655, 551, 664 Flags: Print Annotation: Subtype: Link Rect: 404, 646, 419, 654 Flags: Print Annotation: Subtype: Link Rect: 527, 608, 551, 616 Flags: Print Annotation: Subtype: Link Rect: 404, 599, 513, 607 Flags: Print Annotation: Subtype: Link Rect: 515, 532, 551, 541 Flags: Print Annotation: Subtype: Link Rect: 404, 523, 493, 531 Flags: Print Checksum: e3ca8cc4 Type: CRC32 Checksum: 5440ee7064bc71c80e93fb8481c9d26f Type: MD5 Checksum: 25e1ec8c7a978e8ffd0298cf01baa12574b63dd7 Type: SHA-1 Checksum: 80cf41fad59a96da24df31642e621d4fe96597c4d3352f5bea276c705557f91c Type: SHA-256