a8a6ab0b5310f18ef6a0551180342827 329539.pdf 7468d3e0cd45aa98850a1948e4132f40d9aaeb87 329539.pdf e2ea0b28b84334339ab271a449856247dc6174b696c12f27a30c5ae1f0309e5e 329539.pdf Title: Clinical and Economic Impact of Hybrid Closed-Loop Systems for T1 Diabetes Management in Spain Subject: Endocrine Practice, 31 (2025) 1530-1537. doi:10.1016/j.eprac.2025.08.002 Author: Aesha Khan-Mirón MSc Creator: Elsevier Producer: PDFlib+PDI 10.0.2p2 (C++/Win64) CreationDate: Wed Nov 19 16:50:15 2025 CET ModDate: Sat Nov 29 11:44:59 2025 CET Custom Metadata: yes Metadata Stream: yes Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 8 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 1424888 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- DJKDIV+ESSTIX-Five Type 1C Builtin yes yes yes 3086 0 GHRDUD+Gulliver Type 1C Custom yes yes yes 3044 0 GlyphLessFont CID TrueType Identity-H yes no yes 3046 0 BRWWWZ+TeX_CM_Roman Type 1C Builtin yes yes yes 3050 0 IAPKCE+TimesNewRomanPSMT CID TrueType Identity-H yes yes yes 3052 0 ZKIXFO+Gulliver-Italic Type 1C Custom yes yes yes 3056 0 LOAVMZ+GulliverSCOsF Type 1C Custom yes yes yes 3061 0 NBTTQX+CM_Maths_Symbols Type 1C Builtin yes yes yes 3067 0 YOEISO+ESSTIX-Two Type 1C Builtin yes yes yes 3070 0 NYRVLK+STIX-Regular Type 1C Custom yes yes yes 3074 0 RSORVR+Gulliver-Bold Type 1C Custom yes yes yes 3078 0 QUOXOT+Montserrat-ExtraBold CID TrueType Identity-H yes yes yes 3089 0 RERJVF+Montserrat-Regular CID TrueType Identity-H yes yes yes 3090 0 JOYQAL+HelveticaNeue-Bold Type 1C Custom yes yes yes 59 0 SYDESI+HelveticaNeue-Roman Type 1C Custom yes yes yes 60 0 WGYAHF+ESSTIX-Ten Type 1C Builtin yes yes yes 107 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2026-07-17 04:45:53 CEST RepresentationInformation: 329539.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2026-07-16 11:31:57 CEST Size: 1424888 Format: PDF Version: 1.7 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ErrorMessage: Invalid indirect destination - referenced object 'appsec1' cannot be found ID: PDF-HUL-149 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found ID: PDF-HUL-122 Offset: 1345380 MIMEtype: application/pdf Profile: Linearized PDF, Tagged PDF PDFMetadata: Objects: 3190 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: true NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: Clinical and Economic Impact of Hybrid Closed-Loop Systems for T1 Diabetes Management in Spain Destination: titlink1 Children: Item: Title: Introduction Destination: flink1 Item: Title: Methods Destination: flink2 Children: Item: Title: Model Overview Destination: slink1 Item: Title: Cohort Characteristics Destination: slink2 Item: Title: Highlights Destination: flink1editors_rh_textbox Item: Title: Clinical Relevance Destination: flink2editors_rh_textbox Children: Item: Title: Clinical Inputs: Treatment Effect Destination: slink3 Item: Title: Costs and Time Horizon Destination: slink4 Item: Title: Utilities Destination: slink5 Item: Title: Sensitivity Analysis Destination: slink6 Item: Title: Ethics Destination: slink7 Item: Title: Results Destination: flink3 Item: Title: Discussion Destination: flink4 Item: Title: Conclusion Destination: flink5 Item: Title: Disclosure Destination: aclink2 Item: Title: Acknowledgment Destination: aclink3 Item: Title: Author Contributions Destination: flink6 Item: Title: Data Availability Destination: flink7 Item: Title: Ethics Statement Destination: flink8 Item: Title: References Destination: blink1 Info: Title: Clinical and Economic Impact of Hybrid Closed-Loop Systems for T1 Diabetes Management in Spain Author: Aesha Khan-Mirón MSc Subject: Endocrine Practice, 31 (2025) 1530-1537. doi:10.1016/j.eprac.2025.08.002 Creator: Elsevier Producer: PDFlib+PDI 10.0.2p2 (C++/Win64) CreationDate: Wed Nov 19 17:20:15 CET 2025 ModDate: Sat Nov 29 12:14:59 CET 2025 ID: 0xc11612283c98edd942dd2a0520aa7c7c, 0x57a0933f4999d44491c5d0278c802692 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 218 ImageHeight: 291 BitsPerSample: 8 BitsPerSampleUnit: integer ColorSpace: ICCBased Fonts: Type0: Font: BaseFont: QUOXOT+Montserrat-ExtraBold Encoding: Identity-H ToUnicode: true Font: BaseFont: RERJVF+Montserrat-Regular Encoding: Identity-H ToUnicode: true Font: BaseFont: GlyphLessFont Encoding: Identity-H ToUnicode: true Font: BaseFont: IAPKCE+TimesNewRomanPSMT Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: ZKIXFO+Gulliver-Italic FontSubset: true FirstChar: 1 LastChar: 61 FontDescriptor: FontName: ZKIXFO+Gulliver-Italic Flags: Nonsymbolic, Italic FontBBox: -141, -232, 1053, 972 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: NYRVLK+STIX-Regular FontSubset: true FirstChar: 1 LastChar: 4 FontDescriptor: FontName: NYRVLK+STIX-Regular Flags: Nonsymbolic FontBBox: -970, -486, 2208, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: GHRDUD+Gulliver FontSubset: true FirstChar: 1 LastChar: 82 FontDescriptor: FontName: GHRDUD+Gulliver Flags: Nonsymbolic FontBBox: -115, -251, 1042, 986 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: LOAVMZ+GulliverSCOsF FontSubset: true FirstChar: 1 LastChar: 12 FontDescriptor: FontName: LOAVMZ+GulliverSCOsF Flags: Nonsymbolic FontBBox: -115, -251, 1407, 986 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: RSORVR+Gulliver-Bold FontSubset: true FirstChar: 1 LastChar: 45 FontDescriptor: FontName: RSORVR+Gulliver-Bold Flags: Nonsymbolic, ForceBold FontBBox: -150, -250, 1131, 998 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: BRWWWZ+TeX_CM_Roman FontSubset: true FirstChar: 1 LastChar: 128 FontDescriptor: FontName: BRWWWZ+TeX_CM_Roman Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: NBTTQX+CM_Maths_Symbols FontSubset: true FirstChar: 1 LastChar: 138 FontDescriptor: FontName: NBTTQX+CM_Maths_Symbols Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: JOYQAL+HelveticaNeue-Bold FontSubset: true FirstChar: 1 LastChar: 14 FontDescriptor: FontName: JOYQAL+HelveticaNeue-Bold Flags: Nonsymbolic, ForceBold FontBBox: -166, -218, 1078, 975 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: WGYAHF+ESSTIX-Ten FontSubset: true FirstChar: 48 LastChar: 122 FontDescriptor: FontName: WGYAHF+ESSTIX-Ten Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: SYDESI+HelveticaNeue-Roman FontSubset: true FirstChar: 1 LastChar: 37 FontDescriptor: FontName: SYDESI+HelveticaNeue-Roman Flags: Nonsymbolic FontBBox: -166, -210, 1076, 952 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: DJKDIV+ESSTIX-Five FontSubset: true FirstChar: 33 LastChar: 116 FontDescriptor: FontName: DJKDIV+ESSTIX-Five Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: YOEISO+ESSTIX-Two FontSubset: true FirstChar: 33 LastChar: 168 FontDescriptor: FontName: YOEISO+ESSTIX-Two Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true CIDFontType2: Font: BaseFont: QUOXOT+Montserrat-ExtraBold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: QUOXOT+Montserrat-ExtraBold Flags: Nonsymbolic, ForceBold FontBBox: -906, -268, 1715, 1088 FontFile2: true Font: BaseFont: IAPKCE+TimesNewRomanPSMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: IAPKCE+TimesNewRomanPSMT Flags: Nonsymbolic FontBBox: -568, -307, 2000, 1007 FontFile2: true Font: BaseFont: RERJVF+Montserrat-Regular CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: RERJVF+Montserrat-Regular Flags: Nonsymbolic FontBBox: -823, -262, 1586, 1043 FontFile2: true Font: BaseFont: GlyphLessFont CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: GlyphLessFont Flags: FixedPitch, Symbolic FontBBox: 0, 0, 500, 1000 FontFile2: true XMP: application/pdf doi:10.1016/j.eprac.2025.08.002 Clinical and Economic Impact of Hybrid Closed-Loop Systems for T1 Diabetes Management in Spain Aesha Khan-Mirón MSc Maria-Eleni Syleouni MA MSc PhD Giovanni Brusaferri MSc MBA Myriel Nyffeler MSc PhD Ana Chico MD PhD Jesús Moreno-Fernández MD PhD Pilar I. Beato-Víbora MD PhD clinical impact economic impact hybrid closed-loop Spain type 1 diabetes mellitus automated insulin delivery Endocrine Practice, 31 (2025) 1530-1537. doi:10.1016/j.eprac.2025.08.002 AACE journal Endocrine Practice © 2025 AACE. Published by Elsevier Inc. 1530-891X 31 12 December 2025 1530-1537 1530 1537 10.1016/j.eprac.2025.08.002 https://doi.org/10.1016/j.eprac.2025.08.002 2010-04-23 true 10.1016/j.eprac.2025.08.002 elsevier.com sciencedirect.com VoR 7.0.1 10.1016/j.eprac.2025.08.002 noindex 2010-04-23 true PStill version 1.84.42 sciencedirect.com elsevier.com Elsevier 2025-11-19T21:20:15+05:30 2025-11-29T16:14:59+05:30 2025-11-29T16:14:59+05:30 True 1 https://www.elsevier.com/tdm/tdmrep-policy.json PDFlib+PDI 10.0.2p2 (C++/Win64) uuid:a1d58055-73b7-4545-a542-ebcea4fcde79 uuid:2f8b5a68-29b7-414e-9ddb-66d54fc85414 http://creativecommons.org/licenses/by/4.0/ Pages: Page: Label: 1530 Annotations: Annotation: Subtype: Link Contents: Rect: 37, 715, 37, 715 Flags: Print Annotation: Subtype: Link Contents: Rect: 163, 562, 168, 573 Flags: Print Destination: 3003 Annotation: Subtype: Link Contents: Rect: 171, 562, 175, 573 Flags: Print Destination: 3003 Annotation: Subtype: Link Contents: Rect: 369, 562, 374, 573 Flags: Print Destination: 3003 Annotation: Subtype: Link Contents: Rect: 195, 549, 200, 560 Flags: Print Destination: 3003 Annotation: Subtype: Link Contents: Rect: 337, 549, 341, 560 Flags: Print Destination: 3003 Annotation: Subtype: Link Contents: Rect: 345, 549, 349, 560 Flags: Print Destination: 3003 Annotation: Subtype: Link Contents: Rect: 459, 549, 463, 560 Flags: Print Destination: 3003 Annotation: Subtype: Link Contents: Rect: 467, 549, 472, 560 Flags: Print Destination: 3003 Annotation: Subtype: Link Contents: Rect: 476, 549, 481, 560 Flags: Print Destination: 3003 Annotation: Subtype: Link Contents: Rect: 217, 536, 222, 547 Flags: Print Destination: 3003 Annotation: Subtype: Link Contents: Rect: 226, 536, 231, 547 Flags: Print Destination: 3003 Annotation: Subtype: Link Contents: Rect: 393, 536, 397, 547 Flags: Print Destination: 3003 Annotation: Subtype: Link Contents: Rect: 401, 536, 406, 547 Flags: Print Destination: 3003 Annotation: Subtype: Link Contents: Rect: 535, 217, 557, 224 Flags: Print Annotation: Subtype: Link Contents: Rect: 422, 208, 553, 215 Flags: Print Annotation: Subtype: Link Contents: Rect: 339, 115, 342, 123 Flags: Print Destination: 21 Annotation: Subtype: Link Contents: Rect: 336, 105, 340, 113 Flags: Print Destination: 21 Annotation: Subtype: Link Contents: Rect: 133, 564, 133, 566 Flags: Print Annotation: Subtype: Link Contents: Rect: 171, 570, 175, 575 Flags: Print Destination: 3003 Annotation: Subtype: Link Contents: Rect: 288, 564, 288, 566 Flags: Print Annotation: Subtype: Link Contents: Rect: 135, 551, 135, 553 Flags: Print Annotation: Subtype: Link Contents: Rect: 281, 551, 281, 553 Flags: Print Annotation: Subtype: Link Contents: Rect: 406, 551, 406, 553 Flags: Print Annotation: Subtype: Link Contents: Rect: 163, 538, 163, 540 Flags: Print Annotation: Subtype: Link Contents: Rect: 338, 538, 338, 540 Flags: Print Annotation: Subtype: Link Contents: Rect: 97, 77, 186, 83 Flags: Print Annotation: Subtype: Link Contents: Rect: 501, 586, 529, 615 Flags: Print Annotation: Subtype: Link Contents: Rect: 222, 651, 366, 661 Flags: Print Annotation: Subtype: Link Contents: Rect: 37, 686, 59, 686 Flags: Print Annotation: Subtype: Link Contents: Rect: 37, 58, 168, 65 Flags: Print Annotation: Subtype: Link Contents: Rect: 369, 50, 505, 56 Flags: Print Annotation: Subtype: Link Contents: Rect: 237, 739, 358, 745 Flags: Print Page: Label: 1531 Sequence: 2 Annotations: Annotation: Subtype: Link Contents: Rect: 67, 719, 71, 727 Flags: Print Destination: 21 Annotation: Subtype: Link Contents: Rect: 229, 719, 233, 727 Flags: Print Destination: 21 Annotation: Subtype: Link Contents: Rect: 178, 686, 182, 694 Flags: Print Destination: 21 Annotation: Subtype: Link Contents: Rect: 54, 676, 57, 684 Flags: Print Destination: 21 Annotation: Subtype: Link Contents: Rect: 252, 665, 256, 673 Flags: Print Destination: 21 Annotation: Subtype: Link Contents: Rect: 261, 643, 265, 651 Flags: Print Destination: 21 Annotation: Subtype: Link Contents: Rect: 266, 643, 270, 651 Flags: Print Destination: 21 Annotation: Subtype: Link Contents: Rect: 174, 633, 177, 640 Flags: Print Destination: 21 Annotation: Subtype: Link Contents: Rect: 237, 579, 243, 587 Flags: Print Destination: 21 Annotation: Subtype: Link Contents: Rect: 120, 503, 126, 511 Flags: Print Destination: 21 Annotation: Subtype: Link Contents: Rect: 104, 493, 111, 501 Flags: Print Destination: 21 Annotation: Subtype: Link Contents: Rect: 282, 439, 288, 447 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 85, 331, 101, 339 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 61, 300, 67, 308 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 281, 258, 288, 266 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 132, 237, 138, 245 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 282, 153, 288, 161 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 332, 369, 339, 377 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 532, 285, 539, 293 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 550, 225, 557, 233 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 525, 215, 531, 222 Flags: Print Destination: 24 Page: Label: 1532 Sequence: 3 Annotations: Annotation: Subtype: Link Contents: Rect: 272, 578, 279, 586 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 253, 568, 281, 576 Flags: Print Destination: 4 Annotation: Subtype: Link Contents: Rect: 282, 568, 288, 576 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 196, 547, 283, 555 Flags: Print Destination: null Annotation: Subtype: Link Contents: Rect: 40, 472, 68, 480 Flags: Print Destination: 4 Annotation: Subtype: Link Contents: Rect: 40, 177, 69, 185 Flags: Print Destination: 8 Annotation: Subtype: Link Contents: Rect: 74, 177, 90, 185 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 165, 135, 172, 143 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 530, 708, 538, 716 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 515, 457, 522, 465 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 525, 384, 552, 392 Flags: Print Destination: 8 Annotation: Subtype: Link Contents: Rect: 309, 185, 337, 193 Flags: Print Destination: 12 Annotation: Subtype: Link Contents: Rect: 341, 185, 433, 193 Flags: Print Destination: null Annotation: Subtype: Link Contents: Rect: 452, 185, 457, 193 Flags: Print Destination: null Annotation: Subtype: Link Contents: Rect: 400, 164, 411, 172 Flags: Print Destination: 12 Annotation: Subtype: Link Contents: Rect: 186, 712, 192, 718 Flags: Print Destination: 24 Page: Label: 1533 Sequence: 4 Annotations: Annotation: Subtype: Link Contents: Rect: 365, 65, 393, 73 Flags: Print Destination: 17 Annotation: Subtype: Link Contents: Rect: 528, 677, 534, 683 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 528, 667, 534, 674 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 514, 658, 519, 664 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 514, 648, 519, 655 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 505, 639, 510, 645 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 503, 630, 509, 636 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 499, 620, 505, 626 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 499, 611, 505, 617 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 499, 601, 504, 608 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 500, 592, 506, 598 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 500, 582, 506, 589 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 493, 564, 499, 570 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 493, 554, 499, 561 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 493, 545, 499, 551 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 493, 535, 499, 542 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 493, 526, 499, 532 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 493, 517, 499, 523 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 488, 498, 494, 504 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 494, 488, 500, 495 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 494, 479, 500, 485 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 489, 469, 495, 476 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 489, 460, 495, 466 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 500, 441, 506, 448 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 500, 432, 506, 438 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 508, 422, 514, 429 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 508, 413, 514, 419 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 499, 394, 504, 400 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 499, 385, 504, 391 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 499, 375, 504, 382 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 499, 366, 504, 372 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 499, 356, 504, 363 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 499, 347, 504, 353 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 499, 338, 504, 344 Flags: Print Destination: 24 Page: Label: 1534 Sequence: 5 Annotations: Annotation: Subtype: Link Contents: Rect: 484, 565, 486, 572 Flags: Print Destination: 12 Page: Label: 1535 Sequence: 6 Annotations: Annotation: Subtype: Link Contents: Rect: 123, 384, 130, 392 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 131, 384, 148, 392 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 57, 374, 63, 382 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 65, 374, 71, 382 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 225, 311, 232, 319 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 139, 91, 146, 99 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 264, 91, 271, 99 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 272, 91, 288, 99 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 134, 81, 142, 89 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 143, 81, 150, 89 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 106, 70, 114, 78 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 115, 70, 122, 78 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 335, 395, 341, 403 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 342, 395, 350, 403 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 535, 321, 542, 329 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 346, 164, 353, 172 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 393, 123, 400, 131 Flags: Print Destination: 24 Page: Label: 1536 Sequence: 7 Annotations: Annotation: Subtype: Link Contents: Rect: 181, 645, 188, 653 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 123, 604, 130, 612 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 229, 551, 236, 559 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 58, 520, 65, 528 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 136, 520, 143, 528 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 247, 468, 254, 475 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 172, 447, 179, 455 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 273, 394, 280, 402 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 281, 394, 288, 402 Flags: Print Destination: 24 Annotation: Subtype: Link Contents: Rect: 319, 368, 557, 375 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 360, 557, 367 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 352, 491, 359 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 344, 557, 351 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 336, 557, 343 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 328, 489, 335 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 320, 557, 327 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 313, 557, 319 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 305, 378, 311 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 297, 557, 303 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 289, 557, 295 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 281, 557, 287 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 273, 388, 279 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 265, 557, 271 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 257, 557, 263 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 249, 557, 255 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 241, 395, 247 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 233, 557, 239 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 225, 557, 231 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 217, 557, 223 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 209, 358, 215 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 201, 557, 207 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 193, 557, 199 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 185, 557, 191 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 177, 490, 183 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 169, 557, 175 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 161, 557, 167 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 153, 557, 159 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 145, 339, 152 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 137, 557, 144 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 129, 526, 136 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 121, 557, 128 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 113, 557, 120 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 105, 496, 112 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 97, 557, 104 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 89, 557, 96 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 81, 557, 88 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 73, 335, 80 Flags: Print Annotation: Subtype: Link Contents: Rect: 459, 50, 557, 56 Flags: Print Page: Label: 1537 Sequence: 8 Annotations: Annotation: Subtype: Link Contents: Rect: 50, 720, 287, 727 Flags: Print Annotation: Subtype: Link Contents: Rect: 50, 712, 103, 719 Flags: Print Annotation: Subtype: Link Contents: Rect: 50, 704, 288, 711 Flags: Print Annotation: Subtype: Link Contents: Rect: 50, 696, 288, 703 Flags: Print Annotation: Subtype: Link Contents: Rect: 50, 688, 126, 695 Flags: Print Annotation: Subtype: Link Contents: Rect: 50, 680, 288, 687 Flags: Print Annotation: Subtype: Link Contents: Rect: 50, 672, 288, 679 Flags: Print Annotation: Subtype: Link Contents: Rect: 50, 664, 288, 671 Flags: Print Annotation: Subtype: Link Contents: Rect: 50, 656, 288, 663 Flags: Print Annotation: Subtype: Link Contents: Rect: 50, 648, 270, 655 Flags: Print Annotation: Subtype: Link Contents: Rect: 50, 640, 288, 647 Flags: Print Annotation: Subtype: Link Contents: Rect: 50, 632, 288, 639 Flags: Print Annotation: Subtype: Link Contents: Rect: 50, 625, 78, 631 Flags: Print Annotation: Subtype: Link Contents: Rect: 50, 617, 288, 623 Flags: Print Annotation: Subtype: Link Contents: Rect: 50, 609, 288, 615 Flags: Print Annotation: Subtype: Link Contents: Rect: 50, 601, 288, 607 Flags: Print Annotation: Subtype: Link Contents: Rect: 50, 593, 209, 599 Flags: Print Annotation: Subtype: Link Contents: Rect: 50, 585, 288, 591 Flags: Print Annotation: Subtype: Link Contents: Rect: 50, 577, 288, 583 Flags: Print Annotation: Subtype: Link Contents: Rect: 50, 569, 288, 575 Flags: Print Annotation: Subtype: Link Contents: Rect: 50, 561, 288, 567 Flags: Print Annotation: Subtype: Link Contents: Rect: 50, 553, 119, 559 Flags: Print Annotation: Subtype: Link Contents: Rect: 50, 545, 288, 551 Flags: Print Annotation: Subtype: Link Contents: Rect: 50, 537, 288, 543 Flags: Print Annotation: Subtype: Link Contents: Rect: 50, 529, 288, 535 Flags: Print Annotation: Subtype: Link Contents: Rect: 50, 521, 93, 527 Flags: Print Annotation: Subtype: Link Contents: Rect: 50, 513, 288, 519 Flags: Print Annotation: Subtype: Link Contents: Rect: 50, 505, 288, 511 Flags: Print Annotation: Subtype: Link Contents: Rect: 50, 497, 191, 503 Flags: Print Annotation: Subtype: Link Contents: Rect: 50, 489, 288, 495 Flags: Print Annotation: Subtype: Link Contents: Rect: 50, 481, 241, 487 Flags: Print Annotation: Subtype: Link Contents: Rect: 50, 473, 288, 479 Flags: Print Annotation: Subtype: Link Contents: Rect: 50, 465, 288, 472 Flags: Print Annotation: Subtype: Link Contents: Rect: 50, 457, 109, 464 Flags: Print Annotation: Subtype: Link Contents: Rect: 50, 449, 288, 456 Flags: Print Annotation: Subtype: Link Contents: Rect: 50, 441, 288, 448 Flags: Print Annotation: Subtype: Link Contents: Rect: 50, 433, 157, 440 Flags: Print Annotation: Subtype: Link Contents: Rect: 50, 425, 288, 432 Flags: Print Annotation: Subtype: Link Contents: Rect: 50, 417, 288, 424 Flags: Print Annotation: Subtype: Link Contents: Rect: 50, 409, 288, 416 Flags: Print Annotation: Subtype: Link Contents: Rect: 50, 401, 128, 408 Flags: Print Annotation: Subtype: Link Contents: Rect: 50, 393, 288, 400 Flags: Print Annotation: Subtype: Link Contents: Rect: 50, 385, 288, 392 Flags: Print Annotation: Subtype: Link Contents: Rect: 50, 377, 288, 384 Flags: Print Annotation: Subtype: Link Contents: Rect: 50, 369, 115, 376 Flags: Print Annotation: Subtype: Link Contents: Rect: 50, 362, 288, 368 Flags: Print Annotation: Subtype: Link Contents: Rect: 50, 354, 288, 360 Flags: Print Annotation: Subtype: Link Contents: Rect: 50, 346, 169, 352 Flags: Print Annotation: Subtype: Link Contents: Rect: 50, 338, 288, 344 Flags: Print Annotation: Subtype: Link Contents: Rect: 50, 330, 288, 336 Flags: Print Annotation: Subtype: Link Contents: Rect: 50, 322, 276, 328 Flags: Print Annotation: Subtype: Link Contents: Rect: 50, 314, 288, 320 Flags: Print Annotation: Subtype: Link Contents: Rect: 50, 306, 288, 312 Flags: Print Annotation: Subtype: Link Contents: Rect: 50, 298, 172, 304 Flags: Print Annotation: Subtype: Link Contents: Rect: 50, 290, 288, 296 Flags: Print Annotation: Subtype: Link Contents: Rect: 50, 282, 288, 288 Flags: Print Annotation: Subtype: Link Contents: Rect: 50, 274, 161, 280 Flags: Print Annotation: Subtype: Link Contents: Rect: 50, 266, 288, 272 Flags: Print Annotation: Subtype: Link Contents: Rect: 50, 258, 288, 264 Flags: Print Annotation: Subtype: Link Contents: Rect: 50, 250, 253, 256 Flags: Print Annotation: Subtype: Link Contents: Rect: 50, 242, 288, 248 Flags: Print Annotation: Subtype: Link Contents: Rect: 50, 234, 288, 240 Flags: Print Annotation: Subtype: Link Contents: Rect: 50, 226, 126, 232 Flags: Print Annotation: Subtype: Link Contents: Rect: 50, 210, 159, 216 Flags: Print Annotation: Subtype: Link Contents: Rect: 50, 202, 288, 208 Flags: Print Annotation: Subtype: Link Contents: Rect: 50, 194, 288, 201 Flags: Print Annotation: Subtype: Link Contents: Rect: 50, 186, 288, 193 Flags: Print Annotation: Subtype: Link Contents: Rect: 50, 178, 115, 185 Flags: Print Annotation: Subtype: Link Contents: Rect: 534, 720, 557, 727 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 712, 522, 719 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 696, 557, 703 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 688, 557, 695 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 680, 358, 687 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 672, 557, 679 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 664, 557, 671 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 656, 347, 663 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 648, 557, 655 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 640, 469, 647 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 632, 557, 639 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 625, 557, 631 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 617, 404, 623 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 609, 557, 615 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 601, 557, 607 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 593, 557, 599 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 585, 425, 591 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 577, 557, 583 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 569, 557, 575 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 561, 384, 567 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 553, 557, 559 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 545, 557, 551 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 537, 557, 543 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 529, 395, 535 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 521, 557, 527 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 513, 557, 519 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 505, 557, 511 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 497, 557, 503 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 489, 395, 495 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 481, 557, 487 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 473, 557, 479 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 465, 557, 472 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 457, 384, 464 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 449, 557, 456 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 441, 557, 448 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 433, 557, 440 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 425, 347, 432 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 417, 557, 424 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 409, 557, 416 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 401, 557, 408 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 393, 370, 400 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 385, 557, 392 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 377, 557, 384 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 369, 557, 376 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 362, 384, 368 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 354, 557, 360 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 346, 557, 352 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 338, 347, 344 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 330, 557, 336 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 322, 557, 328 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 314, 473, 320 Flags: Print Annotation: Subtype: Link Contents: Rect: 395, 282, 557, 288 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 274, 348, 280 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 266, 557, 272 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 258, 557, 264 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 250, 557, 256 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 242, 348, 248 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 234, 557, 240 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 226, 557, 232 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 218, 441, 224 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 210, 557, 216 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 202, 544, 208 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 194, 557, 201 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 186, 557, 193 Flags: Print Annotation: Subtype: Link Contents: Rect: 319, 178, 363, 185 Flags: Print Checksum: ee41e223 Type: CRC32 Checksum: a8a6ab0b5310f18ef6a0551180342827 Type: MD5 Checksum: 7468d3e0cd45aa98850a1948e4132f40d9aaeb87 Type: SHA-1 Checksum: e2ea0b28b84334339ab271a449856247dc6174b696c12f27a30c5ae1f0309e5e Type: SHA-256