95f586297f2866d0ea8d40e7927f52cd 329544.pdf 82426d497b3eee7e2b43e26b99cec643da74309f 329544.pdf 2aef6c7888a8d1094d2a8e2f00767c46ea9458a09473750ef497c7cb84c9faf1 329544.pdf Title: Associations of lifestyle factors with amyloid pathology in persons without dementia Author: Julie E OomensConceptualizationData curationFormal analysisInvestigationMethodologyProject administrationValidationVisualizationWriting – original draftWriting – review & editing, Nancy N MaserejianMethodologyWriting – review & editing, Mercè BoadaInvestigationResourcesWriting – review & editing, Mira DidicInvestigationResourcesWriting – review & editing, Sebastiaan EngelborghsInvestigationResourcesWriting – review & editing, Tormod FladbyInvestigationResourcesWriting – review & editing, Wiesje M van der FlierInvestigationResourcesWriting – review & editing, Giovanni B FrisoniInvestigationResourcesWriting – review & editing, Lutz FröhlichInvestigationResourcesWriting – review & editing, Kiran Dip 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ZetterbergInvestigationResourcesWriting – review & editing, Daniel Alcolea, Ricardo F Allegri, Daniele Altomare, Randall J Bateman, Simone Baiardi, Ines Baldeiras, Kaj Blennow, Anouk den Braber, Mark A van Buchem, Min Soo Byun, Jiří Cerman, Kewei Chen, Elena Chipi, Gregory S Day, Alexander Drzezga, Laura L Ekblad, Stefan Förster, Juan Fortea, Yvonne Freund-Levi, Lars Frings, Eric GuedjInvestigationResourcesWriting – review & editing, Christian G Habeck, Ron Handels, Lucrezia Hausner, Sabine Hellwig, Julio F Jiménez-Bonilla, Ane Iriondo Juaristi, Ramesh Kandimalla, Silke Kern, Bjørn-Eivind S Bordewick Kirsebom, Johannes Kornhuber, Nienke Legdeur, Johannes Levin, Wolfgang Maier, Marta Marquié, Shinobu Minatani, Silvia Daniela Morbelli, Barbara Mroczko, Eva Ntanasi, Catarina Resende de Oliveira, Adelina Orellana, Oliver Peters, Sudesh Prabhakar, Inez H Ramakers, Eloy Rodríguez-Rodriguez, Agustín Ruiz, Eckart Rüther, Jayant Sakhardande, Per Selnes, Dina Silva, Hilkka Soininen, Luiza Spiru, Akitoshi Takeda, Charlotte E Teunissen, Betty M Tijms, Lisa Vermunt, Åsa K Wallin, Wietse Wiels, Mary Yannakoulia, Dahyun Yi, Anna Zettergren, for the Alzheimer's Disease Neuroimaging Initiative (ADNI), A4 Study group, Dominantly Inherited Alzheimer Network (DIAN), European Prevention of Alzheimer's Dementia (EPAD) consortium, Fundació ACE Healthy Brain Initiative (FACEHBI), Japan Alzheimer's Disease Neuroimaging Initiative (J-ADNI), Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's Disease (KBASE), Presymptomatic Evaluation of Experimental or Novel Treatments for Alzheimer's Disease (PREVENT-AD) research group, Rik OssenkoppeleInvestigationResourcesWriting – review & editing, Frans RJ VerheyInvestigationResourcesWriting – review & editing, Pieter Jelle VisserConceptualizationData curationMethodologySupervisionWriting – review & editing, Willemijn J JansenConceptualizationFunding acquisitionMethodologyProject 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secsection2D4-13872877251379083 Item: Title: Cognitive activity Destination: secsection2D5-13872877251379083 Item: Title: Social activity Destination: secsection2D6-13872877251379083 Item: Title: Other covariates Destination: secsection2E-13872877251379083 Item: Title: Statistical analysis Destination: secsection2F-13872877251379083 Item: Title: Results Destination: secsection3-13872877251379083 Children: Item: Title: Participant characteristics Destination: secsection3A-13872877251379083 Item: Title: Associations between dichotomous lifestyle factors and amyloid pathology Destination: secsection3B-13872877251379083 Children: Item: Title: Individuals with NC Destination: secsection3B1-13872877251379083 Item: Title: Individuals with MCI Destination: secsection3B2-13872877251379083 Item: Title: Associations of continuous lifestyle factors with amyloid pathology Destination: secsection3C-13872877251379083 Children: Item: Title: Individuals with NC Destination: secsection3C1-13872877251379083 Item: Title: Individuals with MCI Destination: secsection4-13872877251379083 Item: Title: Discussion Destination: secsection5-13872877251379083 Children: Item: Title: Alcohol consumption and smoking behavior Destination: secsection5A-13872877251379083 Item: Title: Sleep duration and quality Destination: secsection5B-13872877251379083 Item: Title: Cognitive activity Destination: secsection5C-13872877251379083 Item: Title: Physical activity Destination: secsection5D-13872877251379083 Item: Title: Social activity Destination: secsection5E-13872877251379083 Item: Title: Harmonization of lifestyle data Destination: secsection5F-13872877251379083 Item: Title: Strengths and limitations Destination: secsection5G-13872877251379083 Item: Title: Conclusion Destination: secsection5H-13872877251379083 Item: Title: Acknowledgements Destination: acknow Item: Title: References Destination: reflist Info: Title: Associations of lifestyle factors with amyloid pathology in persons without dementia Author: Julie E OomensConceptualizationData curationFormal analysisInvestigationMethodologyProject administrationValidationVisualizationWriting   original draftWriting   review & editing, Nancy N MaserejianMethodologyWriting   review & editing, Mercè BoadaInvestigationResourcesWriting   review & editing, Mira DidicInvestigationResourcesWriting   review & editing, Sebastiaan EngelborghsInvestigationResourcesWriting   review & editing, Tormod FladbyInvestigationResourcesWriting   review & editing, Wiesje M van der FlierInvestigationResourcesWriting   review & editing, Giovanni B FrisoniInvestigationResourcesWriting   review & editing, Lutz FröhlichInvestigationResourcesWriting   review & editing, Kiran Dip GillInvestigationResourcesWriting   review & editing, Timo GrimmerInvestigationResourcesWriting   review & editing, Jakub HortInvestigationResourcesWriting   review & editing, Yoshiaki ItohInvestigationResourcesWriting   review & editing, Takeshi IwatsuboInvestigationResourcesWriting   review & editing, Aleksandra Klimkowicz-MrowiecInvestigationResourcesWriting   review & editing, Susan M LandauInvestigationResourcesWriting   review & editing, Dong Young LeeInvestigationResourcesWriting   review & editing, Alberto LleóInvestigationResourcesWriting   review & editing, Pablo Martinez-LageInvestigationResourcesWriting   review & editing, Alexandre de MendonçaInvestigationResourcesWriting   review & editing, Philipp T MeyerInvestigationResourcesWriting   review & editing, Piero ParchiInvestigationResourcesWriting   review & editing, Matteo PardiniInvestigationResourcesWriting   review & editing, Lucilla ParnettiInvestigationResourcesWriting   review & editing, Julius PoppInvestigationResourcesWriting   review & editing, Lorena RamiInvestigationResourcesWriting   review & editing, Eric M ReimanInvestigationResourcesWriting   review & editing, Juha O RinneInvestigationResourcesWriting   review & editing, Karen M 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Alexander Drzezga, Laura L Ekblad, Stefan Förster, Juan Fortea, Yvonne Freund-Levi, Lars Frings, Eric GuedjInvestigationResourcesWriting   review & editing, Christian G Habeck, Ron Handels, Lucrezia Hausner, Sabine Hellwig, Julio F Jiménez-Bonilla, Ane Iriondo Juaristi, Ramesh Kandimalla, Silke Kern, Bjørn-Eivind S Bordewick Kirsebom, Johannes Kornhuber, Nienke Legdeur, Johannes Levin, Wolfgang Maier, Marta Marquié, Shinobu Minatani, Silvia Daniela Morbelli, Barbara Mroczko, Eva Ntanasi, Catarina Resende de Oliveira, Adelina Orellana, Oliver Peters, Sudesh Prabhakar, Inez H Ramakers, Eloy Rodríguez-Rodriguez, Agustín Ruiz, Eckart Rüther, Jayant Sakhardande, Per Selnes, Dina Silva, Hilkka Soininen, Luiza Spiru, Akitoshi Takeda, Charlotte E Teunissen, Betty M Tijms, Lisa Vermunt, Åsa K Wallin, Wietse Wiels, Mary Yannakoulia, Dahyun Yi, Anna Zettergren, for the Alzheimer's Disease Neuroimaging Initiative (ADNI), A4 Study group, Dominantly Inherited Alzheimer Network (DIAN), European Prevention of Alzheimer's Dementia (EPAD) consortium, Fundació ACE Healthy Brain Initiative (FACEHBI), Japan Alzheimer's Disease Neuroimaging Initiative (J-ADNI), Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's Disease (KBASE), Presymptomatic Evaluation of Experimental or Novel Treatments for Alzheimer's Disease (PREVENT-AD) research group, Rik OssenkoppeleInvestigationResourcesWriting   review & editing, Frans RJ VerheyInvestigationResourcesWriting   review & editing, Pieter Jelle VisserConceptualizationData curationMethodologySupervisionWriting   review & editing, Willemijn J JansenConceptualizationFunding acquisitionMethodologyProject administrationSupervisionValidationVisualizationWriting   review & editing Creator: Arbortext Advanced Print Publisher 10.0.1465/W Unicode Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Thu Nov 20 13:22:33 CET 2025 ModDate: Thu Nov 20 13:22:33 CET 2025 ID: 0x201983651df50bbe7fa4e1dc0829c960, 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editing, Giovanni B FrisoniInvestigationResourcesWriting – review & editing, Lutz FröhlichInvestigationResourcesWriting – review & editing, Kiran Dip GillInvestigationResourcesWriting – review & editing, Timo GrimmerInvestigationResourcesWriting – review & editing, Jakub HortInvestigationResourcesWriting – review & editing, Yoshiaki ItohInvestigationResourcesWriting – review & editing, Takeshi IwatsuboInvestigationResourcesWriting – review & editing, Aleksandra Klimkowicz-MrowiecInvestigationResourcesWriting – review & editing, Susan M LandauInvestigationResourcesWriting – review & editing, Dong Young LeeInvestigationResourcesWriting – review & editing, Alberto LleóInvestigationResourcesWriting – review & editing, Pablo Martinez-LageInvestigationResourcesWriting – review & editing, Alexandre de MendonçaInvestigationResourcesWriting – review & editing, Philipp T MeyerInvestigationResourcesWriting – review & editing, Piero ParchiInvestigationResourcesWriting – review & editing, Matteo PardiniInvestigationResourcesWriting – review & editing, Lucilla ParnettiInvestigationResourcesWriting – review & editing, Julius PoppInvestigationResourcesWriting – review & editing, Lorena RamiInvestigationResourcesWriting – review & editing, Eric M ReimanInvestigationResourcesWriting – review & editing, Juha O RinneInvestigationResourcesWriting – review & editing, Karen M RodrigueInvestigationResourcesWriting – review & editing, Pascual Sánchez-JuanInvestigationResourcesWriting – review & editing, Isabel SantanaInvestigationResourcesWriting – review & editing, Nikolaos ScarmeasInvestigationResourcesWriting – review & editing, Philip ScheltensInvestigationResourcesWriting – review & editing, Ingmar SkoogInvestigationResourcesWriting – review & editing, Reisa A SperlingInvestigationResourcesWriting – review & editing, Yaakov SternInvestigationResourcesWriting – review & editing, Sylvia VilleneuveInvestigationResourcesWriting – review & editing, Gunhild WaldemarInvestigationResourcesWriting – review & editing, Jens WiltfangInvestigationResourcesWriting – review & editing, Henrik ZetterbergInvestigationResourcesWriting – review & editing, Daniel Alcolea, Ricardo F Allegri, Daniele Altomare, Randall J Bateman, Simone Baiardi, Ines Baldeiras, Kaj Blennow, Anouk den Braber, Mark A van Buchem, Min Soo Byun, Jiří Cerman, Kewei Chen, Elena Chipi, Gregory S Day, Alexander Drzezga, Laura L Ekblad, Stefan Förster, Juan Fortea, Yvonne Freund-Levi, Lars Frings, Eric GuedjInvestigationResourcesWriting – review & editing, Christian G Habeck, Ron Handels, Lucrezia Hausner, Sabine Hellwig, Julio F Jiménez-Bonilla, Ane Iriondo Juaristi, Ramesh Kandimalla, Silke Kern, Bjørn-Eivind S Bordewick Kirsebom, Johannes Kornhuber, Nienke Legdeur, Johannes Levin, Wolfgang Maier, Marta Marquié, Shinobu Minatani, Silvia Daniela Morbelli, Barbara Mroczko, Eva Ntanasi, Catarina Resende de Oliveira, Adelina Orellana, Oliver Peters, Sudesh Prabhakar, Inez H Ramakers, 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