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Prof Dominik Paul Modest MD Subject: Lancet Oncology, 26 (2025) 1240-1251. doi:10.1016/S1470-2045(25)00352-3 Keywords: Creator: Elsevier Producer: Acrobat Distiller 6.0 for Windows CreationDate: Sun Aug 17 01:55:03 CEST 2025 ModDate: Sat Aug 30 08:16:42 CEST 2025 ID: 0xc0f71449dcda23468732fc217f5e452b, 0xce583ea731fce645aa4a22cf37904ba1 Filters: FilterPipeline: FlateDecode Fonts: Type1: Font: BaseFont: VHKCMH+Shaker2Lancet-Regular FontSubset: true FirstChar: 1 LastChar: 173 FontDescriptor: FontName: VHKCMH+Shaker2Lancet-Regular Flags: Nonsymbolic FontBBox: -158, -241, 1019, 980 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: GCCWXC+Shaker2Lancet-Bold FontSubset: true FirstChar: 32 LastChar: 150 FontDescriptor: FontName: GCCWXC+Shaker2Lancet-Bold Flags: Nonsymbolic FontBBox: -164, -241, 1109, 981 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: VHKCMH+Shaker2Lancet-Regular FontSubset: true FirstChar: 32 LastChar: 124 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VHKCMH+Shaker2Lancet-Regular Flags: Nonsymbolic FontBBox: -158, -241, 1019, 980 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: GCCWXC+Shaker2Lancet-Bold FontSubset: true FirstChar: 1 LastChar: 173 FontDescriptor: FontName: GCCWXC+Shaker2Lancet-Bold Flags: Nonsymbolic FontBBox: -164, -241, 1109, 981 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true XMP: application/pdf doi:10.1016/S1470-2045(25)00352-3 Health-related quality of life in patients with KRASG12C-mutated chemorefractory metastatic colorectal cancer treated with sotorasib plus panitumumab or standard of care (CodeBreaK 300): results from a phase 3, randomised clinical trial Prof Dominik Paul Modest MD Prof Marwan Fakih MD Lisa Salvatore MD Taito Esaki MD David Páez Lopez-Bravo MD Julien Taieb MD PhD Michalis Karamouzis MD PhD Erika Ruiz-Garcia MD Tae Won Kim MD PhD Yasutoshi Kuboki MD Fausto Meriggi MD David Cunningham MD Kun-Huei Yeh MD PhD Chiara Cremolini MD PhD Qui Tran PhD Emily Chan MD PhD Joseph Chao MD Istvan Matyas Majer PhD Filippo Pietrantonio MD Lancet Oncology, 26 (2025) 1240-1251. doi:10.1016/S1470-2045(25)00352-3 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license journal Lancet Oncology Copyright © 2025 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license. 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