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Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 864 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Circulating tumor DNA in patients with cancer: insights from clinical laboratory Destination: flink1 Item: Title: Introduction Destination: flink2 Item: Title: Circulating DNA Destination: flink3 Children: Item: Title: Characteristics of blood-based ctDNA Destination: slink1 Item: Title: ctDNA in non-blood body fluids Destination: slink2 Item: Title: Preanalytical considerations of ctDNA analysis Destination: flink4 Children: Item: Title: Specimen types Destination: slink3 Item: Title: Blood collection and transport Destination: slink4 Item: Title: Plasma separation and quality control Destination: slink5 Item: Title: Plasma storage conditions Destination: slink6 Item: Title: Extraction methods of ctDNA Destination: slink7 Item: Title: Quality assessment and storage of ctDNA Destination: slink8 Item: Title: Analytical considerations of ctDNA analysis Destination: flink5 Children: Item: Title: Clonal hematopoiesis Destination: slink9 Item: Title: Germline variants Destination: slink10 Item: Title: External and internal QC Destination: slink11 Item: Title: Analytical validation Destination: slink12 Item: Title: Analytical limitations Destination: slink13 Item: Title: Methods for the analysis of gene variants in ctDNA Destination: flink6 Item: Title: Comprehensive interpretation of gene variant results in ctDNA assays Destination: flink7 Item: Title: Clinical applications of ctDNA Destination: flink8 Children: Item: Title: Currently recommended applications: advanced disease Destination: slink14 Item: Title: Potential applications Destination: slink15 Item: Title: Reporting of gene variants detected in ctDNA Destination: flink9 Item: Title: Future perspectives of ctDNA Destination: flink10 Item: Title: Conclusions Destination: 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