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     Item: 
      Title: Endocrine-disrupting chemicals exposure: cardiometabolic health risk in humans
      Children: 
       Item: 
        Title: Abstract
       Item: 
        Title: Introduction
       Item: 
        Title: Literature search and selection criteria
       Item: 
        Title: Identification of specific EDCs and their sources
        Children: 
         Item: 
          Title: Identification of EDCs
         Item: 
          Title: EDCs sources for human
       Item: 
        Title:  Mechanistic evidence on the role of EDCs in cardiometabolic disease
        Children: 
         Item: 
          Title: Proximal mechanisms of endocrine disruption
          Children: 
           Item: 
            Title: Activation of hormone receptors
           Item: 
            Title: Antagonism of hormone receptors
           Item: 
            Title: Alteration of hormone receptor expression
           Item: 
            Title: Disruption of hormone synthesis
           Item: 
            Title: Hormone mimicry
           Item: 
            Title: Hormone–EDC coupling reactions
           Item: 
            Title: Modification of hormone transport and degradation
           Item: 
            Title: Interference with receptor-mediated signal transduction
           Item: 
            Title: Alteration of hormone-producing or hormone-responsive cell fate
       Item: 
        Title: Intermediate events
        Children: 
         Item: 
          Title: Oxidative stress and inflammation
         Item: 
          Title: Insulin resistance
         Item: 
          Title: Epigenetic alterations
       Item: 
        Title: Organ-specific effects
       Item: 
        Title: Epidemiological evidence linking EDCs exposure and cardiometabolic disease
        Children: 
         Item: 
          Title: Obesity
          Children: 
           Item: 
            Title: Prenatal exposure to EDCs
           Item: 
            Title: Early childhood and adulthood exposure to EDCs
           Item: 
            Title: Characteristics of EDCs on obesity during life development
       Item: 
        Title: Type 2 diabetes mellitus
        Children: 
         Item: 
          Title: Phenols
         Item: 
          Title: Phthalate
         Item: 
          Title: Triclocarban
         Item: 
          Title: PFAS
         Item: 
          Title: Organochlorine and organophosphate pollutants
         Item: 
          Title: Flame retardants
         Item: 
          Title: Metals
       Item: 
        Title: Cardiovascular risk
        Children: 
         Item: 
          Title: Calcifications of the coronary and aortic arteries
         Item: 
          Title: Blood pressure
         Item: 
          Title: Blood lipids
         Item: 
          Title: Cardiometabolic risk in children
       Item: 
        Title: Opportunities for prevention
        Children: 
         Item: 
          Title: Health care & education
         Item: 
          Title: Lifestyle measures
         Item: 
          Title: Regulating EDCs
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        Title: Critical appraisal and future perspectives
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        Title: References
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