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Hinson Creator: Elsevier Producer: PDFlib+PDI 10.0.2p2 (C++/Win64) CreationDate: Tue Dec 2 14:14:02 2025 CET ModDate: Tue Dec 2 14:18:50 2025 CET Custom Metadata: yes Metadata Stream: yes Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 16 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 18081053 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MTPTGL+Shaker2Lancet-Bold Type 1C Custom yes yes yes 3223 0 GlyphLessFont CID TrueType Identity-H yes no yes 3225 0 XDOEJS+Shaker2Lancet-Italic Type 1C Custom yes yes yes 3229 0 QUSUNH+CM_Maths_Symbols Type 1C Builtin yes yes yes 3233 0 IRGQYC+Shaker2Lancet-Regular Type 1C Custom yes yes yes 3237 0 IOJPVI+ScalaLF-Bold CID TrueType Identity-H yes yes yes 3240 0 FQOTLS+ScalaLF-Regular CID TrueType Identity-H yes yes yes 3248 0 VDHOKS+ScalaLF-Italic CID TrueType Identity-H yes yes yes 3246 0 ZEFUGE+STIX-Regular Type 1C Custom yes yes yes 112 0 UDZRZO+Shaker-RBI CID TrueType Identity-H yes yes yes 182 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2026-08-01 05:18:45 CEST RepresentationInformation: 334592.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2026-07-31 13:51:38 CEST Size: 18081053 Format: PDF Version: 1.7 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ErrorMessage: Invalid indirect destination - referenced object 'appsec1' cannot be found ID: PDF-HUL-149 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'appsec1' cannot be found ID: PDF-HUL-122 Offset: 17997073 MIMEtype: application/pdf Profile: Linearized PDF, Tagged PDF PDFMetadata: Objects: 3384 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: true NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: Neural synaptic vesicle autoimmunity following aerosolized porcine neural tissue exposure: insights into autoimmune inflamm ... Destination: titlink1 Children: Item: Title: Introduction Destination: flink1 Item: Title: Methods Destination: flink2 Children: Item: Title: Ethics Destination: slink1 Item: Title: Study design and patient selection Destination: slink2 Item: Title: Phage immunoprecipitation sequencing (PhIP-Seq) Destination: slink3 Item: Title: Tissue immunofluorescence assay (TIFA) Destination: slink4 Item: Title: ELISAs Destination: slink5 Item: Title: Transfected cell-based assays Destination: slink6 Item: Title: Teased nerve and nodo-paranodal antibody assays Destination: slink7 Item: Title: Live rat hippocampal neuron assay Destination: slink8 Item: Title: Live induced human pluripotent stem cells (iPSC) derived sensory neuron assay Destination: slink9 Item: Title: Validation procedures Destination: slink10 Item: Title: Statistics Destination: slink11 Item: Title: Role of funders Destination: slink12 Item: Title: Results Destination: flink3 Children: Item: Title: Autoantigen identification Destination: slink13 Item: Title: Confirmation of synaptophysin- and GAP43-IgG specificities Destination: slink14 Item: Title: Idiopathic IPN patient IgG binds to live neurons and co-localises with synaptophysin Destination: slink15 Item: Title: Clinical, radiological and electrodiagnostic characteristics of seropositive patients with occupational inflammatory polyra ... Destination: slink16 Item: Title: Clinical, radiological and electrodiagnostic characteristics of synaptophysin-IgG seropositive patients with idiopathic inf ... Destination: slink17 Item: Title: Discussion Destination: flink4 Item: Title: ContributorsSRH and PG: Literature search, study design, figures, data collection, analysis and interpretation and manuscri ... Destination: blink1 Item: Title: Data sharing statementDeidentified participant data can be shared with qualified investigators on request to the correspond ... Destination: blink2 Item: Title: Declaration of interests Destination: blink3 Item: Title: Acknowledgements Destination: blink4 Item: Title: Appendix A. Supplementary data Destination: flink5 Item: Title: References Destination: blink5 Info: Title: Neural synaptic vesicle autoimmunity following aerosolized porcine neural tissue exposure: insights into autoimmune inflammatory polyradiculoneuropathy Author: Shannon R. Hinson Subject: eBioMedicine, 122 (2025) 106053. doi:10.1016/j.ebiom.2025.106053 Creator: Elsevier Producer: PDFlib+PDI 10.0.2p2 (C++/Win64) CreationDate: Tue Dec 02 14:44:02 CET 2025 ModDate: Tue Dec 02 14:48:50 CET 2025 ID: 0x36d8774be0af5c9a94a5708306789442, 0x58e139ffb3de4647b8b11d0f56db4381 Filters: FilterPipeline: FlateDecode Fonts: Type0: Font: BaseFont: FQOTLS+ScalaLF-Regular Encoding: Identity-H ToUnicode: true Font: BaseFont: UDZRZO+Shaker-RBI Encoding: Identity-H ToUnicode: true Font: BaseFont: IOJPVI+ScalaLF-Bold Encoding: Identity-H ToUnicode: true Font: BaseFont: GlyphLessFont Encoding: Identity-H ToUnicode: true Font: BaseFont: VDHOKS+ScalaLF-Italic Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: ZEFUGE+STIX-Regular FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: ZEFUGE+STIX-Regular Flags: Nonsymbolic FontBBox: -970, -486, 2208, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: QUSUNH+CM_Maths_Symbols FontSubset: true FirstChar: 1 LastChar: 138 FontDescriptor: FontName: QUSUNH+CM_Maths_Symbols Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: IRGQYC+Shaker2Lancet-Regular FontSubset: true FirstChar: 1 LastChar: 76 FontDescriptor: FontName: IRGQYC+Shaker2Lancet-Regular Flags: Nonsymbolic FontBBox: -158, -241, 1019, 980 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MTPTGL+Shaker2Lancet-Bold FontSubset: true FirstChar: 1 LastChar: 65 FontDescriptor: FontName: MTPTGL+Shaker2Lancet-Bold Flags: Nonsymbolic, ForceBold FontBBox: -164, -241, 1109, 981 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: XDOEJS+Shaker2Lancet-Italic FontSubset: true FirstChar: 1 LastChar: 48 FontDescriptor: FontName: XDOEJS+Shaker2Lancet-Italic Flags: Nonsymbolic, Italic FontBBox: -177, -241, 960, 980 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true CIDFontType2: Font: BaseFont: VDHOKS+ScalaLF-Italic CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: VDHOKS+ScalaLF-Italic Flags: Nonsymbolic FontBBox: -174, -256, 1200, 843 FontFile2: true Font: BaseFont: UDZRZO+Shaker-RBI CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: UDZRZO+Shaker-RBI Flags: Nonsymbolic, Italic FontBBox: -120, -245, 953, 837 FontFile2: true Font: BaseFont: GlyphLessFont CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: GlyphLessFont Flags: FixedPitch, Symbolic FontBBox: 0, 0, 500, 1000 FontFile2: true Font: BaseFont: IOJPVI+ScalaLF-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: IOJPVI+ScalaLF-Bold Flags: Nonsymbolic, ForceBold FontBBox: -62, -256, 1199, 892 FontFile2: true Font: BaseFont: FQOTLS+ScalaLF-Regular CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: FQOTLS+ScalaLF-Regular Flags: Nonsymbolic FontBBox: -64, -256, 1200, 870 FontFile2: true XMP: application/pdf doi:10.1016/j.ebiom.2025.106053 Neural synaptic vesicle autoimmunity following aerosolized porcine neural tissue exposure: insights into autoimmune inflammatory polyradiculoneuropathy Shannon R. Hinson Pranjal Gupta Naveen K. Paramasivan P. James B. Dyck Vanda A. Lennon Daniel H. Lachance Andrew M. Knight Mohamed Rezk Carley Karsten Reghann G. LaFrance-Corey Nathan P. Staff Sybil C. Hrstka Jack Wu Christopher J. Klein Anastasia Zekeridou Andrew McKeon Sean J. Pittock Cinta Lleixà Luis Querol Surendra Dasari John R. Mills Divyanshu Dubey Inflammatory polyradiculopathy Synaptophysin GAP-43 Porcine neural tissue Inhalational autoimmunity eBioMedicine, 122 (2025) 106053. doi:10.1016/j.ebiom.2025.106053 The Author(s) journal eBioMedicine © 2025 The Author(s). 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