0fbb1c737551cbd32007498e3a7c7e89  plaphy_a2025m10v199n2pkiaf420.pdf
6d466fb82b7246a5f7b3616ed440e406f8df26d7  plaphy_a2025m10v199n2pkiaf420.pdf
532843c303b83c08bb99d28ff3368ff82e7d1f43776332a77f301565b7bba1af  plaphy_a2025m10v199n2pkiaf420.pdf

Title:           Glycosylated sterols enhance cold tolerance in tomato via membrane stabilization and jasmonate signaling
Subject:         DOI: 10.1093/plphys/kiaf420; Plant Physiology, 199, 2, 2025-09-23.; Abstract: Free and glycosylated sterols play a central role in maintaining the structural integrity and proper functioning of the plasma membrane, which serves as the primary sensor of cold and initiates signaling cascades to mitigate chilling-induced damage. Here, we characterize the cold-response of tomato (Solanum lycopersicum cv. Micro-Tom) mutants with higher and lower ratios of glycosylated to free sterols than wild-type plants, resulting from the overexpression and silencing of the STEROL GLYCOSYLTRANSFERASES 1 and 2 (SlSGT2 and SlSGT1), respectively. The SlSGT2 overexpressing mutants show increased cold tolerance, membrane stability, and oxidative stress responses, while silencing of the SlSGT1 gene causes the opposite phenotypes. Furthermore, changes in the glycosylated to free sterols ratio activate distinct transcriptional programs that establish a preconditioned stress-responsive state under basal conditions and trigger a more efficient response to cold in the SlSGT2 overexpressing mutants, as well as compromise the capacity to withstand the effects of cold stress in the SlSGT1-silenced mutants. The SlSGT2 overexpressing mutants also contain higher levels of jasmonates under basal conditions and display enhanced biosynthesis of these hormones under cold stress compared to SlSGT1-silenced and control plants. The facilitating effect of elevated glycosylated to free sterols ratio on jasmonic acid (JA) biosynthesis and signaling leads to the activation of cold-responsive genes, including those of the CBF–COR pathway, antioxidant defenses, and polyamine biosynthesis. Our findings provide key insights into the mechanisms by which glycosylated sterols help improve cold tolerance in tomato.
Keywords:        
Author:          Cuiyun Deng
Creator:         Servigistics Arbortext Advanced Print Publisher 11.1.4546/W-x64
Producer:        PDFlib+PDI 9.0.7p3 (C++/Win64); modified using iTextSharp.LGPLv2.Core 3.7.4.0
CreationDate:    Fri Oct 10 08:33:57 2025 CEST
ModDate:         Wed Sep 16 15:56:51 2026 CEST
Custom Metadata: yes
Metadata Stream: yes
Tagged:          yes
UserProperties:  no
Suspects:        no
Form:            none
JavaScript:      no
Pages:           15
Encrypted:       no
Page size:       595.276 x 782.362 pts
Page rot:        0
File size:       3549723 bytes
Optimized:       no
PDF version:     1.6


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
POIXQZ+TimesNewRomanPSMT             CID TrueType      Identity-H       yes yes yes     98  0
EWGJMM+CaeciliaLTStd-LightItalic     Type 1C           Custom           yes yes yes     39  0
FNCZJA+CaeciliaLTStd-Light           Type 1C           Custom           yes yes yes     37  0
COSLZQ+CaeciliaLTStd-Bold            Type 1C           Custom           yes yes yes     36  0
XTFEVQ+CaeciliaLTStd-Heavy           Type 1C           Custom           yes yes yes     38  0
FGVSLO+ArialMT                       TrueType          WinAnsi          yes yes no       1  0
COUHEC+STIXGeneral-Regular           Type 1C           Custom           yes yes yes     40  0
Helvetica-Bold                       Type 1            Custom           no  no  no     100  0
Helvetica-Bold                       Type 1            Custom           no  no  no     110  0
Helvetica-Bold                       Type 1            Custom           no  no  no     129  0
Helvetica-Bold                       Type 1            Custom           no  no  no     144  0
Helvetica-Bold                       Type 1            Custom           no  no  no     160  0
Helvetica-Bold                       Type 1            Custom           no  no  no     193  0
Helvetica-Bold                       Type 1            Custom           no  no  no     252  0
DBFRCZ+TimesNewRomanPS-ItalicMT      CID TrueType      Identity-H       yes yes yes    286  0
IEKZHD+CaeciliaLTStd-BoldItalic      Type 1C           Custom           yes yes yes    287  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2026-09-17 04:14:01 CEST
 RepresentationInformation: plaphy_a2025m10v199n2pkiaf420.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2026-09-16 15:57:54 CEST
  Size: 3549723
  Format: PDF
  Version: 1.6
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  Profile: Tagged PDF
  PDFMetadata: 
   Objects: 1489
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: true
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: OneColumn
    PageMode: UseOutlines
    Language: en
    Outlines: 
     Item: 
      Title: Glycosylated sterols enhance cold tolerance in tomato via membrane stabilization and jasmonate signaling
      Destination: head1
      Children: 
       Item: 
        Title: Introduction
        Destination: seckiaf420-s1
       Item: 
        Title: Results
        Destination: seckiaf420-s2
        Children: 
         Item: 
          Title: Differential impact of contrasting membrane sterol profiles on tomato cold tolerance
          Destination: seckiaf420-s2.1
         Item: 
          Title: The imbalance of membrane sterols alters the response to cold-induced oxidative damage
          Destination: seckiaf420-s2.2
         Item: 
          Title: Transcriptome-wide analysis of SGT1ami and SGT2ox plants uncovers antagonistic acclimation states to cold treatment
          Destination: seckiaf420-s2.3
         Item: 
          Title: Membrane sterol imbalance alters polyamines and jasmonates levels
          Destination: seckiaf420-s2.4
       Item: 
        Title: Discussion
        Destination: seckiaf420-s3
       Item: 
        Title: Materials and methods
        Destination: seckiaf420-s4
        Children: 
         Item: 
          Title: Plant growth conditions and cold treatment
          Destination: seckiaf420-s4.1
          Children: 
           Item: 
            Title: Generation of transgenic lines overexpressing SlSGT2
            Destination: seckiaf420-s4.1.1
         Item: 
          Title: RNA isolation and quantitative real-time PCR analysis
          Destination: seckiaf420-s4.2
         Item: 
          Title: Sterol analysis
          Destination: seckiaf420-s4.3
         Item: 
          Title: Electrolyte leakage assay
          Destination: seckiaf420-s4.4
         Item: 
          Title: Chlorophyll content determination
          Destination: seckiaf420-s4.5
         Item: 
          Title: Maximum quantum efficiency of PSII (Fv/Fm)
          Destination: seckiaf420-s4.6
         Item: 
          Title: Histochemical detection of reactive oxygen Species (ROS)
          Destination: seckiaf420-s4.7
         Item: 
          Title: MDA quantification
          Destination: seckiaf420-s4.8
         Item: 
          Title: Enzyme activity assays
          Destination: seckiaf420-s4.9
         Item: 
          Title: Transcriptome profiling and analysis
          Destination: seckiaf420-s4.10
         Item: 
          Title: Quantification of jasmonates
          Destination: seckiaf420-s4.11
         Item: 
          Title: Polyamine analysis
          Destination: seckiaf420-s4.12
         Item: 
          Title: Statistical analysis
          Destination: seckiaf420-s4.13
         Item: 
          Title: Accession numbers
          Destination: seckiaf420-s4.14
       Item: 
        Title: Acknowledgments
        Destination: acknow
       Item: 
        Title: Author contributions
        Destination: seckiaf420-s5
       Item: 
        Title: Supplementary data
        Destination: seckiaf420-s6
       Item: 
        Title: Funding
        Destination: seckiaf420-s7
       Item: 
        Title: References
        Destination: reflist
   Info: 
    Title: Glycosylated sterols enhance cold tolerance in tomato via membrane stabilization and jasmonate signaling
    Author: Cuiyun Deng
    Subject: DOI: 10.1093/plphys/kiaf420; Plant Physiology, 199, 2, 2025-09-23.; Abstract: Free and glycosylated sterols play a central role in maintaining the structural integrity and proper functioning of the plasma membrane, which serves as the primary sensor of cold and initiates signaling cascades to mitigate chilling-induced damage. Here, we characterize the cold-response of tomato (Solanum lycopersicum cv. Micro-Tom) mutants with higher and lower ratios of glycosylated to free sterols than wild-type plants, resulting from the overexpression and silencing of the STEROL GLYCOSYLTRANSFERASES 1 and 2 (SlSGT2 and SlSGT1), respectively. The SlSGT2 overexpressing mutants show increased cold tolerance, membrane stability, and oxidative stress responses, while silencing of the SlSGT1 gene causes the opposite phenotypes. Furthermore, changes in the glycosylated to free sterols ratio activate distinct transcriptional programs that establish a preconditioned stress-responsive state under basal conditions and trigger a more efficient response to cold in the SlSGT2 overexpressing mutants, as well as compromise the capacity to withstand the effects of cold stress in the SlSGT1-silenced mutants. The SlSGT2 overexpressing mutants also contain higher levels of jasmonates under basal conditions and display enhanced biosynthesis of these hormones under cold stress compared to SlSGT1-silenced and control plants. The facilitating effect of elevated glycosylated to free sterols ratio on jasmonic acid (JA) biosynthesis and signaling leads to the activation of cold-responsive genes, including those of the CBF COR pathway, antioxidant defenses, and polyamine biosynthesis. Our findings provide key insights into the mechanisms by which glycosylated sterols help improve cold tolerance in tomato.
    Keywords: 
    Creator: Servigistics Arbortext Advanced Print Publisher 11.1.4546/W-x64
    Producer: PDFlib+PDI 9.0.7p3 (C++/Win64); modified using iTextSharp.LGPLv2.Core 3.7.4.0
    CreationDate: Fri Oct 10 09:03:57 CEST 2025
    ModDate: Wed Sep 16 15:56:51 CEST 2026
   ID: 0x32883b8e3ba8d0a598626adef2660c37, 0xe339147497103f8b67aab1b78ced2681
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 666
      ImageHeight: 751
      BitsPerSample: 8
      BitsPerSampleUnit: integer
   Fonts: 
    Type0: 
     Font: 
      BaseFont: POIXQZ+TimesNewRomanPSMT
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: DBFRCZ+TimesNewRomanPS-ItalicMT
      Encoding: Identity-H
      ToUnicode: true
    Type1: 
     Font: 
      BaseFont: COSLZQ+CaeciliaLTStd-Bold
      FontSubset: true
      FirstChar: 1
      LastChar: 62
      FontDescriptor: 
       FontName: COSLZQ+CaeciliaLTStd-Bold
       Flags: Nonsymbolic, ForceBold
       FontBBox: -166, -273, 1141, 938
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: FNCZJA+CaeciliaLTStd-Light
      FontSubset: true
      FirstChar: 1
      LastChar: 95
      FontDescriptor: 
       FontName: FNCZJA+CaeciliaLTStd-Light
       Flags: Nonsymbolic
       FontBBox: -164, -266, 1130, 908
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: XTFEVQ+CaeciliaLTStd-Heavy
      FontSubset: true
      FirstChar: 1
      LastChar: 30
      FontDescriptor: 
       FontName: XTFEVQ+CaeciliaLTStd-Heavy
       Flags: Nonsymbolic, ForceBold
       FontBBox: -170, -277, 1146, 970
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: EWGJMM+CaeciliaLTStd-LightItalic
      FontSubset: true
      FirstChar: 1
      LastChar: 65
      FontDescriptor: 
       FontName: EWGJMM+CaeciliaLTStd-LightItalic
       Flags: Nonsymbolic, Italic
       FontBBox: -166, -267, 1033, 909
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: COUHEC+STIXGeneral-Regular
      FontSubset: true
      FirstChar: 1
      LastChar: 10
      FontDescriptor: 
       FontName: COUHEC+STIXGeneral-Regular
       Flags: Nonsymbolic
       FontBBox: -995, -455, 2000, 1055
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: IEKZHD+CaeciliaLTStd-BoldItalic
      FontSubset: true
      FirstChar: 1
      LastChar: 5
      FontDescriptor: 
       FontName: IEKZHD+CaeciliaLTStd-BoldItalic
       Flags: Nonsymbolic, Italic, ForceBold
       FontBBox: -169, -273, 1082, 932
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
    TrueType: 
     Font: 
      BaseFont: FGVSLO+ArialMT
      FontSubset: true
      FirstChar: 32
      LastChar: 121
      FontDescriptor: 
       FontName: FGVSLO+ArialMT
       Flags: Nonsymbolic
       FontBBox: -664, -324, 2000, 1039
       FontFile2: true
      Encoding: WinAnsiEncoding
    CIDFontType2: 
     Font: 
      BaseFont: DBFRCZ+TimesNewRomanPS-ItalicMT
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: DBFRCZ+TimesNewRomanPS-ItalicMT
       Flags: Nonsymbolic, Italic
       FontBBox: -498, -307, 1333, 1023
       FontFile2: true
     Font: 
      BaseFont: POIXQZ+TimesNewRomanPSMT
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: POIXQZ+TimesNewRomanPSMT
       Flags: Nonsymbolic
       FontBBox: -568, -307, 2046, 1040
       FontFile2: true
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="Adobe XMP Core 5.4-c006 80.159825, 2016/09/16-03:31:08        ">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about="" xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/" xmlns:xmpRights="http://ns.adobe.com/xap/1.0/rights/" xmlns:pdf="http://ns.adobe.com/pdf/1.3/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/" xmlns:xmp="http://ns.adobe.com/xap/1.0/" xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/" xmlns:pdfuaid="http://www.aiim.org/pdfua/ns/id/" xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/" xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#" xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#">
         <xmpMM:InstanceID>uuid:d7a1beba-7a19-4272-af5e-522adc58190e</xmpMM:InstanceID>
         <xmpMM:DocumentID>uuid:D0DCE567-E528-9503-0A29-CC52890E62E1</xmpMM:DocumentID>
         <xmpRights:Marked>True</xmpRights:Marked>
         <pdf:Producer>PDFlib+PDI 9.0.7p3 (C++/Win64); modified using iTextSharp.LGPLv2.Core 3.7.4.0</pdf:Producer>
         <pdf:Keywords />
         <dc:format>application/pdf</dc:format>
         <dc:identifier>10.1093/plphys/kiaf420</dc:identifier>
         <dc:lang>en</dc:lang>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>Oxford University Press</rdf:li>
            </rdf:Bag>
         </dc:publisher>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Glycosylated sterols enhance cold tolerance in tomato via membrane stabilization and jasmonate signaling</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Cuiyun Deng</rdf:li>
               <rdf:li>Antoni Garcia-Molina</rdf:li>
               <rdf:li>Aurelio Gómez-Cadenas</rdf:li>
               <rdf:li>Vicente Vives-Peris</rdf:li>
               <rdf:li>Rubén Alcázar</rdf:li>
               <rdf:li>Albert Ferrer</rdf:li>
               <rdf:li>Teresa Altabella</rdf:li>
            </rdf:Seq>
         </dc:creator>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">DOI: 10.1093/plphys/kiaf420; Plant Physiology, 199, 2, 2025-09-23.; Abstract: Free and glycosylated sterols play a central role in maintaining the structural integrity and proper functioning of the plasma membrane, which serves as the primary sensor of cold and initiates signaling cascades to mitigate chilling-induced damage. Here, we characterize the cold-response of tomato (Solanum lycopersicum cv. Micro-Tom) mutants with higher and lower ratios of glycosylated to free sterols than wild-type plants, resulting from the overexpression and silencing of the STEROL GLYCOSYLTRANSFERASES 1 and 2 (SlSGT2 and SlSGT1), respectively. The SlSGT2 overexpressing mutants show increased cold tolerance, membrane stability, and oxidative stress responses, while silencing of the SlSGT1 gene causes the opposite phenotypes. Furthermore, changes in the glycosylated to free sterols ratio activate distinct transcriptional programs that establish a preconditioned stress-responsive state under basal conditions and trigger a more efficient response to cold in the SlSGT2 overexpressing mutants, as well as compromise the capacity to withstand the effects of cold stress in the SlSGT1-silenced mutants. The SlSGT2 overexpressing mutants also contain higher levels of jasmonates under basal conditions and display enhanced biosynthesis of these hormones under cold stress compared to SlSGT1-silenced and control plants. The facilitating effect of elevated glycosylated to free sterols ratio on jasmonic acid (JA) biosynthesis and signaling leads to the activation of cold-responsive genes, including those of the CBF–COR pathway, antioxidant defenses, and polyamine biosynthesis. Our findings provide key insights into the mechanisms by which glycosylated sterols help improve cold tolerance in tomato.</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:rights>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">© The Author(s) 2025. Published by Oxford University Press on behalf of American Society of Plant Biologists.</rdf:li>
            </rdf:Alt>
         </dc:rights>
         <prism:aggregationType>Journal</prism:aggregationType>
         <prism:publicationName>Plant Physiology</prism:publicationName>
         <prism:copyright>© The Author(s) 2025. Published by Oxford University Press on behalf of American Society of Plant Biologists.</prism:copyright>
         <prism:issn>0032-0889</prism:issn>
         <prism:elssn>1532-2548</prism:elssn>
         <prism:volume>199</prism:volume>
         <prism:number>2</prism:number>
         <prism:issueName />
         <prism:startingPage>1</prism:startingPage>
         <prism:endingPage>15</prism:endingPage>
         <prism:doi>10.1093/plphys/kiaf420</prism:doi>
         <prism:url>https://doi.org/10.1093/plphys/kiaf420</prism:url>
         <xmp:CreateDate>2025-10-10T12:03:57+05:30</xmp:CreateDate>
         <xmp:ModifyDate>2026-09-16T13:56:51+00:00</xmp:ModifyDate>
         <xmp:CreatorTool>Servigistics Arbortext Advanced Print Publisher 11.1.4546/W-x64</xmp:CreatorTool>
         <xmp:MetadataDate>2026-09-16T13:56:51+00:00</xmp:MetadataDate>
         <pdfx:EPSprocessor>PStill version 1.84.42</pdfx:EPSprocessor>
         <pdfuaid:part>1</pdfuaid:part>
         <pdfaExtension:schemas>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <pdfaSchema:schema>PDF/UA Universal Accessibility Schema</pdfaSchema:schema>
                  <pdfaSchema:namespaceURI>http://www.aiim.org/pdfua/ns/id/</pdfaSchema:namespaceURI>
                  <pdfaSchema:prefix>pdfuaid</pdfaSchema:prefix>
                  <pdfaSchema:property>
                     <rdf:Seq>
                        <rdf:li rdf:parseType="Resource">
                           <pdfaProperty:name>part</pdfaProperty:name>
                           <pdfaProperty:valueType>Integer</pdfaProperty:valueType>
                           <pdfaProperty:category>internal</pdfaProperty:category>
                           <pdfaProperty:description>Indicates, which part of ISO 14289 standard is followed</pdfaProperty:description>
                        </rdf:li>
                     </rdf:Seq>
                  </pdfaSchema:property>
               </rdf:li>
            </rdf:Bag>
         </pdfaExtension:schemas>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 98, 623, 102, 631
       Flags: Print
       Destination: 651
      Annotation: 
       Subtype: Link
       Rect: 102, 620, 112, 630
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 196, 623, 200, 631
       Flags: Print
       Destination: 651
      Annotation: 
       Subtype: Link
       Rect: 200, 620, 210, 630
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 304, 623, 307, 631
       Flags: Print
       Destination: 651
      Annotation: 
       Subtype: Link
       Rect: 307, 620, 317, 630
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 393, 623, 396, 631
       Flags: Print
       Destination: 651
      Annotation: 
       Subtype: Link
       Rect: 396, 620, 406, 630
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 465, 623, 468, 631
       Flags: Print
       Destination: 651
      Annotation: 
       Subtype: Link
       Rect: 468, 620, 478, 630
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 530, 623, 533, 631
       Flags: Print
       Destination: 651
      Annotation: 
       Subtype: Link
       Rect: 535, 623, 538, 631
       Flags: Print
       Destination: 651
      Annotation: 
       Subtype: Link
       Rect: 540, 620, 542, 627
       Flags: Print
       Destination: 651
      Annotation: 
       Subtype: Link
       Rect: 542, 620, 552, 630
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 109, 608, 112, 616
       Flags: Print
       Destination: 651
      Annotation: 
       Subtype: Link
       Rect: 114, 608, 117, 616
       Flags: Print
       Destination: 651
      Annotation: 
       Subtype: Link
       Rect: 119, 605, 121, 612
       Flags: Print
       Destination: 651
      Annotation: 
       Subtype: Link
       Rect: 121, 605, 131, 615
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 48, 591, 50, 597
       Flags: Print
       Destination: 651
      Annotation: 
       Subtype: Link
       Rect: 48, 573, 50, 579
       Flags: Print
       Destination: 651
      Annotation: 
       Subtype: Link
       Rect: 48, 564, 50, 570
       Flags: Print
       Destination: 651
      Annotation: 
       Subtype: Link
       Rect: 48, 555, 50, 561
       Flags: Print
       Destination: 651
      Annotation: 
       Subtype: Link
       Rect: 48, 546, 50, 552
       Flags: Print
       Destination: 651
      Annotation: 
       Subtype: Link
       Rect: 48, 534, 50, 540
       Flags: Print
       Destination: 651
      Annotation: 
       Subtype: Link
       Rect: 138, 534, 230, 540
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 251, 534, 353, 540
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 77, 516, 270, 522
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 145, 250, 244, 258
       Flags: Print
       Destination: 425
      Annotation: 
       Subtype: Link
       Rect: 397, 210, 459, 218
       Flags: Print
       Destination: 342
      Annotation: 
       Subtype: Link
       Rect: 351, 153, 433, 161
       Flags: Print
       Destination: 425
      Annotation: 
       Subtype: Link
       Rect: 459, 77, 552, 83
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 48, 67, 117, 74
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 419, 730, 552, 737
       Flags: Print
    Page: 
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 252, 721, 285, 728
       Flags: Print
       Destination: 342
      Annotation: 
       Subtype: Link
       Rect: 42, 710, 80, 717
       Flags: Print
       Destination: 342
      Annotation: 
       Subtype: Link
       Rect: 142, 677, 207, 684
       Flags: Print
       Destination: 342
      Annotation: 
       Subtype: Link
       Rect: 212, 677, 281, 684
       Flags: Print
       Destination: 342
      Annotation: 
       Subtype: Link
       Rect: 137, 666, 206, 673
       Flags: Print
       Destination: 425
      Annotation: 
       Subtype: Link
       Rect: 211, 666, 283, 673
       Flags: Print
       Destination: 342
      Annotation: 
       Subtype: Link
       Rect: 231, 655, 285, 662
       Flags: Print
       Destination: 425
      Annotation: 
       Subtype: Link
       Rect: 42, 644, 89, 651
       Flags: Print
       Destination: 425
      Annotation: 
       Subtype: Link
       Rect: 199, 611, 266, 618
       Flags: Print
       Destination: 342
      Annotation: 
       Subtype: Link
       Rect: 130, 578, 194, 585
       Flags: Print
       Destination: 425
      Annotation: 
       Subtype: Link
       Rect: 199, 578, 283, 585
       Flags: Print
       Destination: 425
      Annotation: 
       Subtype: Link
       Rect: 289, 578, 289, 585
       Flags: Print
       Destination: 342
      Annotation: 
       Subtype: Link
       Rect: 42, 567, 102, 574
       Flags: Print
       Destination: 342
      Annotation: 
       Subtype: Link
       Rect: 44, 512, 132, 519
       Flags: Print
       Destination: 342
      Annotation: 
       Subtype: Link
       Rect: 96, 479, 171, 486
       Flags: Print
       Destination: 425
      Annotation: 
       Subtype: Link
       Rect: 159, 446, 229, 453
       Flags: Print
       Destination: 342
      Annotation: 
       Subtype: Link
       Rect: 72, 391, 121, 398
       Flags: Print
       Destination: 425
      Annotation: 
       Subtype: Link
       Rect: 71, 358, 122, 365
       Flags: Print
       Destination: 425
      Annotation: 
       Subtype: Link
       Rect: 170, 325, 278, 332
       Flags: Print
       Destination: 425
      Annotation: 
       Subtype: Link
       Rect: 160, 281, 212, 288
       Flags: Print
       Destination: 425
      Annotation: 
       Subtype: Link
       Rect: 61, 226, 119, 233
       Flags: Print
       Destination: 342
      Annotation: 
       Subtype: Link
       Rect: 240, 193, 285, 200
       Flags: Print
       Destination: 342
      Annotation: 
       Subtype: Link
       Rect: 42, 182, 59, 189
       Flags: Print
       Destination: 342
      Annotation: 
       Subtype: Link
       Rect: 65, 182, 135, 189
       Flags: Print
       Destination: 425
      Annotation: 
       Subtype: Link
       Rect: 141, 182, 216, 189
       Flags: Print
       Destination: 342
      Annotation: 
       Subtype: Link
       Rect: 222, 182, 285, 189
       Flags: Print
       Destination: 342
      Annotation: 
       Subtype: Link
       Rect: 42, 171, 82, 178
       Flags: Print
       Destination: 342
      Annotation: 
       Subtype: Link
       Rect: 235, 138, 285, 145
       Flags: Print
       Destination: 425
      Annotation: 
       Subtype: Link
       Rect: 42, 127, 98, 134
       Flags: Print
       Destination: 425
      Annotation: 
       Subtype: Link
       Rect: 104, 127, 169, 134
       Flags: Print
       Destination: 342
      Annotation: 
       Subtype: Link
       Rect: 125, 83, 184, 90
       Flags: Print
       Destination: 425
      Annotation: 
       Subtype: Link
       Rect: 188, 83, 239, 90
       Flags: Print
       Destination: 342
      Annotation: 
       Subtype: Link
       Rect: 76, 39, 134, 46
       Flags: Print
       Destination: 342
      Annotation: 
       Subtype: Link
       Rect: 138, 39, 160, 46
       Flags: Print
       Destination: 342
      Annotation: 
       Subtype: Link
       Rect: 165, 39, 187, 46
       Flags: Print
       Destination: 342
      Annotation: 
       Subtype: Link
       Rect: 191, 39, 212, 46
       Flags: Print
       Destination: 342
      Annotation: 
       Subtype: Link
       Rect: 361, 456, 426, 464
       Flags: Print
       Destination: 342
      Annotation: 
       Subtype: Link
       Rect: 306, 412, 391, 420
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 306, 379, 332, 387
       Flags: Print
       Destination: 95
      Annotation: 
       Subtype: Link
       Rect: 359, 357, 384, 365
       Flags: Print
       Destination: 95
      Annotation: 
       Subtype: Link
       Rect: 391, 357, 460, 365
       Flags: Print
       Destination: 342
      Annotation: 
       Subtype: Link
       Rect: 394, 335, 413, 343
       Flags: Print
       Destination: 95
      Annotation: 
       Subtype: Link
       Rect: 340, 313, 434, 321
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 519, 291, 544, 299
       Flags: Print
       Destination: 106
      Annotation: 
       Subtype: Link
       Rect: 306, 280, 373, 288
       Flags: Print
       Destination: 342
      Annotation: 
       Subtype: Link
       Rect: 337, 181, 393, 189
       Flags: Print
       Destination: 106
      Annotation: 
       Subtype: Link
       Rect: 306, 148, 402, 156
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 306, 49, 396, 57
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 376, 38, 434, 46
       Flags: Print
       Destination: 106
    Page: 
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 505, 82, 552, 90
       Flags: Print
       Destination: 125
      Annotation: 
       Subtype: Link
       Rect: 309, 71, 314, 79
       Flags: Print
       Destination: 125
      Annotation: 
       Subtype: Link
       Rect: 369, 60, 423, 68
       Flags: Print
       Destination: 125
      Annotation: 
       Subtype: Link
       Rect: 345, 38, 406, 46
       Flags: Print
       Destination: 125
    Page: 
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 256, 159, 281, 167
       Flags: Print
       Destination: 125
      Annotation: 
       Subtype: Link
       Rect: 57, 137, 82, 145
       Flags: Print
       Destination: 125
      Annotation: 
       Subtype: Link
       Rect: 245, 93, 265, 101
       Flags: Print
       Destination: 95
      Annotation: 
       Subtype: Link
       Rect: 306, 60, 398, 68
       Flags: Print
    Page: 
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 180, 203, 205, 211
       Flags: Print
       Destination: 140
      Annotation: 
       Subtype: Link
       Rect: 95, 192, 120, 200
       Flags: Print
       Destination: 140
      Annotation: 
       Subtype: Link
       Rect: 232, 148, 286, 156
       Flags: Print
       Destination: 140
      Annotation: 
       Subtype: Link
       Rect: 225, 60, 250, 68
       Flags: Print
       Destination: 140
      Annotation: 
       Subtype: Link
       Rect: 368, 261, 388, 269
       Flags: Print
       Destination: 155
      Annotation: 
       Subtype: Link
       Rect: 381, 228, 435, 236
       Flags: Print
       Destination: 155
      Annotation: 
       Subtype: Link
       Rect: 311, 195, 335, 203
       Flags: Print
       Destination: 155
      Annotation: 
       Subtype: Link
       Rect: 307, 410, 391, 417
       Flags: Print
    Page: 
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 154, 60, 181, 68
       Flags: Print
       Destination: 188
      Annotation: 
       Subtype: Link
       Rect: 186, 60, 281, 68
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 331, 126, 356, 134
       Flags: Print
       Destination: 188
      Annotation: 
       Subtype: Link
       Rect: 361, 126, 455, 134
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 332, 38, 391, 46
       Flags: Print
       Destination: 188
    Page: 
     Sequence: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 176, 137, 269, 145
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 48, 126, 142, 134
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 235, 115, 269, 123
       Flags: Print
       Destination: 188
      Annotation: 
       Subtype: Link
       Rect: 48, 104, 140, 112
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 50, 71, 134, 79
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 494, 666, 552, 673
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 309, 655, 334, 662
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 311, 578, 339, 585
       Flags: Print
       Destination: 188
      Annotation: 
       Subtype: Link
       Rect: 358, 578, 450, 585
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 311, 490, 395, 497
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 447, 468, 467, 475
       Flags: Print
       Destination: 140
      Annotation: 
       Subtype: Link
       Rect: 347, 446, 481, 453
       Flags: Print
       Destination: 425
      Annotation: 
       Subtype: Link
       Rect: 402, 435, 471, 442
       Flags: Print
       Destination: 425
      Annotation: 
       Subtype: Link
       Rect: 431, 424, 482, 431
       Flags: Print
       Destination: 425
      Annotation: 
       Subtype: Link
       Rect: 495, 402, 552, 409
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 309, 391, 333, 398
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 477, 358, 548, 365
       Flags: Print
       Destination: 425
      Annotation: 
       Subtype: Link
       Rect: 459, 325, 507, 332
       Flags: Print
       Destination: 425
      Annotation: 
       Subtype: Link
       Rect: 419, 292, 472, 299
       Flags: Print
       Destination: 425
      Annotation: 
       Subtype: Link
       Rect: 480, 292, 552, 299
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 309, 281, 318, 288
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 381, 215, 466, 222
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 476, 193, 548, 200
       Flags: Print
       Destination: 342
      Annotation: 
       Subtype: Link
       Rect: 311, 116, 367, 123
       Flags: Print
       Destination: 342
      Annotation: 
       Subtype: Link
       Rect: 465, 105, 548, 112
       Flags: Print
    Page: 
     Sequence: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 409, 56, 485, 63
       Flags: Print
    Page: 
     Sequence: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 68, 662, 140, 670
       Flags: Print
       Destination: 342
      Annotation: 
       Subtype: Link
       Rect: 145, 662, 199, 670
       Flags: Print
       Destination: 342
      Annotation: 
       Subtype: Link
       Rect: 204, 662, 269, 670
       Flags: Print
       Destination: 342
      Annotation: 
       Subtype: Link
       Rect: 74, 574, 100, 582
       Flags: Print
       Destination: 248
      Annotation: 
       Subtype: Link
       Rect: 145, 541, 172, 549
       Flags: Print
       Destination: 248
      Annotation: 
       Subtype: Link
       Rect: 122, 497, 148, 505
       Flags: Print
       Destination: 248
      Annotation: 
       Subtype: Link
       Rect: 153, 486, 178, 494
       Flags: Print
       Destination: 248
      Annotation: 
       Subtype: Link
       Rect: 50, 442, 74, 450
       Flags: Print
       Destination: 248
      Annotation: 
       Subtype: Link
       Rect: 74, 398, 100, 406
       Flags: Print
       Destination: 248
      Annotation: 
       Subtype: Link
       Rect: 64, 170, 128, 178
       Flags: Print
       Destination: 425
      Annotation: 
       Subtype: Link
       Rect: 50, 60, 121, 68
       Flags: Print
       Destination: 342
      Annotation: 
       Subtype: Link
       Rect: 125, 60, 224, 68
       Flags: Print
       Destination: 425
      Annotation: 
       Subtype: Link
       Rect: 423, 710, 527, 717
       Flags: Print
       Destination: 425
      Annotation: 
       Subtype: Link
       Rect: 532, 710, 552, 717
       Flags: Print
       Destination: 342
      Annotation: 
       Subtype: Link
       Rect: 309, 699, 349, 706
       Flags: Print
       Destination: 342
      Annotation: 
       Subtype: Link
       Rect: 533, 688, 552, 695
       Flags: Print
       Destination: 425
      Annotation: 
       Subtype: Link
       Rect: 309, 677, 348, 684
       Flags: Print
       Destination: 425
      Annotation: 
       Subtype: Link
       Rect: 353, 677, 423, 684
       Flags: Print
       Destination: 342
      Annotation: 
       Subtype: Link
       Rect: 383, 655, 452, 662
       Flags: Print
       Destination: 342
      Annotation: 
       Subtype: Link
       Rect: 457, 655, 548, 662
       Flags: Print
       Destination: 342
      Annotation: 
       Subtype: Link
       Rect: 341, 578, 425, 585
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 446, 567, 466, 574
       Flags: Print
       Destination: 95
      Annotation: 
       Subtype: Link
       Rect: 454, 556, 548, 563
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 472, 545, 550, 552
       Flags: Print
       Destination: 342
      Annotation: 
       Subtype: Link
       Rect: 311, 534, 331, 541
       Flags: Print
       Destination: 95
      Annotation: 
       Subtype: Link
       Rect: 455, 523, 550, 530
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 309, 512, 329, 519
       Flags: Print
       Destination: 95
      Annotation: 
       Subtype: Link
       Rect: 397, 468, 422, 475
       Flags: Print
       Destination: 106
      Annotation: 
       Subtype: Link
       Rect: 311, 446, 339, 453
       Flags: Print
       Destination: 106
      Annotation: 
       Subtype: Link
       Rect: 393, 446, 421, 453
       Flags: Print
       Destination: 140
      Annotation: 
       Subtype: Link
       Rect: 324, 424, 417, 431
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 422, 424, 442, 431
       Flags: Print
       Destination: 95
      Annotation: 
       Subtype: Link
       Rect: 311, 402, 336, 409
       Flags: Print
       Destination: 106
      Annotation: 
       Subtype: Link
       Rect: 364, 391, 392, 398
       Flags: Print
       Destination: 106
      Annotation: 
       Subtype: Link
       Rect: 397, 391, 407, 398
       Flags: Print
       Destination: 140
      Annotation: 
       Subtype: Link
       Rect: 402, 358, 473, 365
       Flags: Print
       Destination: 425
      Annotation: 
       Subtype: Link
       Rect: 311, 325, 396, 332
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 401, 325, 456, 332
       Flags: Print
       Destination: 106
      Annotation: 
       Subtype: Link
       Rect: 359, 281, 378, 288
       Flags: Print
       Destination: 140
      Annotation: 
       Subtype: Link
       Rect: 510, 248, 552, 255
       Flags: Print
       Destination: 342
      Annotation: 
       Subtype: Link
       Rect: 309, 237, 352, 244
       Flags: Print
       Destination: 342
      Annotation: 
       Subtype: Link
       Rect: 409, 226, 428, 233
       Flags: Print
       Destination: 155
      Annotation: 
       Subtype: Link
       Rect: 311, 83, 403, 90
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 333, 50, 352, 57
       Flags: Print
       Destination: 95
    Page: 
     Sequence: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 44, 302, 148, 310
       Flags: Print
       Destination: 425
      Annotation: 
       Subtype: Link
       Rect: 154, 302, 217, 310
       Flags: Print
       Destination: 425
      Annotation: 
       Subtype: Link
       Rect: 223, 302, 285, 310
       Flags: Print
       Destination: 425
      Annotation: 
       Subtype: Link
       Rect: 42, 291, 59, 299
       Flags: Print
       Destination: 425
      Annotation: 
       Subtype: Link
       Rect: 231, 269, 285, 277
       Flags: Print
       Destination: 425
      Annotation: 
       Subtype: Link
       Rect: 42, 258, 88, 266
       Flags: Print
       Destination: 425
      Annotation: 
       Subtype: Link
       Rect: 92, 258, 153, 266
       Flags: Print
       Destination: 342
      Annotation: 
       Subtype: Link
       Rect: 155, 225, 212, 233
       Flags: Print
       Destination: 342
      Annotation: 
       Subtype: Link
       Rect: 217, 225, 238, 233
       Flags: Print
       Destination: 342
      Annotation: 
       Subtype: Link
       Rect: 212, 203, 281, 211
       Flags: Print
       Destination: 425
      Annotation: 
       Subtype: Link
       Rect: 236, 159, 285, 167
       Flags: Print
       Destination: 342
      Annotation: 
       Subtype: Link
       Rect: 42, 148, 59, 156
       Flags: Print
       Destination: 342
      Annotation: 
       Subtype: Link
       Rect: 44, 126, 63, 134
       Flags: Print
       Destination: 248
      Annotation: 
       Subtype: Link
       Rect: 218, 93, 244, 101
       Flags: Print
       Destination: 188
      Annotation: 
       Subtype: Link
       Rect: 228, 82, 285, 90
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 42, 71, 73, 79
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 412, 324, 499, 332
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 427, 203, 446, 211
       Flags: Print
       Destination: 248
      Annotation: 
       Subtype: Link
       Rect: 397, 148, 485, 156
       Flags: Print
       Destination: 342
      Annotation: 
       Subtype: Link
       Rect: 490, 148, 542, 156
       Flags: Print
       Destination: 342
      Annotation: 
       Subtype: Link
       Rect: 503, 137, 546, 145
       Flags: Print
       Destination: 425
      Annotation: 
       Subtype: Link
       Rect: 303, 126, 320, 134
       Flags: Print
       Destination: 425
      Annotation: 
       Subtype: Link
       Rect: 306, 93, 351, 101
       Flags: Print
       Destination: 125
      Annotation: 
       Subtype: Link
       Rect: 360, 82, 445, 90
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 407, 71, 522, 79
       Flags: Print
       Destination: 425
      Annotation: 
       Subtype: Link
       Rect: 421, 49, 444, 57
       Flags: Print
       Destination: 248
      Annotation: 
       Subtype: Link
       Rect: 347, 38, 422, 46
       Flags: Print
       Destination: 342
    Page: 
     Sequence: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 67, 699, 124, 706
       Flags: Print
       Destination: 342
      Annotation: 
       Subtype: Link
       Rect: 168, 644, 250, 651
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 140, 622, 198, 629
       Flags: Print
       Destination: 425
      Annotation: 
       Subtype: Link
       Rect: 221, 611, 241, 618
       Flags: Print
       Destination: 281
      Annotation: 
       Subtype: Link
       Rect: 432, 721, 497, 728
       Flags: Print
       Destination: 425
      Annotation: 
       Subtype: Link
       Rect: 467, 688, 548, 695
       Flags: Print
       Destination: 425
      Annotation: 
       Subtype: Link
       Rect: 439, 284, 532, 292
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 422, 218, 497, 226
       Flags: Print
       Destination: 342
      Annotation: 
       Subtype: Link
       Rect: 320, 185, 391, 193
       Flags: Print
       Destination: 342
      Annotation: 
       Subtype: Link
       Rect: 407, 38, 523, 46
       Flags: Print
       Destination: 342
    Page: 
     Sequence: 12
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 42, 699, 134, 706
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 638, 131, 646
       Flags: Print
       Destination: 342
      Annotation: 
       Subtype: Link
       Rect: 221, 418, 261, 426
       Flags: Print
       Destination: 425
      Annotation: 
       Subtype: Link
       Rect: 191, 363, 231, 371
       Flags: Print
       Destination: 425
      Annotation: 
       Subtype: Link
       Rect: 181, 231, 235, 239
       Flags: Print
       Destination: 342
      Annotation: 
       Subtype: Link
       Rect: 221, 181, 285, 189
       Flags: Print
       Destination: 342
      Annotation: 
       Subtype: Link
       Rect: 42, 170, 59, 178
       Flags: Print
       Destination: 342
      Annotation: 
       Subtype: Link
       Rect: 527, 640, 547, 648
       Flags: Print
       Destination: 342
      Annotation: 
       Subtype: Link
       Rect: 303, 629, 378, 637
       Flags: Print
       Destination: 342
      Annotation: 
       Subtype: Link
       Rect: 346, 159, 440, 167
       Flags: Print
       Destination: 342
      Annotation: 
       Subtype: Link
       Rect: 385, 148, 546, 156
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 303, 137, 384, 145
       Flags: Print
    Page: 
     Sequence: 13
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 146, 710, 248, 717
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 196, 666, 291, 673
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 48, 655, 77, 662
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 50, 608, 135, 616
       Flags: Print
       Destination: 425
      Annotation: 
       Subtype: Link
       Rect: 71, 421, 154, 429
       Flags: Print
       Destination: 342
      Annotation: 
       Subtype: Link
       Rect: 91, 242, 155, 250
       Flags: Print
       Destination: 425
      Annotation: 
       Subtype: Link
       Rect: 319, 458, 419, 466
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 319, 436, 416, 444
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 319, 403, 417, 411
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 319, 381, 416, 389
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 319, 359, 416, 367
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 319, 337, 416, 345
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 319, 315, 421, 323
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 319, 282, 416, 290
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 319, 260, 415, 268
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 319, 227, 415, 235
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 319, 205, 413, 213
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 319, 183, 421, 191
       Flags: Print
    Page: 
     Sequence: 14
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 189, 644, 285, 652
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 42, 633, 71, 641
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 42, 588, 285, 596
       Flags: Print
       Destination: 155
      Annotation: 
       Subtype: Link
       Rect: 54, 577, 177, 585
       Flags: Print
       Destination: 155
      Annotation: 
       Subtype: Link
       Rect: 54, 555, 215, 563
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 42, 544, 207, 552
       Flags: Print
       Destination: 35
      Annotation: 
       Subtype: Link
       Rect: 95, 500, 216, 508
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 42, 489, 285, 497
       Flags: Print
       Destination: 281
      Annotation: 
       Subtype: Link
       Rect: 54, 478, 204, 486
       Flags: Print
       Destination: 281
      Annotation: 
       Subtype: Link
       Rect: 202, 445, 285, 453
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 434, 125, 442
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 42, 423, 285, 431
       Flags: Print
       Destination: 35
      Annotation: 
       Subtype: Link
       Rect: 54, 412, 94, 420
       Flags: Print
       Destination: 35
      Annotation: 
       Subtype: Link
       Rect: 136, 390, 275, 398
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 42, 379, 285, 387
       Flags: Print
       Destination: 35
      Annotation: 
       Subtype: Link
       Rect: 54, 368, 219, 376
       Flags: Print
       Destination: 35
      Annotation: 
       Subtype: Link
       Rect: 116, 335, 285, 343
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 42, 324, 105, 332
       Flags: Print
       Destination: 304
      Annotation: 
       Subtype: Link
       Rect: 221, 302, 285, 310
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 291, 130, 299
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 42, 280, 285, 288
       Flags: Print
       Destination: 35
      Annotation: 
       Subtype: Link
       Rect: 54, 269, 263, 277
       Flags: Print
       Destination: 35
      Annotation: 
       Subtype: Link
       Rect: 202, 247, 285, 255
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 236, 99, 244
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 42, 225, 220, 233
       Flags: Print
       Destination: 35
      Annotation: 
       Subtype: Link
       Rect: 87, 203, 230, 211
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 42, 192, 146, 200
       Flags: Print
       Destination: 35
      Annotation: 
       Subtype: Link
       Rect: 246, 181, 285, 189
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 170, 172, 178
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 42, 159, 222, 167
       Flags: Print
       Destination: 200
      Annotation: 
       Subtype: Link
       Rect: 125, 137, 242, 145
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 42, 126, 177, 134
       Flags: Print
       Destination: 35
      Annotation: 
       Subtype: Link
       Rect: 146, 104, 285, 112
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 42, 93, 168, 101
       Flags: Print
       Destination: 35
      Annotation: 
       Subtype: Link
       Rect: 246, 71, 285, 79
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 60, 186, 68
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 42, 49, 181, 57
       Flags: Print
       Destination: 35
      Annotation: 
       Subtype: Link
       Rect: 482, 721, 547, 728
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 315, 710, 411, 717
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 303, 699, 430, 706
       Flags: Print
       Destination: 35
      Annotation: 
       Subtype: Link
       Rect: 315, 665, 475, 672
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 303, 654, 375, 661
       Flags: Print
       Destination: 35
      Annotation: 
       Subtype: Link
       Rect: 315, 631, 502, 639
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 303, 620, 546, 628
       Flags: Print
       Destination: 320
      Annotation: 
       Subtype: Link
       Rect: 315, 609, 379, 617
       Flags: Print
       Destination: 320
      Annotation: 
       Subtype: Link
       Rect: 355, 575, 468, 583
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 303, 564, 546, 572
       Flags: Print
       Destination: 35
      Annotation: 
       Subtype: Link
       Rect: 315, 553, 546, 561
       Flags: Print
       Destination: 35
      Annotation: 
       Subtype: Link
       Rect: 315, 542, 380, 549
       Flags: Print
       Destination: 35
      Annotation: 
       Subtype: Link
       Rect: 400, 508, 532, 516
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 303, 497, 449, 505
       Flags: Print
       Destination: 651
      Annotation: 
       Subtype: Link
       Rect: 507, 486, 547, 493
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 315, 475, 433, 482
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 303, 464, 547, 471
       Flags: Print
       Destination: 35
      Annotation: 
       Subtype: Link
       Rect: 315, 452, 416, 460
       Flags: Print
       Destination: 35
      Annotation: 
       Subtype: Link
       Rect: 348, 430, 483, 438
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 303, 419, 547, 427
       Flags: Print
       Destination: 304
      Annotation: 
       Subtype: Link
       Rect: 315, 408, 350, 415
       Flags: Print
       Destination: 304
      Annotation: 
       Subtype: Link
       Rect: 374, 374, 529, 382
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 303, 363, 544, 371
       Flags: Print
       Destination: 35
      Annotation: 
       Subtype: Link
       Rect: 399, 329, 542, 337
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 303, 318, 547, 326
       Flags: Print
       Destination: 155
      Annotation: 
       Subtype: Link
       Rect: 315, 307, 379, 315
       Flags: Print
       Destination: 155
      Annotation: 
       Subtype: Link
       Rect: 433, 273, 547, 281
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 315, 262, 359, 270
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 303, 251, 547, 259
       Flags: Print
       Destination: 35
      Annotation: 
       Subtype: Link
       Rect: 315, 240, 363, 247
       Flags: Print
       Destination: 35
      Annotation: 
       Subtype: Link
       Rect: 491, 217, 547, 225
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 315, 206, 380, 214
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 303, 195, 409, 203
       Flags: Print
       Destination: 304
      Annotation: 
       Subtype: Link
       Rect: 395, 173, 517, 180
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 303, 162, 464, 169
       Flags: Print
       Destination: 248
      Annotation: 
       Subtype: Link
       Rect: 315, 128, 454, 135
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 303, 117, 392, 124
       Flags: Print
       Destination: 281
      Annotation: 
       Subtype: Link
       Rect: 463, 94, 547, 102
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 315, 83, 372, 91
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 303, 72, 546, 80
       Flags: Print
       Destination: 200
      Annotation: 
       Subtype: Link
       Rect: 315, 61, 420, 68
       Flags: Print
       Destination: 200
      Annotation: 
       Subtype: Link
       Rect: 428, 38, 541, 46
       Flags: Print
    Page: 
     Sequence: 15
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 48, 721, 240, 728
       Flags: Print
       Destination: 155
      Annotation: 
       Subtype: Link
       Rect: 265, 698, 291, 706
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 60, 687, 152, 695
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 48, 676, 291, 684
       Flags: Print
       Destination: 651
      Annotation: 
       Subtype: Link
       Rect: 60, 665, 291, 672
       Flags: Print
       Destination: 651
      Annotation: 
       Subtype: Link
       Rect: 60, 654, 64, 661
       Flags: Print
       Destination: 651
      Annotation: 
       Subtype: Link
       Rect: 227, 642, 291, 650
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 60, 631, 152, 639
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 48, 620, 244, 628
       Flags: Print
       Destination: 320
      Annotation: 
       Subtype: Link
       Rect: 60, 575, 219, 583
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 48, 564, 271, 572
       Flags: Print
       Destination: 248
      Annotation: 
       Subtype: Link
       Rect: 227, 530, 291, 538
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 60, 519, 173, 527
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 48, 508, 291, 516
       Flags: Print
       Destination: 35
      Annotation: 
       Subtype: Link
       Rect: 60, 497, 86, 504
       Flags: Print
       Destination: 35
      Annotation: 
       Subtype: Link
       Rect: 237, 474, 291, 482
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 60, 463, 159, 471
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 48, 452, 291, 460
       Flags: Print
       Destination: 248
      Annotation: 
       Subtype: Link
       Rect: 60, 441, 132, 448
       Flags: Print
       Destination: 248
      Annotation: 
       Subtype: Link
       Rect: 207, 418, 291, 426
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 60, 407, 163, 414
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 48, 396, 289, 403
       Flags: Print
       Destination: 651
      Annotation: 
       Subtype: Link
       Rect: 93, 374, 250, 381
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 48, 363, 159, 370
       Flags: Print
       Destination: 35
      Annotation: 
       Subtype: Link
       Rect: 252, 340, 291, 347
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 60, 329, 149, 336
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 48, 318, 130, 325
       Flags: Print
       Destination: 35
      Annotation: 
       Subtype: Link
       Rect: 60, 295, 197, 303
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 48, 284, 140, 292
       Flags: Print
       Destination: 200
      Annotation: 
       Subtype: Link
       Rect: 60, 250, 225, 258
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 48, 239, 77, 247
       Flags: Print
       Destination: 304
      Annotation: 
       Subtype: Link
       Rect: 252, 217, 291, 224
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 60, 206, 166, 213
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 48, 195, 231, 202
       Flags: Print
       Destination: 155
      Annotation: 
       Subtype: Link
       Rect: 265, 172, 291, 180
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 60, 161, 188, 168
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 48, 150, 127, 157
       Flags: Print
       Destination: 35
      Annotation: 
       Subtype: Link
       Rect: 227, 139, 291, 146
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 60, 127, 150, 135
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 48, 116, 219, 124
       Flags: Print
       Destination: 35
      Annotation: 
       Subtype: Link
       Rect: 309, 721, 383, 728
       Flags: Print
       Destination: 35
      Annotation: 
       Subtype: Link
       Rect: 380, 699, 505, 706
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 309, 688, 386, 695
       Flags: Print
       Destination: 35
      Annotation: 
       Subtype: Link
       Rect: 499, 677, 552, 684
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 321, 666, 425, 673
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 309, 655, 491, 662
       Flags: Print
       Destination: 200
      Annotation: 
       Subtype: Link
       Rect: 362, 622, 500, 629
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 309, 611, 472, 618
       Flags: Print
       Destination: 35
      Annotation: 
       Subtype: Link
       Rect: 436, 578, 552, 585
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 321, 567, 362, 574
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 309, 556, 552, 563
       Flags: Print
       Destination: 35
      Annotation: 
       Subtype: Link
       Rect: 321, 545, 416, 552
       Flags: Print
       Destination: 35
      Annotation: 
       Subtype: Link
       Rect: 409, 523, 537, 530
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 309, 512, 385, 519
       Flags: Print
       Destination: 248
      Annotation: 
       Subtype: Link
       Rect: 469, 490, 552, 497
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 321, 479, 361, 486
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 309, 468, 552, 475
       Flags: Print
       Destination: 320
      Annotation: 
       Subtype: Link
       Rect: 321, 457, 399, 464
       Flags: Print
       Destination: 320
      Annotation: 
       Subtype: Link
       Rect: 490, 435, 552, 442
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 321, 424, 402, 431
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 309, 413, 396, 420
       Flags: Print
       Destination: 35
      Annotation: 
       Subtype: Link
       Rect: 415, 391, 541, 398
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 309, 380, 496, 387
       Flags: Print
       Destination: 155
      Annotation: 
       Subtype: Link
       Rect: 354, 347, 470, 354
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 309, 336, 448, 343
       Flags: Print
       Destination: 155
      Annotation: 
       Subtype: Link
       Rect: 371, 303, 492, 310
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 309, 292, 550, 299
       Flags: Print
       Destination: 155
      Annotation: 
       Subtype: Link
       Rect: 432, 259, 552, 266
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 321, 248, 345, 255
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 309, 237, 467, 244
       Flags: Print
       Destination: 281
      Annotation: 
       Subtype: Link
       Rect: 359, 204, 497, 211
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 309, 193, 450, 200
       Flags: Print
       Destination: 281
      Annotation: 
       Subtype: Link
       Rect: 499, 171, 552, 178
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 321, 160, 394, 167
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 309, 149, 552, 156
       Flags: Print
       Destination: 35
      Annotation: 
       Subtype: Link
       Rect: 321, 138, 392, 145
       Flags: Print
       Destination: 35
      Annotation: 
       Subtype: Link
       Rect: 464, 105, 552, 112
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 321, 94, 405, 101
       Flags: Print
  Checksum: 91b5fe28
   Type: CRC32
  Checksum: 0fbb1c737551cbd32007498e3a7c7e89
   Type: MD5
  Checksum: 6d466fb82b7246a5f7b3616ed440e406f8df26d7
   Type: SHA-1
  Checksum: 532843c303b83c08bb99d28ff3368ff82e7d1f43776332a77f301565b7bba1af
   Type: SHA-256