f4c89812ff75b1f31c2879ed321800b5 335902.pdf 44464efe3788e49ee354246b8761813f31249a97 335902.pdf 996d62271728d05edd8559afa9594d226155f8fa65d6729524e13f50c6ad3afc 335902.pdf Title: Donor age as an independent predictor of inferior outcomes after haploidentical hematopoietic cell transplantation in acute myeloid leukemia. Study conducted on behalf of GETH-TC Subject: Munárriz D, Pérez-López E, Martín Rodríguez C, Luque M, Esquirol A, Calvo CM, Aparicio C, Peña-Muñóz F, Heras Fernando I, Oiartzabal Ormtegi I, Sáez Marín AJ, Fernández-Luis S, Domínguez-García JJ, Villar Fernández S, López-Lorenzo JL, Acosta Fleitas C, González-Rodriguez AP, García L, Torrado T, Filaferro S, Balsalobre P, Pascual Cascon MJ, Rovira M and Queralt Salas M (2025) Donor age as an independent predictor of inferior outcomes after haploidentical hematopoietic cell transplantation in acute myeloid leukemia. Study conducted on behalf of GETH-TC. Front. Immunol. 16:1700463. doi: 10.3389/fimmu.2025.1700463 Keywords: donor age; allo-HCT; haplo-HCT; PTCY; AML Author: Daniel Munárriz CreationDate: Tue Nov 25 09:34:06 2025 CET ModDate: Tue Nov 25 09:34:06 2025 CET Custom Metadata: no Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 11 Encrypted: no Page size: 595.389 x 841.663 pts (A4) Page rot: 0 File size: 2398123 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- NBKEDA+AdvTTd3a5f740 Type 1C WinAnsi yes yes no 552 0 NBKFIB+AdvTTd168d80a.I Type 1C WinAnsi yes yes no 660 0 NBKEEB+AdvPSA18C Type 1C WinAnsi yes yes no 661 0 NBKEEC+AdvTTd3a5f740+01 Type 1C MacRoman yes yes no 662 0 NBKEED+AdvTT9b12cd41 Type 1C WinAnsi yes yes no 551 0 NBKEEE+AdvTT9b12cd41+01 Type 1C MacRoman yes yes no 663 0 NBKEEF+AdvPSA323 Type 1C WinAnsi yes yes no 555 0 NBKEEG+AdvTT9b12cd41+20 Type 1C WinAnsi yes yes no 664 0 NBKEFH+AdvTT9b12cd41+fb Type 1C Custom yes yes yes 665 0 NBKFEC+AdvTT2c8ce45a Type 1C WinAnsi yes yes no 550 0 NBKFLB+AdvTT9b12cd41+22 Type 1C Custom yes yes yes 675 0 NBKFLC+AdvOT1ef757c0 Type 1C WinAnsi yes yes no 546 0 NBKFLD+AdvOT1ef757c0+fb Type 1C Custom yes yes yes 547 0 NBKFMD+AdvOT7d6df7ab.I Type 1C WinAnsi yes yes no 676 0 NBKFME+AdvTT58d178b9+03 Type 1C Custom yes yes yes 677 0 NBKFMF+AdvOT1ef757c0+01 Type 1C MacRoman yes yes no 678 0 NBKFMG+AdvTTd3a5f740+fb Type 1C Custom yes yes yes 679 0 NBKFNH+AdvOT1ef757c0+20 Type 1C WinAnsi yes yes no 548 0 NBKGAH+AdvTTd3a5f740+22 Type 1C Custom yes yes yes 680 0 NBKGAI+AdvOT1ef757c0+22 Type 1C Custom yes yes yes 549 0 NBKGAJ+AdvOTb65e897d.B Type 1C WinAnsi yes yes no 554 0 NBKIBM+AdvTT749c1f5a.I Type 1C WinAnsi yes yes no 553 0 NBLGDB+AdvTTd3a5f740+20 Type 1C WinAnsi yes yes no 696 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2026-09-09 04:10:05 CEST RepresentationInformation: 335902.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2026-09-08 10:09:32 CEST Size: 2398123 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 762 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: true NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en-US Outlines: Item: Title: Donor age as an independent predictor of inferior outcomes after haploidentical hematopoietic cell transplantation in acute myeloid leukemia. Study conducted on behalf of GETH-TC Destination: bmark_1889833959 Children: Item: Title: Introduction Destination: s1 Item: Title: Methods Destination: s2 Children: Item: Title: Study design and patient selection Destination: s2_1 Item: Title: Donor election practices across institutions, allo-HCT information and main definitions Destination: s2_2 Item: Title: Statistical analysis Destination: s2_3 Item: Title: Results Destination: s3 Children: Item: Title: Patient characteristics and main outcomes Destination: s3_1 Item: Title: Donor age cut-off determination and impact on outcomes Destination: s3_2 Item: Title: Patient and allo-HCT information according to donor-age groups Destination: s3_3 Item: Title: Post-transplant information and disease relapse according to donor age Destination: s3_4 Item: Title: Donor age and post-transplant outcomes Destination: s3_5 Item: Title: Donor age as an independent predictive factor for survival Destination: s3_6 Item: Title: Discussion Destination: s4 Item: Title: Data availability statement Destination: bmark_-1258588262 Item: Title: Ethics statement Destination: bmark_1370551237 Item: Title: Author contributions Destination: bmark_-1208584890 Item: Title: Funding Destination: bmark_1865464027 Item: Title: Acknowledgments Destination: bmark_-366698314 Item: Title: Conflict of interest Destination: bmark_1089982005 Item: Title: Generative AI statement Destination: bmark_-1453097031 Item: Title: Publisher’s note Destination: bmark_-1256977648 Item: Title: References Destination: bmark_2090415954 Info: Title: Donor age as an independent predictor of inferior outcomes after haploidentical hematopoietic cell transplantation in acute myeloid leukemia. Study conducted on behalf of GETH-TC Author: Daniel Munárriz Subject: Munárriz D, Pérez-López E, Martín Rodríguez C, Luque M, Esquirol A, Calvo CM, Aparicio C, Peña-Muñóz F, Heras Fernando I, Oiartzabal Ormtegi I, Sáez Marín AJ, Fernández-Luis S, Domínguez-García JJ, Villar Fernández S, López-Lorenzo JL, Acosta Fleitas C, González-Rodriguez AP, García L, Torrado T, Filaferro S, Balsalobre P, Pascual Cascon MJ, Rovira M and Queralt Salas M (2025) Donor age as an independent predictor of inferior outcomes after haploidentical hematopoietic cell transplantation in acute myeloid leukemia. Study conducted on behalf of GETH-TC. Front. 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FontDescriptor: FontName: NBKEFH+AdvTT9b12cd41+fb Flags: Symbolic FontBBox: 0, 0, 854, 697 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true XMP: application/pdf Daniel Munárriz Estefanía Pérez-López Carlos Martín Rodríguez Marta Luque Albert Esquirol Carmen Martín Calvo Clara Aparicio Felipe Peña-Muñóz Inmaculada Heras Fernando Itziar Oiartzabal Ormtegi Adolfo Jesús Sáez Marín Sara Fernández-Luis Juan José Domínguez-García Sara Villar Fernández Jose Luis López-Lorenzo Cynthia Acosta Fleitas Ana Pilar González-Rodriguez Lucía García Tamara Torrado Silvia Filaferro Pascual Balsalobre María Jesús Pascual Cascon Montserrat Rovira María Queralt Salas Munárriz D, Pérez-López E, Martín Rodríguez C, Luque M, Esquirol A, Calvo CM, Aparicio C, Peña-Muñóz F, Heras Fernando I, Oiartzabal Ormtegi I, Sáez Marín AJ, Fernández-Luis S, Domínguez-García JJ, Villar Fernández S, López-Lorenzo JL, Acosta Fleitas C, González-Rodriguez AP, García L, Torrado T, Filaferro S, Balsalobre P, Pascual Cascon MJ, Rovira M and Queralt Salas M (2025) Donor age as an independent predictor of inferior outcomes after haploidentical hematopoietic cell transplantation in acute myeloid leukemia. Study conducted on behalf of GETH-TC. Front. Immunol. 16:1700463. doi: 10.3389/fimmu.2025.1700463 Copyright © 2025 Munárriz, Pérez-López, Martín Rodríguez, Luque, Esquirol, Calvo, Aparicio, Peña-Muñóz, Heras Fernando, Oiartzabal Ormtegi, Sáez Marín, Fernández-Luis, Domínguez-García, Villar Fernández, López-Lorenzo, Acosta Fleitas, González-Rodriguez, García, Torrado, Filaferro, Balsalobre, Pascual Cascon, Rovira and Queralt Salas.. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. donor age allo-HCT haplo-HCT PTCY AML Donor age as an independent predictor of inferior outcomes after haploidentical hematopoietic cell transplantation in acute myeloid leukemia. 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