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Oncol. 15:1679589. doi: 10.3389/fonc.2025.1679589 Keywords: oral mucositis; radiotherapy; cetuximab; cisplatin; pharyngeal mucositis Author: Alicia Lozano-Borbalas CreationDate: Thu Nov 13 04:39:49 2025 CET ModDate: Thu Nov 13 04:40:05 2025 CET Custom Metadata: no Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 12 Encrypted: no Page size: 595.389 x 841.663 pts (A4) Page rot: 0 File size: 12398384 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- IGNOLG+AdvTTd3a5f740 Type 1C WinAnsi yes yes no 270 0 IGNOLH+AdvTT9b12cd41 Type 1C WinAnsi yes yes no 273 0 IGNOLI+AdvTT9b12cd41+20 Type 1C WinAnsi yes yes no 684 0 IGNOLJ+AdvPSA323 Type 1C WinAnsi yes yes no 685 0 IGNOLK+AdvTT2c8ce45a Type 1C WinAnsi yes yes no 272 0 IGNOML+AdvTT9b12cd41+fb Type 1C Custom yes yes yes 430 0 IGNOMM+AdvTT9b12cd41+22 Type 1C Custom yes yes yes 686 0 IGNOMN+AdvTTd168d80a.I Type 1C WinAnsi yes yes no 687 0 IGOEKL+AdvOT1ef757c0+20 Type 1C WinAnsi yes yes no 266 0 IGOEKM+AdvOT1ef757c0+fb Type 1C Custom yes yes yes 267 0 IGOELM+AdvOT1ef757c0+22 Type 1C Custom yes yes yes 269 0 IGOELN+AdvOT7d6df7ab.I Type 1C WinAnsi yes yes no 268 0 IGOEKK+AdvOT1ef757c0 Type 1C Custom yes yes yes 265 0 IGOENO+AdvOTd877c31c Type 1C WinAnsi yes yes no 271 0 IGOEOO+AdvTTc8b77491.I Type 1C WinAnsi yes yes no 697 0 IGOEOP+AdvTT749c1f5a.I Type 1C WinAnsi yes yes no 334 0 IHDCGE+AdvTT2c8ce45a+20 Type 1C WinAnsi yes yes no 333 0 IHDCKE+AdvOTb1404cd8+20 Type 1C WinAnsi yes yes no 407 0 IHDKDG+AdvTT2c8ce45a+fb Type 1C Custom yes yes yes 408 0 IHDKHG+AdvOT2f02755f.I Type 1C WinAnsi yes yes no 429 0 IHHKCP+AdvTT58d178b9+03 Type 1C Custom yes yes yes 723 0 IHHKDA+AdvOT1ef757c0+01 Type 1C MacRoman yes yes no 724 0 IHHKEB+AdvTTd3a5f740+fb Type 1C Custom yes yes yes 725 0 IHHKFC+AdvTTd3a5f740+20 Type 1C WinAnsi yes yes no 726 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2026-09-09 04:10:01 CEST RepresentationInformation: 335903.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2026-09-08 10:17:52 CEST Size: 12398384 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 788 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: true NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en-US Outlines: Item: Title: Impact of clinical and dosimetric factors on severe oral mucositis in head and neck cancer: insights from a phase II clinical trial Destination: bmark_-908453442 Children: Item: Title: Introduction Destination: s1 Item: Title: Materials and methods Destination: s2 Children: Item: Title: Treatment characteristics Destination: s2_1 Item: Title: Simulation and volume design Destination: s2_2 Item: Title: Prescription and planning Destination: s2_3 Item: Title: Outcome assessment Destination: s2_4 Item: Title: Statistical analysis Destination: s2_5 Item: Title: Results Destination: s3 Children: Item: Title: Patient characteristics Destination: s3_1 Item: Title: Univariate analyses Destination: s3_2 Children: Item: Title: Clinical variables Destination: s3_2_1 Item: Title: Dosimetric variables Destination: s3_2_2 Item: Title: Multivariate analysis Destination: s3_3 Item: Title: Discussion Destination: s4 Item: Title: Data availability statement Destination: bmark_-1258588262 Item: Title: Ethics statement Destination: bmark_1370551237 Item: Title: Author contributions Destination: bmark_-1208584890 Item: Title: Funding Destination: bmark_1865464027 Item: Title: Conflict of interest Destination: bmark_1089982005 Item: Title: Generative AI statement Destination: bmark_-1453097031 Item: Title: Publisher’s note Destination: bmark_-1256977648 Item: Title: References Destination: bmark_2090415954 Info: Title: Impact of clinical and dosimetric factors on severe oral mucositis in head and neck cancer: insights from a phase II clinical trial Author: Alicia Lozano-Borbalas Subject: Lozano-Borbalas A, Jordi-Ollero O, Marruecos J, Farre N, Planas I, Toledo MD, Mesia R and Navarro-Martin A (2025) Impact of clinical and dosimetric factors on severe oral mucositis in head and neck cancer: insights from a phase II clinical trial. Front. 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Isabel Planas Maria Dolores Toledo Ricard Mesia Arturo Navarro-Martin Lozano-Borbalas A, Jordi-Ollero O, Marruecos J, Farre N, Planas I, Toledo MD, Mesia R and Navarro-Martin A (2025) Impact of clinical and dosimetric factors on severe oral mucositis in head and neck cancer: insights from a phase II clinical trial. Front. Oncol. 15:1679589. doi: 10.3389/fonc.2025.1679589 Copyright © 2025 Lozano-Borbalas, Jordi-Ollero, Marruecos, Farre, Planas, Toledo, Mesia and Navarro-Martin.. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. 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