46e917ea45261c6143c51dc4d84075d6 335915.pdf 123f23c8116d76bdb9375d95e9edf46c31f4435b 335915.pdf 9baed8ada83fdcc39e0725c057391a6ce740c0d6bb71391a79b216a24d9eb59e 335915.pdf Title: Reduced Growth and Inflammation in Lrp5−/− Mice Adipose Tissue Subject: J Cellular Molecular Medi 2025.29:e70670 Creator: Adobe InDesign 19.5 (Windows) Producer: Adobe PDF Library 17.0; modified using iText 4.2.0 by 1T3XT CreationDate: Mon Sep 29 09:48:47 2025 CEST ModDate: Thu Sep 17 11:04:45 2026 CEST Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 15 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 1355707 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- QRNWNX+STIXTwoText Type 1C Custom yes yes yes 55 0 DQARNX+STIXTwoText-BoldItalic Type 1C WinAnsi yes yes yes 122 0 FGBIPT+STIXTwoText-Italic Type 1C Custom yes yes yes 57 0 JPTWTL+ArialRoundedMTBold Type 1C WinAnsi yes yes no 443 0 KGKHHJ+STIXTwoText-Bold Type 1C Custom yes yes yes 123 0 YWJIVH+STIX-Italic Type 1C Custom yes yes yes 56 0 IQJQFN+STIX-BoldItalic Type 1C Custom yes yes yes 124 0 Times-Roman Type 1 WinAnsi no no no 5 0 PGTGZZ+Arial-BoldMT Type 1C WinAnsi yes yes no 190 0 PGTGZZ+ArialMT Type 1C WinAnsi yes yes no 191 0 OHJALB+Arial-BoldItalicMT Type 1C WinAnsi yes yes no 192 0 PGTGZZ+Arial-BoldMT Type 1C WinAnsi yes yes no 193 0 PGTGZZ+ArialMT Type 1C WinAnsi yes yes no 208 0 OHJALB+Arial-BoldItalicMT Type 1C WinAnsi yes yes no 209 0 PGTGZZ+Arial-BoldMT Type 1C WinAnsi yes yes no 210 0 PGTGZZ+Arial-BoldMT Type 1C WinAnsi yes yes no 211 0 PGTGZZ+ArialMT Type 1C WinAnsi yes yes no 264 0 OHJALB+Arial-BoldItalicMT Type 1C WinAnsi yes yes no 265 0 PGTGZZ+Arial-BoldMT Type 1C WinAnsi yes yes no 266 0 PGTGZZ+ArialMT Type 1C WinAnsi yes yes no 276 0 OHJALB+Arial-BoldItalicMT Type 1C WinAnsi yes yes no 277 0 PGTGZZ+Arial-BoldMT Type 1C WinAnsi yes yes no 278 0 PGTGZZ+Arial-BoldMT Type 1C WinAnsi yes yes no 295 0 PGTGZZ+ArialMT Type 1C WinAnsi yes yes no 296 0 OHJALB+Arial-BoldItalicMT Type 1C WinAnsi yes yes no 297 0 PGTGZZ+Arial-BoldMT Type 1C WinAnsi yes yes no 303 0 PGTGZZ+ArialMT Type 1C WinAnsi yes yes no 304 0 OHJALB+Arial-BoldItalicMT Type 1C WinAnsi yes yes no 305 0 PGTGZZ+Arial-BoldMT Type 1C WinAnsi yes yes no 306 0 DOUMNX+STIX-Regular Type 1C Custom yes yes yes 312 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2026-09-18 04:27:18 CEST RepresentationInformation: 335915.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2026-09-17 11:05:06 CEST Size: 1355707 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 2 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Language: en-US Outlines: Item: Title: Reduced Growth and Inflammation in Lrp5−/− Mice Adipose Tissue Children: Item: Title: ABSTRACT Item: Title: 1   |   Introduction Item: Title: 2   |   Results Children: Item: Title: 2.1   |   Reduced Adipose Tissue Growth in Lrp5−/− Mice Item: Title: 2.2   |   Increased LRP5 and LRP1 Expression in Hypercholesterolemic Mice Item: Title: 2.3   |   Increased LRP5 and LRP1 Expression in Obese Patients Item: Title: 2.4   |   Adipocyte Markers Are Increased in Hypercholesterolemic Mice Item: Title: 2.5   |   Macrophage Markers Are Reduced in Lrp5−/− Mice Adipose Tissues Item: Title: 2.6   |   Pro-Inflammatory Profile in Mice Adipose Tissues Item: Title: 2.7   |   Anti-Inflammatory Profile Is Preserved in Lrp5−/− Mice Adipose Tissues Item: Title: 3   |   Discussion Item: Title: 4   |   Methods Children: Item: Title: 4.1   |   Animal Protocols Item: Title: 4.2   |   Human Adipose Tissue Collection Item: Title: 4.3   |   Tissue Processing Item: Title: 4.4   |   Statistical Analysis Item: Title: Author Contributions Item: Title: Acknowledgements Item: Title: Ethics Statement Item: Title: Conflicts of Interest Item: Title: Data Availability Statement Item: Title: References Filters: FilterPipeline: FlateDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 228 ImageHeight: 45 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 228 ImageHeight: 45 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1810 ImageHeight: 705 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: Separation Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2020 ImageHeight: 2703 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: Separation Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1995 ImageHeight: 2430 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: Separation Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1964 ImageHeight: 2179 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: Separation Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1935 ImageHeight: 2688 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: Separation Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2009 ImageHeight: 2291 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: Separation Intent: RelativeColorimetric Name: X Fonts: Type1: Font: BaseFont: OHJALB+Arial-BoldItalicMT FontSubset: true FirstChar: 32 LastChar: 116 FontDescriptor: FontName: OHJALB+Arial-BoldItalicMT Flags: Nonsymbolic FontBBox: -560, -376, 1390, 1018 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PGTGZZ+Arial-BoldMT FontSubset: true FirstChar: 32 LastChar: 119 FontDescriptor: FontName: PGTGZZ+Arial-BoldMT Flags: Nonsymbolic FontBBox: -628, -376, 2000, 1056 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PGTGZZ+ArialMT FontSubset: true FirstChar: 42 LastChar: 55 FontDescriptor: FontName: PGTGZZ+ArialMT Flags: Nonsymbolic FontBBox: -665, -325, 2000, 1040 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OHJALB+Arial-BoldItalicMT FontSubset: true FirstChar: 32 LastChar: 116 FontDescriptor: FontName: OHJALB+Arial-BoldItalicMT Flags: Nonsymbolic FontBBox: -560, -376, 1390, 1018 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PGTGZZ+Arial-BoldMT FontSubset: true FirstChar: 32 LastChar: 119 FontDescriptor: FontName: PGTGZZ+Arial-BoldMT Flags: Nonsymbolic FontBBox: -628, -376, 2000, 1056 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PGTGZZ+ArialMT FontSubset: true FirstChar: 42 LastChar: 53 FontDescriptor: FontName: PGTGZZ+ArialMT Flags: Nonsymbolic FontBBox: -665, -325, 2000, 1040 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OHJALB+Arial-BoldItalicMT FontSubset: true FirstChar: 32 LastChar: 116 FontDescriptor: FontName: OHJALB+Arial-BoldItalicMT Flags: Nonsymbolic FontBBox: -560, -376, 1390, 1018 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PGTGZZ+Arial-BoldMT FontSubset: true FirstChar: 32 LastChar: 119 FontDescriptor: FontName: PGTGZZ+Arial-BoldMT Flags: Nonsymbolic FontBBox: -628, -376, 2000, 1056 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PGTGZZ+Arial-BoldMT FontSubset: true FirstChar: 32 LastChar: 119 FontDescriptor: FontName: PGTGZZ+Arial-BoldMT Flags: Nonsymbolic FontBBox: -628, -376, 2000, 1056 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PGTGZZ+ArialMT FontSubset: true FirstChar: 42 LastChar: 55 FontDescriptor: FontName: PGTGZZ+ArialMT Flags: Nonsymbolic FontBBox: -665, -325, 2000, 1040 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OHJALB+Arial-BoldItalicMT FontSubset: true FirstChar: 32 LastChar: 116 FontDescriptor: FontName: OHJALB+Arial-BoldItalicMT Flags: Nonsymbolic FontBBox: -560, -376, 1390, 1018 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PGTGZZ+Arial-BoldMT FontSubset: true FirstChar: 32 LastChar: 119 FontDescriptor: FontName: PGTGZZ+Arial-BoldMT Flags: Nonsymbolic FontBBox: -628, -376, 2000, 1056 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PGTGZZ+Arial-BoldMT FontSubset: true FirstChar: 32 LastChar: 119 FontDescriptor: FontName: PGTGZZ+Arial-BoldMT Flags: Nonsymbolic FontBBox: -628, -376, 2000, 1056 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PGTGZZ+ArialMT FontSubset: true FirstChar: 42 LastChar: 55 FontDescriptor: FontName: PGTGZZ+ArialMT Flags: Nonsymbolic FontBBox: -665, -325, 2000, 1040 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OHJALB+Arial-BoldItalicMT FontSubset: true FirstChar: 32 LastChar: 116 FontDescriptor: FontName: OHJALB+Arial-BoldItalicMT Flags: Nonsymbolic FontBBox: -560, -376, 1390, 1018 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PGTGZZ+Arial-BoldMT FontSubset: true FirstChar: 32 LastChar: 117 FontDescriptor: FontName: PGTGZZ+Arial-BoldMT Flags: Nonsymbolic FontBBox: -628, -376, 2000, 1056 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PGTGZZ+ArialMT FontSubset: true FirstChar: 42 LastChar: 57 FontDescriptor: FontName: PGTGZZ+ArialMT Flags: Nonsymbolic FontBBox: -665, -325, 2000, 1040 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: OHJALB+Arial-BoldItalicMT FontSubset: true FirstChar: 32 LastChar: 116 FontDescriptor: FontName: OHJALB+Arial-BoldItalicMT Flags: Nonsymbolic FontBBox: -560, -376, 1390, 1018 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PGTGZZ+Arial-BoldMT FontSubset: true FirstChar: 32 LastChar: 119 FontDescriptor: FontName: PGTGZZ+Arial-BoldMT Flags: Nonsymbolic FontBBox: -628, -376, 2000, 1056 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: QRNWNX+STIXTwoText FontSubset: true FirstChar: 24 LastChar: 253 FontDescriptor: FontName: QRNWNX+STIXTwoText Flags: Serif, Nonsymbolic FontBBox: -948, -373, 1297, 1047 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: YWJIVH+STIX-Italic FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: YWJIVH+STIX-Italic Flags: Serif, Nonsymbolic, Italic FontBBox: -970, -305, 1429, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: DOUMNX+STIX-Regular FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: DOUMNX+STIX-Regular Flags: Serif, Nonsymbolic FontBBox: -970, -486, 2208, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: FGBIPT+STIXTwoText-Italic FontSubset: true FirstChar: 31 LastChar: 243 FontDescriptor: FontName: FGBIPT+STIXTwoText-Italic Flags: Serif, Nonsymbolic, Italic FontBBox: -893, -362, 1298, 1047 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: DQARNX+STIXTwoText-BoldItalic FontSubset: true FirstChar: 32 LastChar: 117 FontDescriptor: FontName: DQARNX+STIXTwoText-BoldItalic Flags: Serif, Nonsymbolic, Italic FontBBox: -893, -427, 1451, 1047 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: JPTWTL+ArialRoundedMTBold FontSubset: true FirstChar: 32 LastChar: 83 FontDescriptor: FontName: JPTWTL+ArialRoundedMTBold Flags: Nonsymbolic FontBBox: -174, -211, 1185, 946 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: KGKHHJ+STIXTwoText-Bold FontSubset: true FirstChar: 26 LastChar: 124 FontDescriptor: FontName: KGKHHJ+STIXTwoText-Bold Flags: Serif, Nonsymbolic FontBBox: -948, -434, 1429, 1047 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: IQJQFN+STIX-BoldItalic FontSubset: true FirstChar: 31 LastChar: 31 FontDescriptor: FontName: IQJQFN+STIX-BoldItalic Flags: Serif, Nonsymbolic, Italic FontBBox: -753, -359, 1430, 1004 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: PGTGZZ+Arial-BoldMT FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: PGTGZZ+Arial-BoldMT Flags: Nonsymbolic FontBBox: -628, -376, 2000, 1056 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: PGTGZZ+ArialMT FontSubset: true FirstChar: 42 LastChar: 56 FontDescriptor: FontName: PGTGZZ+ArialMT Flags: Nonsymbolic FontBBox: -665, -325, 2000, 1040 FontFile3: true Encoding: WinAnsiEncoding XMP: application/pdfdoi:10.1111/jcmm.70670 10.1111/jcmm.70670https://doi.org/10.1111/jcmm.70670 2025-10-13trueonlinelibrary.wiley.com10.1111/jcmm.70670 onlinelibrary.wiley.comtrue10.1111/jcmm.706702025-10-13 VoR Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 45, 26, 151, 16 Annotation: Subtype: Link Rect: 158, 672, 213, 656 Annotation: Subtype: Link Rect: 104, 582, 112, 569 ActionDest: 381 Annotation: Subtype: Link Rect: 184, 582, 193, 569 ActionDest: 381 Annotation: Subtype: Link Rect: 266, 582, 274, 569 ActionDest: 381 Annotation: Subtype: Link Rect: 340, 582, 348, 569 ActionDest: 381 Annotation: Subtype: Link Rect: 436, 582, 436, 569 Annotation: Subtype: Link Rect: 436, 582, 444, 569 ActionDest: 381 Annotation: Subtype: Link Rect: 444, 583, 457, 571 Annotation: Subtype: Link Rect: 176, 530, 256, 519 Annotation: Subtype: Link Rect: 326, 156, 340, 143 ActionDest: 371 Annotation: Subtype: Link Rect: 202, 78, 297, 68 Annotation: Subtype: Link Rect: 519, 782, 595, 767 Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 161, 740, 174, 727 ActionDest: 371 Annotation: Subtype: Link Rect: 133, 717, 137, 704 ActionDest: 371 Annotation: Subtype: Link Rect: 156, 648, 161, 635 ActionDest: 371 Annotation: Subtype: Link Rect: 69, 590, 73, 578 ActionDest: 371 Annotation: Subtype: Link Rect: 47, 510, 56, 497 ActionDest: 371 Annotation: Subtype: Link Rect: 141, 487, 149, 474 ActionDest: 371 Annotation: Subtype: Link Rect: 78, 452, 101, 440 ActionDest: 371 Annotation: Subtype: Link Rect: 79, 441, 88, 428 ActionDest: 371 Annotation: Subtype: Link Rect: 200, 383, 221, 371 ActionDest: 371 Annotation: Subtype: Link Rect: 206, 349, 214, 336 ActionDest: 371 Annotation: Subtype: Link Rect: 275, 326, 283, 313 ActionDest: 371 Annotation: Subtype: Link Rect: 163, 291, 171, 279 ActionDest: 371 Annotation: Subtype: Link Rect: 136, 234, 144, 221 ActionDest: 371 Annotation: Subtype: Link Rect: 204, 188, 213, 175 ActionDest: 371 Annotation: Subtype: Link Rect: 94, 153, 102, 141 ActionDest: 373 Annotation: Subtype: Link Rect: 66, 73, 75, 60 ActionDest: 373 Annotation: Subtype: Link Rect: 405, 751, 413, 739 ActionDest: 373 Annotation: Subtype: Link Rect: 338, 728, 360, 716 ActionDest: 373 Annotation: Subtype: Link Rect: 407, 671, 416, 658 ActionDest: 373 Annotation: Subtype: Link Rect: 520, 602, 528, 589 ActionDest: 373 Annotation: Subtype: Link Rect: 437, 498, 446, 486 ActionDest: 373 Annotation: Subtype: Link Rect: 410, 429, 434, 417 ActionDest: 373 Annotation: Subtype: Link Rect: 329, 383, 338, 371 ActionDest: 373 Annotation: Subtype: Link Rect: 494, 303, 516, 290 ActionDest: 373 Annotation: Subtype: Link Rect: 501, 222, 523, 210 ActionDest: 373 Annotation: Subtype: Link Rect: 496, 211, 505, 198 ActionDest: 373 Annotation: Subtype: Link Rect: 536, 188, 544, 175 ActionDest: 373 Annotation: Subtype: Link Rect: 326, 119, 334, 106 ActionDest: 373 Annotation: Subtype: Link Rect: 421, 96, 430, 83 ActionDest: 373 Annotation: Subtype: Link Rect: 536, 73, 544, 60 ActionDest: 373 Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 160, 740, 169, 727 ActionDest: 373 Annotation: Subtype: Link Rect: 272, 475, 283, 463 ActionDest: 187 Annotation: Subtype: Link Rect: 199, 464, 209, 451 ActionDest: 187 Annotation: Subtype: Link Rect: 273, 464, 283, 451 ActionDest: 187 Annotation: Subtype: Link Rect: 98, 452, 109, 440 ActionDest: 187 Annotation: Subtype: Link Rect: 185, 452, 196, 440 ActionDest: 187 Annotation: Subtype: Link Rect: 137, 429, 146, 417 ActionDest: 187 Annotation: Subtype: Link Rect: 99, 372, 129, 359 ActionDest: 187 Annotation: Subtype: Link Rect: 252, 360, 283, 348 ActionDest: 187 Annotation: Subtype: Link Rect: 193, 314, 202, 302 ActionDest: 187 Annotation: Subtype: Link Rect: 191, 280, 214, 267 ActionDest: 373 Annotation: Subtype: Link Rect: 252, 280, 267, 267 ActionDest: 375 Annotation: Subtype: Link Rect: 79, 234, 94, 221 ActionDest: 375 Annotation: Subtype: Link Rect: 147, 188, 161, 175 ActionDest: 375 Annotation: Subtype: Link Rect: 142, 176, 156, 164 ActionDest: 375 Annotation: Subtype: Link Rect: 246, 96, 269, 83 ActionDest: 373 Annotation: Subtype: Link Rect: 398, 740, 409, 727 ActionDest: 215 Annotation: Subtype: Link Rect: 439, 705, 450, 693 ActionDest: 215 Annotation: Subtype: Link Rect: 382, 694, 392, 681 ActionDest: 215 Annotation: Subtype: Link Rect: 471, 694, 481, 681 ActionDest: 215 Annotation: Subtype: Link Rect: 533, 613, 544, 601 ActionDest: 215 Annotation: Subtype: Link Rect: 337, 579, 348, 566 ActionDest: 215 Annotation: Subtype: Link Rect: 425, 510, 444, 497 ActionDest: 215 Annotation: Subtype: Link Rect: 470, 395, 481, 382 ActionDest: 215 Annotation: Subtype: Link Rect: 446, 372, 457, 359 ActionDest: 215 Annotation: Subtype: Link Rect: 369, 337, 381, 325 ActionDest: 215 Annotation: Subtype: Link Rect: 506, 199, 517, 187 ActionDest: 262 Annotation: Subtype: Link Rect: 533, 176, 544, 164 ActionDest: 262 Annotation: Subtype: Link Rect: 448, 142, 458, 129 ActionDest: 262 Annotation: Subtype: Link Rect: 338, 107, 349, 95 ActionDest: 262 Annotation: Subtype: Link Rect: 525, 73, 544, 60 ActionDest: 262 Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 117, 141, 138, 128 ActionDest: 262 Annotation: Subtype: Link Rect: 358, 118, 380, 105 ActionDest: 274 Annotation: Subtype: Link Rect: 492, 84, 513, 71 ActionDest: 274 Page: Sequence: 5 Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 76, 624, 98, 611 ActionDest: 274 Annotation: Subtype: Link Rect: 78, 509, 88, 496 ActionDest: 293 Annotation: Subtype: Link Rect: 273, 498, 283, 485 ActionDest: 293 Annotation: Subtype: Link Rect: 76, 452, 86, 439 ActionDest: 293 Annotation: Subtype: Link Rect: 193, 383, 204, 370 ActionDest: 293 Annotation: Subtype: Link Rect: 273, 371, 283, 358 ActionDest: 293 Annotation: Subtype: Link Rect: 229, 337, 239, 324 ActionDest: 293 Annotation: Subtype: Link Rect: 190, 314, 200, 301 ActionDest: 293 Annotation: Subtype: Link Rect: 273, 233, 283, 220 ActionDest: 293 Annotation: Subtype: Link Rect: 215, 153, 225, 140 ActionDest: 293 Annotation: Subtype: Link Rect: 273, 84, 283, 71 ActionDest: 293 Annotation: Subtype: Link Rect: 427, 647, 439, 634 ActionDest: 293 Annotation: Subtype: Link Rect: 533, 544, 544, 531 ActionDest: 301 Annotation: Subtype: Link Rect: 508, 521, 518, 508 ActionDest: 301 Annotation: Subtype: Link Rect: 474, 498, 493, 485 ActionDest: 301 Annotation: Subtype: Link Rect: 407, 475, 417, 462 ActionDest: 301 Annotation: Subtype: Link Rect: 378, 429, 399, 416 ActionDest: 301 Annotation: Subtype: Link Rect: 535, 337, 544, 324 ActionDest: 373 Annotation: Subtype: Link Rect: 337, 302, 345, 289 ActionDest: 373 Annotation: Subtype: Link Rect: 352, 233, 361, 220 ActionDest: 373 Annotation: Subtype: Link Rect: 446, 141, 455, 128 ActionDest: 373 Annotation: Subtype: Link Rect: 308, 107, 317, 94 ActionDest: 373 Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 465, 84, 488, 71 ActionDest: 373 Annotation: Subtype: Link Rect: 522, 72, 544, 59 ActionDest: 375 Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 48, 118, 56, 105 ActionDest: 375 Annotation: Subtype: Link Rect: 221, 84, 230, 71 ActionDest: 375 Annotation: Subtype: Link Rect: 410, 95, 433, 82 ActionDest: 375 Annotation: Subtype: Link Rect: 353, 72, 361, 59 ActionDest: 375 Annotation: Subtype: Link Rect: 466, 61, 475, 48 ActionDest: 375 Page: Sequence: 9 Page: Sequence: 10 Page: Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 48, 728, 56, 716 ActionDest: 375 Annotation: Subtype: Link Rect: 219, 705, 241, 693 ActionDest: 375 Annotation: Subtype: Link Rect: 131, 602, 139, 589 ActionDest: 371 Annotation: Subtype: Link Rect: 82, 510, 91, 497 ActionDest: 375 Annotation: Subtype: Link Rect: 275, 429, 283, 417 ActionDest: 375 Annotation: Subtype: Link Rect: 89, 395, 111, 382 ActionDest: 375 Annotation: Subtype: Link Rect: 109, 337, 131, 325 ActionDest: 375 Annotation: Subtype: Link Rect: 163, 291, 171, 279 ActionDest: 375 Annotation: Subtype: Link Rect: 275, 268, 283, 256 ActionDest: 375 Annotation: Subtype: Link Rect: 71, 222, 80, 210 ActionDest: 375 Annotation: Subtype: Link Rect: 214, 96, 222, 83 ActionDest: 375 Annotation: Subtype: Link Rect: 415, 728, 423, 716 ActionDest: 373 Annotation: Subtype: Link Rect: 308, 694, 317, 681 ActionDest: 373 Annotation: Subtype: Link Rect: 382, 625, 390, 612 ActionDest: 375 Annotation: Subtype: Link Rect: 462, 602, 470, 589 ActionDest: 375 Annotation: Subtype: Link Rect: 384, 579, 393, 566 ActionDest: 375 Annotation: Subtype: Link Rect: 517, 556, 525, 543 ActionDest: 375 Annotation: Subtype: Link Rect: 536, 510, 544, 497 ActionDest: 375 Annotation: Subtype: Link Rect: 341, 441, 349, 428 ActionDest: 375 Annotation: Subtype: Link Rect: 440, 326, 448, 313 ActionDest: 375 Annotation: Subtype: Link Rect: 350, 291, 358, 279 ActionDest: 375 Annotation: Subtype: Link Rect: 473, 245, 481, 233 ActionDest: 375 Annotation: Subtype: Link Rect: 372, 188, 376, 175 ActionDest: 371 Annotation: Subtype: Link Rect: 392, 73, 400, 60 ActionDest: 375 Annotation: Subtype: Link Rect: 308, 61, 317, 49 ActionDest: 375 Page: Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 119, 648, 127, 635 ActionDest: 375 Page: Sequence: 13 Page: Sequence: 14 Page: Sequence: 15 Checksum: b2644f6d Type: CRC32 Checksum: 46e917ea45261c6143c51dc4d84075d6 Type: MD5 Checksum: 123f23c8116d76bdb9375d95e9edf46c31f4435b Type: SHA-1 Checksum: 9baed8ada83fdcc39e0725c057391a6ce740c0d6bb71391a79b216a24d9eb59e Type: SHA-256