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analyses with PDAC risk Destination: B2 Item: Title: Gene-based association analysis with PDAC risk and established PDAC risk factors Destination: B3 Item: Title: Functional in silico analyses Destination: B4 Item: Title: Prognostic associations of CS-related genes in PDAC patients Destination: B5 Item: Title: Prognostic CS-based gene signatures for patient stratification Destination: B6 Item: Title: Patients stratified according to CS-related gene expression have distinct immune cell infiltration profiles Destination: B7 Item: Title: Discussion Destination: A2 Item: Title: Methods Destination: A3 Children: Item: Title: Study populations Destination: B8 Item: Title: Single variant association analysis with PDAC risk Destination: B9 Item: Title: Gene-based association analysis with PDAC risk Destination: B10 Item: Title: Survival analysis of CS-related genes at germline and somatic levels Destination: B11 Item: Title: Ethics Statement Destination: B12 Item: Title: Reporting summary 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Löhr Christoph W. Michalski José Perea Michael O’Rorke Victor M. Barberà Adonina Tardón Antoni Farré Luís Muñoz-Bellvís Tatjana Crnogorac-Jurcevic Enrique Domínguez-Muñoz Thomas M. Gress William Greenhalf Linda Sharp Joaquim Balsells Eithne Costello Jörg Kleeff Bo Kong Josefina Mora Damian O’Driscoll Aldo Scarpa Weimin Ye Francisco X. Real Evangelina López de Maturana Núria Malats Alberto Langtry Lola Alonso Sergio Sabroso-Lasa Ane Moreno-Oya Paulina Gómez-Rubio Esther Molina-Montes Mirari Márquez Roger Milne Ana Alfaro Tania Lobato Lidia Estudillo Francisco X. Real Núria Malats Aldo Scarpa Rita Lawlor Stefania Beghelli Rafael Alvarez-Gallego Antonio Cubillo Manuel Hidalgo Paloma Peinado Isabel Salas Jesús Rodríguez Pascual Alfredo Carrato Julie Earl Alejandra Caminoa Carmen Guillén-Ponce Mercedes Rodríguez-Garrote Federico Longo-Muñoz Reyes Ferreiro Vanessa Pachón M. Ángeles Vaz María Muñoz Mar Iglesias Lucas Ilzarbe Cristina Álvarez-Urturi Xavier Bessa Felipe Bory Lucía Márquez Ignasi Poves Fernando Burdío Luis Grande Javier Gimeno Xavier Molero Luisa Guarner Joaquín Balcells Mayte Salcedo Xavier Merino Christoph W. Michalski Irene Esposito Jörg Kleeff Bo Kong Carmen Mota Matthias J. Löhr Jiaqui Huang Caroline Verbeke Weimin Ye Jingru Yu Carmelo Loinaz José Perea José Luis Rodríguez-Peralto Ana Teijo Pablo Peláez Antoni Farré Josefina Mora Marta Martín Vicenç Artigas Carlos Guarner Francesc J. Sancho Mar Concepción Teresa Ramón y Cajal Justyna Szafranska Michael O’Rorke Liam Murray Marie Cantwell Victor M. Barberà Javier Gallego Adonina Tardón Luis Barneo MM Rodriguez-Suarez Enrique Domínguez-Muñoz Yolanda Pazos Antonio Lozano Maria Luaces Francisco Blanco-Antona J. M. Sayagués Manzano M. L. Gutiérrez Troncoso A. Orfao de Matos Luís Muñoz-Bellvís Thomas M. Gress Malte Buchholz Albrecht Neesse William Greenhalf Eithne Costello Tatjana Crnogorac-Jurcevic Hemant M. Kocher Satyajit Bhattacharya Ajit T. Abraham Darren Ennis Thomas Dowe Tomasz Radon Damian O’Driscoll Linda Sharp Springer US Nature Communications, doi:10.1038/s41467-025-65811-y springer.com springerlink.com springer.com springerlink.com Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 95, 223, 97, 228 Flags: Print AppearanceDictionary: true Destination: 242 Annotation: Subtype: Link Rect: 99, 223, 101, 228 Flags: Print AppearanceDictionary: true Destination: 242 Annotation: Subtype: Link Rect: 173, 202, 175, 207 Flags: Print AppearanceDictionary: true Destination: 242 Annotation: Subtype: Link Rect: 177, 202, 179, 207 Flags: Print AppearanceDictionary: true Destination: 242 Annotation: Subtype: Link Rect: 200, 116, 202, 121 Flags: Print AppearanceDictionary: true Destination: 242 Annotation: Subtype: Link Rect: 203, 116, 206, 121 Flags: Print AppearanceDictionary: true Destination: 242 Annotation: Subtype: Link Rect: 340, 169, 343, 174 Flags: Print AppearanceDictionary: true Destination: 242 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