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Title:           Mining the heparinome for cryptic antimicrobial peptides that selectively kill Gram-negative bacteria
Subject:         Molecular Systems Biology, doi:10.1038/s44320-025-00120-6
Keywords:        Antimicrobial Peptide; Heparin-binding Protein; Lipopolysaccharide; Heparin; Glycosaminoglycans
Author:          Roberto Bello-Madruga
Creator:         Springer
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     Item: 
      Title: Mining the heparinome for cryptic antimicrobial peptides that selectively kill Gram-negative bacteria
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       Item: 
        Title: Introduction
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       Item: 
        Title: Results
        Destination: A2
        Children: 
         Item: 
          Title: Linking heparin affinity and antimicrobial activity
          Destination: B1
         Item: 
          Title: Validation of cryptic AMPs by synthetic HBPs
          Destination: B2
         Item: 
          Title: Mechanism of action
          Destination: B3
         Item: 
          Title: Structural characterization
          Destination: B4
         Item: 
          Title: Insights into the CPC’ motif of HBP-5 and its implication on the antibacterial mechanism
          Destination: B5
         Item: 
          Title: Optimization of HBP-5 peptide and in vivo studies
          Destination: B6
       Item: 
        Title: Discussion
        Destination: A3
       Item: 
        Title: Methods
        Destination: A4
        Children: 
         Item: 
          Title: Antimicrobial activity prediction and docking
          Destination: B7
         Item: 
          Title: Peptides
          Destination: B8
         Item: 
          Title: Heparin-binding affinity assay
          Destination: B9
         Item: 
          Title: Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC)
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         Item: 
          Title: Killing curve assay
          Destination: B11
         Item: 
          Title: Hemolytic activity
          Destination: B12
         Item: 
          Title: LPS-binding affinity
          Destination: B13
         Item: 
          Title: Bacterial membrane depolarization
          Destination: B14
         Item: 
          Title: Outer membrane permeabilization
          Destination: B15
         Item: 
          Title: Scanning electron microscopy (SEM)
          Destination: B16
         Item: 
          Title: Cytotoxicity in mammalian cells
          Destination: B17
         Item: 
          Title: Circular dichroism
          Destination: B18
         Item: 
          Title: NMR spectroscopy
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         Item: 
          Title: Molecular dynamics simulations
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         Item: 
          Title: Serum stability
          Destination: B21
         Item: 
          Title: Mouse systemic infection
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       Item: 
        Title: Data availability
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       Item: 
        Title: References
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        Children: 
         Item: 
          Title: Acknowledgements
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         Item: 
          Title: Author contributions
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       Item: 
        Title: ACKNOWLEDGMENTS
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    Title: Mining the heparinome for cryptic antimicrobial peptides that selectively kill Gram-negative bacteria
    Author: Roberto Bello-Madruga
    Subject: Molecular Systems Biology, doi:10.1038/s44320-025-00120-6
    Keywords: Antimicrobial Peptide; Heparin-binding Protein; Lipopolysaccharide; Heparin; Glycosaminoglycans
    Creator: Springer
    CreationDate: Wed Jun 25 12:09:35 CEST 2025
    ModDate: Wed Jun 25 12:10:47 CEST 2025
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  Checksum: 18b073b2
   Type: CRC32
  Checksum: 89d55d5b821bff1ec68a41ec45ddaa49
   Type: MD5
  Checksum: 47bde9ab7ddedd28f8fefbeac2e571a144cda907
   Type: SHA-1
  Checksum: 7a89c3f683eb5af82fbdd55633bcbbb2864c42494bb1b45f8fd3ed422559691d
   Type: SHA-256