866141848ff0033b6b78e5f21f2f7e49 336379.pdf db889a5674e7825aedc5a1b90f59eca733821eb1 336379.pdf d5f618f4b14dd4570dbb5a1357a63cbeaccedd11e19d8c5df7e1986b05ea665b 336379.pdf Title: Parkinson’s disease medication adjustments based on wearable device information compared to other methods: randomized clinical trial Subject: npj Parkinson’s Disease, doi:10.1038/s41531-025-00977-2 Keywords: Author: Alejandro Rodríguez-Molinero Creator: Springer Producer: iText® 5.5.13.4 ©2000-2024 iText Group NV (SPRINGER SBM; licensed version) CreationDate: Sat Aug 16 14:13:59 2025 CEST ModDate: Wed Aug 20 14:35:34 2025 CEST Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 9 Encrypted: no Page size: 595.276 x 790.866 pts Page rot: 0 File size: 709679 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- DALFNA+GraphikNaturel-Regular Type 1C WinAnsi yes yes no 545 0 DALGLE+AdvTT691e30a0 Type 1C WinAnsi yes yes no 546 0 DALGLF+AdvOTf0129623+fb Type 1C Custom yes yes yes 84 0 DALGLG+AdvTT7b515deb Type 1C WinAnsi yes yes no 36 0 DALGLH+AdvOT1ef757c0 Type 1C WinAnsi yes yes no 37 0 DALGLI+AdvOT1ef757c0+20 Type 1C WinAnsi yes yes no 38 0 DALGLJ+AdvOT1ef757c0+fb Type 1C Custom yes yes yes 39 0 DALHDH+AdvOTf94803d4+20 Type 1C WinAnsi yes yes no 40 0 DALFOB+AdvOT0c200bf0 Type 1C WinAnsi yes yes no 547 0 DALFOC+AdvOT0c200bf0+20 Type 1C WinAnsi yes yes no 548 0 DALFOD+AdvOT34fe1490.B Type 1C WinAnsi yes yes no 43 0 DALFPD+AdvOTf0129623 Type 1C WinAnsi yes yes no 44 0 DALFPE+AdvOTf0129623+20 Type 1C WinAnsi yes yes no 89 0 DALGDE+AdvOTf94803d4 Type 1C WinAnsi yes yes no 45 0 DALGDF+AdvOTfbba3ace.B Type 1C WinAnsi yes yes no 549 0 DALGDG+AdvOTfbba3ace.B+20 Type 1C WinAnsi yes yes no 550 0 DALHEH+AdvOT7d6df7ab.I Type 1C WinAnsi yes yes no 41 0 DALHJG+AdvOTb65e897d.B Type 1C WinAnsi yes yes no 42 0 DALIED+AdvTTab7e17fd+22 Type 1C Custom yes yes no 85 0 DALIFE+AdvOT6601a1b9.BI Type 1C WinAnsi yes yes no 86 0 DALIFF+AdvOT3a037357.I Type 1C WinAnsi yes yes no 87 0 DALIFG+AdvOT34fe1490.B+20 Type 1C WinAnsi yes yes no 88 0 DALIIG+AdvOT34fe1490.B+fb Type 1C Custom yes yes yes 108 0 DALIMF+AdvOT1ef757c0+03 Type 1C Custom yes yes yes 168 0 DALIMG+AdvOTa20b42a7 Type 1C WinAnsi yes yes no 169 0 DALIOH+AdvOT3a037357.I+20 Type 1C WinAnsi yes yes no 192 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2026-10-07 04:15:33 CEST RepresentationInformation: 336379.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2026-10-06 17:23:22 CEST Size: 709679 Format: PDF Version: 1.4 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff21' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff26' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff5' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff40' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff36' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff12' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff31' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff17' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff22' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff25' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff15' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff32' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff39' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff4' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff28' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff35' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff18' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff11' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff42' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff7' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff2' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff19' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff38' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff33' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff14' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff8' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff3' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff24' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff29' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff10' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff43' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff41' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff6' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff1' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff34' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff13' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff27' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff20' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff16' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff9' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff30' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff37' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'bm_Aff23' cannot be found ID: PDF-HUL-149 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff8' cannot be found ID: PDF-HUL-122 Offset: 68988 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff27' cannot be found ID: PDF-HUL-122 Offset: 68988 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff18' cannot be found ID: PDF-HUL-122 Offset: 68988 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff3' cannot be found ID: PDF-HUL-122 Offset: 68988 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff13' cannot be found ID: PDF-HUL-122 Offset: 68988 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff37' cannot be found ID: PDF-HUL-122 Offset: 68988 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff31' cannot be found ID: PDF-HUL-122 Offset: 68988 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff32' cannot be found ID: PDF-HUL-122 Offset: 68988 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff17' cannot be found ID: PDF-HUL-122 Offset: 68988 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff36' cannot be found ID: PDF-HUL-122 Offset: 68988 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff22' cannot be found ID: PDF-HUL-122 Offset: 68988 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff41' cannot be found ID: PDF-HUL-122 Offset: 68988 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff42' cannot be found ID: PDF-HUL-122 Offset: 68988 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff4' cannot be found ID: PDF-HUL-122 Offset: 68988 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff14' cannot be found ID: PDF-HUL-122 Offset: 68988 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff38' cannot be found ID: PDF-HUL-122 Offset: 68988 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff11' cannot be found ID: PDF-HUL-122 Offset: 68988 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff7' cannot be found ID: PDF-HUL-122 Offset: 68988 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff35' cannot be found ID: PDF-HUL-122 Offset: 68988 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff21' cannot be found ID: PDF-HUL-122 Offset: 68988 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff28' cannot be found ID: PDF-HUL-122 Offset: 68988 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff34' cannot be found ID: PDF-HUL-122 Offset: 68988 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff39' cannot be found ID: PDF-HUL-122 Offset: 68988 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff10' cannot be found ID: PDF-HUL-122 Offset: 68988 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff43' cannot be found ID: PDF-HUL-122 Offset: 68988 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff25' cannot be found ID: PDF-HUL-122 Offset: 68988 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff24' cannot be found ID: PDF-HUL-122 Offset: 68988 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff6' cannot be found ID: PDF-HUL-122 Offset: 68988 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff1' cannot be found ID: PDF-HUL-122 Offset: 68988 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff29' cannot be found ID: PDF-HUL-122 Offset: 68988 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff20' cannot be found ID: PDF-HUL-122 Offset: 68988 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff15' cannot be found ID: PDF-HUL-122 Offset: 68988 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff26' cannot be found ID: PDF-HUL-122 Offset: 68988 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff33' cannot be found ID: PDF-HUL-122 Offset: 68988 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff30' cannot be found ID: PDF-HUL-122 Offset: 68988 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff2' cannot be found ID: PDF-HUL-122 Offset: 68988 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff12' cannot be found ID: PDF-HUL-122 Offset: 68988 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff9' cannot be found ID: PDF-HUL-122 Offset: 68988 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff19' cannot be found ID: PDF-HUL-122 Offset: 68988 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff5' cannot be found ID: PDF-HUL-122 Offset: 68988 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff23' cannot be found ID: PDF-HUL-122 Offset: 68988 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff40' cannot be found ID: PDF-HUL-122 Offset: 68988 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'bm_Aff16' cannot be found ID: PDF-HUL-122 Offset: 68988 MIMEtype: application/pdf PDFMetadata: Objects: 639 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Parkinson’s disease medication adjustments based on wearable device information compared to other methods: randomized clinical trial Destination: title_link Children: Item: Title: Results Destination: A1 Children: Item: Title: Characteristics of study patients Destination: B1 Item: Title: Primary outcome Destination: B2 Item: Title: Secondary outcomes Destination: B3 Item: Title: Discussion Destination: A2 Item: Title: Methods Destination: A3 Children: Item: Title: Trial design Destination: B4 Item: Title: Participating Neurologists and Patients Destination: B5 Item: Title: Interventions Destination: B6 Item: Title: Data collection and visits Destination: B7 Item: Title: Outcomes and variables Destination: B8 Item: Title: Sample size Destination: B9 Item: Title: Randomization and blinding Destination: B10 Item: Title: Statistical methods Destination: B11 Item: Title: Data availability Destination: A4 Item: Title: References Destination: A5 Item: Title: Acknowledgements Destination: A6 Item: Title: Author contributions Destination: A7 Item: Title: Competing interests Destination: A8 Item: Title: Additional information Destination: M3 Info: Title: Parkinson’s disease medication adjustments based on wearable device information compared to other methods: randomized clinical trial Author: Alejandro Rodríguez-Molinero Subject: npj Parkinson’s Disease, doi:10.1038/s41531-025-00977-2 Keywords: Creator: Springer Producer: iText® 5.5.13.4 ©2000-2024 iText Group NV (SPRINGER SBM; licensed version) CreationDate: Sat Aug 16 14:43:59 CEST 2025 ModDate: Wed Aug 20 14:35:34 CEST 2025 ID: 0x9a4103bc31d5c471d9aa17414b12c554, 0xcd773ae1d6f3227fe06daaaf14360b00 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 46 ImageHeight: 40 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 250 ImageHeight: 80 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: Perceptual Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Fonts: Type1: Font: BaseFont: DALIOH+AdvOT3a037357.I+20 FontSubset: true FirstChar: 146 LastChar: 146 FontDescriptor: FontName: DALIOH+AdvOT3a037357.I+20 Flags: Nonsymbolic FontBBox: -156, -145, 1010, 718 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DALGLF+AdvOTf0129623+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: DALGLF+AdvOTf0129623+fb Flags: Symbolic FontBBox: 0, 0, 500, 718 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DALIED+AdvTTab7e17fd+22 FontSubset: true FirstChar: 21 LastChar: 21 FontDescriptor: FontName: DALIED+AdvTTab7e17fd+22 Flags: Nonsymbolic FontBBox: -156, -218, 937, 947 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: DALIFE+AdvOT6601a1b9.BI FontSubset: true FirstChar: 45 LastChar: 112 FontDescriptor: FontName: DALIFE+AdvOT6601a1b9.BI Flags: Nonsymbolic FontBBox: -125, -208, 1020, 968 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DALIFF+AdvOT3a037357.I FontSubset: true FirstChar: 40 LastChar: 121 FontDescriptor: FontName: DALIFF+AdvOT3a037357.I Flags: Nonsymbolic FontBBox: -125, -208, 979, 947 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DALIFG+AdvOT34fe1490.B+20 FontSubset: true FirstChar: 145 LastChar: 146 FontDescriptor: FontName: DALIFG+AdvOT34fe1490.B+20 Flags: Nonsymbolic FontBBox: -156, -166, 1072, 718 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DALFPE+AdvOTf0129623+20 FontSubset: true FirstChar: 145 LastChar: 150 FontDescriptor: FontName: DALFPE+AdvOTf0129623+20 Flags: Nonsymbolic FontBBox: -156, -145, 1072, 718 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DALFNA+GraphikNaturel-Regular FontSubset: true FirstChar: 32 LastChar: 124 FontDescriptor: FontName: DALFNA+GraphikNaturel-Regular Flags: Nonsymbolic FontBBox: -230, -252, 1092, 1113 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DALGLE+AdvTT691e30a0 FontSubset: true FirstChar: 42 LastChar: 42 FontDescriptor: FontName: DALGLE+AdvTT691e30a0 Flags: Nonsymbolic FontBBox: -31, -250, 1020, 895 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DALFOB+AdvOT0c200bf0 FontSubset: true FirstChar: 97 LastChar: 115 FontDescriptor: FontName: DALFOB+AdvOT0c200bf0 Flags: Nonsymbolic FontBBox: -10, -208, 906, 958 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DALGLG+AdvTT7b515deb FontSubset: true FirstChar: 174 LastChar: 174 FontDescriptor: FontName: DALGLG+AdvTT7b515deb Flags: Nonsymbolic FontBBox: -93, -187, 854, 843 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DALFOC+AdvOT0c200bf0+20 FontSubset: true FirstChar: 146 LastChar: 146 FontDescriptor: FontName: DALFOC+AdvOT0c200bf0+20 Flags: Nonsymbolic FontBBox: -229, -104, 1083, 770 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DALGLH+AdvOT1ef757c0 FontSubset: true FirstChar: 37 LastChar: 177 FontDescriptor: FontName: DALGLH+AdvOT1ef757c0 Flags: Serif, Nonsymbolic FontBBox: -20, -250, 947, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DALGDF+AdvOTfbba3ace.B FontSubset: true FirstChar: 58 LastChar: 122 FontDescriptor: FontName: DALGDF+AdvOTfbba3ace.B Flags: Nonsymbolic FontBBox: -31, -229, 968, 947 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DALGLI+AdvOT1ef757c0+20 FontSubset: true FirstChar: 145 LastChar: 151 FontDescriptor: FontName: DALGLI+AdvOT1ef757c0+20 Flags: Nonsymbolic FontBBox: -135, -187, 1010, 833 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DALGDG+AdvOTfbba3ace.B+20 FontSubset: true FirstChar: 146 LastChar: 146 FontDescriptor: FontName: DALGDG+AdvOTfbba3ace.B+20 Flags: Nonsymbolic FontBBox: -166, -166, 1093, 718 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DALGLJ+AdvOT1ef757c0+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: DALGLJ+AdvOT1ef757c0+fb Flags: Symbolic FontBBox: 0, -10, 781, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DALHDH+AdvOTf94803d4+20 FontSubset: true FirstChar: 146 LastChar: 146 FontDescriptor: FontName: DALHDH+AdvOTf94803d4+20 Flags: Nonsymbolic FontBBox: -156, -156, 1062, 718 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DALIMF+AdvOT1ef757c0+03 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: DALIMF+AdvOT1ef757c0+03 Flags: Symbolic FontBBox: -125, -270, 854, 791 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DALHEH+AdvOT7d6df7ab.I FontSubset: true FirstChar: 110 LastChar: 112 FontDescriptor: FontName: DALHEH+AdvOT7d6df7ab.I Flags: Nonsymbolic FontBBox: -135, -250, 1000, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DALIMG+AdvOTa20b42a7 FontSubset: true FirstChar: 48 LastChar: 118 FontDescriptor: FontName: DALIMG+AdvOTa20b42a7 Flags: Serif, Nonsymbolic FontBBox: -72, -239, 979, 906 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DALHJG+AdvOTb65e897d.B FontSubset: true FirstChar: 46 LastChar: 124 FontDescriptor: FontName: DALHJG+AdvOTb65e897d.B Flags: Nonsymbolic FontBBox: -20, -250, 968, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DALFOD+AdvOT34fe1490.B FontSubset: true FirstChar: 38 LastChar: 250 FontDescriptor: FontName: DALFOD+AdvOT34fe1490.B Flags: Nonsymbolic FontBBox: -52, -208, 937, 968 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DALFPD+AdvOTf0129623 FontSubset: true FirstChar: 34 LastChar: 250 FontDescriptor: FontName: DALFPD+AdvOTf0129623 Flags: Nonsymbolic FontBBox: -52, -208, 906, 947 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: DALIIG+AdvOT34fe1490.B+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: DALIIG+AdvOT34fe1490.B+fb Flags: Symbolic FontBBox: 0, 0, 552, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: DALGDE+AdvOTf94803d4 FontSubset: true FirstChar: 35 LastChar: 124 FontDescriptor: FontName: DALGDE+AdvOTf94803d4 Flags: Nonsymbolic FontBBox: -41, -218, 937, 947 FontFile3: true Encoding: WinAnsiEncoding XMP: Parkinson’s disease medication adjustments based on wearable device information compared to other methods: randomized clinical trial Alejandro Rodríguez-Molinero Carlos Pérez-López Nuria Caballol Mariateresa Buongiorno María Asunción Ávila Rivera Núria López Ariztegui Lydia López-Manzanares Jorge Hernández-Vara Àngels Bayes-Rusiñol Alexandre Gironell Carreró María Álvarez Saúco Elisabet Franquet Gomez David A. Pérez-Martínez Sonia Escalante Arroyo Silvia Martí-Martínez Pablo Mir José Mª Salom Juan Juan Carlos Martínez-Castrillo Cristian Tebé Anna Planas-Ballvé Pau Pastor Ignacio Alvarez Mª Isabel Morales Casado Sara Lucas del Pozo Anna Prats Álvaro Sánchez-Ferro Antonio Méndez Guerrero Carlos Leiva Santana Laura Muñoz-Delgado Daniel Macías-García Silvia Jesús Astrid Adarmes-Gómez Antonio Salvador Aliaga Gema Sánchez Esther Cubo Lourdes Ispierto González Ramiro Álvarez-Ramo Dolores Vilas Rolan Antonio Koukoulis Fernández Mª Gema Alonso Losada Jon Infante María Sierra Peña Isabel González Aramburu Mª Victoria Sánchez Peláez Marina Mata Álvarez-Santullano Carmen Borrúe Fernández Mª Concepción Jimeno Montero Lydia Vela Desojo Berta Solano Vila Anna Cots Foraster Daniel López Domínguez Esteban Peña Llamas Pilar Sánchez Alonso Elisa Gamo Gonzalez Sabela Novo Ponte Alfredo López López Mª José Gómez Heredia Francisco Pérez Errazquin Mª Pilar Solís Pérez Esther Blanco Vicente Rafael García Ruiz Ana Rita Santos Pinto Marta Recio-Bermejo Ernest Balaguer Antonio Hernández Vidal Rocío García-Ramos Eva López Valdés Rubén Alonso Redondo Jessica González Ardura Teresa Muñoz Ruiz Lucía Flores García Javier Ruiz Martínez Ana Vinagre Aragón Ioana Croitoru Esther Catena Ruiz Victor Puente Irene Navalpotro Gómez Antonio Miñarro Springer US npj Parkinson’s Disease, doi:10.1038/s41531-025-00977-2 springer.com springerlink.com springer.com springerlink.com Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 471, 531, 479, 563 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 479, 534, 576, 544 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 479, 534, 576, 544 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 167, 523, 170, 528 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 270, 523, 273, 528 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 337, 523, 340, 528 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 448, 523, 451, 528 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 158, 510, 161, 516 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 256, 510, 259, 516 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 371, 510, 374, 516 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 136, 497, 139, 503 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 140, 497, 143, 503 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 241, 497, 244, 503 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 362, 497, 365, 503 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 457, 497, 460, 503 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 146, 485, 152, 490 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 259, 485, 265, 490 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 369, 485, 375, 490 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 467, 485, 473, 490 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 79, 472, 85, 478 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 87, 472, 93, 478 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 94, 472, 100, 478 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 190, 472, 196, 478 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 329, 472, 335, 478 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 401, 472, 407, 478 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 131, 191, 133, 196 Flags: Print AppearanceDictionary: true Destination: 126 Annotation: Subtype: Link Rect: 167, 159, 169, 164 Flags: Print AppearanceDictionary: true Destination: 126 Annotation: Subtype: Link Rect: 170, 159, 173, 164 Flags: Print AppearanceDictionary: true Destination: 126 Annotation: Subtype: Link Rect: 93, 127, 95, 132 Flags: Print AppearanceDictionary: true Destination: 126 Annotation: Subtype: Link Rect: 200, 95, 202, 100 Flags: Print AppearanceDictionary: true Destination: 126 Annotation: Subtype: Link Rect: 442, 212, 444, 218 Flags: Print AppearanceDictionary: true Destination: 178 Annotation: Subtype: Link Rect: 405, 180, 407, 186 Flags: Print AppearanceDictionary: true Destination: 178 Annotation: Subtype: Link Rect: 537, 148, 540, 154 Flags: Print AppearanceDictionary: true Destination: 178 Annotation: Subtype: Link Rect: 541, 148, 543, 154 Flags: Print AppearanceDictionary: true Destination: 178 Annotation: Subtype: Link Rect: 457, 127, 459, 132 Flags: Print AppearanceDictionary: true Destination: 178 Annotation: Subtype: Link Rect: 475, 95, 480, 100 Flags: Print AppearanceDictionary: true Destination: 178 Annotation: Subtype: Link Rect: 74, 48, 147, 55 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 39, 19, 126, 27 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 204, 609, 209, 614 Flags: Print AppearanceDictionary: true Destination: 178 Annotation: Subtype: Link Rect: 210, 609, 215, 614 Flags: Print AppearanceDictionary: true Destination: 178 Annotation: Subtype: Link Rect: 137, 523, 142, 529 Flags: Print AppearanceDictionary: true Destination: 178 Annotation: Subtype: Link Rect: 145, 523, 150, 529 Flags: Print AppearanceDictionary: true Destination: 178 Annotation: Subtype: Link Rect: 79, 480, 84, 486 Flags: Print AppearanceDictionary: true Destination: 178 Annotation: Subtype: Link Rect: 85, 480, 90, 486 Flags: Print AppearanceDictionary: true Destination: 178 Annotation: Subtype: Link Rect: 323, 636, 327, 645 Flags: Print AppearanceDictionary: true Destination: 3 Annotation: Subtype: Link Rect: 336, 604, 340, 613 Flags: Print AppearanceDictionary: true Destination: 52 Annotation: Subtype: Link Rect: 486, 551, 490, 560 Flags: Print AppearanceDictionary: true Destination: 52 Annotation: Subtype: Link Rect: 468, 540, 472, 549 Flags: Print AppearanceDictionary: true Destination: 52 Annotation: Subtype: Link Rect: 327, 454, 331, 463 Flags: Print AppearanceDictionary: true Destination: 52 Annotation: Subtype: Link Rect: 39, 19, 126, 27 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 175, 668, 179, 677 Flags: Print AppearanceDictionary: true Destination: 52 Annotation: Subtype: Link Rect: 285, 615, 289, 624 Flags: Print AppearanceDictionary: true Destination: 90 Annotation: Subtype: Link Rect: 435, 722, 439, 731 Flags: Print AppearanceDictionary: true Destination: 90 Annotation: Subtype: Link Rect: 448, 711, 452, 720 Flags: Print AppearanceDictionary: true Destination: 102 Annotation: Subtype: Link Rect: 390, 626, 395, 635 Flags: Print AppearanceDictionary: true Destination: 102 Annotation: Subtype: Link Rect: 426, 593, 430, 602 Flags: Print AppearanceDictionary: true Destination: 112 Annotation: Subtype: Link Rect: 379, 405, 384, 411 Flags: Print AppearanceDictionary: true Destination: 178 Annotation: Subtype: Link Rect: 473, 362, 478, 368 Flags: Print AppearanceDictionary: true Destination: 178 Annotation: Subtype: Link Rect: 554, 341, 559, 346 Flags: Print AppearanceDictionary: true Destination: 178 Annotation: Subtype: Link Rect: 372, 298, 377, 304 Flags: Print AppearanceDictionary: true Destination: 178 Annotation: Subtype: Link Rect: 378, 298, 383, 304 Flags: Print AppearanceDictionary: true Destination: 178 Annotation: Subtype: Link Rect: 509, 277, 514, 282 Flags: Print AppearanceDictionary: true Destination: 178 Annotation: Subtype: Link Rect: 515, 277, 520, 282 Flags: Print AppearanceDictionary: true Destination: 178 Annotation: Subtype: Link Rect: 39, 19, 126, 27 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 337, 555, 342, 561 Flags: Print AppearanceDictionary: true Destination: 178 Annotation: Subtype: Link Rect: 370, 534, 375, 539 Flags: Print AppearanceDictionary: true Destination: 178 Annotation: Subtype: Link Rect: 453, 437, 458, 443 Flags: Print AppearanceDictionary: true Destination: 178 Annotation: Subtype: Link Rect: 39, 19, 126, 27 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 39, 19, 126, 27 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 456, 395, 461, 400 Flags: Print AppearanceDictionary: true Destination: 178 Annotation: Subtype: Link Rect: 445, 234, 450, 239 Flags: Print AppearanceDictionary: true Destination: 178 Annotation: Subtype: Link Rect: 514, 223, 519, 229 Flags: Print AppearanceDictionary: true Destination: 178 Annotation: Subtype: Link Rect: 514, 148, 519, 154 Flags: Print AppearanceDictionary: true Destination: 178 Annotation: Subtype: Link Rect: 39, 19, 126, 27 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 271, 705, 276, 711 Flags: Print AppearanceDictionary: true Destination: 178 Annotation: Subtype: Link Rect: 274, 277, 279, 282 Flags: Print AppearanceDictionary: true Destination: 178 Annotation: Subtype: Link Rect: 280, 277, 285, 282 Flags: Print AppearanceDictionary: true Destination: 178 Annotation: Subtype: Link Rect: 287, 277, 292, 282 Flags: Print AppearanceDictionary: true Destination: 178 Annotation: Subtype: Link Rect: 99, 255, 104, 261 Flags: Print AppearanceDictionary: true Destination: 178 Annotation: Subtype: Link Rect: 167, 245, 172, 250 Flags: Print AppearanceDictionary: true Destination: 178 Annotation: Subtype: Link Rect: 173, 245, 178, 250 Flags: Print AppearanceDictionary: true Destination: 178 Annotation: Subtype: Link Rect: 112, 170, 117, 175 Flags: Print AppearanceDictionary: true Destination: 178 Annotation: Subtype: Link Rect: 254, 138, 259, 143 Flags: Print AppearanceDictionary: true Destination: 178 Annotation: Subtype: Link Rect: 260, 138, 265, 143 Flags: Print AppearanceDictionary: true Destination: 178 Annotation: Subtype: Link Rect: 80, 105, 85, 111 Flags: Print AppearanceDictionary: true Destination: 178 Annotation: Subtype: Link Rect: 240, 105, 245, 111 Flags: Print AppearanceDictionary: true Destination: 178 Annotation: Subtype: Link Rect: 189, 52, 194, 57 Flags: Print AppearanceDictionary: true Destination: 178 Annotation: Subtype: Link Rect: 338, 330, 343, 336 Flags: Print AppearanceDictionary: true Destination: 178 Annotation: Subtype: Link Rect: 349, 69, 553, 77 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 323, 58, 551, 66 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 323, 47, 351, 55 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 323, 47, 351, 55 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 39, 19, 126, 27 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 8 Annotations: Annotation: Subtype: Link Rect: 269, 240, 294, 248 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 56, 230, 273, 237 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 56, 219, 176, 227 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 56, 219, 176, 227 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 39, 19, 126, 27 Flags: Print AppearanceDictionary: true Thumb: true Page: Label: 9 Annotations: Annotation: Subtype: Link Rect: 39, 647, 194, 655 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 39, 583, 147, 591 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 417, 594, 560, 602 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 306, 583, 342, 591 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 190, 398, 261, 405 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 120, 347, 123, 353 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 174, 347, 180, 353 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 249, 347, 255, 353 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 369, 347, 372, 353 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 463, 347, 466, 353 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 467, 347, 470, 353 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 521, 347, 524, 353 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 525, 347, 531, 353 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 130, 334, 136, 340 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 250, 334, 255, 340 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 349, 334, 355, 340 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 453, 334, 459, 340 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 461, 334, 466, 340 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 67, 322, 73, 327 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 74, 322, 80, 327 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 134, 322, 140, 327 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 141, 322, 147, 327 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 250, 322, 256, 327 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 257, 322, 263, 327 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 368, 322, 374, 327 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 442, 322, 448, 327 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 505, 322, 511, 327 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 149, 309, 155, 315 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 252, 309, 258, 315 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 344, 309, 350, 315 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 478, 309, 484, 315 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 70, 296, 76, 302 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 128, 296, 134, 302 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 135, 296, 141, 302 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 221, 296, 226, 302 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 228, 296, 234, 302 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 349, 296, 355, 302 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 356, 296, 362, 302 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 481, 296, 487, 302 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 488, 296, 494, 302 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 118, 284, 124, 289 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 125, 284, 131, 289 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 245, 284, 251, 289 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 389, 284, 395, 289 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 472, 284, 478, 289 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 552, 284, 558, 289 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 121, 271, 127, 277 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 236, 271, 242, 277 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 337, 271, 343, 277 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 436, 271, 442, 277 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 536, 271, 542, 277 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 119, 258, 125, 264 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 216, 258, 222, 264 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 328, 258, 334, 264 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 449, 258, 455, 264 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 541, 258, 547, 264 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 132, 246, 138, 251 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 220, 246, 226, 251 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 321, 246, 327, 251 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 423, 246, 429, 251 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 501, 246, 507, 251 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 142, 233, 148, 238 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 241, 233, 247, 238 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 325, 233, 331, 238 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 435, 233, 441, 238 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 550, 233, 556, 238 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 118, 220, 124, 226 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 208, 220, 214, 226 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 302, 220, 307, 226 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 394, 220, 400, 226 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 463, 220, 469, 226 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 552, 220, 558, 226 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 96, 207, 102, 213 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 209, 207, 215, 213 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 293, 207, 299, 213 Flags: Print AppearanceDictionary: true Destination: null Annotation: Subtype: Link Rect: 39, 19, 126, 27 Flags: Print AppearanceDictionary: true Thumb: true Checksum: b4c58c40 Type: CRC32 Checksum: 866141848ff0033b6b78e5f21f2f7e49 Type: MD5 Checksum: db889a5674e7825aedc5a1b90f59eca733821eb1 Type: SHA-1 Checksum: d5f618f4b14dd4570dbb5a1357a63cbeaccedd11e19d8c5df7e1986b05ea665b Type: SHA-256