d77677d794859682e1a6cb413a841b1a 337101.pdf c4c5dc646b685a8c5810ba2ae6146186edd3dbe7 337101.pdf 4a5c8c37067a960ff5f94807d1ab038d7ccbd1ae634daaf783c085126aecf2da 337101.pdf Title: Genetically determined Alzheimer's disease research advances: The Down Syndrome & Autosomal Dominant Alzheimer's Disease 2024 Conference Subject: Keywords: Author: Creator: LaTeX with hyperref package Producer: Acrobat Distiller 10.0.0 (Windows) CreationDate: Wed Jul 2 08:37:33 2025 CEST ModDate: Wed Jul 2 08:38:18 2025 CEST Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 15 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 949404 bytes Optimized: yes PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- CIGMKK+Lato-Regular Type 1C WinAnsi yes yes no 453 0 CIGNAJ+Lato-Bold Type 1C WinAnsi yes yes no 456 0 CIGNOE+Lato-Italic Type 1C WinAnsi yes yes no 459 0 CIHEEL+STIXTwoMath Type 1C Custom yes yes yes 3 0 CIHEEM+STIXTwoText-Italic Type 1C Custom yes yes yes 122 0 CIHEMK+STIX-Regular Type 1C Custom yes yes yes 127 0 CIHENL+Lato-Black Type 1C WinAnsi yes yes no 132 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2026-10-14 04:06:56 CEST RepresentationInformation: 337101.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2026-10-13 17:21:08 CEST Size: 949404 Format: PDF Version: 1.6 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 583 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Genetically determined Alzheimer’s disease research advances: The Down Syndrome & Autosomal Dominant Alzheimer’s Disease 2024 Conference Destination: chapter..1 Children: Item: Title: Abstract Destination: section*.2 Item: Title: 1 | INTRODUCTION Destination: section..1.1 Item: Title: 2 | DSAD-ADAD CONFERENCE STRUCTURE OVERVIEW Destination: section..1.2 Item: Title: 3 | PATHOPHYSIOLOGY OF DSAD AND ADAD Destination: section..1.3 Children: Item: Title: 3.1 | Vascular changes in DSAD and ADAD Destination: subsection..1.3.1 Item: Title: 3.2 | Inflammation and metabolic dysregulation Destination: subsection..1.3.2 Item: Title: 3.3 | Gene expression Destination: subsection..1.3.3 Item: Title: 4 | CLINICAL PICTURE Destination: section..1.4 Item: Title: 5 | BIOMARKERS Destination: section..1.5 Children: Item: Title: 5.1 | Fluid AD biomarkers (CSF and plasma) Destination: subsection..1.5.1 Item: Title: 5.2 | Proteomic and molecular studies Destination: subsection..1.5.2 Item: Title: 5.3 | Detection of co-pathologies and co-occurring medical conditions Destination: subsection..1.5.3 Item: Title: 6 | NEUROIMAGING Destination: section..1.6 Children: Item: Title: 6.1 | Amyloid and tau PET Destination: subsection..1.6.1 Item: Title: 6.2 | Hypometabolism: Fluorodeoxyglucose-PET (FDG-PET) Destination: subsection..1.6.2 Item: Title: 6.3 | Structural MRI and cerebrovascular disease markers Destination: subsection..1.6.3 Children: Item: Title: 6.3.1 | Medial temporal lobe atrophy in DSAD Destination: subsubsection..1.6.3.1 Item: Title: 6.3.2 | Cortical thickness patterns in ADAD and DSAD Destination: subsubsection..1.6.3.2 Item: Title: 6.3.3 | Cerebrovascular alterations in DSAD Destination: subsubsection..1.6.3.3 Item: Title: 7 | NATURAL HISTORY MODELS Destination: section..1.7 Children: Item: Title: 7.1 | DSAD Destination: subsection..1.7.1 Item: Title: 7.2 | APOE4 homozygotes: A new type of genetic AD? Destination: subsection..1.7.2 Item: Title: 8 | STANDARDIZING COHORTS OF GENETICALLY DETERMINED FORMS OF AD AND CLINICAL TRIALS Destination: section..1.8 Children: Item: Title: 8.1 | Single-center cohorts Destination: subsection..1.8.1 Item: Title: 8.2 | Multicenter collaboration and clinical trials Destination: subsection..1.8.2 Children: Item: Title: 8.2.1 | DSAD Destination: subsubsection..1.8.2.1 Item: Title: 8.2.2 | ADAD Destination: subsubsection..1.8.2.2 Item: Title: 9 | COLLABORATION AND NETWORKING OPPORTUNITIES FOR AD RESEARCH IN INDIVIDUALS WITH DS AND ADAD Destination: section..1.9 Item: Title: 10 | ETHICAL CONSIDERATIONS AND IMPLICATIONS OF AD RESEARCH IN INDIVIDUALS WITH DSAD AND ADAD WITH THE APPROVAL OF NEW TREATMENTS Destination: section..1.10 Item: Title: 11 | CONCLUSIONS Destination: section..1.11 Item: Title: AFFILIATIONS Destination: section*.4 Item: Title: ACKNOWLEDGMENTS Destination: section*.6 Item: Title: CONFLICT OF INTEREST STATEMENT Destination: section*.8 Item: Title: ORCID Destination: section*.10 Item: Title: REFERENCES Destination: section*.12 Item: Title: SUPPORTING INFORMATION Destination: section*.14 Info: Title: Genetically determined Alzheimer's disease research advances: The Down Syndrome & Autosomal Dominant Alzheimer's Disease 2024 Conference Author: Subject: Keywords: Creator: LaTeX with hyperref package Producer: Acrobat Distiller 10.0.0 (Windows) CreationDate: Wed Jul 02 09:07:33 CEST 2025 ModDate: Wed Jul 02 09:08:18 CEST 2025 ID: 0xe0b5d4d3bba9e15c1fb00ad3cc064572, 0x888403df320ec88d9a53c3b31721177e Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1060 ImageHeight: 2800 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2036 ImageHeight: 1359 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type1: Font: 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