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Title:           Disease spectrum and long-term prognosis of patients with BAG3-associated neuromuscular diseases in Europe
Subject:         DOI: 10.1093/brain/awaf223; Brain, 148, 12, 2025-06-10.; Abstract: De novo or autosomal dominant BAG3 gene variants cause a wide range of skeletal and cardiac muscle diseases encompassing Charcot–Marie–Tooth disease, myofibrillar myopathy, cardiomyopathy or a combination of them. Given the severity and rarity of BAG3-neuromuscular diseases (NMDs), series of patients are lacking. Our aim was to characterize the clinical and genetic spectrum, in addition to the natural history of BAG3-NMDs in Europe.In this multicentre retrospective study, we collected clinical, ancillary and genetic data of patients with NMD and BAG3 variants, identified from European paediatric and adult neuromuscular reference centres from May to December 2023 following a call circulated through the European Reference Network EURO-NMD and other partners. Responses were received from 35 centres in 17 countries. Twenty-six patients (65.4% males, 34.6% females) with BAG3-NMD from 18 different families were included in 
Keywords:        BAG3; neuromyopathy; cardiomyopathy; autophagy
Author:          Gorka Fernández-Eulate
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      Title: Disease spectrum and long-term prognosisof patients with BAG3-associatedneuromuscular diseases in Europe
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        Title: Introduction
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       Item: 
        Title: Materials and methods
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          Title: Study design and population
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          Title: Clinical and ancillary data
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          Title: Genetics
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          Title: Statistical analysis
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        Title: Results
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          Title: Patient series and genetics
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          Title: Baseline characteristics
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           Item: 
            Title: Patient group carrying the p.(Pro209Leu) variant&italic/;
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            Title: Patient group carrying other BAG3-NMD variants&italic/;
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          Title: Long-term outcomes
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          Title: Other genotype phenotype considerations
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          Title: BAG3-NMD is a rare disease with two distinct genetic subgroups
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          Title: The cardiomyopathy in p.(Pro209Leu) patients is restrictive and severe
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          Title: Fast disease progression in p.(Pro209Leu) patients argues in favour of proactive and anticipatory management
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        Title: Conclusion
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        Title: Data availability
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        Title: Acknowledgements
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        Title: Funding
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        Title: Competing interests
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   Type: CRC32
  Checksum: 78dc72db5f942f0f5540e414ea7fe03c
   Type: MD5
  Checksum: 4d7e802e971b8ea3429d83c6efff65510ddbfed6
   Type: SHA-1
  Checksum: 781ab459dedadd7137a45f33d2193be7ed5ab0e6b96c0ed0cc3e580c7d50e737
   Type: SHA-256