ce44992e35b2c29b073c8154ade0b652 337124.pdf 51275c21caa9e6d7c529d2b2128693d6f332d828 337124.pdf 6c66c32e274500029e63b0787b685757bbe06d6a6eac16f9c02077cf10338c19 337124.pdf Title: Measuring the effect of rozanolixizumab using the Myasthenia Gravis Impairment Index: analyses from the randomized phase 3 MycarinG study Subject: Journal of Neurology, https://doi.org/10.1007/s00415-025-13480-8 Keywords: Myasthenia gravis; Generalized myasthenia gravis; Myasthenia gravis impairment index; Rozanolixizumab; Phase 3 clinical trial Author: Carolina Barnett-Tapia Creator: Springer Producer: Acrobat Distiller 10.1.8 (Windows) CreationDate: Sat Nov 8 05:37:35 2025 CET ModDate: Thu Dec 4 13:43:41 2025 CET Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: AcroForm JavaScript: no Pages: 13 Encrypted: no Page size: 595.276 x 790.866 pts Page rot: 0 File size: 1799814 bytes Optimized: yes PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MyriadPro-SemiCn Type 1C WinAnsi yes no yes 604 0 MyriadPro-Semibold Type 1C Custom yes no yes 605 0 MyriadPro-SemiboldSemiCn Type 1C Custom yes no yes 615 0 WYPIOA+MyriadPro-Bold Type 1C WinAnsi yes yes yes 616 0 RRTVNP+STIX-Regular Type 1C Custom yes yes yes 617 0 JBWYKU+Wingdings-Regular Type 1C WinAnsi yes yes yes 628 0 MyriadPro-BoldSemiCn Type 1C Custom yes no yes 317 0 STIX-Italic Type 1C WinAnsi yes no yes 343 0 GKIGQE+STIX-Bold Type 1C WinAnsi yes yes yes 370 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2026-10-21 03:57:27 CEST RepresentationInformation: 337124.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2026-10-20 18:55:29 CEST Size: 1799814 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 702 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en-US Outlines: Item: Title: Measuring the effect of rozanolixizumab using the Myasthenia Gravis Impairment Index: analyses from the randomized phase 3 MycarinG study Children: Item: Title: Abstract Children: Item: Title: Background Item: Title: Methods Item: Title: Results Item: Title: Conclusion Item: Title: Trial registration Item: Title: Introduction Item: Title: Methods Children: Item: Title: Study design and patient population Item: Title: Outcomes and assessments Item: Title: Statistical analysis Item: Title: Results Children: Item: Title: MycarinG study population and MGII data collection Item: Title: Change from baseline to Day 43 in MGII total score Item: Title: MGII response rates at Day 43 Item: Title: MGII item-level and shift analyses Item: Title: Indirect PASS responder rates Item: Title: MGII responsiveness to change Item: Title: Discussion Item: Title: Acknowledgements Item: Title: References Info: Title: Measuring the effect of rozanolixizumab using the Myasthenia Gravis Impairment Index: analyses from the randomized phase 3 MycarinG study Author: Carolina Barnett-Tapia Subject: Journal of Neurology, https://doi.org/10.1007/s00415-025-13480-8 Keywords: Myasthenia gravis; Generalized myasthenia gravis; Myasthenia gravis impairment index; Rozanolixizumab; Phase 3 clinical trial Creator: Springer Producer: Acrobat Distiller 10.1.8 (Windows) CreationDate: Sat Nov 08 06:07:35 CET 2025 ModDate: Thu Dec 04 14:13:41 CET 2025 ID: 0xf2a79e745f25b74e89f536accf5fe661, 0x88e427ed2a5e6c4191d4a1baff3542d4 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2031 ImageHeight: 1013 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2032 ImageHeight: 1028 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1500 ImageHeight: 1637 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2028 ImageHeight: 2240 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1500 ImageHeight: 1576 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1500 ImageHeight: 1549 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1500 ImageHeight: 842 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2031 ImageHeight: 1088 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Fonts: Type1: Font: BaseFont: GKIGQE+STIX-Bold FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: GKIGQE+STIX-Bold Flags: Serif, Nonsymbolic FontBBox: -998, -552, 2000, 1055 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: JBWYKU+Wingdings-Regular FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: JBWYKU+Wingdings-Regular Flags: Nonsymbolic FontBBox: 0, -103, 1359, 439 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MyriadPro-SemiboldSemiCn FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-SemiboldSemiCn Flags: Nonsymbolic FontBBox: -131, -250, 1115, 886 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: STIX-Italic FirstChar: 0 LastChar: 255 FontDescriptor: FontName: STIX-Italic Flags: Serif, Nonsymbolic, Italic FontBBox: -970, -305, 1429, 1023 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: WYPIOA+MyriadPro-Bold FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: WYPIOA+MyriadPro-Bold Flags: Nonsymbolic FontBBox: -163, -250, 1256, 989 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: RRTVNP+STIX-Regular FontSubset: true FirstChar: 23 LastChar: 243 FontDescriptor: FontName: RRTVNP+STIX-Regular Flags: Serif, Nonsymbolic FontBBox: -970, -486, 2208, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-SemiCn FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-SemiCn Flags: Nonsymbolic FontBBox: -128, -250, 1059, 876 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MyriadPro-Semibold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Semibold Flags: Nonsymbolic FontBBox: -161, -250, 1198, 972 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-BoldSemiCn FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-BoldSemiCn Flags: Nonsymbolic FontBBox: -133, -250, 1161, 894 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true XMP: 2025-11-08T10:07:35+05:30 Springer 2025-12-04T18:13:41+05:30 2025-12-04T18:13:41+05:30 Acrobat Distiller 10.1.8 (Windows) Myasthenia gravis; Generalized myasthenia gravis; Myasthenia gravis impairment index; Rozanolixizumab; Phase 3 clinical trial application/pdf https://doi.org/10.1007/s00415-025-13480-8 Springer Berlin Heidelberg Journal of Neurology, https://doi.org/10.1007/s00415-025-13480-8 Myasthenia gravis Generalized myasthenia gravis Myasthenia gravis impairment index Rozanolixizumab Phase 3 clinical trial Measuring the effect of rozanolixizumab using the Myasthenia Gravis Impairment Index: analyses from the randomized phase 3 MycarinG study Carolina Barnett-Tapia Elena Cortés Vicente Robert M. Pascuzzi Kimiaki Utsugisawa Jos Bloemers Fiona Grimson Thaïs Tarancón Vera Bril 10.1007/s00415-025-13480-8 2010-04-23 true springer.com springerlink.com https://doi.org/10.1007/s00415-025-13480-8 10.1007/s00415-025-13480-8 1432-1459 272 12 1 13 journal Journal of Neurology The Author(s) 2010-04-23 true 10.1007/s00415-025-13480-8 noindex springer.com springerlink.com VoR uuid:da56f207-3651-4e26-9f52-b6801e69994e uuid:ecb03a66-6d7d-4687-ac46-8763064165e8 default 1 converted uuid:7729b125-f123-484e-9d4e-c4d2ae725ae4 converted to PDF/A-2b pdfToolbox 2025-12-04T18:13:11+05:30 converted uuid:e076bf0f-11ed-4705-ac0a-ed2af322cc4f converted to PDF/A-2b pdfToolbox 2025-12-04T18:13:41+05:30 2 B Carolina Barnett-Tapia http://orcid.org/0000-0001-5546-0221 http://ns.adobe.com/pdfx/1.3/ pdfx Adobe Document Info PDF eXtension Schema external Mirrors crossmark:MajorVersionDate CrossmarkMajorVersionDate Text external Mirrors crossmark:CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal Mirrors crossmark:DOI doi Text external Mirrors crossmark:CrosMarkDomains CrossMarkDomains seq Text internal A name object indicating whether the document has been modified to include trapping information robots Text internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text http://crossref.org/crossmark/1.0/ crossmark Crossmark Schema internal Usual same as prism:doi DOI Text external The date when a publication was publishe. MajorVersionDate Text internal CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal CrossMarkDomains CrossMarkDomains seq Text http://prismstandard.org/namespaces/basic/2.0/ prism Prism Schema external This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. url URI external The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). doi Text external ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. issn Text internal Volume number volume Text internal Issue number number Text internal Starting page startingPage Text internal Ending page endingPage Text external The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. aggregationType Text external Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” publicationName Text external Copyright copyright Text http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. DocumentID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI internal A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original. DerivedFrom ResourceRef Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced. http://ns.adobe.com/xap/1.0/sType/Part# stPart Part http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text Springer Nature ORCID Schema http://springernature.com/ns/xmpExtensions/2.0/ sn authorInfo Bag AuthorInformation external Author information: contains the name of each author and his/her ORCiD (ORCiD: Open Researcher and Contributor ID). An ORCiD is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors. AuthorInformation http://springernature.com/ns/xmpExtensions/2.0/authorInfo/ author Specifies the types of author information: name and ORCID of an author. name Text Gives the name of an author. orcid URI Gives the ORCID of an author. http://ns.adobe.com/xap/1.0/t/pg/ xmpTPg XMP Paged-Text internal XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents). PlateNames Seq Text http://www.niso.org/schemas/jav/1.0/ jav NISO external Values for Journal Article Version are one of the following: AO = Author’s Original SMUR = Submitted Manuscript Under Review AM = Accepted Manuscript P = Proof VoR = Version of Record CVoR = Corrected Version of Record EVoR = Enhanced Version of Record journal_article_version Closed Choice of Text Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 513, 726, 546, 694 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 154, 616, 167, 604 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 161, 671, 166, 656 Flags: Print AppearanceDictionary: true Destination: 148 Annotation: Subtype: Link Rect: 98, 634, 103, 619 Flags: Print AppearanceDictionary: true Destination: 148 Annotation: Subtype: Link Rect: 108, 634, 114, 619 Flags: Print AppearanceDictionary: true Destination: 148 Annotation: Subtype: Link Rect: 115, 596, 120, 581 Flags: Print AppearanceDictionary: true Destination: 148 Annotation: Subtype: Link Rect: 129, 559, 134, 544 Flags: Print AppearanceDictionary: true Destination: 148 Annotation: Subtype: Link Rect: 194, 521, 199, 506 Flags: Print AppearanceDictionary: true Destination: 148 Annotation: Subtype: Link Rect: 205, 521, 210, 506 Flags: Print AppearanceDictionary: true Destination: 148 Annotation: Subtype: Link Rect: 170, 446, 175, 431 Flags: Print AppearanceDictionary: true Destination: 148 Annotation: Subtype: Link Rect: 181, 446, 186, 431 Flags: Print AppearanceDictionary: true Destination: 148 Annotation: Subtype: Link Rect: 54, 396, 59, 381 Flags: Print AppearanceDictionary: true Destination: 148 Annotation: Subtype: Link Rect: 65, 396, 70, 381 Flags: Print AppearanceDictionary: true Destination: 148 Annotation: Subtype: Link Rect: 117, 371, 122, 356 Flags: Print AppearanceDictionary: true Destination: 148 Annotation: Subtype: Link Rect: 127, 371, 132, 356 Flags: Print AppearanceDictionary: true Destination: 148 Annotation: Subtype: Link Rect: 137, 334, 142, 319 Flags: Print AppearanceDictionary: true Destination: 148 Annotation: Subtype: Link Rect: 147, 334, 152, 319 Flags: Print AppearanceDictionary: true Destination: 148 Annotation: Subtype: Link Rect: 102, 321, 107, 306 Flags: Print AppearanceDictionary: true Destination: 148 Annotation: Subtype: Link Rect: 281, 259, 286, 244 Flags: Print AppearanceDictionary: true Destination: 148 Annotation: Subtype: Link Rect: 51, 246, 56, 231 Flags: Print AppearanceDictionary: true Destination: 148 Annotation: Subtype: Link Rect: 123, 209, 128, 194 Flags: Print AppearanceDictionary: true Destination: 148 Annotation: Subtype: Link Rect: 134, 209, 139, 194 Flags: Print AppearanceDictionary: true Destination: 148 Annotation: Subtype: Link Rect: 144, 209, 149, 194 Flags: Print AppearanceDictionary: true Destination: 148 Annotation: Subtype: Link Rect: 171, 121, 182, 106 Flags: Print AppearanceDictionary: true Destination: 148 Annotation: Subtype: Link Rect: 187, 121, 198, 106 Flags: Print AppearanceDictionary: true Destination: 148 Annotation: Subtype: Link Rect: 458, 735, 468, 720 Flags: Print AppearanceDictionary: true Destination: 148 Annotation: Subtype: Link Rect: 495, 648, 500, 633 Flags: Print AppearanceDictionary: true Destination: 39 Annotation: Subtype: Link Rect: 509, 648, 519, 633 Flags: Print AppearanceDictionary: true Destination: 148 Annotation: Subtype: Link Rect: 378, 598, 389, 583 Flags: Print AppearanceDictionary: true Destination: 148 Annotation: Subtype: Link Rect: 394, 598, 404, 583 Flags: Print AppearanceDictionary: true Destination: 148 Annotation: Subtype: Link Rect: 389, 548, 399, 533 Flags: Print AppearanceDictionary: true Destination: 148 Annotation: Subtype: Link Rect: 404, 548, 414, 533 Flags: Print AppearanceDictionary: true Destination: 203 Annotation: Subtype: Link Rect: 527, 473, 538, 458 Flags: Print AppearanceDictionary: true Destination: 203 Annotation: Subtype: Link Rect: 470, 423, 480, 408 Flags: Print AppearanceDictionary: true Destination: 203 Annotation: Subtype: Link Rect: 362, 373, 372, 358 Flags: Print AppearanceDictionary: true Destination: 203 Annotation: Subtype: Link Rect: 335, 160, 345, 145 Flags: Print AppearanceDictionary: true Destination: 203 Thumb: true Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 217, 274, 222, 259 Flags: Print AppearanceDictionary: true Destination: 148 Annotation: Subtype: Link Rect: 103, 186, 113, 171 Flags: Print AppearanceDictionary: true Destination: 148 Annotation: Subtype: Link Rect: 259, 174, 264, 159 Flags: Print AppearanceDictionary: true Destination: 39 Annotation: Subtype: Link Rect: 309, 323, 320, 308 Flags: Print AppearanceDictionary: true Destination: 203 Annotation: Subtype: Link Rect: 527, 248, 538, 233 Flags: Print AppearanceDictionary: true Destination: 203 Annotation: Subtype: Link Rect: 475, 173, 485, 158 Flags: Print AppearanceDictionary: true Destination: 203 Thumb: true Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 54, 736, 64, 721 Flags: Print AppearanceDictionary: true Destination: 203 Annotation: Subtype: Link Rect: 140, 549, 150, 534 Flags: Print AppearanceDictionary: true Destination: 203 Annotation: Subtype: Link Rect: 278, 486, 283, 471 Flags: Print AppearanceDictionary: true Destination: 148 Annotation: Subtype: Link Rect: 369, 711, 379, 696 Flags: Print AppearanceDictionary: true Destination: 203 Annotation: Subtype: Link Rect: 528, 524, 538, 509 Flags: Print AppearanceDictionary: true Destination: 203 Annotation: Subtype: Link Rect: 262, 124, 270, 111 Flags: Print AppearanceDictionary: true Destination: 203 Annotation: Subtype: Link Rect: 326, 114, 489, 101 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 5 Annotations: Annotation: Subtype: Link Rect: 215, 685, 220, 670 Flags: Print AppearanceDictionary: true Destination: 50 Annotation: Subtype: Link Rect: 252, 473, 258, 458 Flags: Print AppearanceDictionary: true Destination: 64 Annotation: Subtype: Link Rect: 327, 673, 333, 658 Flags: Print AppearanceDictionary: true Destination: 75 Annotation: Subtype: Link Rect: 353, 548, 358, 533 Flags: Print AppearanceDictionary: true Destination: 87 Annotation: Subtype: Link Rect: 143, 94, 152, 81 Flags: Print AppearanceDictionary: true Destination: 203 Thumb: true Page: Sequence: 6 Thumb: true Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 152, 91, 157, 76 Flags: Print AppearanceDictionary: true Destination: 111 Thumb: true Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 121, 211, 126, 196 Flags: Print AppearanceDictionary: true Destination: 111 Annotation: Subtype: Link Rect: 434, 136, 444, 121 Flags: Print AppearanceDictionary: true Destination: 203 Annotation: Subtype: Link Rect: 527, 86, 537, 71 Flags: Print AppearanceDictionary: true Destination: 203 Thumb: true Page: Sequence: 9 Annotations: Annotation: Subtype: Link Rect: 158, 236, 163, 221 Flags: Print AppearanceDictionary: true Destination: 148 Annotation: Subtype: Link Rect: 168, 236, 173, 221 Flags: Print AppearanceDictionary: true Destination: 148 Annotation: Subtype: Link Rect: 178, 236, 183, 221 Flags: Print AppearanceDictionary: true Destination: 148 Annotation: Subtype: Link Rect: 188, 236, 198, 221 Flags: Print AppearanceDictionary: true Destination: 203 Annotation: Subtype: Link Rect: 262, 86, 267, 71 Flags: Print AppearanceDictionary: true Destination: 148 Annotation: Subtype: Link Rect: 273, 86, 283, 71 Flags: Print AppearanceDictionary: true Destination: 148 Annotation: Subtype: Link Rect: 354, 299, 359, 284 Flags: Print AppearanceDictionary: true Destination: 148 Annotation: Subtype: Link Rect: 436, 174, 446, 159 Flags: Print AppearanceDictionary: true Destination: 148 Annotation: Subtype: Link Rect: 339, 124, 349, 109 Flags: Print AppearanceDictionary: true Destination: 203 Thumb: true Page: Sequence: 10 Thumb: true Page: Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 181, 724, 191, 709 Flags: Print AppearanceDictionary: true Destination: 148 Annotation: Subtype: Link Rect: 232, 574, 237, 559 Flags: Print AppearanceDictionary: true Destination: 148 Annotation: Subtype: Link Rect: 242, 574, 252, 559 Flags: Print AppearanceDictionary: true Destination: 203 Annotation: Subtype: Link Rect: 257, 574, 267, 559 Flags: Print AppearanceDictionary: true Destination: 203 Annotation: Subtype: Link Rect: 272, 574, 282, 559 Flags: Print AppearanceDictionary: true Destination: 203 Annotation: Subtype: Link Rect: 54, 524, 64, 509 Flags: Print AppearanceDictionary: true Destination: 148 Annotation: Subtype: Link Rect: 155, 449, 165, 434 Flags: Print AppearanceDictionary: true Destination: 148 Annotation: Subtype: Link Rect: 170, 449, 180, 434 Flags: Print AppearanceDictionary: true Destination: 203 Annotation: Subtype: Link Rect: 186, 449, 196, 434 Flags: Print AppearanceDictionary: true Destination: 203 Annotation: Subtype: Link Rect: 251, 324, 261, 309 Flags: Print AppearanceDictionary: true Destination: 148 Annotation: Subtype: Link Rect: 261, 286, 271, 271 Flags: Print AppearanceDictionary: true Destination: 203 Annotation: Subtype: Link Rect: 152, 224, 162, 209 Flags: Print AppearanceDictionary: true Destination: 203 Annotation: Subtype: Link Rect: 261, 199, 271, 184 Flags: Print AppearanceDictionary: true Destination: 203 Annotation: Subtype: Link Rect: 276, 199, 286, 184 Flags: Print AppearanceDictionary: true Destination: 203 Annotation: Subtype: Link Rect: 51, 186, 61, 171 Flags: Print AppearanceDictionary: true Destination: 203 Annotation: Subtype: Link Rect: 67, 186, 77, 171 Flags: Print AppearanceDictionary: true Destination: 203 Annotation: Subtype: Link Rect: 163, 86, 173, 71 Flags: Print AppearanceDictionary: true Destination: 203 Annotation: Subtype: Link Rect: 527, 661, 538, 646 Flags: Print AppearanceDictionary: true Destination: 203 Annotation: Subtype: Link Rect: 445, 611, 455, 596 Flags: Print AppearanceDictionary: true Destination: 203 Annotation: Subtype: Link Rect: 349, 561, 359, 546 Flags: Print AppearanceDictionary: true Destination: 203 Annotation: Subtype: Link Rect: 392, 536, 402, 521 Flags: Print AppearanceDictionary: true Destination: 203 Annotation: Subtype: Link Rect: 377, 486, 382, 471 Flags: Print AppearanceDictionary: true Destination: 148 Annotation: Subtype: Link Rect: 391, 367, 542, 354 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 404, 297, 517, 284 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 223, 706, 274, 693 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 506, 726, 544, 713 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 306, 716, 444, 703 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 520, 639, 544, 626 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 323, 629, 448, 616 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 462, 589, 544, 576 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 323, 579, 395, 566 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 395, 549, 536, 536 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 373, 509, 490, 496 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 428, 479, 544, 466 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 323, 469, 340, 456 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 493, 439, 544, 426 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 323, 429, 391, 416 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 492, 399, 544, 386 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 323, 389, 451, 376 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 403, 349, 544, 336 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 323, 339, 348, 326 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 444, 299, 544, 286 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 323, 289, 344, 276 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 440, 259, 544, 246 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 323, 249, 382, 236 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 461, 219, 544, 206 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 323, 209, 409, 196 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 453, 199, 544, 186 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 323, 189, 397, 176 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 453, 179, 544, 166 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 323, 169, 397, 156 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 453, 159, 544, 146 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 323, 149, 397, 136 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 453, 139, 544, 126 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 323, 129, 397, 116 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 458, 99, 544, 86 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 323, 89, 359, 76 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 13 Annotations: Annotation: Subtype: Link Rect: 85, 696, 208, 683 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 125, 656, 247, 643 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 125, 616, 247, 603 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 68, 576, 188, 563 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 120, 536, 245, 523 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 133, 496, 289, 483 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 264, 446, 289, 433 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 68, 436, 213, 423 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 138, 376, 289, 363 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 68, 366, 98, 353 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 323, 726, 488, 713 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 425, 696, 544, 683 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 323, 686, 370, 673 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 378, 646, 535, 633 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 484, 596, 544, 583 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 323, 586, 407, 573 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 463, 546, 544, 533 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 323, 536, 395, 523 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 442, 496, 544, 483 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 323, 486, 372, 473 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 492, 456, 544, 443 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 323, 446, 425, 433 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 393, 416, 544, 403 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 492, 376, 544, 363 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 323, 366, 427, 353 Flags: Print AppearanceDictionary: true Thumb: true Checksum: 99bedfc1 Type: CRC32 Checksum: ce44992e35b2c29b073c8154ade0b652 Type: MD5 Checksum: 51275c21caa9e6d7c529d2b2128693d6f332d828 Type: SHA-1 Checksum: 6c66c32e274500029e63b0787b685757bbe06d6a6eac16f9c02077cf10338c19 Type: SHA-256