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Title:           Melatonin as a Possible Stimulus to Unmask an Oxytocin-Deficient State in Hypopituitarism and Hypothalamic Damage
Subject:         DOI: 10.1210/clinem/dgaf201; The Journal of Clinical Endocrinology & Metabolism, 110, 12, 2025-04-1.; Abstract:  Context: Increasing evidence supports the presence of oxytocin deficiency (OXT-D) in hypopituitarism and hypothalamic damage (HHD). Identifying an applicable and reliable test to diagnose OXT-D is an unmet need. Melatonin (MEL) might be a candidate for such a test as it regulates OXT release in animals. Objective: This work aimed to examine the effects of melatonin on OXT release in HHD compared to healthy controls (HCs) and to describe the psychopathology, sexual function, and quality of life (QoL) and their associations with OXT. Methods: This proof-of-concept study (NCT05319301) included 20 participants with HHD (11 women) and 20 HCs (11 women). Blood samples were collected over 120 minutes to assess plasma OXT. A linear mixed-effects regression model was used to evaluate the change in OXT in response to MEL in HHD compared to HCs. Results: MEL significantly increased O
Keywords:        hypopituitarism; melatonin; oxytocin; arginine-vasopressin deficiency; pineal gland; stimulation test
Author:          Queralt Asla
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      Title: Melatonin as a Possible Stimulus to Unmask an Oxytocin-Deficient State in Hypopituitarism and Hypothalamic Damage
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        Title: Materials and Methods
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          Title: Study Participants
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          Title: Procedures
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          Title: Biochemical Measurements
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         Item: 
          Title: Statistical Analysis
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        Title: Results
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         Item: 
          Title: Sample Characteristics
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         Item: 
          Title: Oxytocin Levels in Response to Melatonin
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         Item: 
          Title: Adverse Events
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          Title: Psychopathology, Sexual Function, and Quality of Life Across Groups
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          Title: Psychopathology, Sexual Function, and Quality of Life and Their Associations With Oxytocin
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        Title: Disclosures
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    Title: Melatonin as a Possible Stimulus to Unmask an Oxytocin-Deficient State in Hypopituitarism and Hypothalamic Damage
    Author: Queralt Asla
    Subject: DOI: 10.1210/clinem/dgaf201; The Journal of Clinical Endocrinology & Metabolism, 110, 12, 2025-04-1.; Abstract:  Context: Increasing evidence supports the presence of oxytocin deficiency (OXT-D) in hypopituitarism and hypothalamic damage (HHD). Identifying an applicable and reliable test to diagnose OXT-D is an unmet need. Melatonin (MEL) might be a candidate for such a test as it regulates OXT release in animals. Objective: This work aimed to examine the effects of melatonin on OXT release in HHD compared to healthy controls (HCs) and to describe the psychopathology, sexual function, and quality of life (QoL) and their associations with OXT. Methods: This proof-of-concept study (NCT05319301) included 20 participants with HHD (11 women) and 20 HCs (11 women). Blood samples were collected over 120 minutes to assess plasma OXT. A linear mixed-effects regression model was used to evaluate the change in OXT in response to MEL in HHD compared to HCs. Results: MEL significantly increased O
    Keywords: hypopituitarism; melatonin; oxytocin; arginine-vasopressin deficiency; pineal gland; stimulation test
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      Annotation: 
       Subtype: Link
       Rect: 302, 516, 311, 524
       Flags: Print
       Destination: 58
      Annotation: 
       Subtype: Link
       Rect: 302, 484, 311, 492
       Flags: Print
       Destination: 58
      Annotation: 
       Subtype: Link
       Rect: 302, 452, 311, 460
       Flags: Print
       Destination: 58
  Checksum: 1d5f31c3
   Type: CRC32
  Checksum: 3b8ba076ebc915e1269755f87d310d01
   Type: MD5
  Checksum: 9d7261a56c24cdcc50c0f7ad920caee2988b92ef
   Type: SHA-1
  Checksum: 19ee800527b72147a8f46a45386d74ace9412fa7387c5909dc2685d528670038
   Type: SHA-256