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Title:           Insights on genomic profiles of drug resistance and virulence in a cohort of Leishmania infantum isolates from the Mediterranean area
Subject:         Parasites & Vectors, https://doi.org/10.1186/s13071-025-07105-2
Keywords:        Leishmania infantum; Copy number variation; Drug-resistance biomarkers; Virulence biomarkers; Canine leishmaniosis; Human leishmaniosis
Author:          Marina Carrasco-Martin 
Creator:         Springer
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     Item: 
      Title: Insights on genomic profiles of drug resistance and virulence in a cohort of Leishmania infantum isolates from the Mediterranean area
      Children: 
       Item: 
        Title: Abstract 
        Children: 
         Item: 
          Title: Background 
         Item: 
          Title: Methods 
         Item: 
          Title: Results 
         Item: 
          Title: Conclusions 
       Item: 
        Title: Background
       Item: 
        Title: Methods
        Children: 
         Item: 
          Title: Samples
         Item: 
          Title: DNA extraction and nanopore sequencing
         Item: 
          Title: Chromosomal somy and gene copy number variation analysis
         Item: 
          Title: Genome de novo assembly and annotation
         Item: 
          Title: Identification of repeated sequences in the drug resistance associated loci of L. infantum
         Item: 
          Title: Data analysis and visualization
       Item: 
        Title: Results
        Children: 
         Item: 
          Title: Detection of aneuploidies and genome plasticity in the L. infantum genome by nanopore-only whole-genome sequencing
         Item: 
          Title: Selection of CNVs as drug resistance and virulence biomarkers in L. infantum
         Item: 
          Title: L. infantum isolates from dogs and humans show distinct drug-resistance biomarker status while mostly preserving virulence
         Item: 
          Title: Locus-specific structure and repeat-driven rearrangements underpin the co-occurrence of drug resistance biomarkers in L. infantum
         Item: 
          Title: Biomarker for antimonial resistance: amplification of the extended H-locus and reduction of the aqp1 CNV
         Item: 
          Title: Biomarker for allopurinol resistance: reduction of the METK locus CNV
         Item: 
          Title: Biomarker for amphotericin B resistance: reduction of the LdSMT locus CNV
         Item: 
          Title: Drug-resistance biomarkers to miltefosine: LdMT and LdRos3 genes
         Item: 
          Title: Drug-resistance biomarkers to paromomycin: b-cat and d-ldh genes
       Item: 
        Title: Discussion
        Children: 
         Item: 
          Title: Detection of aneuploidies and genome plasticity in L. infantum genomes by nanopore-only whole-genome sequencing
         Item: 
          Title: L. infantum isolates from dogs and humans show distinct drug-resistance biomarker status while mostly preserving virulence
         Item: 
          Title: CNV for drug resistance biomarkers in L. infantum
       Item: 
        Title: Conclusions
       Item: 
        Title: Acknowledgements
       Item: 
        Title: References
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    Author: Marina Carrasco-Martin 
    Subject: Parasites & Vectors, https://doi.org/10.1186/s13071-025-07105-2
    Keywords: Leishmania infantum; Copy number variation; Drug-resistance biomarkers; Virulence biomarkers; Canine leishmaniosis; Human leishmaniosis
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