767517b06f65ecf1820b1fcf147062d3 Dufau_2025_publicado.pdf f743021c17efe70feadad4b710f54930dd6bf7ad Dufau_2025_publicado.pdf 5129379eac05948767591776d8ad9fcf0772d4fdf70697851589042549dba0eb Dufau_2025_publicado.pdf Title: CMET4114_grabs 1..1 Subject: Cell Metabolism, Corrected proof. doi:10.1016/j.cmet.2025.09.014 Author: Jérémy Dufau Creator: Elsevier Producer: PDFlib+PDI 10.0.2p2 (C++/Win64) CreationDate: Tue Oct 21 17:29:50 2025 CEST ModDate: Tue Oct 21 17:42:22 2025 CEST Custom Metadata: yes Metadata Stream: yes Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 24 Encrypted: no Page size: 602.986 x 782.986 pts Page rot: 0 File size: 9708575 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- SACQIF+HelveticaNeue-Heavy Type 1 Builtin yes yes yes 4877 0 GlyphLessFont CID TrueType Identity-H yes no yes 4882 0 YEGTDP+HelveticaNeue-Medium Type 1C Builtin yes yes yes 4884 0 TVJBYZ+CM_Maths_Symbols Type 1 Builtin yes yes yes 4880 0 MHJHDG+HelveticaNeue-MediumItalic Type 1C Builtin yes yes yes 4891 0 XBNGEJ+STIX-Bold Type 1C Custom yes yes yes 4896 0 VSNFOE+Rockwell Type 1C Custom yes yes yes 4904 0 TBMTSC+Helvetica-Bold Type 1C WinAnsi yes yes no 4916 0 SACQIF+HelveticaNeue-Heavy Type 1 Builtin yes yes yes 218 0 RGVZMW+HelveticaNeue-Bold Type 1C Builtin yes yes yes 215 0 YEGTDP+HelveticaNeue-Medium Type 1C Builtin yes yes yes 217 0 XFANEM+HelveticaNeue-Roman Type 1C Builtin yes yes yes 183 0 XBNGEJ+STIX-Bold Type 1C Custom yes yes yes 203 0 MHJHDG+HelveticaNeue-MediumItalic Type 1C Builtin yes yes yes 184 0 ONQJRU+STIX-Regular Type 1C Custom yes yes yes 204 0 DJTPIK+HelveticaNeue-Italic Type 1C Builtin yes yes yes 205 0 JQEXGK+HelveticaNeue-Light Type 1C Builtin yes yes yes 192 0 HXBKGX+HelveticaNeue-HeavyItalic Type 1C Builtin yes yes yes 285 0 TVJBYZ+CM_Maths_Symbols Type 1 Builtin yes yes yes 286 0 VHDPHK+TeX_CM_Roman Type 1C Builtin yes yes yes 973 0 JGEMDA+TrebuchetMS CID TrueType Identity-H yes yes yes 1204 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-10-29 03:10:42 CET RepresentationInformation: Dufau_2025_publicado.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-10-28 09:39:56 CET Size: 9708575 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF, Tagged PDF PDFMetadata: Objects: 5001 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: true NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en Outlines: Item: Title: CMET4114_proof.pdf Children: Item: Title: Nuclear hormone-sensitive lipase regulates adipose tissue mass and adipocyte metabolism Destination: titlink1 Children: Item: Title: Introduction Destination: flink1 Item: Title: Results Destination: flink2 Children: Item: Title: HSL is localized in the nuclei of adipocytes Destination: slink1 Item: Title: In vivo relevance of nuclear HSL Destination: slink2 Item: Title: HSL regulates mitochondrial metabolism and extracellular matrix remodeling Destination: slink3 Item: Title: Nuclear HSL controls mitochondria independently of its enzymatic activity Destination: slink4 Item: Title: HSL mediates the repression of PGC-1α Destination: slink5 Item: Title: TGF-β signaling regulates the nuclear accumulation of HSL Destination: slink6 Item: Title: PKA signaling regulates nuclear HSL export Destination: slink7 Item: Title: Discussion Destination: flink3 Children: Item: Title: Limitations of the study Destination: slink8 Item: Title: Resource availability Destination: flink4 Children: Item: Title: Lead contact Destination: slink9 Item: Title: Materials availability Destination: slink10 Item: Title: Data and code availability Destination: slink11 Item: Title: Acknowledgments Destination: flink5 Item: Title: Author contributions Destination: flink6 Item: Title: Declaration of interests Destination: flink7 Item: Title: Supplemental information Destination: falink8 Item: Title: References Destination: blink1 Item: Title: STAR★Methods Destination: flink9 Children: Item: Title: Key resources table Destination: slink12 Item: Title: Experimental model and study participant details Destination: slink13 Children: Item: Title: Mouse models Destination: tlink1 Item: Title: Cell models Destination: tlink2 Item: Title: Method details Destination: slink14 Children: Item: Title: Measurements in human cells Destination: tlink3 Children: Item: Title: RNA interference Destination: ftlink4 Item: Title: Pharmacological treatments Destination: ftlink5 Item: Title: Oxygen consumption rate Destination: ftlink6 Item: Title: Mitochondrial DNA quantitation Destination: ftlink7 Item: Title: Oleate oxidation assays Destination: ftlink8 Item: Title: Chromatin isolation Destination: ftlink9 Item: Title: DNA microarray Destination: ftlink10 Item: Title: DNA constructs and cell transfection Destination: ftlink11 Item: Title: In situ proximity ligation assay and immunofluorescence Destination: ftlink12 Item: Title: Analysis of HSL interactomes following immunoprecipitation Destination: ftlink13 Item: Title: Protein analyses in human adipocyte culture media Destination: ftlink14 Item: Title: Protein analyses in human adipocyte nuclear extracts Destination: ftlink15 Item: Title: Measurements in mouse models Destination: tlink16 Children: Item: Title: Nutritional challenges Destination: ftlink17 Item: Title: Adipose tissue histology Destination: ftlink18 Item: Title: Mating trials Destination: ftlink19 Item: Title: Adeno-associated viral vectors Destination: ftlink20 Item: Title: HSL enzymatic activity Destination: ftlink21 Item: Title: Mouse adipose tissue explants Destination: ftlink22 Item: Title: Isolation of mouse adipocyte nuclei Destination: ftlink23 Item: Title: Glucose tolerance test Destination: ftlink24 Item: Title: Blood analyses Destination: ftlink25 Item: Title: Electron microscopy Destination: ftlink26 Item: Title: Measurements common to mouse and human models Destination: tlink27 Children: Item: Title: Gene and protein expression analysis Destination: ftlink28 Item: Title: qPCR primers and assay-on-demands Destination: ftlink29 Item: Title: Antibodies for western blotting Destination: ftlink30 Item: Title: Subcellular fractionation Destination: ftlink31 Item: Title: Immunoprecipitation Destination: ftlink32 Item: Title: Quantification and statistical analysis Destination: slink15 Info: Title: CMET4114_grabs 1..1 Author: Jérémy Dufau Subject: Cell Metabolism, Corrected proof. doi:10.1016/j.cmet.2025.09.014 Creator: Elsevier Producer: PDFlib+PDI 10.0.2p2 (C++/Win64) CreationDate: Tue Oct 21 17:59:50 CEST 2025 ModDate: Tue Oct 21 18:12:22 CEST 2025 ID: 0x8af6d2bb83b0e351b7bd6f35393b02b7, 0xcd47b0175d501f40806694306bc9a5bb Filters: FilterPipeline: FlateDecode Fonts: Type0: Font: BaseFont: GlyphLessFont Encoding: Identity-H ToUnicode: true Font: BaseFont: JGEMDA+TrebuchetMS Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: XBNGEJ+STIX-Bold FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: XBNGEJ+STIX-Bold Flags: Nonsymbolic, ForceBold FontBBox: -998, -552, 2000, 1055 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: JQEXGK+HelveticaNeue-Light FontSubset: true FirstChar: 32 LastChar: 251 FontDescriptor: FontName: JQEXGK+HelveticaNeue-Light Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: VSNFOE+Rockwell FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: VSNFOE+Rockwell Flags: Nonsymbolic FontBBox: -148, -223, 1054, 917 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: XBNGEJ+STIX-Bold FontSubset: true FirstChar: 1 LastChar: 2 FontDescriptor: FontName: XBNGEJ+STIX-Bold Flags: Nonsymbolic, ForceBold FontBBox: -998, -552, 2000, 1055 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: ONQJRU+STIX-Regular FontSubset: true FirstChar: 1 LastChar: 8 FontDescriptor: FontName: ONQJRU+STIX-Regular Flags: Nonsymbolic FontBBox: -970, -486, 2208, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: SACQIF+HelveticaNeue-Heavy FontSubset: true FirstChar: 32 LastChar: 251 FontDescriptor: FontName: SACQIF+HelveticaNeue-Heavy Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile: true FontFile3: true ToUnicode: true Font: BaseFont: DJTPIK+HelveticaNeue-Italic FontSubset: true FirstChar: 32 LastChar: 251 FontDescriptor: FontName: DJTPIK+HelveticaNeue-Italic Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: VHDPHK+TeX_CM_Roman FontSubset: true FirstChar: 1 LastChar: 128 FontDescriptor: FontName: VHDPHK+TeX_CM_Roman Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: TVJBYZ+CM_Maths_Symbols FontSubset: true FirstChar: 1 LastChar: 138 FontDescriptor: FontName: TVJBYZ+CM_Maths_Symbols Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile: true FontFile3: true ToUnicode: true Font: BaseFont: YEGTDP+HelveticaNeue-Medium FontSubset: true FirstChar: 32 LastChar: 251 FontDescriptor: FontName: YEGTDP+HelveticaNeue-Medium Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: RGVZMW+HelveticaNeue-Bold FontSubset: true FirstChar: 32 LastChar: 251 FontDescriptor: FontName: RGVZMW+HelveticaNeue-Bold Flags: Symbolic, ForceBold FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: XFANEM+HelveticaNeue-Roman FontSubset: true FirstChar: 32 LastChar: 251 FontDescriptor: FontName: XFANEM+HelveticaNeue-Roman Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: MHJHDG+HelveticaNeue-MediumItalic FontSubset: true FirstChar: 32 LastChar: 251 FontDescriptor: FontName: MHJHDG+HelveticaNeue-MediumItalic Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: YEGTDP+HelveticaNeue-Medium FontSubset: true FirstChar: 32 LastChar: 251 FontDescriptor: FontName: YEGTDP+HelveticaNeue-Medium Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: SACQIF+HelveticaNeue-Heavy FontSubset: true FirstChar: 32 LastChar: 251 FontDescriptor: FontName: SACQIF+HelveticaNeue-Heavy Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile: true FontFile3: true ToUnicode: true Font: BaseFont: MHJHDG+HelveticaNeue-MediumItalic FontSubset: true FirstChar: 32 LastChar: 251 FontDescriptor: FontName: MHJHDG+HelveticaNeue-MediumItalic Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: HXBKGX+HelveticaNeue-HeavyItalic FontSubset: true FirstChar: 32 LastChar: 251 FontDescriptor: FontName: HXBKGX+HelveticaNeue-HeavyItalic Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: TVJBYZ+CM_Maths_Symbols FontSubset: true FirstChar: 1 LastChar: 138 FontDescriptor: FontName: TVJBYZ+CM_Maths_Symbols Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile: true FontFile3: true ToUnicode: true CIDFontType2: Font: BaseFont: JGEMDA+TrebuchetMS CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: JGEMDA+TrebuchetMS Flags: Nonsymbolic FontBBox: -532, -262, 1311, 985 FontFile2: true Font: BaseFont: GlyphLessFont CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: GlyphLessFont Flags: FixedPitch, Symbolic FontBBox: 0, 0, 500, 1000 FontFile2: true XMP: application/pdf doi:10.1016/j.cmet.2025.09.014 CMET4114_grabs 1..1 Jérémy Dufau Emeline Recazens Laura Bottin Camille Bergoglio Aline Mairal Karima Chaoui Marie-Adeline Marques Veronica Jimenez Miquel García Tongtong Wang Henrik Laurell Jason S. Iacovoni Remy Flores-Flores Pierre-Damien Denechaud Khalil Acheikh Ibn Oumar Ez-Zoubir Amri Catherine Postic Jean-Paul Concordet Pierre Gourdy Niklas Mejhert Mikael Rydén Odile Burlet-Schiltz Fatima Bosch Christian Wolfrum Etienne Mouisel Genevieve Tavernier Dominique Langin hormone-sensitive lipase adipocyte adipose tissue cell nucleus protein-protein interaction TGF-β signaling mitochondrial oxidative phosphorylation extracellular matrix obesity lipodystrophy Cell Metabolism, Corrected proof. doi:10.1016/j.cmet.2025.09.014 The Authors journal Cell Metabolism © 2025 The Authors. Published by Elsevier Inc. 1550-4131 10.1016/j.cmet.2025.09.014 https://doi.org/10.1016/j.cmet.2025.09.014 P 10.1016/j.cmet.2025.09.014 noindex true PStill version 1.84.42 Elsevier 2025-10-21T20:59:50+05:30 2025-10-21T21:12:22+05:30 2025-10-21T21:12:22+05:30 True 1 https://www.elsevier.com/tdm/tdmrep-policy.json PDFlib+PDI 10.0.2p2 (C++/Win64) uuid:ae457a5a-0cb2-4e9c-ad6f-b255d20f02b0 uuid:5fe027bc-acf7-4d02-b2b9-1341c005c642 http://creativecommons.org/licenses/by/4.0/ Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Contents: Rect: 354, 517, 482, 527 Flags: Print Annotation: Subtype: Link Contents: Rect: 104, 48, 270, 56 Flags: Print Page: Label: 1 Annotations: Annotation: Subtype: Link Contents: Rect: 53, 681, 53, 681 Flags: Print Annotation: Subtype: Link Contents: Rect: 113, 605, 118, 614 Flags: Print Destination: 1 Annotation: Subtype: Link Contents: Rect: 118, 605, 126, 614 Flags: Print Destination: 1 Annotation: Subtype: Link Contents: Rect: 206, 605, 212, 614 Flags: Print Destination: 1 Annotation: Subtype: Link Contents: Rect: 212, 605, 219, 614 Flags: Print Destination: 1 Annotation: Subtype: Link Contents: Rect: 275, 605, 279, 614 Flags: Print Destination: 1 Annotation: Subtype: Link Contents: Rect: 357, 605, 361, 614 Flags: Print Destination: 1 Annotation: Subtype: Link Contents: Rect: 414, 605, 418, 614 Flags: Print Destination: 1 Annotation: Subtype: Link Contents: Rect: 484, 605, 487, 614 Flags: Print Destination: 1 Annotation: Subtype: Link Contents: Rect: 151, 595, 155, 604 Flags: Print Destination: 1 Annotation: Subtype: Link Contents: Rect: 232, 595, 237, 604 Flags: Print Destination: 1 Annotation: Subtype: Link Contents: Rect: 237, 595, 243, 604 Flags: Print Destination: 1 Annotation: Subtype: Link Contents: Rect: 243, 595, 247, 604 Flags: Print Destination: 1 Annotation: Subtype: Link Contents: Rect: 308, 595, 314, 604 Flags: Print Destination: 1 Annotation: Subtype: Link Contents: Rect: 314, 595, 319, 604 Flags: Print Destination: 1 Annotation: Subtype: Link Contents: Rect: 319, 595, 323, 604 Flags: Print Destination: 1 Annotation: Subtype: Link Contents: Rect: 394, 595, 397, 604 Flags: Print Destination: 1 Annotation: Subtype: Link Contents: Rect: 458, 595, 462, 604 Flags: Print Destination: 1 Annotation: Subtype: Link Contents: Rect: 539, 595, 543, 604 Flags: Print Destination: 1 Annotation: Subtype: Link Contents: Rect: 136, 585, 140, 594 Flags: Print Destination: 1 Annotation: Subtype: Link Contents: Rect: 254, 585, 258, 594 Flags: Print Destination: 1 Annotation: Subtype: Link Contents: Rect: 367, 585, 371, 594 Flags: Print Destination: 1 Annotation: Subtype: Link Contents: Rect: 438, 585, 442, 594 Flags: Print Destination: 1 Annotation: Subtype: Link Contents: Rect: 515, 585, 519, 594 Flags: Print Destination: 1 Annotation: Subtype: Link Contents: Rect: 143, 575, 147, 584 Flags: Print Destination: 1 Annotation: Subtype: Link Contents: Rect: 209, 575, 215, 584 Flags: Print Destination: 1 Annotation: Subtype: Link Contents: Rect: 215, 575, 222, 584 Flags: Print Destination: 1 Annotation: Subtype: Link Contents: Rect: 286, 575, 294, 584 Flags: Print Destination: 1 Annotation: Subtype: Link Contents: Rect: 355, 575, 362, 584 Flags: Print Destination: 1 Annotation: Subtype: Link Contents: Rect: 447, 575, 451, 584 Flags: Print Destination: 1 Annotation: Subtype: Link Contents: Rect: 513, 575, 519, 584 Flags: Print Destination: 1 Annotation: Subtype: Link Contents: Rect: 519, 575, 524, 584 Flags: Print Destination: 1 Annotation: Subtype: Link Contents: Rect: 524, 575, 528, 584 Flags: Print Destination: 1 Annotation: Subtype: Link Contents: Rect: 129, 565, 133, 574 Flags: Print Destination: 1 Annotation: Subtype: Link Contents: Rect: 204, 565, 209, 574 Flags: Print Destination: 1 Annotation: Subtype: Link Contents: Rect: 209, 565, 217, 574 Flags: Print Destination: 1 Annotation: Subtype: Link Contents: Rect: 306, 565, 312, 574 Flags: Print Destination: 1 Annotation: Subtype: Link Contents: Rect: 312, 565, 321, 574 Flags: Print Destination: 1 Annotation: Subtype: Link Contents: Rect: 321, 565, 329, 574 Flags: Print Destination: 1 Annotation: Subtype: Link Contents: Rect: 424, 565, 430, 574 Flags: Print Destination: 1 Annotation: Subtype: Link Contents: Rect: 430, 565, 439, 574 Flags: Print Destination: 1 Annotation: Subtype: Link Contents: Rect: 439, 565, 448, 574 Flags: Print Destination: 1 Annotation: Subtype: Link Contents: Rect: 448, 565, 458, 574 Flags: Print Destination: 1 Annotation: Subtype: Link Contents: Rect: 458, 566, 461, 574 Flags: Print Destination: 1 Annotation: Subtype: Link Contents: Rect: 119, 386, 217, 394 Flags: Print Annotation: Subtype: Link Contents: Rect: 53, 376, 205, 384 Flags: Print Annotation: Subtype: Link Contents: Rect: 212, 112, 216, 120 Flags: Print Destination: 41 Annotation: Subtype: Link Contents: Rect: 217, 112, 221, 120 Flags: Print Destination: 41 Annotation: Subtype: Link Contents: Rect: 102, 46, 106, 55 Flags: Print Destination: 41 Annotation: Subtype: Link Contents: Rect: 108, 46, 111, 55 Flags: Print Destination: 45 Annotation: Subtype: Link Contents: Rect: 375, 134, 378, 142 Flags: Print Destination: 41 Annotation: Subtype: Link Contents: Rect: 380, 134, 384, 142 Flags: Print Destination: 45 Annotation: Subtype: Link Contents: Rect: 523, 101, 527, 109 Flags: Print Destination: 45 Annotation: Subtype: Link Contents: Rect: 471, 68, 475, 77 Flags: Print Destination: 45 Annotation: Subtype: Link Contents: Rect: 477, 68, 480, 77 Flags: Print Destination: 45 Annotation: Subtype: Link Contents: Rect: 358, 9, 516, 17 Flags: Print Page: Label: 1 Annotations: Annotation: Subtype: Link Contents: Rect: 100, 212, 103, 221 Flags: Print Destination: 45 Annotation: Subtype: Link Contents: Rect: 78, 103, 82, 111 Flags: Print Destination: 45 Annotation: Subtype: Link Contents: Rect: 131, 81, 148, 89 Flags: Print Destination: 45 Annotation: Subtype: Link Contents: Rect: 336, 114, 371, 122 Flags: Print Destination: 5 Annotation: Subtype: Link Contents: Rect: 411, 114, 421, 122 Flags: Print Destination: 41 Annotation: Subtype: Link Contents: Rect: 312, 92, 348, 100 Flags: Print Destination: 41 Annotation: Subtype: Link Contents: Rect: 369, 59, 399, 67 Flags: Print Destination: 5 Annotation: Subtype: Link Contents: Rect: 512, 37, 519, 45 Flags: Print Destination: 45 Page: Label: 1 Annotations: Annotation: Subtype: Link Contents: Rect: 55, 662, 94, 670 Flags: Print Destination: 41 Annotation: Subtype: Link Contents: Rect: 237, 640, 268, 648 Flags: Print Destination: 5 Annotation: Subtype: Link Contents: Rect: 55, 607, 86, 615 Flags: Print Destination: 5 Annotation: Subtype: Link Contents: Rect: 155, 585, 162, 593 Flags: Print Destination: 45 Annotation: Subtype: Link Contents: Rect: 55, 574, 88, 582 Flags: Print Destination: 5 Annotation: Subtype: Link Contents: Rect: 97, 574, 107, 582 Flags: Print Destination: 41 Annotation: Subtype: Link Contents: Rect: 98, 519, 133, 528 Flags: Print Destination: 5 Annotation: Subtype: Link Contents: Rect: 144, 519, 154, 528 Flags: Print Destination: 41 Annotation: Subtype: Link Contents: Rect: 200, 519, 207, 528 Flags: Print Destination: 45 Annotation: Subtype: Link Contents: Rect: 99, 442, 134, 451 Flags: Print Destination: 41 Annotation: Subtype: Link Contents: Rect: 104, 410, 146, 418 Flags: Print Destination: 41 Annotation: Subtype: Link Contents: Rect: 264, 410, 268, 418 Flags: Print Destination: 45 Annotation: Subtype: Link Contents: Rect: 270, 410, 277, 418 Flags: Print Destination: 45 Annotation: Subtype: Link Contents: Rect: 187, 388, 228, 396 Flags: Print Destination: 41 Annotation: Subtype: Link Contents: Rect: 55, 355, 91, 363 Flags: Print Destination: 41 Annotation: Subtype: Link Contents: Rect: 102, 355, 109, 363 Flags: Print Destination: 45 Annotation: Subtype: Link Contents: Rect: 111, 355, 118, 363 Flags: Print Destination: 45 Annotation: Subtype: Link Contents: Rect: 116, 333, 153, 341 Flags: Print Destination: 41 Annotation: Subtype: Link Contents: Rect: 99, 234, 103, 243 Flags: Print Destination: 45 Annotation: Subtype: Link Contents: Rect: 104, 234, 108, 243 Flags: Print Destination: 45 Annotation: Subtype: Link Contents: Rect: 184, 190, 226, 199 Flags: Print Destination: 41 Annotation: Subtype: Link Contents: Rect: 112, 168, 146, 177 Flags: Print Destination: 13 Annotation: Subtype: Link Contents: Rect: 169, 168, 179, 177 Flags: Print Destination: 41 Annotation: Subtype: Link Contents: Rect: 55, 136, 89, 144 Flags: Print Destination: 13 Annotation: Subtype: Link Contents: Rect: 216, 114, 254, 122 Flags: Print Destination: 41 Annotation: Subtype: Link Contents: Rect: 122, 59, 157, 67 Flags: Print Destination: 13 Annotation: Subtype: Link Contents: Rect: 469, 673, 506, 681 Flags: Print Destination: 41 Annotation: Subtype: Link Contents: Rect: 349, 607, 388, 615 Flags: Print Destination: 41 Annotation: Subtype: Link Contents: Rect: 402, 585, 443, 593 Flags: Print Destination: 41 Annotation: Subtype: Link Contents: Rect: 395, 563, 432, 572 Flags: Print Destination: 41 Annotation: Subtype: Link Contents: Rect: 306, 486, 342, 495 Flags: Print Destination: 13 Annotation: Subtype: Link Contents: Rect: 380, 486, 390, 495 Flags: Print Destination: 41 Annotation: Subtype: Link Contents: Rect: 431, 464, 465, 473 Flags: Print Destination: 13 Annotation: Subtype: Link Contents: Rect: 502, 464, 513, 473 Flags: Print Destination: 41 Annotation: Subtype: Link Contents: Rect: 450, 453, 454, 462 Flags: Print Destination: 45 Annotation: Subtype: Link Contents: Rect: 460, 453, 497, 462 Flags: Print Destination: 41 Annotation: Subtype: Link Contents: Rect: 518, 442, 525, 451 Flags: Print Destination: 45 Annotation: Subtype: Link Contents: Rect: 527, 442, 534, 451 Flags: Print Destination: 45 Annotation: Subtype: Link Contents: Rect: 536, 442, 543, 451 Flags: Print Destination: 45 Annotation: Subtype: Link Contents: Rect: 437, 366, 473, 374 Flags: Print Destination: 41 Annotation: Subtype: Link Contents: Rect: 351, 267, 386, 276 Flags: Print Destination: 17 Annotation: Subtype: Link Contents: Rect: 428, 267, 438, 276 Flags: Print Destination: 41 Annotation: Subtype: Link Contents: Rect: 448, 267, 455, 276 Flags: Print Destination: 45 Annotation: Subtype: Link Contents: Rect: 457, 267, 464, 276 Flags: Print Destination: 45 Annotation: Subtype: Link Contents: Rect: 482, 223, 518, 232 Flags: Print Destination: 17 Annotation: Subtype: Link Contents: Rect: 304, 212, 314, 221 Flags: Print Destination: 41 Annotation: Subtype: Link Contents: Rect: 409, 179, 446, 188 Flags: Print Destination: 41 Annotation: Subtype: Link Contents: Rect: 407, 147, 449, 155 Flags: Print Destination: 41 Annotation: Subtype: Link Contents: Rect: 498, 147, 505, 155 Flags: Print Destination: 45 Annotation: Subtype: Link Contents: Rect: 507, 147, 514, 155 Flags: Print Destination: 45 Annotation: Subtype: Link Contents: Rect: 431, 114, 462, 122 Flags: Print Destination: 17 Annotation: Subtype: Link Contents: Rect: 420, 81, 454, 89 Flags: Print Destination: 17 Annotation: Subtype: Link Contents: Rect: 493, 81, 503, 89 Flags: Print Destination: 41 Annotation: Subtype: Link Contents: Rect: 338, 48, 372, 56 Flags: Print Destination: 17 Annotation: Subtype: Link Contents: Rect: 413, 48, 423, 56 Flags: Print Destination: 41 Page: Label: 1 Annotations: Annotation: Subtype: Link Contents: Rect: 95, 136, 135, 144 Flags: Print Destination: 41 Annotation: Subtype: Link Contents: Rect: 215, 125, 222, 133 Flags: Print Destination: 45 Annotation: Subtype: Link Contents: Rect: 224, 125, 231, 133 Flags: Print Destination: 45 Annotation: Subtype: Link Contents: Rect: 485, 147, 492, 155 Flags: Print Destination: 45 Annotation: Subtype: Link Contents: Rect: 444, 136, 483, 144 Flags: Print Destination: 41 Annotation: Subtype: Link Contents: Rect: 313, 92, 350, 100 Flags: Print Destination: 41 Annotation: Subtype: Link Contents: Rect: 482, 70, 513, 78 Flags: Print Destination: 17 Annotation: Subtype: Link Contents: Rect: 454, 37, 485, 45 Flags: Print Destination: 21 Annotation: Subtype: Link Contents: Rect: 495, 37, 502, 45 Flags: Print Destination: 45 Page: Label: 1 Annotations: Annotation: Subtype: Link Contents: Rect: 102, 278, 136, 287 Flags: Print Destination: 21 Annotation: Subtype: Link Contents: Rect: 161, 278, 171, 287 Flags: Print Destination: 41 Annotation: Subtype: Link Contents: Rect: 181, 278, 185, 287 Flags: Print Destination: 41 Annotation: Subtype: Link Contents: Rect: 160, 245, 177, 254 Flags: Print Destination: 45 Annotation: Subtype: Link Contents: Rect: 183, 212, 213, 221 Flags: Print Destination: 21 Annotation: Subtype: Link Contents: Rect: 55, 125, 95, 133 Flags: Print Destination: 41 Annotation: Subtype: Link Contents: Rect: 74, 92, 109, 100 Flags: Print Destination: 21 Annotation: Subtype: Link Contents: Rect: 132, 59, 166, 67 Flags: Print Destination: 21 Annotation: Subtype: Link Contents: Rect: 177, 59, 184, 67 Flags: Print Destination: 45 Annotation: Subtype: Link Contents: Rect: 208, 37, 238, 45 Flags: Print Destination: 21 Annotation: Subtype: Link Contents: Rect: 306, 289, 342, 297 Flags: Print Destination: 21 Annotation: Subtype: Link Contents: Rect: 386, 289, 396, 297 Flags: Print Destination: 41 Annotation: Subtype: Link Contents: Rect: 497, 267, 532, 276 Flags: Print Destination: 41 Annotation: Subtype: Link Contents: Rect: 306, 223, 341, 232 Flags: Print Destination: 21 Annotation: Subtype: Link Contents: Rect: 368, 136, 375, 144 Flags: Print Destination: 45 Annotation: Subtype: Link Contents: Rect: 376, 136, 383, 144 Flags: Print Destination: 45 Annotation: Subtype: Link Contents: Rect: 388, 136, 428, 144 Flags: Print Destination: 41 Annotation: Subtype: Link Contents: Rect: 467, 114, 502, 122 Flags: Print Destination: 25 Annotation: Subtype: Link Contents: Rect: 501, 81, 537, 89 Flags: Print Destination: 25 Annotation: Subtype: Link Contents: Rect: 362, 48, 399, 56 Flags: Print Destination: 25 Page: Label: 1 Annotations: Annotation: Subtype: Link Contents: Rect: 237, 81, 269, 89 Flags: Print Destination: 25 Annotation: Subtype: Link Contents: Rect: 135, 48, 166, 56 Flags: Print Destination: 25 Annotation: Subtype: Link Contents: Rect: 371, 70, 404, 78 Flags: Print Destination: 25 Annotation: Subtype: Link Contents: Rect: 377, 48, 407, 56 Flags: Print Destination: 25 Page: Label: 1 Annotations: Annotation: Subtype: Link Contents: Rect: 55, 114, 90, 122 Flags: Print Destination: 41 Annotation: Subtype: Link Contents: Rect: 55, 70, 92, 78 Flags: Print Destination: 41 Annotation: Subtype: Link Contents: Rect: 306, 179, 342, 188 Flags: Print Destination: 41 Annotation: Subtype: Link Contents: Rect: 487, 125, 504, 133 Flags: Print Destination: 45 Annotation: Subtype: Link Contents: Rect: 502, 92, 537, 100 Flags: Print Destination: 29 Annotation: Subtype: Link Contents: Rect: 321, 81, 331, 89 Flags: Print Destination: 41 Annotation: Subtype: Link Contents: Rect: 380, 59, 413, 67 Flags: Print Destination: 29 Page: Label: 1 Annotations: Annotation: Subtype: Link Contents: Rect: 138, 125, 172, 133 Flags: Print Destination: 29 Annotation: Subtype: Link Contents: Rect: 195, 125, 205, 133 Flags: Print Destination: 41 Annotation: Subtype: Link Contents: Rect: 167, 103, 173, 111 Flags: Print Destination: 49 Annotation: Subtype: Link Contents: Rect: 175, 103, 182, 111 Flags: Print Destination: 49 Annotation: Subtype: Link Contents: Rect: 61, 70, 101, 78 Flags: Print Destination: 41 Annotation: Subtype: Link Contents: Rect: 335, 70, 369, 78 Flags: Print Destination: 29 Annotation: Subtype: Link Contents: Rect: 379, 70, 389, 78 Flags: Print Destination: 41 Annotation: Subtype: Link Contents: Rect: 374, 59, 410, 67 Flags: Print Destination: 41 Annotation: Subtype: Link Contents: Rect: 415, 48, 455, 56 Flags: Print Destination: 41 Page: Label: 1 Annotations: Annotation: Subtype: Link Contents: Rect: 98, 158, 133, 166 Flags: Print Destination: 29 Annotation: Subtype: Link Contents: Rect: 159, 158, 169, 166 Flags: Print Destination: 41 Annotation: Subtype: Link Contents: Rect: 188, 147, 218, 155 Flags: Print Destination: 29 Annotation: Subtype: Link Contents: Rect: 76, 103, 113, 111 Flags: Print Destination: 29 Annotation: Subtype: Link Contents: Rect: 143, 103, 153, 111 Flags: Print Destination: 41 Annotation: Subtype: Link Contents: Rect: 192, 70, 227, 78 Flags: Print Destination: 29 Annotation: Subtype: Link Contents: Rect: 271, 70, 281, 78 Flags: Print Destination: 41 Annotation: Subtype: Link Contents: Rect: 221, 48, 258, 56 Flags: Print Destination: 41 Annotation: Subtype: Link Contents: Rect: 467, 125, 502, 133 Flags: Print Destination: 29 Annotation: Subtype: Link Contents: Rect: 524, 125, 534, 133 Flags: Print Destination: 41 Page: Label: 1 Annotations: Annotation: Subtype: Link Contents: Rect: 125, 662, 160, 670 Flags: Print Destination: 33 Annotation: Subtype: Link Contents: Rect: 186, 662, 196, 670 Flags: Print Destination: 41 Annotation: Subtype: Link Contents: Rect: 90, 651, 97, 659 Flags: Print Destination: 49 Annotation: Subtype: Link Contents: Rect: 187, 618, 224, 626 Flags: Print Destination: 41 Annotation: Subtype: Link Contents: Rect: 234, 618, 237, 626 Flags: Print Destination: 45 Annotation: Subtype: Link Contents: Rect: 239, 618, 246, 626 Flags: Print Destination: 49 Annotation: Subtype: Link Contents: Rect: 247, 618, 254, 626 Flags: Print Destination: 49 Annotation: Subtype: Link Contents: Rect: 219, 596, 254, 604 Flags: Print Destination: 41 Annotation: Subtype: Link Contents: Rect: 177, 574, 181, 582 Flags: Print Destination: 45 Annotation: Subtype: Link Contents: Rect: 107, 563, 144, 572 Flags: Print Destination: 41 Annotation: Subtype: Link Contents: Rect: 61, 519, 96, 528 Flags: Print Destination: 33 Annotation: Subtype: Link Contents: Rect: 136, 519, 143, 528 Flags: Print Destination: 49 Annotation: Subtype: Link Contents: Rect: 86, 497, 116, 506 Flags: Print Destination: 33 Annotation: Subtype: Link Contents: Rect: 202, 475, 235, 484 Flags: Print Destination: 33 Annotation: Subtype: Link Contents: Rect: 193, 442, 229, 451 Flags: Print Destination: 33 Annotation: Subtype: Link Contents: Rect: 239, 442, 249, 451 Flags: Print Destination: 41 Annotation: Subtype: Link Contents: Rect: 61, 399, 102, 407 Flags: Print Destination: 41 Annotation: Subtype: Link Contents: Rect: 81, 355, 112, 363 Flags: Print Destination: 33 Annotation: Subtype: Link Contents: Rect: 121, 355, 128, 363 Flags: Print Destination: 49 Annotation: Subtype: Link Contents: Rect: 61, 333, 92, 341 Flags: Print Destination: 33 Annotation: Subtype: Link Contents: Rect: 165, 267, 169, 276 Flags: Print Destination: 45 Annotation: Subtype: Link Contents: Rect: 72, 234, 76, 243 Flags: Print Destination: 45 Annotation: Subtype: Link Contents: Rect: 281, 223, 288, 232 Flags: Print Destination: 49 Annotation: Subtype: Link Contents: Rect: 197, 190, 204, 199 Flags: Print Destination: 49 Annotation: Subtype: Link Contents: Rect: 205, 190, 212, 199 Flags: Print Destination: 49 Annotation: Subtype: Link Contents: Rect: 225, 147, 242, 155 Flags: Print Destination: 45 Annotation: Subtype: Link Contents: Rect: 336, 651, 343, 659 Flags: Print Destination: 49 Annotation: Subtype: Link Contents: Rect: 468, 629, 475, 637 Flags: Print Destination: 49 Annotation: Subtype: Link Contents: Rect: 346, 563, 353, 572 Flags: Print Destination: 49 Annotation: Subtype: Link Contents: Rect: 538, 486, 541, 495 Flags: Print Destination: 41 Annotation: Subtype: Link Contents: Rect: 491, 388, 498, 396 Flags: Print Destination: 49 Annotation: Subtype: Link Contents: Rect: 474, 333, 482, 341 Flags: Print Destination: 45 Annotation: Subtype: Link Contents: Rect: 483, 333, 490, 341 Flags: Print Destination: 49 Annotation: Subtype: Link Contents: Rect: 509, 322, 516, 330 Flags: Print Destination: 49 Annotation: Subtype: Link Contents: Rect: 333, 289, 340, 298 Flags: Print Destination: 49 Annotation: Subtype: Link Contents: Rect: 475, 256, 482, 265 Flags: Print Destination: 49 Annotation: Subtype: Link Contents: Rect: 484, 256, 501, 265 Flags: Print Destination: 49 Annotation: Subtype: Link Contents: Rect: 419, 190, 423, 199 Flags: Print Destination: 45 Annotation: Subtype: Link Contents: Rect: 425, 190, 432, 199 Flags: Print Destination: 45 Annotation: Subtype: Link Contents: Rect: 389, 48, 396, 56 Flags: Print Destination: 45 Page: Label: 1 Annotations: Annotation: Subtype: Link Contents: Rect: 217, 673, 224, 681 Flags: Print Destination: 49 Annotation: Subtype: Link Contents: Rect: 285, 618, 292, 626 Flags: Print Destination: 49 Annotation: Subtype: Link Contents: Rect: 115, 340, 201, 347 Flags: Print Annotation: Subtype: Link Contents: Rect: 253, 292, 292, 299 Flags: Print Destination: 41 Annotation: Subtype: Link Contents: Rect: 234, 254, 259, 261 Flags: Print Destination: 41 Annotation: Subtype: Link Contents: Rect: 158, 225, 196, 232 Flags: Print Destination: 41 Annotation: Subtype: Link Contents: Rect: 324, 340, 406, 347 Flags: Print Destination: 57 Annotation: Subtype: Link Contents: Rect: 324, 330, 520, 337 Flags: Print Destination: 77 Annotation: Subtype: Link Contents: Rect: 324, 302, 384, 309 Flags: Print Destination: 77 Annotation: Subtype: Link Contents: Rect: 324, 264, 477, 271 Flags: Print Destination: 93 Annotation: Subtype: Link Contents: Rect: 465, 223, 543, 230 Flags: Print Annotation: Subtype: Link Contents: Rect: 304, 213, 360, 220 Flags: Print Annotation: Subtype: Link Contents: Rect: 469, 108, 543, 115 Flags: Print Annotation: Subtype: Link Contents: Rect: 316, 99, 382, 106 Flags: Print Annotation: Subtype: Link Contents: Rect: 316, 68, 445, 75 Flags: Print Annotation: Subtype: Link Contents: Rect: 359, 37, 487, 44 Flags: Print Page: Label: 1 Annotations: Annotation: Subtype: Link Contents: Rect: 141, 655, 290, 662 Flags: Print Annotation: Subtype: Link Contents: Rect: 242, 634, 298, 641 Flags: Print Annotation: Subtype: Link Contents: Rect: 72, 625, 157, 632 Flags: Print Annotation: Subtype: Link Contents: Rect: 221, 604, 298, 611 Flags: Print Annotation: Subtype: Link Contents: Rect: 72, 594, 150, 601 Flags: Print Annotation: Subtype: Link Contents: Rect: 264, 564, 298, 571 Flags: Print Annotation: Subtype: Link Contents: Rect: 72, 554, 180, 561 Flags: Print Annotation: Subtype: Link Contents: Rect: 156, 514, 283, 521 Flags: Print Annotation: Subtype: Link Contents: Rect: 213, 474, 298, 481 Flags: Print Annotation: Subtype: Link Contents: Rect: 72, 465, 116, 472 Flags: Print Annotation: Subtype: Link Contents: Rect: 130, 416, 249, 423 Flags: Print Annotation: Subtype: Link Contents: Rect: 103, 376, 215, 383 Flags: Print Annotation: Subtype: Link Contents: Rect: 276, 336, 298, 343 Flags: Print Annotation: Subtype: Link Contents: Rect: 72, 326, 178, 333 Flags: Print Annotation: Subtype: Link Contents: Rect: 224, 296, 298, 303 Flags: Print Annotation: Subtype: Link Contents: Rect: 72, 286, 111, 293 Flags: Print Annotation: Subtype: Link Contents: Rect: 252, 246, 298, 253 Flags: Print Annotation: Subtype: Link Contents: Rect: 72, 237, 131, 244 Flags: Print Annotation: Subtype: Link Contents: Rect: 138, 206, 249, 213 Flags: Print Annotation: Subtype: Link Contents: Rect: 252, 167, 298, 174 Flags: Print Annotation: Subtype: Link Contents: Rect: 72, 157, 152, 164 Flags: Print Annotation: Subtype: Link Contents: Rect: 170, 117, 284, 124 Flags: Print Annotation: Subtype: Link Contents: Rect: 72, 68, 200, 75 Flags: Print Annotation: Subtype: Link Contents: Rect: 493, 674, 549, 681 Flags: Print Annotation: Subtype: Link Contents: Rect: 323, 665, 402, 672 Flags: Print Annotation: Subtype: Link Contents: Rect: 462, 614, 549, 621 Flags: Print Annotation: Subtype: Link Contents: Rect: 323, 605, 354, 612 Flags: Print Annotation: Subtype: Link Contents: Rect: 423, 536, 531, 543 Flags: Print Annotation: Subtype: Link Contents: Rect: 429, 486, 549, 493 Flags: Print Annotation: Subtype: Link Contents: Rect: 323, 476, 344, 483 Flags: Print Annotation: Subtype: Link Contents: Rect: 354, 445, 489, 452 Flags: Print Annotation: Subtype: Link Contents: Rect: 369, 404, 476, 411 Flags: Print Annotation: Subtype: Link Contents: Rect: 342, 363, 480, 370 Flags: Print Annotation: Subtype: Link Contents: Rect: 323, 323, 439, 330 Flags: Print Annotation: Subtype: Link Contents: Rect: 515, 301, 549, 308 Flags: Print Annotation: Subtype: Link Contents: Rect: 323, 291, 416, 298 Flags: Print Annotation: Subtype: Link Contents: Rect: 472, 260, 549, 267 Flags: Print Annotation: Subtype: Link Contents: Rect: 323, 251, 383, 258 Flags: Print Annotation: Subtype: Link Contents: Rect: 358, 200, 498, 207 Flags: Print Annotation: Subtype: Link Contents: Rect: 503, 169, 549, 176 Flags: Print Annotation: Subtype: Link Contents: Rect: 323, 160, 425, 167 Flags: Print Annotation: Subtype: Link Contents: Rect: 493, 128, 549, 135 Flags: Print Annotation: Subtype: Link Contents: Rect: 323, 119, 393, 126 Flags: Print Annotation: Subtype: Link Contents: Rect: 418, 78, 520, 85 Flags: Print Annotation: Subtype: Link Contents: Rect: 381, 37, 515, 44 Flags: Print Page: Label: 1 Annotations: Annotation: Subtype: Link Contents: Rect: 189, 646, 292, 653 Flags: Print Annotation: Subtype: Link Contents: Rect: 65, 636, 106, 643 Flags: Print Annotation: Subtype: Link Contents: Rect: 96, 605, 232, 612 Flags: Print Annotation: Subtype: Link Contents: Rect: 235, 583, 292, 590 Flags: Print Annotation: Subtype: Link Contents: Rect: 65, 574, 138, 581 Flags: Print Annotation: Subtype: Link Contents: Rect: 200, 543, 292, 550 Flags: Print Annotation: Subtype: Link Contents: Rect: 65, 533, 136, 540 Flags: Print Annotation: Subtype: Link Contents: Rect: 193, 502, 292, 509 Flags: Print Annotation: Subtype: Link Contents: Rect: 65, 493, 88, 500 Flags: Print Annotation: Subtype: Link Contents: Rect: 235, 462, 292, 469 Flags: Print Annotation: Subtype: Link Contents: Rect: 65, 452, 151, 459 Flags: Print Annotation: Subtype: Link Contents: Rect: 235, 412, 292, 419 Flags: Print Annotation: Subtype: Link Contents: Rect: 65, 402, 135, 409 Flags: Print Annotation: Subtype: Link Contents: Rect: 156, 362, 288, 369 Flags: Print Annotation: Subtype: Link Contents: Rect: 178, 321, 288, 328 Flags: Print Annotation: Subtype: Link Contents: Rect: 111, 281, 238, 288 Flags: Print Annotation: Subtype: Link Contents: Rect: 135, 250, 243, 257 Flags: Print Annotation: Subtype: Link Contents: Rect: 65, 200, 192, 207 Flags: Print Annotation: Subtype: Link Contents: Rect: 65, 159, 194, 166 Flags: Print Annotation: Subtype: Link Contents: Rect: 96, 118, 201, 125 Flags: Print Annotation: Subtype: Link Contents: Rect: 65, 68, 199, 75 Flags: Print Annotation: Subtype: Link Contents: Rect: 131, 37, 262, 44 Flags: Print Annotation: Subtype: Link Contents: Rect: 486, 646, 543, 653 Flags: Print Annotation: Subtype: Link Contents: Rect: 316, 636, 403, 643 Flags: Print Annotation: Subtype: Link Contents: Rect: 509, 576, 543, 583 Flags: Print Annotation: Subtype: Link Contents: Rect: 316, 567, 397, 574 Flags: Print Annotation: Subtype: Link Contents: Rect: 347, 526, 489, 533 Flags: Print Annotation: Subtype: Link Contents: Rect: 520, 485, 543, 492 Flags: Print Annotation: Subtype: Link Contents: Rect: 316, 475, 432, 482 Flags: Print Annotation: Subtype: Link Contents: Rect: 469, 444, 543, 451 Flags: Print Annotation: Subtype: Link Contents: Rect: 316, 435, 394, 441 Flags: Print Annotation: Subtype: Link Contents: Rect: 509, 394, 543, 400 Flags: Print Annotation: Subtype: Link Contents: Rect: 316, 384, 386, 391 Flags: Print Annotation: Subtype: Link Contents: Rect: 355, 334, 481, 341 Flags: Print Annotation: Subtype: Link Contents: Rect: 316, 283, 445, 290 Flags: Print Annotation: Subtype: Link Contents: Rect: 432, 252, 541, 259 Flags: Print Annotation: Subtype: Link Contents: Rect: 395, 201, 533, 208 Flags: Print Annotation: Subtype: Link Contents: Rect: 455, 170, 543, 177 Flags: Print Annotation: Subtype: Link Contents: Rect: 316, 160, 345, 167 Flags: Print Annotation: Subtype: Link Contents: Rect: 399, 119, 532, 126 Flags: Print Annotation: Subtype: Link Contents: Rect: 316, 69, 425, 76 Flags: Print Page: Label: 1 Annotations: Annotation: Subtype: Link Contents: Rect: 215, 674, 298, 681 Flags: Print Annotation: Subtype: Link Contents: Rect: 72, 665, 105, 672 Flags: Print Annotation: Subtype: Link Contents: Rect: 178, 634, 298, 641 Flags: Print Annotation: Subtype: Link Contents: Rect: 72, 625, 95, 632 Flags: Print Annotation: Subtype: Link Contents: Rect: 140, 585, 251, 592 Flags: Print Annotation: Subtype: Link Contents: Rect: 264, 545, 298, 552 Flags: Print Annotation: Subtype: Link Contents: Rect: 72, 536, 156, 543 Flags: Print Annotation: Subtype: Link Contents: Rect: 515, 674, 549, 681 Flags: Print Annotation: Subtype: Link Contents: Rect: 323, 665, 397, 672 Flags: Print Annotation: Subtype: Link Contents: Rect: 447, 641, 549, 648 Flags: Print Annotation: Subtype: Link Contents: Rect: 323, 632, 355, 639 Flags: Print Annotation: Subtype: Link Contents: Rect: 475, 609, 549, 616 Flags: Print Annotation: Subtype: Link Contents: Rect: 323, 599, 389, 606 Flags: Print Annotation: Subtype: Link Contents: Rect: 475, 557, 549, 564 Flags: Print Annotation: Subtype: Link Contents: Rect: 323, 547, 360, 554 Flags: Print Annotation: Subtype: Link Contents: Rect: 414, 505, 513, 512 Flags: Print Page: Label: 1 Page: Label: 1 Page: Label: 1 Page: Label: 1 Annotations: Annotation: Subtype: Link Contents: Rect: 161, 423, 191, 431 Flags: Print Destination: 41 Annotation: Subtype: Link Contents: Rect: 158, 401, 188, 409 Flags: Print Destination: 41 Annotation: Subtype: Link Contents: Rect: 153, 379, 182, 386 Flags: Print Destination: 41 Annotation: Subtype: Link Contents: Rect: 59, 347, 89, 354 Flags: Print Destination: 41 Annotation: Subtype: Link Contents: Rect: 394, 321, 486, 328 Flags: Print Annotation: Subtype: Link Contents: Rect: 394, 287, 486, 294 Flags: Print Annotation: Subtype: Link Contents: Rect: 394, 275, 496, 282 Flags: Print Annotation: Subtype: Link Contents: Rect: 59, 69, 86, 77 Flags: Print Destination: 41 Page: Label: 1 Annotations: Annotation: Subtype: Link Contents: Rect: 352, 596, 359, 604 Flags: Print Destination: 49 Annotation: Subtype: Link Contents: Rect: 93, 574, 100, 582 Flags: Print Destination: 49 Annotation: Subtype: Link Contents: Rect: 280, 552, 363, 561 Flags: Print Annotation: Subtype: Link Contents: Rect: 368, 552, 375, 561 Flags: Print Destination: 49 Annotation: Subtype: Link Contents: Rect: 181, 541, 214, 550 Flags: Print Destination: 41 Annotation: Subtype: Link Contents: Rect: 93, 442, 100, 451 Flags: Print Destination: 49 Annotation: Subtype: Link Contents: Rect: 239, 388, 246, 396 Flags: Print Destination: 45 Annotation: Subtype: Link Contents: Rect: 497, 300, 505, 309 Flags: Print Destination: 49 Annotation: Subtype: Link Contents: Rect: 516, 245, 523, 254 Flags: Print Destination: 49 Annotation: Subtype: Link Contents: Rect: 157, 201, 164, 210 Flags: Print Destination: 49 Annotation: Subtype: Link Contents: Rect: 166, 201, 173, 210 Flags: Print Destination: 49 Annotation: Subtype: Link Contents: Rect: 175, 201, 182, 210 Flags: Print Destination: 49 Annotation: Subtype: Link Contents: Rect: 436, 190, 443, 199 Flags: Print Destination: 49 Page: Label: 1 Annotations: Annotation: Subtype: Link Contents: Rect: 59, 662, 93, 670 Flags: Print Destination: 41 Annotation: Subtype: Link Contents: Rect: 258, 618, 265, 626 Flags: Print Destination: 45 Annotation: Subtype: Link Contents: Rect: 94, 453, 126, 462 Flags: Print Destination: 41 Annotation: Subtype: Link Contents: Rect: 195, 377, 202, 385 Flags: Print Destination: 49 Annotation: Subtype: Link Contents: Rect: 389, 300, 396, 309 Flags: Print Destination: 49 Annotation: Subtype: Link Contents: Rect: 319, 289, 450, 298 Flags: Print Annotation: Subtype: Link Contents: Rect: 499, 234, 506, 243 Flags: Print Destination: 45 Annotation: Subtype: Link Contents: Rect: 442, 59, 449, 67 Flags: Print Destination: 53 Annotation: Subtype: Link Contents: Rect: 451, 59, 458, 67 Flags: Print Destination: 53 Page: Label: 1 Annotations: Annotation: Subtype: Link Contents: Rect: 376, 662, 543, 670 Flags: Print Annotation: Subtype: Link Contents: Rect: 53, 651, 203, 659 Flags: Print Annotation: Subtype: Link Contents: Rect: 347, 344, 354, 352 Flags: Print Destination: 53 Page: Label: 1 Annotations: Annotation: Subtype: Link Contents: Rect: 154, 640, 161, 648 Flags: Print Destination: 45 Annotation: Subtype: Link Contents: Rect: 61, 618, 170, 626 Flags: Print Annotation: Subtype: Link Contents: Rect: 522, 410, 529, 418 Flags: Print Destination: 53 Annotation: Subtype: Link Contents: Rect: 359, 355, 366, 363 Flags: Print Destination: 53 Annotation: Subtype: Link Contents: Rect: 431, 278, 438, 287 Flags: Print Destination: 49 Annotation: Subtype: Link Contents: Rect: 127, 223, 134, 232 Flags: Print Destination: 49 Annotation: Subtype: Link Contents: Rect: 505, 201, 512, 210 Flags: Print Destination: 53 Page: Label: 1 Annotations: Annotation: Subtype: Link Contents: Rect: 456, 607, 463, 615 Flags: Print Destination: 45 Annotation: Subtype: Link Contents: Rect: 70, 585, 103, 593 Flags: Print Destination: 41 Annotation: Subtype: Link Contents: Rect: 250, 136, 257, 144 Flags: Print Destination: 53 Annotation: Subtype: Link Contents: Rect: 259, 136, 266, 144 Flags: Print Destination: 53 Checksum: 140d0c07 Type: CRC32 Checksum: 767517b06f65ecf1820b1fcf147062d3 Type: MD5 Checksum: f743021c17efe70feadad4b710f54930dd6bf7ad Type: SHA-1 Checksum: 5129379eac05948767591776d8ad9fcf0772d4fdf70697851589042549dba0eb Type: SHA-256