ead59b7b739898d6d75b282870bd7aab sbae140.pdf 3d94b7eb551d34928b8b7db2be88fdb649977acb sbae140.pdf 03d97421ef725d131884f0aa797c41b7493aad0313212b5e5c8efcdea87b4256 sbae140.pdf Title: Predictive Validity of Psychometrically Assessed Schizotypy for Psychopathology Dimensions and Functioning in an 8-Year Multiwave Study Subject: DOI: 10.1093/schbul/sbae140 , Volume. 51, Issue. S2, XX XX XXXX Background and Hypothesis: Although the psychometric high-risk method based on schizotypy has proven to be a highly cost-effective strategy for unraveling etiological factors for schizophrenia-spectrum disorders, there is a paucity of longitudinal studies with nonclinical populations. This study analyzed the predictive validity of positive and negative schizotypy in a longitudinal project (Barcelona Longitudinal Investigation of Schizotypy; BLISS) spanning a total of 7.8 years. Study Design: At Time 1 (T1), 547 college students completed the Wisconsin Schizotypy Scales. We re-assessed subsamples (oversampled for high schizotypy to ensure variability) at 4 re-assessments. This study reports psychopathology, psychological, and functional outcomes assessed with self-report and interview (CAARMS, Negative Symptom Manual, SCID-II Cluster A) measures at T4 (n = 89; 4.4 years after T1) and self-report measures at T5 (n = 169; 7.8 years after T1). T1 positive and negative schizotypy were entered simultaneously as predictors in linear regression models. Study Results: Positive schizotypy predicted positive symptoms at T4, whereas negative schizotypy predicted interview-rated negative symptoms and schizoid personality traits (even when controlling for mood and avoidant personality), and impaired social and global functioning. Both dimensions predicted suspiciousness, and schizotypal and paranoid personality traits, as well as low self-esteem and depression. Similarly, both dimensions predicted suspiciousness, depression, and poor social support at T5, whereas only positive schizotypy predicted low self-esteem, anxiety, and perceived stress. Conclusions: Both schizotypy dimensions consistently showed a meaningful pattern of hypothesized differential and overlapping predictions, which supports their validity as distinct dimensions and their predictive validity in nonclinical samples. Author: Neus Barrantes-Vidal Creator: Adobe InDesign 15.1 (Windows) Producer: Adobe PDF Library 15.0; modified using iTextSharp 4.1.6 by 1T3XT CreationDate: Fri Feb 28 13:35:19 2025 CET ModDate: Mon Jul 28 13:52:22 2025 CEST Custom Metadata: no Metadata Stream: yes Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 11 Encrypted: no Page size: 593.858 x 782.929 pts Page rot: 0 File size: 662481 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- JRSAAA+TimesNewRomanMTStd-Italic Type 1C WinAnsi yes yes yes 34 0 KQHGOY+TimesNewRomanMTStd-BoldIt Type 1C WinAnsi yes yes yes 113 0 MTGSQU+TimesNewRomanMTStd-Bold Type 1C WinAnsi yes yes yes 35 0 OWFESQ+TimesNewRomanMTStd Type 1C Custom yes yes yes 36 0 LKKAZD+ArialMT TrueType WinAnsi yes yes no 1 0 HJTOYE+TimesLTStd-Italic Type 1C WinAnsi yes yes yes 61 0 GKEIKG+GandhariUnicode-Italic Type 1C Custom yes yes yes 87 0 DDQQUM+GandhariUnicode-Roman Type 1C Custom yes yes yes 114 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-07-30 02:08:19 CEST RepresentationInformation: sbae140.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-07-29 03:53:41 CEST Size: 662481 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Tagged PDF PDFMetadata: Objects: 2442 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Language: en-US Outlines: Item: Title: Predictive Validity of Psychometrically Assessed Schizotypy for Psychopathology Dimensions and Functioning in an 8-Year Multiwave Study Children: Item: Title: Introduction Children: Item: Title: BLISS Study Item: Title: Method Children: Item: Title: Participants and Procedure Item: Title: Materials Children: Item: Title: Time 1 Questionnaires At T1, participants completed the WSS and CAPE37 scales, and the SPQ-Suspiciousness36 subscale. The WSS is one of the most extensively used instruments for assessing schizotypy. It comprises the Perceptual Aberration (PerAb28), Magic Item: Title: Time 4 Measures  Children: Item: Title: Questionnaire Measures Participants completed the short forms of the WSS (WSS-SF39) from which positive and negative schizotypy factor scores were derived following the same procedure as in Kwapil et al25 WSS-SF comprise a short version of the 4 original Item: Title: Interview measures Symptoms of clinical risk for psychosis were measured with the Comprehensive Assessment of At-Risk Mental States (CAARMS43). The CAARMS is a structured interview that can be used to assess positive symptoms in nonclinical populations.44 Item: Title: Time 5 Measures Participants completed the short forms of the WSS (WSS-SF39) and the SPQ-Suspiciousness subscale.36 Social functioning was assessed with the Multidimensional Scale of Perceived Social Support (MSPSS48), a 12-item measure designed to assess Item: Title: Data Analysis Item: Title: Results Children: Item: Title: Time 4 Re-assessment Item: Title: Time 5 Re-assessment Item: Title: Discussion Item: Title: Supplementary Material Item: Title: Acknowledgments Item: Title: References Info: Title: Predictive Validity of Psychometrically Assessed Schizotypy for Psychopathology Dimensions and Functioning in an 8-Year Multiwave Study Author: Neus Barrantes-Vidal Subject: DOI: 10.1093/schbul/sbae140 , Volume. 51, Issue. S2, XX XX XXXX Background and Hypothesis: Although the psychometric high-risk method based on schizotypy has proven to be a highly cost-effective strategy for unraveling etiological factors for schizophrenia-spectrum disorders, there is a paucity of longitudinal studies with nonclinical populations. This study analyzed the predictive validity of positive and negative schizotypy in a longitudinal project (Barcelona Longitudinal Investigation of Schizotypy; BLISS) spanning a total of 7.8 years. Study Design: At Time 1 (T1), 547 college students completed the Wisconsin Schizotypy Scales. We re-assessed subsamples (oversampled for high schizotypy to ensure variability) at 4 re-assessments. This study reports psychopathology, psychological, and functional outcomes assessed with self-report and interview (CAARMS, Negative Symptom Manual, SCID-II Cluster A) measures at T4 (n = 89; 4.4 years after T1) and self-report measures at T5 (n = 169; 7.8 years after T1). T1 positive and negative schizotypy were entered simultaneously as predictors in linear regression models. Study Results: Positive schizotypy predicted positive symptoms at T4, whereas negative schizotypy predicted interview-rated negative symptoms and schizoid personality traits (even when controlling for mood and avoidant personality), and impaired social and global functioning. Both dimensions predicted suspiciousness, and schizotypal and paranoid personality traits, as well as low self-esteem and depression. Similarly, both dimensions predicted suspiciousness, depression, and poor social support at T5, whereas only positive schizotypy predicted low self-esteem, anxiety, and perceived stress. Conclusions: Both schizotypy dimensions consistently showed a meaningful pattern of hypothesized differential and overlapping predictions, which supports their validity as distinct dimensions and their predictive validity in nonclinical samples. 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S2, XX XX XXXX Background and Hypothesis: Although the psychometric high-risk method based on schizotypy has proven to be a highly cost-effective strategy for unraveling etiological factors for schizophrenia-spectrum disorders, there is a paucity of longitudinal studies with nonclinical populations. This study analyzed the predictive validity of positive and negative schizotypy in a longitudinal project (Barcelona Longitudinal Investigation of Schizotypy; BLISS) spanning a total of 7.8 years. Study Design: At Time 1 (T1), 547 college students completed the Wisconsin Schizotypy Scales. We re-assessed subsamples (oversampled for high schizotypy to ensure variability) at 4 re-assessments. This study reports psychopathology, psychological, and functional outcomes assessed with self-report and interview (CAARMS, Negative Symptom Manual, SCID-II Cluster A) measures at T4 (n = 89; 4.4 years after T1) and self-report measures at T5 (n = 169; 7.8 years after T1). T1 positive and negative schizotypy were entered simultaneously as predictors in linear regression models. Study Results: Positive schizotypy predicted positive symptoms at T4, whereas negative schizotypy predicted interview-rated negative symptoms and schizoid personality traits (even when controlling for mood and avoidant personality), and impaired social and global functioning. Both dimensions predicted suspiciousness, and schizotypal and paranoid personality traits, as well as low self-esteem and depression. Similarly, both dimensions predicted suspiciousness, depression, and poor social support at T5, whereas only positive schizotypy predicted low self-esteem, anxiety, and perceived stress. Conclusions: Both schizotypy dimensions consistently showed a meaningful pattern of hypothesized differential and overlapping predictions, which supports their validity as distinct dimensions and their predictive validity in nonclinical samples. © The Author(s) 2025. 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