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Title:           Short-term polystyrene nanoplastic exposure alters zebrafish male and female germline and reproductive outcomes, unveiling pollutant-impacted molecular pathways
Subject:         Journal of Hazardous Materials, 481 (2025) 136529. doi:10.1016/j.jhazmat.2024.136529
Keywords:        Nanoplastics,Germ cells,Zebrafish,Testis,Fertility
Author:          Gala Pujol
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      Title: Short-term polystyrene nanoplastic exposure alters zebrafish male and female germline and reproductive outcomes, unveiling  ...
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        Title: 1 Introduction
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        Title: 2 Material and methods
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          Title: 2.1 Fish maintenance
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          Title: 2.2 Experimental design
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          Title: 2.3 Nanoparticles characterization
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          Title: 2.4 Gonadal sampling for histology and immunofluorescence
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          Title: 2.5 Histological analysis
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          Title: 2.6 Apoptosis analysis
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          Title: 2.7 Spermatocyte spreads and immunofluorescence
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          Title: 2.8 DMC1 foci analysis
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          Title: 2.9 Sperm motility assay
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          Title: 2.10 Fertility assay
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          Title: 2.11 Larvae physiology
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          Title: 2.12 Gene expression
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          Title: 2.13 Exposure to labeled nanoparticles
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          Title: 2.14 Flow cytometry analysis
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          Title: 2.15 Germ cell enrichment analysis
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          Title: 2.16 Quantification and statistical analysis
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        Title: 3 Results
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          Title: 3.1 Acute exposure to PS-NPs affects spermatogenesis and sperm motility
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          Title: 3.2 Internalization of PS-NPs in male germ cells
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          Title: 3.3 Acute exposure to PS-NPs induces apoptosis and increases meiotic DNA repair
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          Title: 3.4 PS-NPs exposure alters expression of genes regulating meiosis and chromatin structure
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          Title: 3.5 Oocyte growth is not severely affected after PS-NPs acute exposure
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          Title: 3.6 Fertility assays
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        Title: Environmental implications
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        Title: Funding
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        Title: CRediT authorship contribution statement
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        Title: Declaration of Competing Interest
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        Title: Acknowledgments
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        Title: Appendix A Supporting information
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        Title: References
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  Checksum: 02f64461
   Type: CRC32
  Checksum: 919072de32082e2da1df78dc1c889dcb
   Type: MD5
  Checksum: 09eae3a0bba65092b137fa2824c4e2bcb37813fd
   Type: SHA-1
  Checksum: a3d9ae0fb5ef7bb171c6fe6e1f38fe530f8ce5d0d53b4c8dbcff145880aafd48
   Type: SHA-256