4f0ae0755e314aac39796f6e1509070d 88_Marin-Gual_et_al_Science_Adv_25_.pdf 791e5b22f4dd33dc77bbc003e1bf412d45d0a453 88_Marin-Gual_et_al_Science_Adv_25_.pdf 73e7b9733f0e8e2a8965ff66c905d5b0486df4819626acd5f487ecfa89f8ead2 88_Marin-Gual_et_al_Science_Adv_25_.pdf Title: Meiotic cohesin RAD21L shapes 3D genome structure and transcription in the male germline Subject: Sci. Adv. 2025.11:eadv2283 Creator: Adobe InDesign 19.5 (Windows) Producer: Adobe PDF Library 17.0; modified using iText 4.2.0 by 1T3XT CreationDate: Mon Sep 22 18:58:43 2025 CEST ModDate: Thu Oct 2 02:59:39 2025 CEST Custom Metadata: no Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 17 Encrypted: no Page size: 594 x 756 pts Page rot: 0 File size: 3897512 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- SLRAII+MyriadPro-Regular Type 1C Custom yes yes yes 62 0 ELOUUK+MyriadPro-Bold Type 1C Custom yes yes yes 63 0 FPDAII+MyriadPro-It Type 1C WinAnsi yes yes yes 64 0 DUCJGM+STIX-Regular Type 1C Custom yes yes yes 68 0 YCRKOW+MyriadPro-Semibold Type 1C Custom yes yes yes 820 0 CIPISO+MyriadPro-Light Type 1C WinAnsi yes yes yes 67 0 GBQGWG+MinionPro-It Type 1C WinAnsi yes yes yes 69 0 WZSYMA+MinionPro-Regular Type 1C Custom yes yes yes 66 0 Times-Roman Type 1 WinAnsi no no no 5 0 BRDXEQ+MyriadPro-BoldIt Type 1C WinAnsi yes yes yes 65 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-10-28 03:24:34 CET RepresentationInformation: 88_Marin-Gual_et_al_Science_Adv_25_.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-10-23 05:42:55 CEST Size: 3897512 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 2 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Language: en-US Outlines: Item: Title: Meiotic cohesin RAD21L shapes 3D genome structure and transcription in the male germline Children: Item: Title: INTRODUCTION Item: Title: RESULTS Children: Item: Title: Deletion of RAD21L-containing cohesin complexes reshapes chromatin reorganization in premeiotic and meiotic cells Item: Title: RAD21L counteracts nuclear compartmentalization in prophase I Item: Title: Rad21l deletion increases telomeric heterologous interactions in prophase I and impairs bouquet formation Item: Title: Rad21l deletion is associated with TAD reorganization in both premeiotic and meiotic cells Item: Title: RAD21L deficiency alters transcriptional landscapes of key meiotic genes Item: Title: Meiotic sex chromosome inactivation is impaired in RAD21L-deficient mice Item: Title: DISCUSSION Item: Title: MATERIALS AND METHODS Children: Item: Title: Animals and cell lines Item: Title: Spermatocyte spreads and immunofluorescence Item: Title: FACS of mouse male germ cells Item: Title: In nuclei Hi-C Item: Title: Hi-C data processing, binning, and normalization Item: Title: Averaged contact probability P(s) and its slope Item: Title: Inter- and intrachromosomal interaction analysis Item: Title: Intercentromeric and intertelomeric interaction quantification Item: Title: Long-range interchromosomal interactions Item: Title: A/B compartmentalization Item: Title: TAD calling and insulator score Item: Title: Single-cell RNA-seq, data processing, filtering, and normalization Item: Title: Dimensionality reduction, cell type assignation, and data integration Item: Title: Differential gene expression analysis Item: Title: Classification of RAD21L-binding genes and RAD21L-free genes Item: Title: Gene ontology enrichment analysis Item: Title: Multiassociation analysis Item: Title: Statistics and reproducibility Item: Title: Supplementary Materials Children: Item: Title: This PDF file includes: Item: Title: REFERENCES AND NOTES Item: Title: Acknowledgments Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 228 ImageHeight: 45 ColorSpace: RGB 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