ec130495b6840109ef20be0a32fa4e8b pmc_11820017.pdf 1e63b906e5d747a79228d57c5c1392689e6bdd86 pmc_11820017.pdf 92ef7d969dc3a41fbe93f184113d5b569bc80a061ce688e5af15db5a49b35677 pmc_11820017.pdf Title: Multilayered Manufacturing Method for Microfluidic Systems Using Low-Cost, Resin-Based Three-Dimensional Printing Subject: This work presents a multilamination method for fabricating microfluidic devices or analytical microsystems using commercial 3D printers and photocurable resins as primary components. The developed method was validated by fabricating devices for the colorimetric measurement of copper ions in aqueous solutions, achieving results comparable to traditional cyclic olefin copolymer (COC) systems. The microfluidic platforms demonstrated stability and functionality over a twelve-week testing period. Channels with minimum dimensions of 0.4 mm 0.4 mm were fabricated, and the feasibility of using resin modules for optical applications was demonstrated. This study highlights the potential of combining 3D printing with multilamination procedures as a versatile alternative, offering flexibility through the selection of a variety of available resins and commercial printers, as well as the ease of design development. This method offers significant reductions in cost, time, and manufacturing complexity by eliminating the need for equipment such as CNC machines, presses, and ovens, which are typically required in other multilamination technologies like LTCC and COC. Keywords: microfluidics; resin-based 3D printing; fabrication Author: Victor Edi Manqueros-Avilés, Hesner Coto-Fuentes, Karla Victoria Guevara-Amatón, Francisco Valdés-Perezgasga and Julian Alonso-Chamarro Creator: LaTeX with hyperref Producer: pdfTeX-1.40.25 CreationDate: Fri Jan 24 09:39:06 2025 CET ModDate: Fri Jan 24 09:41:21 2025 CET Custom Metadata: no Metadata Stream: no Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 13 Encrypted: no Page size: 595.276 x 841.89 pts (A4) Page rot: 0 File size: 5037772 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- WSQKGI+URWPalladioL-Roma Type 1 Custom yes yes yes 10 0 TVZNRY+URWPalladioL-Bold Type 1 Custom yes yes yes 16 0 UUHAIZ+URWPalladioL-Ital Type 1 Custom yes yes yes 21 0 DVCMRV+CMSY10 Type 1 Builtin yes yes yes 26 0 BCDEEE+PalatinoLinotype-Bold TrueType WinAnsi yes yes no 63 0 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TrueType Identity-H yes yes yes 528 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2025-02-26 02:08:21 CET RepresentationInformation: pmc_11820017.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2025-02-26 02:04:02 CET Size: 5037772 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 643 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseNone Outlines: Item: Title: Introduction Destination: section.1 Item: Title: Materials and Methods Destination: section.2 Children: Item: Title: Microfluidic Platform Fabrication Method Destination: subsection.2.1 Item: Title: Removal of Uncured Resin Destination: subsection.2.2 Item: Title: Assembly of Blocks Destination: subsection.2.3 Item: Title: Results and Discussion Destination: section.3 Item: Title: Conclusions Destination: section.4 Item: Title: References Destination: section.5 Info: Title: Multilayered Manufacturing Method for Microfluidic Systems Using Low-Cost, Resin-Based Three-Dimensional Printing Author: Victor Edi Manqueros-Avilés, Hesner Coto-Fuentes, Karla Victoria Guevara-Amatón, Francisco Valdés-Perezgasga and Julian Alonso-Chamarro Subject: This work presents a multilamination method for fabricating microfluidic devices or analytical microsystems using commercial 3D printers and photocurable resins as primary components. The developed method was validated by fabricating devices for the colorimetric measurement of copper ions in aqueous solutions, achieving results comparable to traditional cyclic olefin copolymer (COC) systems. The microfluidic platforms demonstrated stability and functionality over a twelve-week testing period. Channels with minimum dimensions of 0.4 mm 0.4 mm were fabricated, and the feasibility of using resin modules for optical applications was demonstrated. This study highlights the potential of combining 3D printing with multilamination procedures as a versatile alternative, offering flexibility through the selection of a variety of available resins and commercial printers, as well as the ease of design development. This method offers significant reductions in cost, time, and manufacturing complexity by eliminating the need for equipment such as CNC machines, presses, and ovens, which are typically required in other multilamination technologies like LTCC and COC. 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