05ccc776cdc6b1c29c0b7f94e6d79ac3 327044.pdf 07d2f76fcfd374d4f33b6721853634f7a926ea70 327044.pdf 1a347bc7e371ae9220bf507d14796a54ebcb8b9487a21ff1df8803b9c3135a77 327044.pdf Title: Study of brain perfusion in adults with Down syndrome along the Alzheimer's disease continuum Subject: Keywords: Author: Creator: LaTeX with hyperref package Producer: Acrobat Distiller 10.0.0 (Windows) CreationDate: Thu Sep 11 08:28:08 2025 CEST ModDate: Thu Sep 11 08:28:58 2025 CEST Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 19 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 9747086 bytes Optimized: yes PDF version: 1.6 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- AEIEKF+Lato-Regular Type 1C Custom yes yes no 756 0 AEIFBD+Lato-Bold Type 1C WinAnsi yes yes no 760 0 AEJDEH+Lato-Italic Type 1C WinAnsi yes yes no 763 0 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continuum Destination: chapter..1 Children: Item: Title: Abstract Destination: section*.2 Item: Title: 1 | BACKGROUND Destination: section..1.1 Item: Title: 2 | METHODS Destination: section..1.2 Children: Item: Title: 2.1 | Study participants Destination: subsection..1.2.1 Item: Title: 2.2 | Clinical and neuropsychological assessment Destination: subsection..1.2.2 Item: Title: 2.3 | Neuroimaging data Destination: subsection..1.2.3 Children: Item: Title: 2.3.1 | MRI acquisition protocol Destination: subsubsection..1.2.3.1 Item: Title: 2.3.2 | Quality control Destination: subsubsection..1.2.3.2 Item: Title: 2.3.3 | MRI preprocessing and CBF/ATT quantification Destination: subsubsection..1.2.3.3 Item: Title: 2.3.4 | Cerebrovascular lesions Destination: subsubsection..1.2.3.4 Item: Title: 2.4 | Fluid biomarkers Destination: subsection..1.2.4 Item: Title: 2.5 | Statistical analysis Destination: subsection..1.2.5 Item: Title: 3 | RESULTS Destination: section..1.3 Children: Item: Title: 3.1 | Sample composition Destination: subsection..1.3.1 Item: Title: 3.2 | Effect of age Destination: subsection..1.3.2 Item: Title: 3.3 | Effect of sex Destination: subsection..1.3.3 Item: Title: 3.4 | Effect of the diagnostic group on global GM perfusion and ATT Destination: subsection..1.3.4 Item: Title: 3.5 | Pattern of CBF and ATT Destination: subsection..1.3.5 Item: Title: 3.6 | Effect of the diagnostic group on regional CBF Destination: subsection..1.3.6 Item: Title: 3.7 | Effect of the diagnostic group on regional ATT Destination: subsection..1.3.7 Item: Title: 3.8 | Relationship to AD biomarkers Destination: subsection..1.3.8 Item: Title: 3.9 | Correlation with vascular imaging features Destination: subsection..1.3.9 Item: Title: 4 | DISCUSSION Destination: section..1.4 Item: Title: ACKNOWLEDGMENTS Destination: section*.4 Item: Title: CONFLICT OF INTEREST STATEMENT Destination: section*.6 Item: Title: CONSENT STATEMENT Destination: section*.8 Item: Title: ORCID Destination: 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