ba96f0a20238e827fe8c2ae7cd887149  Impact_of_fludarabine.pdf
b0ace93e70c7cc28078741e4b111bd85a77dea6c  Impact_of_fludarabine.pdf
38fbacdf439c71a5de0cd53817fa512b93126c8975de5e930c3b1c362853ef86  Impact_of_fludarabine.pdf

Title:           Impact of fludarabine exposure on CAR T-cell outcomes in patients with large B-cell lymphoma
Subject:         BLOOD ADVANCES, 10 (2026) 5460-5468. doi:10.1182/bloodadvances.2025019264
Author:          Mario Andrés Sánchez-Salinas∗
Creator:         Elsevier
Producer:        PDFlib+PDI 10.0.2p2 (C++/Win64)
CreationDate:    Sat Aug  1 12:11:30 2026 CEST
ModDate:         Sat Aug  1 12:19:16 2026 CEST
Custom Metadata: yes
Metadata Stream: yes
Tagged:          yes
UserProperties:  no
Suspects:        no
Form:            none
JavaScript:      no
Pages:           9
Encrypted:       no
Page size:       593.972 x 782.986 pts
Page rot:        0
File size:       385231 bytes
Optimized:       yes
PDF version:     1.7


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
SMUPHK+StixTwoMathSymbols            Type 1C           Builtin          yes yes yes   1370  0
ZTIHWU+DroidSerif                    CID TrueType      Identity-H       yes yes yes   1341  0
BLMNWH+AkzidenzGroteskBE-Regular     Type 1C           Custom           yes yes yes   1345  0
JNFDPV+AkzidenzGroteskBE-Bold        Type 1C           Custom           yes yes yes   1353  0
VRZKYK+STIX-Regular                  Type 1C           Custom           yes yes yes   1362  0
HENTTC+DroidSerif-Italic             CID TrueType      Identity-H       yes yes yes   1364  0
LOGFLA+AkzidenzGroteskBE-It          Type 1C           Custom           yes yes yes   1376  0
QFJJIB+AkzidenzGroteskBE-Md          Type 1C           Custom           yes yes yes   1372  0
BRWWWZ+StixTwoExtendedRoman          Type 1C           Builtin          yes yes yes   1349  0
UBPJJG+CM_Maths_Symbols              Type 1C           Builtin          yes yes yes    146  0
FJGWHE+AkzidenzGroteskBE-Bold        Type 1C           WinAnsi          yes yes no      28  0
FJGWHE+AkzidenzGroteskBE-Cn          Type 1C           WinAnsi          yes yes no      29  0
TRCCVC+AkzidenzGroteskBE-Regular     Type 1C           WinAnsi          yes yes no      30  0
JVSXVG+AkzidenzGroteskBE-BoldIt      Type 1C           Custom           yes yes yes    211  0
FJGWHE+AkzidenzGroteskBE-Bold        Type 1C           WinAnsi          yes yes no      50  0
TRCCVC+AkzidenzGroteskBE-Regular     Type 1C           WinAnsi          yes yes no      51  0
MRKWDQ+AkzidenzGroteskBE-It          Type 1C           WinAnsi          yes yes no      52  0
FJGWHE+AkzidenzGroteskBE-Cn          Type 1C           WinAnsi          yes yes no      53  0
FJGWHE+AkzidenzGroteskBE-Bold        Type 1C           WinAnsi          yes yes no      66  0
NKKMMS+SymbolMT                      CID TrueType      Identity-H       yes yes yes     73  0
MRKWDQ+AkzidenzGroteskBE-It          Type 1C           WinAnsi          yes yes no      74  0
TRCCVC+AkzidenzGroteskBE-Regular     Type 1C           WinAnsi          yes yes no      75  0
FJGWHE+AkzidenzGroteskBE-Cn          Type 1C           WinAnsi          yes yes no      76  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2026-10-08 04:10:37 CEST
 RepresentationInformation: Impact_of_fludarabine.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2026-10-07 18:22:57 CEST
  Size: 385231
  Format: PDF
  Version: 1.7
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  Profile: Linearized PDF, Tagged PDF
  PDFMetadata: 
   Objects: 1477
   FreeObjects: 1
   IncrementalUpdates: 1
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: true
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: English
    Outlines: 
     Item: 
      Title: Impact of fludarabine exposure on CAR T-cell outcomes in patients with large B-cell lymphoma
      Destination: titlink1
      Children: 
       Item: 
        Title: Introduction
        Destination: flink1
       Item: 
        Title: Methods
        Destination: flink2
        Children: 
         Item: 
          Title: Study population
          Destination: slink1
         Item: 
          Title: Patient management
          Destination: slink2
         Item: 
          Title: Determination of fludarabine exposure
          Destination: slink3
         Item: 
          Title: Definitions and end points
          Destination: slink4
         Item: 
          Title: Statistical analysis
          Destination: slink5
       Item: 
        Title: Results
        Destination: flink3
        Children: 
         Item: 
          Title: Characteristics of the patient population
          Destination: slink6
         Item: 
          Title: Determination of fludarabine exposure
          Destination: slink7
         Item: 
          Title: Fludarabine exposure and efficacy
          Destination: slink8
         Item: 
          Title: Fludarabine exposure and toxicity
          Destination: slink9
         Item: 
          Title: Fludarabine exposure and CAR T-cell kinetics
          Destination: slink10
       Item: 
        Title: Discussion
        Destination: flink4
       Item: 
        Title: Acknowledgment
        Destination: flink5
       Item: 
        Title: Authorship
        Destination: flink6
       Item: 
        Title: References
        Destination: blink1
   Info: 
    Title: Impact of fludarabine exposure on CAR T-cell outcomes in patients with large B-cell lymphoma
    Author: Mario Andrés Sánchez-Salinas∗
    Subject: BLOOD ADVANCES, 10 (2026) 5460-5468. doi:10.1182/bloodadvances.2025019264
    Creator: Elsevier
    Producer: PDFlib+PDI 10.0.2p2 (C++/Win64)
    CreationDate: Sat Aug 01 12:41:30 CEST 2026
    ModDate: Sat Aug 01 12:49:16 CEST 2026
   ID: 0x7db658794004a5fb868a61037d8fa09b, 0xeb8b77ebf11edb45b89a51505c2b1af4
   Filters: 
    FilterPipeline: FlateDecode
   Fonts: 
    Type0: 
     Font: 
      BaseFont: HENTTC+DroidSerif-Italic
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: ZTIHWU+DroidSerif
      Encoding: Identity-H
      ToUnicode: true
    Type1: 
     Font: 
      BaseFont: LOGFLA+AkzidenzGroteskBE-It
      FontSubset: true
      FirstChar: 1
      LastChar: 34
      FontDescriptor: 
       FontName: LOGFLA+AkzidenzGroteskBE-It
       Flags: Nonsymbolic, Italic
       FontBBox: -123, -250, 1303, 952
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: BLMNWH+AkzidenzGroteskBE-Regular
      FontSubset: true
      FirstChar: 1
      LastChar: 91
      FontDescriptor: 
       FontName: BLMNWH+AkzidenzGroteskBE-Regular
       Flags: Nonsymbolic
       FontBBox: -155, -250, 1227, 944
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: VRZKYK+STIX-Regular
      FontSubset: true
      FirstChar: 1
      LastChar: 5
      FontDescriptor: 
       FontName: VRZKYK+STIX-Regular
       Flags: Nonsymbolic
       FontBBox: -970, -486, 2208, 1023
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: UBPJJG+CM_Maths_Symbols
      FontSubset: true
      FirstChar: 1
      LastChar: 138
      FontDescriptor: 
       FontName: UBPJJG+CM_Maths_Symbols
       Flags: Symbolic
       FontBBox: -50, -180, 1000, 720
       FontFile3: true
      ToUnicode: true
     Font: 
      BaseFont: JVSXVG+AkzidenzGroteskBE-BoldIt
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: JVSXVG+AkzidenzGroteskBE-BoldIt
       Flags: Nonsymbolic, Italic, ForceBold
       FontBBox: -216, -250, 1154, 946
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: BRWWWZ+StixTwoExtendedRoman
      FontSubset: true
      FirstChar: 1
      LastChar: 128
      FontDescriptor: 
       FontName: BRWWWZ+StixTwoExtendedRoman
       Flags: Symbolic
       FontBBox: -50, -180, 1000, 720
       FontFile3: true
      ToUnicode: true
     Font: 
      BaseFont: JNFDPV+AkzidenzGroteskBE-Bold
      FontSubset: true
      FirstChar: 1
      LastChar: 58
      FontDescriptor: 
       FontName: JNFDPV+AkzidenzGroteskBE-Bold
       Flags: Nonsymbolic, ForceBold
       FontBBox: -166, -250, 1222, 927
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: SMUPHK+StixTwoMathSymbols
      FontSubset: true
      FirstChar: 1
      LastChar: 138
      FontDescriptor: 
       FontName: SMUPHK+StixTwoMathSymbols
       Flags: Symbolic
       FontBBox: -50, -180, 1000, 720
       FontFile3: true
      ToUnicode: true
     Font: 
      BaseFont: QFJJIB+AkzidenzGroteskBE-Md
      FontSubset: true
      FirstChar: 1
      LastChar: 37
      FontDescriptor: 
       FontName: QFJJIB+AkzidenzGroteskBE-Md
       Flags: Nonsymbolic
       FontBBox: -145, -250, 1225, 963
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
    CIDFontType2: 
     Font: 
      BaseFont: ZTIHWU+DroidSerif
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: ZTIHWU+DroidSerif
       Flags: Nonsymbolic
       FontBBox: -558, -279, 1246, 1048
       FontFile2: true
     Font: 
      BaseFont: HENTTC+DroidSerif-Italic
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: HENTTC+DroidSerif-Italic
       Flags: Nonsymbolic, Italic
       FontBBox: -255, -240, 1126, 931
       FontFile2: true
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="Adobe XMP Core 4.0-c316 44.253921, Sun Oct 01 2006 17:14:39">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description rdf:about=""
            xmlns:dc="http://purl.org/dc/elements/1.1/">
         <dc:format>application/pdf</dc:format>
         <dc:identifier>doi:10.1182/bloodadvances.2025019264</dc:identifier>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Impact of fludarabine exposure on CAR T-cell outcomes in patients with large B-cell lymphoma</rdf:li>
            </rdf:Alt>
         </dc:title>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Mario Andrés Sánchez-Salinas∗</rdf:li>
               <rdf:li>Javier Varela-González-Aller∗</rdf:li>
               <rdf:li>Gloria Iacoboni</rdf:li>
               <rdf:li>Víctor Navarro</rdf:li>
               <rdf:li>Iñaki Troconiz</rdf:li>
               <rdf:li>Cecilia Carpio</rdf:li>
               <rdf:li>Carla Alonso-Martínez</rdf:li>
               <rdf:li>Maria-Josep Carreras-Soler</rdf:li>
               <rdf:li>Anna Farriols-Danes</rdf:li>
               <rdf:li>María Guerra-González</rdf:li>
               <rdf:li>Alfredo Rivas-Delgado</rdf:li>
               <rdf:li>Lucas Rivera</rdf:li>
               <rdf:li>Samantha Feijoo</rdf:li>
               <rdf:li>Francesc Bosch</rdf:li>
               <rdf:li>Carolina Valdivia</rdf:li>
               <rdf:li>Marta Miarons</rdf:li>
               <rdf:li>Pere Barba</rdf:li>
            </rdf:Seq>
         </dc:creator>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">BLOOD ADVANCES, 10 (2026) 5460-5468. doi:10.1182/bloodadvances.2025019264</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:publisher>
            <rdf:Bag>
               <rdf:li>American Society of Hematology</rdf:li>
            </rdf:Bag>
         </dc:publisher>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:prism="http://prismstandard.org/namespaces/basic/3.0/">
         <prism:aggregationType>journal</prism:aggregationType>
         <prism:publicationName>BLOOD ADVANCES</prism:publicationName>
         <prism:copyright>© 2026 American Society of Hematology. Published by Elsevier Inc. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0), permitting only noncommercial, nonderivative use with attribution. All other rights reserved.</prism:copyright>
         <prism:issn>2473-9529</prism:issn>
         <prism:volume>10</prism:volume>
         <prism:number>15</prism:number>
         <prism:coverDisplayDate>11 August 2026</prism:coverDisplayDate>
         <prism:coverDate>2026-08-11</prism:coverDate>
         <prism:pageRange>5460-5468</prism:pageRange>
         <prism:startingPage>5460</prism:startingPage>
         <prism:endingPage>5468</prism:endingPage>
         <prism:doi>10.1182/bloodadvances.2025019264</prism:doi>
         <prism:url>https://doi.org/10.1182/bloodadvances.2025019264</prism:url>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:jav="http://www.niso.org/schemas/jav/1.0/">
         <jav:journal_article_version>VoR</jav:journal_article_version>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/">
         <pdfx:ElsevierWebPDFSpecifications>7.0.1</pdfx:ElsevierWebPDFSpecifications>
         <pdfx:doi>10.1182/bloodadvances.2025019264</pdfx:doi>
         <pdfx:robots>noindex</pdfx:robots>
         <pdfx:EPSprocessor>PStill version 1.84.42</pdfx:EPSprocessor>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xap="http://ns.adobe.com/xap/1.0/">
         <xap:CreatorTool>Elsevier</xap:CreatorTool>
         <xap:CreateDate>2026-08-01T15:41:30+05:30</xap:CreateDate>
         <xap:ModifyDate>2026-08-01T15:49:16+05:30</xap:ModifyDate>
         <xap:MetadataDate>2026-08-01T15:49:16+05:30</xap:MetadataDate>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xapRights="http://ns.adobe.com/xap/1.0/rights/">
         <xapRights:Marked>True</xapRights:Marked>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:tdm="http://www.w3.org/ns/tdmrep/">
         <tdm:reservation>1</tdm:reservation>
         <tdm:policy>https://www.elsevier.com/tdm/tdmrep-policy.json</tdm:policy>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
         <pdf:Producer>PDFlib+PDI 10.0.2p2 (C++/Win64)</pdf:Producer>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:xapMM="http://ns.adobe.com/xap/1.0/mm/">
         <xapMM:DocumentID>uuid:0530fe6d-fcca-4ab6-a449-66fcdfffdfb7</xapMM:DocumentID>
         <xapMM:InstanceID>uuid:d3720a81-9580-49cc-a071-6876a63c1c92</xapMM:InstanceID>
      </rdf:Description>
      <rdf:Description rdf:about=""
            xmlns:ali="http://www.niso.org/schemas/ali/1.0/">
         <ali:license_ref>
            <rdf:Bag>
               <rdf:li rdf:parseType="Resource">
                  <ali:uri>https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode</ali:uri>
               </rdf:li>
            </rdf:Bag>
         </ali:license_ref>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 5460
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 170, 699, 170, 699
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 154, 619, 154, 621
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 156, 618, 160, 627
       Flags: Print
       Destination: 1286
      Annotation: 
       Subtype: Link
       Rect: 162, 618, 166, 627
       Flags: Print
       Destination: 1286
      Annotation: 
       Subtype: Link
       Rect: 279, 619, 279, 621
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 281, 618, 285, 627
       Flags: Print
       Destination: 1286
      Annotation: 
       Subtype: Link
       Rect: 287, 618, 291, 627
       Flags: Print
       Destination: 1286
      Annotation: 
       Subtype: Link
       Rect: 358, 619, 358, 621
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 360, 618, 364, 627
       Flags: Print
       Destination: 1286
      Annotation: 
       Subtype: Link
       Rect: 366, 618, 369, 627
       Flags: Print
       Destination: 1286
      Annotation: 
       Subtype: Link
       Rect: 427, 619, 427, 621
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 429, 618, 433, 627
       Flags: Print
       Destination: 1286
      Annotation: 
       Subtype: Link
       Rect: 489, 619, 489, 621
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 491, 618, 495, 627
       Flags: Print
       Destination: 1286
      Annotation: 
       Subtype: Link
       Rect: 91, 607, 91, 609
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 93, 606, 97, 615
       Flags: Print
       Destination: 1286
      Annotation: 
       Subtype: Link
       Rect: 99, 606, 103, 615
       Flags: Print
       Destination: 1286
      Annotation: 
       Subtype: Link
       Rect: 191, 607, 191, 609
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 193, 606, 197, 615
       Flags: Print
       Destination: 1286
      Annotation: 
       Subtype: Link
       Rect: 304, 607, 304, 609
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 306, 606, 310, 615
       Flags: Print
       Destination: 1286
      Annotation: 
       Subtype: Link
       Rect: 391, 607, 391, 609
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 393, 606, 397, 615
       Flags: Print
       Destination: 1286
      Annotation: 
       Subtype: Link
       Rect: 488, 607, 488, 609
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 490, 606, 494, 615
       Flags: Print
       Destination: 1286
      Annotation: 
       Subtype: Link
       Rect: 122, 595, 122, 597
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 124, 594, 128, 603
       Flags: Print
       Destination: 1286
      Annotation: 
       Subtype: Link
       Rect: 180, 595, 180, 597
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 182, 594, 186, 603
       Flags: Print
       Destination: 1286
      Annotation: 
       Subtype: Link
       Rect: 253, 595, 253, 597
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 255, 594, 259, 603
       Flags: Print
       Destination: 1286
      Annotation: 
       Subtype: Link
       Rect: 324, 595, 324, 597
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 326, 594, 330, 603
       Flags: Print
       Destination: 1286
      Annotation: 
       Subtype: Link
       Rect: 332, 594, 336, 603
       Flags: Print
       Destination: 1286
      Annotation: 
       Subtype: Link
       Rect: 402, 595, 402, 597
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 404, 594, 408, 603
       Flags: Print
       Destination: 1286
      Annotation: 
       Subtype: Link
       Rect: 465, 595, 465, 597
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 468, 594, 471, 603
       Flags: Print
       Destination: 1286
      Annotation: 
       Subtype: Link
       Rect: 474, 594, 477, 603
       Flags: Print
       Destination: 1286
      Annotation: 
       Subtype: Link
       Rect: 541, 595, 541, 597
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 541, 594, 544, 603
       Flags: Print
       Destination: 1286
      Annotation: 
       Subtype: Link
       Rect: 547, 594, 550, 603
       Flags: Print
       Destination: 1286
      Annotation: 
       Subtype: Link
       Rect: 215, 107, 287, 114
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 36, 98, 125, 105
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 241, 76, 287, 83
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 36, 67, 46, 74
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 305, 96, 556, 103
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 305, 87, 368, 94
       Flags: Print
    Page: 
     Label: 5461
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 64, 711, 68, 720
       Flags: Print
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 69, 711, 73, 720
       Flags: Print
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 106, 700, 116, 709
       Flags: Print
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 201, 678, 205, 687
       Flags: Print
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 261, 678, 271, 687
       Flags: Print
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 283, 667, 287, 676
       Flags: Print
       Destination: 86
      Annotation: 
       Subtype: Link
       Rect: 257, 645, 261, 654
       Flags: Print
       Destination: 86
      Annotation: 
       Subtype: Link
       Rect: 262, 645, 266, 654
       Flags: Print
       Destination: 86
      Annotation: 
       Subtype: Link
       Rect: 142, 623, 149, 632
       Flags: Print
       Destination: 86
      Annotation: 
       Subtype: Link
       Rect: 250, 623, 254, 632
       Flags: Print
       Destination: 86
      Annotation: 
       Subtype: Link
       Rect: 229, 612, 247, 621
       Flags: Print
       Destination: 86
      Annotation: 
       Subtype: Link
       Rect: 76, 591, 84, 600
       Flags: Print
       Destination: 86
      Annotation: 
       Subtype: Link
       Rect: 113, 530, 120, 539
       Flags: Print
       Destination: 86
      Annotation: 
       Subtype: Link
       Rect: 271, 508, 278, 517
       Flags: Print
       Destination: 86
      Annotation: 
       Subtype: Link
       Rect: 280, 508, 287, 517
       Flags: Print
       Destination: 86
      Annotation: 
       Subtype: Link
       Rect: 144, 475, 152, 484
       Flags: Print
       Destination: 86
      Annotation: 
       Subtype: Link
       Rect: 153, 475, 161, 484
       Flags: Print
       Destination: 86
      Annotation: 
       Subtype: Link
       Rect: 125, 421, 133, 430
       Flags: Print
       Destination: 86
      Annotation: 
       Subtype: Link
       Rect: 157, 388, 165, 397
       Flags: Print
       Destination: 86
      Annotation: 
       Subtype: Link
       Rect: 110, 377, 118, 386
       Flags: Print
       Destination: 86
      Annotation: 
       Subtype: Link
       Rect: 217, 344, 225, 353
       Flags: Print
       Destination: 86
      Annotation: 
       Subtype: Link
       Rect: 226, 344, 234, 353
       Flags: Print
       Destination: 86
      Annotation: 
       Subtype: Link
       Rect: 235, 344, 243, 353
       Flags: Print
       Destination: 86
      Annotation: 
       Subtype: Link
       Rect: 478, 689, 486, 698
       Flags: Print
       Destination: 86
      Annotation: 
       Subtype: Link
       Rect: 549, 645, 556, 654
       Flags: Print
       Destination: 86
      Annotation: 
       Subtype: Link
       Rect: 386, 612, 394, 621
       Flags: Print
       Destination: 86
      Annotation: 
       Subtype: Link
       Rect: 549, 397, 556, 406
       Flags: Print
       Destination: 86
      Annotation: 
       Subtype: Link
       Rect: 515, 151, 523, 160
       Flags: Print
       Destination: 86
      Annotation: 
       Subtype: Link
       Rect: 525, 151, 533, 160
       Flags: Print
       Destination: 86
      Annotation: 
       Subtype: Link
       Rect: 534, 151, 542, 160
       Flags: Print
       Destination: 86
    Page: 
     Label: 5462
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 192, 711, 200, 720
       Flags: Print
       Destination: 86
      Annotation: 
       Subtype: Link
       Rect: 96, 600, 104, 609
       Flags: Print
       Destination: 86
      Annotation: 
       Subtype: Link
       Rect: 218, 220, 250, 229
       Flags: Print
       Destination: 9
      Annotation: 
       Subtype: Link
       Rect: 460, 644, 490, 653
       Flags: Print
       Destination: 38
      Annotation: 
       Subtype: Link
       Rect: 365, 357, 400, 366
       Flags: Print
       Destination: 9
      Annotation: 
       Subtype: Link
       Rect: 399, 346, 430, 355
       Flags: Print
       Destination: 9
      Annotation: 
       Subtype: Link
       Rect: 441, 202, 470, 211
       Flags: Print
       Destination: 38
      Annotation: 
       Subtype: Link
       Rect: 403, 109, 435, 118
       Flags: Print
       Destination: 45
      Annotation: 
       Subtype: Link
       Rect: 472, 65, 502, 74
       Flags: Print
       Destination: 38
    Page: 
     Label: 5463
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 75, 244, 108, 253
       Flags: Print
       Destination: 45
      Annotation: 
       Subtype: Link
       Rect: 234, 178, 266, 187
       Flags: Print
       Destination: 45
    Page: 
     Label: 5464
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 148, 266, 181, 274
       Flags: Print
       Destination: 59
      Annotation: 
       Subtype: Link
       Rect: 348, 287, 380, 296
       Flags: Print
       Destination: 59
      Annotation: 
       Subtype: Link
       Rect: 105, 453, 108, 459
       Flags: Print
       Destination: 38
      Annotation: 
       Subtype: Link
       Rect: 106, 440, 108, 446
       Flags: Print
       Destination: 38
      Annotation: 
       Subtype: Link
       Rect: 112, 427, 114, 433
       Flags: Print
       Destination: 38
      Annotation: 
       Subtype: Link
       Rect: 115, 427, 118, 433
       Flags: Print
       Destination: 38
      Annotation: 
       Subtype: Link
       Rect: 125, 414, 128, 420
       Flags: Print
       Destination: 38
    Page: 
     Label: 5465
     Sequence: 6
    Page: 
     Label: 5466
     Sequence: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 200, 263, 208, 272
       Flags: Print
       Destination: 86
      Annotation: 
       Subtype: Link
       Rect: 55, 198, 63, 207
       Flags: Print
       Destination: 86
      Annotation: 
       Subtype: Link
       Rect: 85, 165, 93, 174
       Flags: Print
       Destination: 86
      Annotation: 
       Subtype: Link
       Rect: 280, 165, 287, 174
       Flags: Print
       Destination: 86
      Annotation: 
       Subtype: Link
       Rect: 532, 420, 540, 429
       Flags: Print
       Destination: 86
      Annotation: 
       Subtype: Link
       Rect: 343, 409, 351, 418
       Flags: Print
       Destination: 86
      Annotation: 
       Subtype: Link
       Rect: 345, 333, 353, 342
       Flags: Print
       Destination: 86
      Annotation: 
       Subtype: Link
       Rect: 432, 163, 439, 172
       Flags: Print
       Destination: 86
      Annotation: 
       Subtype: Link
       Rect: 441, 163, 449, 172
       Flags: Print
       Destination: 86
    Page: 
     Label: 5467
     Sequence: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 421, 357, 511, 366
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 533, 357, 556, 366
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 305, 346, 372, 355
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 399, 346, 488, 355
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 510, 346, 556, 355
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 305, 335, 349, 344
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 387, 335, 477, 344
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 533, 335, 556, 344
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 305, 324, 372, 333
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 413, 324, 502, 333
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 533, 324, 556, 333
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 305, 313, 372, 322
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 402, 275, 474, 284
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 216, 556, 224
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 206, 75, 214
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 192, 544, 200
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 182, 124, 190
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 168, 540, 176
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 158, 185, 166
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 144, 543, 152
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 134, 186, 142
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 120, 556, 128
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 110, 297, 118
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 96, 551, 104
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 86, 215, 94
       Flags: Print
    Page: 
     Label: 5468
     Sequence: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 54, 712, 556, 720
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 702, 219, 710
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 688, 556, 696
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 678, 237, 686
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 664, 556, 672
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 654, 204, 662
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 640, 556, 648
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 630, 84, 638
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 616, 556, 624
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 606, 309, 614
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 593, 551, 601
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 583, 298, 591
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 569, 551, 577
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 559, 215, 567
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 545, 556, 553
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 535, 239, 543
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 521, 530, 529
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 511, 297, 519
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 497, 556, 505
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 487, 94, 495
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 473, 556, 481
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 463, 149, 471
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 449, 556, 457
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 439, 206, 447
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 425, 546, 433
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 415, 544, 423
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 401, 551, 409
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 391, 261, 399
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 377, 540, 385
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 367, 206, 375
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 353, 548, 361
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 343, 359, 351
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 330, 556, 338
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 320, 272, 328
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 306, 521, 314
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 296, 225, 304
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 282, 556, 290
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 272, 426, 280
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 258, 556, 266
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 248, 551, 256
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 238, 94, 246
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 224, 556, 232
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 214, 284, 222
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 200, 556, 208
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 190, 199, 198
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 176, 546, 184
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 166, 338, 174
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 152, 556, 160
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 142, 316, 150
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 128, 556, 136
       Flags: Print
      Annotation: 
       Subtype: Link
       Rect: 54, 118, 354, 126
       Flags: Print
  Checksum: 27928c40
   Type: CRC32
  Checksum: ba96f0a20238e827fe8c2ae7cd887149
   Type: MD5
  Checksum: b0ace93e70c7cc28078741e4b111bd85a77dea6c
   Type: SHA-1
  Checksum: 38fbacdf439c71a5de0cd53817fa512b93126c8975de5e930c3b1c362853ef86
   Type: SHA-256