2b056df9f72443907be66aeb73b3e5de  s00228-026-04070-2.pdf
265197f9ceaa88d9238320cf5dada95476bf06f9  s00228-026-04070-2.pdf
df43968134ab07cbbb938329dee436b74bb8ef39d154b99d529a267d90259548  s00228-026-04070-2.pdf

Creator:         Adobe InDesign 18.3 (Windows)
Producer:        Adobe PDF Library 17.0; modified using iText® 5.5.13.4 ©2000-2024 iText Group NV (SPRINGER SBM; licensed version)
CreationDate:    Thu May  7 02:32:11 2026 CEST
ModDate:         Thu May  7 04:09:54 2026 CEST
Custom Metadata: yes
Metadata Stream: yes
Tagged:          yes
UserProperties:  no
Suspects:        no
Form:            none
JavaScript:      no
Pages:           7
Encrypted:       no
Page size:       595.276 x 790.866 pts
Page rot:        0
File size:       826312 bytes
Optimized:       no
PDF version:     1.4


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
TEOZQC+Wingdings-Regular             CID TrueType      Identity-H       yes yes yes    979  0
TYVOQC+TimesNewRomanPSMT             CID TrueType      Identity-H       yes yes yes     21  0
MyriadPro-SemiCn                     Type 1C           WinAnsi          yes no  yes     23  0
MyriadPro-Regular                    Type 1C           WinAnsi          yes no  yes     22  0
MyriadPro-Bold                       Type 1C           WinAnsi          yes no  yes     24  0
MyriadPro-SemiboldSemiCn             Type 1C           WinAnsi          yes no  yes     39  0
MyriadPro-Semibold                   Type 1C           Custom           yes no  yes    980  0
JERBGW+TimesNewRomanPSMT             TrueType          WinAnsi          yes yes yes     25  0
MyriadPro-Semibold                   Type 1C           WinAnsi          yes no  yes   1028  0
Springnew                            TrueType          WinAnsi          yes no  yes    115  0
MyriadPro-SemiCn                     Type 1C           WinAnsi          yes no  yes    119  0
MyriadPro-BoldSemiCn                 Type 1C           WinAnsi          yes no  yes     38  0
CMANXK+TimesNewRomanPS-ItalicMT      TrueType          WinAnsi          yes yes yes     40  0
Springnew                            TrueType          WinAnsi          yes no  yes    135  0
MyriadPro-SemiCn                     Type 1C           WinAnsi          yes no  yes    143  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2026-05-28 03:09:01 CEST
 RepresentationInformation: s00228-026-04070-2.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2026-05-27 12:57:00 CEST
  Size: 826312
  Format: PDF
  Version: 1.4
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  Profile: Tagged PDF
  PDFMetadata: 
   Objects: 1052
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: false
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: en-US
    Outlines: 
     Item: 
      Title: The role of Spanish clinical pharmacologists in economic evaluations of health technologies
      Children: 
       Item: 
        Title: Abstract
       Item: 
        Title: Introduction
       Item: 
        Title: Methods
       Item: 
        Title: Results
        Children: 
         Item: 
          Title: Respondents’ characteristics
         Item: 
          Title: Involvement of CPs in economic evaluations
         Item: 
          Title: Economic evaluations conducted by other professionals
         Item: 
          Title: Opinions on the topic and training
       Item: 
        Title: Discussion
       Item: 
        Title: References
   Info: 
    Creator: Adobe InDesign 18.3 (Windows)
    Producer: Adobe PDF Library 17.0; modified using iText® 5.5.13.4 ©2000-2024 iText Group NV (SPRINGER SBM; licensed version)
    CreationDate: Thu May 07 02:32:11 CEST 2026
    ModDate: Thu May 07 04:09:54 CEST 2026
   ID: 0xd2a07805c5bd28459803bab2176aa6cc, 0xe2beb71fd7ed7b779e9b5d24cac98d99
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1100
      ImageHeight: 90
      ColorSpace: black is zero
      BitsPerSample: 1
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1524
      ImageHeight: 1181
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
   Fonts: 
    Type0: 
     Font: 
      BaseFont: TEOZQC+Wingdings-Regular
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: TYVOQC+TimesNewRomanPSMT
      Encoding: Identity-H
      ToUnicode: true
    Type1: 
     Font: 
      BaseFont: MyriadPro-Semibold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Semibold
       Flags: Nonsymbolic
       FontBBox: -161, -250, 1198, 972
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Regular
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Regular
       Flags: Nonsymbolic
       FontBBox: -157, -250, 1126, 952
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-BoldSemiCn
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-BoldSemiCn
       Flags: Nonsymbolic
       FontBBox: -133, -250, 1161, 894
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-SemiboldSemiCn
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-SemiboldSemiCn
       Flags: Nonsymbolic
       FontBBox: -131, -250, 1115, 886
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-SemiCn
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-SemiCn
       Flags: Nonsymbolic
       FontBBox: -128, -250, 1059, 876
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Bold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Bold
       Flags: Nonsymbolic
       FontBBox: -163, -250, 1256, 989
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
    TrueType: 
     Font: 
      BaseFont: CMANXK+TimesNewRomanPS-ItalicMT
      FontSubset: true
      FirstChar: 78
      LastChar: 110
      FontDescriptor: 
       FontName: CMANXK+TimesNewRomanPS-ItalicMT
       Flags: Serif, Nonsymbolic, Italic
       FontBBox: -498, -307, 1333, 1023
       FontFile2: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: JERBGW+TimesNewRomanPSMT
      FontSubset: true
      FirstChar: 32
      LastChar: 250
      FontDescriptor: 
       FontName: JERBGW+TimesNewRomanPSMT
       Flags: Serif, Nonsymbolic
       FontBBox: -568, -307, 2046, 1040
       FontFile2: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
    CIDFontType2: 
     Font: 
      BaseFont: TEOZQC+Wingdings-Regular
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: TEOZQC+Wingdings-Regular
       Flags: Symbolic
       FontBBox: 0, -211, 1359, 899
       FontFile2: true
     Font: 
      BaseFont: TYVOQC+TimesNewRomanPSMT
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: TYVOQC+TimesNewRomanPSMT
       Flags: Serif, Symbolic
       FontBBox: -568, -307, 2046, 1040
       FontFile2: true
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="Adobe XMP Core 5.1.0-jc003">
  <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
    <rdf:Description rdf:about=""
        xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/"
        xmlns:stRef="http://ns.adobe.com/xap/1.0/sType/ResourceRef#"
        xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#"
        xmlns:xmp="http://ns.adobe.com/xap/1.0/"
        xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/"
        xmlns:crossmark="http://crossref.org/crossmark/1.0/"
        xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/"
        xmlns:jav="http://www.niso.org/schemas/jav/1.0/"
        xmlns:dc="http://purl.org/dc/elements/1.1/"
        xmlns:pdf="http://ns.adobe.com/pdf/1.3/"
        xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/"
        xmlns:sn="http://springernature.com/ns/xmpExtensions/2.0/"
        xmlns:author_1_="http://springernature.com/ns/xmpExtensions/2.0/authorInfo"
        xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/"
        xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#"
        xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#"
        xmlns:pdfaType="http://www.aiim.org/pdfa/ns/type#"
        xmlns:pdfaField="http://www.aiim.org/pdfa/ns/field#"
      xmpMM:InstanceID="uuid:cf96bef9-6697-43cd-9d32-b536496ae0ba"
      xmpMM:OriginalDocumentID="adobe:docid:indd:24bb93d9-bd1e-11dd-84db-a83b50d2aaad"
      xmpMM:DocumentID="xmp.id:970436c6-e17d-2b42-9db1-42307e4acf27"
      xmpMM:RenditionClass="proof:pdf"
      xmpMM:VersionID="1"
      xmp:CreateDate="2026-05-07T02:32:11+02:00"
      xmp:ModifyDate="2026-05-07T04:09:54+02:00"
      xmp:MetadataDate="2026-05-07T04:09:54+02:00"
      xmp:CreatorTool="Adobe InDesign 18.3 (Windows)"
      prism:aggregationType="journal"
      crossmark:DOI="10.1007/s00228-026-04070-2"
      crossmark:MajorVersionDate="2010-04-23"
      crossmark:CrossmarkDomainExclusive="true"
      pdfx:CrossmarkMajorVersionDate="2010-04-23"
      pdfx:CrossmarkDomainExclusive="true"
      pdfx:doi="10.1007/s00228-026-04070-2"
      jav:journal_article_version="VoR"
      dc:format="application/pdf"
      pdf:Producer="Adobe PDF Library 17.0; modified using iText® 5.5.13.4 ©2000-2024 iText Group NV (SPRINGER SBM; licensed version)"
      pdf:Trapped="False"
      pdfaid:part="2"
      pdfaid:conformance="B">
      <xmpMM:DerivedFrom
        stRef:instanceID="xmp.iid:7af6bb37-136e-9e4f-be72-62360e5f3238"
        stRef:documentID="xmp.did:5070f574-536e-6048-995a-39662bfcbfe4"
        stRef:renditionClass="default"/>
      <xmpMM:History>
        <rdf:Seq>
          <rdf:li
            stEvt:action="converted"
            stEvt:parameters="from application/x-indesign to application/pdf"
            stEvt:softwareAgent="Adobe InDesign 18.3 (Windows)"
            stEvt:when="2026-05-07T02:32:11+02:00"/>
          <rdf:li
            stEvt:action="converted"
            stEvt:instanceID="uuid:6d66da1a-5c5b-4ce2-88a8-8d885b0f81c5"
            stEvt:parameters="converted to PDF/A-2b"
            stEvt:softwareAgent="pdfToolbox"
            stEvt:when="2026-05-07T02:43:28+02:00"/>
        </rdf:Seq>
      </xmpMM:History>
      <crossmark:CrossMarkDomains>
        <rdf:Seq>
          <rdf:li>springer.com</rdf:li>
          <rdf:li>springerlink.com</rdf:li>
        </rdf:Seq>
      </crossmark:CrossMarkDomains>
      <pdfx:CrossMarkDomains>
        <rdf:Seq>
          <rdf:li>springer.com</rdf:li>
          <rdf:li>springerlink.com</rdf:li>
        </rdf:Seq>
      </pdfx:CrossMarkDomains>
      <sn:authorInfo>
        <rdf:Bag>
          <rdf:li
            author_1_:name="Claudia Erika Delgado-Espinoza"
            author_1_:orcid="http://orcid.org/0009-0009-9089-4784"/>
          <rdf:li
            author_1_:name="Rosa M. Antonijoan"
            author_1_:orcid="http://orcid.org/0000-0002-7099-5125"/>
          <rdf:li
            author_1_:name="Mar a Jose Mart nez-Zapata"
            author_1_:orcid="http://orcid.org/0000-0002-5836-1138"/>
        </rdf:Bag>
      </sn:authorInfo>
      <pdfaExtension:schemas>
        <rdf:Bag>
          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://ns.adobe.com/xap/1.0/mm/"
              pdfaSchema:prefix="xmpMM"
              pdfaSchema:schema="XMP Media Management">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="UUID based identifier for specific incarnation of a document"
                  pdfaProperty:name="InstanceID"
                  pdfaProperty:valueType="URI"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="The common identifier for all versions and renditions of a document."
                  pdfaProperty:name="OriginalDocumentID"
                  pdfaProperty:valueType="URI"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original."
                  pdfaProperty:name="DerivedFrom"
                  pdfaProperty:valueType="ResourceRef"/>
              </rdf:Seq>
            </pdfaSchema:property>
            <pdfaSchema:valueType>
              <rdf:Seq>
                <rdf:li
                  pdfaType:description="Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced."
                  pdfaType:namespaceURI="http://ns.adobe.com/xap/1.0/sType/Part#"
                  pdfaType:prefix="stPart"
                  pdfaType:type="Part"/>
              </rdf:Seq>
            </pdfaSchema:valueType>
            </rdf:Description>
          </rdf:li>
          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://ns.adobe.com/pdf/1.3/"
              pdfaSchema:prefix="pdf"
              pdfaSchema:schema="Adobe PDF">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="A name object indicating whether the document has been modified to include trapping information"
                  pdfaProperty:name="Trapped"
                  pdfaProperty:valueType="Text"/>
              </rdf:Seq>
            </pdfaSchema:property>
            </rdf:Description>
          </rdf:li>
          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://ns.adobe.com/xap/1.0/t/pg/"
              pdfaSchema:prefix="xmpTPg"
              pdfaSchema:schema="XMP Paged-Text">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents)."
                  pdfaProperty:name="PlateNames"
                  pdfaProperty:valueType="Seq Text"/>
              </rdf:Seq>
            </pdfaSchema:property>
            </rdf:Description>
          </rdf:li>
          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://ns.adobe.com/pdfx/1.3/"
              pdfaSchema:prefix="pdfx"
              pdfaSchema:schema="pdfx">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="ID of PDF/X standard"
                  pdfaProperty:name="GTS_PDFXVersion"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Conformance level of PDF/X standard"
                  pdfaProperty:name="GTS_PDFXConformance"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Company creating the PDF"
                  pdfaProperty:name="Company"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Date when document was last modified"
                  pdfaProperty:name="SourceModified"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="Mirrors crossmark:CrosMarkDomains"
                  pdfaProperty:name="CrossMarkDomains"
                  pdfaProperty:valueType="Seq Text"/>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="Mirrors crossmark:CrossmarkDomainExclusive"
                  pdfaProperty:name="CrossmarkDomainExclusive"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="Mirrors crossmark:MajorVersionDate"
                  pdfaProperty:name="CrossmarkMajorVersionDate"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Mirrors crossmark:DOI"
                  pdfaProperty:name="doi"
                  pdfaProperty:valueType="Text"/>
              </rdf:Seq>
            </pdfaSchema:property>
            </rdf:Description>
          </rdf:li>
          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://www.aiim.org/pdfa/ns/id/"
              pdfaSchema:prefix="pdfaid"
              pdfaSchema:schema="PDF/A ID Schema">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Part of PDF/A standard"
                  pdfaProperty:name="part"
                  pdfaProperty:valueType="Integer"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Amendment of PDF/A standard"
                  pdfaProperty:name="amd"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Conformance level of PDF/A standard"
                  pdfaProperty:name="conformance"
                  pdfaProperty:valueType="Text"/>
              </rdf:Seq>
            </pdfaSchema:property>
            </rdf:Description>
          </rdf:li>
          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://crossref.org/crossmark/1.0/"
              pdfaSchema:prefix="crossmark"
              pdfaSchema:schema="crossmark">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="CrossMarkDomains"
                  pdfaProperty:name="CrossMarkDomains"
                  pdfaProperty:valueType="Seq Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="CrossmarkDomainExclusive"
                  pdfaProperty:name="CrossmarkDomainExclusive"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Usual same as prism:doi"
                  pdfaProperty:name="DOI"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="The date when a publication was published."
                  pdfaProperty:name="MajorVersionDate"
                  pdfaProperty:valueType="Text"/>
              </rdf:Seq>
            </pdfaSchema:property>
            </rdf:Description>
          </rdf:li>
          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://prismstandard.org/namespaces/basic/2.0/"
              pdfaSchema:prefix="prism"
              pdfaSchema:schema="Prism">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="The aggregation type specifies the unit of aggregation for a content collection. &#xA;Comment &#xA;PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. &#xA;Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. &#xA;&#xA;"
                  pdfaProperty:name="aggregationType"
                  pdfaProperty:valueType="Text"/>
              </rdf:Seq>
            </pdfaSchema:property>
            </rdf:Description>
          </rdf:li>
          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://springernature.com/ns/xmpExtensions/2.0/"
              pdfaSchema:prefix="sn"
              pdfaSchema:schema="Springer Nature ORCID Schema">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="Author information: contains the name of each author and his/her ORCID (ORCiD: Open Researcher and Contributor ID). An ORCID is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors."
                  pdfaProperty:name="authorInfo"
                  pdfaProperty:valueType="Bag AuthorInformation"/>
              </rdf:Seq>
            </pdfaSchema:property>
            <pdfaSchema:valueType>
              <rdf:Seq>
                <rdf:li>
                  <rdf:Description
                    pdfaType:description="Specifies the types of author information: name and ORCID of an author."
                    pdfaType:namespaceURI="http://springernature.com/ns/xmpExtensions/2.0/authorInfo/"
                    pdfaType:prefix="author"
                    pdfaType:type="AuthorInformation">
                  <pdfaType:field>
                    <rdf:Seq>
                      <rdf:li
                        pdfaField:description="Gives the ORCID of an author."
                        pdfaField:name="orcid"
                        pdfaField:valueType="URI"/>
                      <rdf:li
                        pdfaField:description="Gives the name of an author."
                        pdfaField:name="name"
                        pdfaField:valueType="Text"/>
                    </rdf:Seq>
                  </pdfaType:field>
                  </rdf:Description>
                </rdf:li>
              </rdf:Seq>
            </pdfaSchema:valueType>
            </rdf:Description>
          </rdf:li>
          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://www.niso.org/schemas/jav/1.0/"
              pdfaSchema:prefix="jav"
              pdfaSchema:schema="NISO">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="Values for Journal Article Version are one of the following:&#xA;AO = Author’s Original&#xA;SMUR = Submitted Manuscript Under Review&#xA;AM = Accepted Manuscript&#xA;P = Proof&#xA;VoR = Version of Record&#xA;CVoR = Corrected Version of Record&#xA;EVoR = Enhanced Version of Record"
                  pdfaProperty:name="journal_article_version"
                  pdfaProperty:valueType="Closed Choice of Text"/>
              </rdf:Seq>
            </pdfaSchema:property>
            </rdf:Description>
          </rdf:li>
        </rdf:Bag>
      </pdfaExtension:schemas>
    </rdf:Description>
  </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 513, 721, 546, 688
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 51, 747, 197, 737
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 65, 187, 173, 176
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 65, 162, 153, 151
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 65, 137, 151, 126
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 199, 634, 212, 622
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 312, 634, 325, 622
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 466, 634, 479, 622
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 151, 618, 156, 604
       Flags: Print
       AppearanceDictionary: true
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 174, 593, 179, 579
       Flags: Print
       AppearanceDictionary: true
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 161, 480, 166, 467
       Flags: Print
       AppearanceDictionary: true
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 240, 443, 245, 429
       Flags: Print
       AppearanceDictionary: true
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 224, 293, 229, 279
       Flags: Print
       AppearanceDictionary: true
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 54, 230, 59, 217
       Flags: Print
       AppearanceDictionary: true
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 96, 143, 101, 129
       Flags: Print
       AppearanceDictionary: true
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 520, 430, 544, 417
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 306, 418, 360, 404
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 76, 655, 81, 642
       Flags: Print
       AppearanceDictionary: true
       Destination: 28
      Annotation: 
       Subtype: Link
       Rect: 330, 705, 335, 692
       Flags: Print
       AppearanceDictionary: true
       Destination: 43
      Annotation: 
       Subtype: Link
       Rect: 386, 218, 391, 204
       Flags: Print
       AppearanceDictionary: true
       Destination: 59
      Annotation: 
       Subtype: Link
       Rect: 331, 155, 337, 142
       Flags: Print
       AppearanceDictionary: true
       Destination: 59
     Thumb: true
    Page: 
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 331, 568, 336, 554
       Flags: Print
       AppearanceDictionary: true
       Destination: 70
      Annotation: 
       Subtype: Link
       Rect: 362, 255, 367, 242
       Flags: Print
       AppearanceDictionary: true
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 372, 255, 382, 242
       Flags: Print
       AppearanceDictionary: true
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 464, 230, 469, 217
       Flags: Print
       AppearanceDictionary: true
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 398, 218, 403, 204
       Flags: Print
       AppearanceDictionary: true
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 513, 205, 523, 192
       Flags: Print
       AppearanceDictionary: true
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 528, 205, 538, 192
       Flags: Print
       AppearanceDictionary: true
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 457, 130, 467, 117
       Flags: Print
       AppearanceDictionary: true
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 536, 105, 541, 92
       Flags: Print
       AppearanceDictionary: true
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 306, 93, 311, 79
       Flags: Print
       AppearanceDictionary: true
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 318, 93, 328, 79
       Flags: Print
       AppearanceDictionary: true
       Destination: 77
     Thumb: true
    Page: 
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 116, 205, 126, 192
       Flags: Print
       AppearanceDictionary: true
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 273, 168, 283, 154
       Flags: Print
       AppearanceDictionary: true
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 346, 405, 356, 392
       Flags: Print
       AppearanceDictionary: true
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 431, 255, 440, 242
       Flags: Print
       AppearanceDictionary: true
       Destination: 77
     Thumb: true
    Page: 
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 213, 243, 218, 229
       Flags: Print
       AppearanceDictionary: true
       Destination: 77
      Annotation: 
       Subtype: Link
       Rect: 376, 297, 525, 285
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 202, 460, 289, 448
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 51, 450, 113, 438
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 146, 290, 289, 278
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 280, 89, 268
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 336, 735, 544, 724
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 725, 385, 714
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 426, 675, 544, 664
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 665, 444, 654
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 428, 625, 544, 614
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 615, 358, 604
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 522, 575, 544, 564
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 565, 448, 554
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 500, 525, 544, 514
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 515, 426, 504
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 367, 465, 534, 454
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 460, 435, 544, 424
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 425, 386, 414
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 381, 395, 544, 384
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 510, 385, 544, 374
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 375, 513, 364
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 409, 355, 544, 344
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 345, 495, 334
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 449, 305, 544, 294
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 295, 539, 284
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
  Checksum: dbd33742
   Type: CRC32
  Checksum: 2b056df9f72443907be66aeb73b3e5de
   Type: MD5
  Checksum: 265197f9ceaa88d9238320cf5dada95476bf06f9
   Type: SHA-1
  Checksum: df43968134ab07cbbb938329dee436b74bb8ef39d154b99d529a267d90259548
   Type: SHA-256