163c6d1e1b999bce48ff9bef5ae56c1c advlabmed_a2026m4v7n2p105-115.pdf 91cd5a99d6c819e874e1f15597a219c57c171ce2 advlabmed_a2026m4v7n2p105-115.pdf 04b37e8f9f7212379fa872171f6ff4b4bb7e519d94fbc066befb60e003203c27 advlabmed_a2026m4v7n2p105-115.pdf Title: Determination of HE4 in pleural fluid and ratio: considerations and diagnostic performance for malignant pleural effusion Author: Elisa Nuez-Zaragoza Creator: Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Fri May 8 11:37:46 2026 CEST ModDate: Fri May 8 11:40:35 2026 CEST Custom Metadata: no Metadata Stream: yes Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 1507388 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- LHCFPP+AdvTT052d8736 Type 1C WinAnsi yes yes no 1170 0 GlyphLessFont CID TrueType Identity-H yes no yes 1173 0 LHCGAA+AdvTT382fe7bb.B Type 1C WinAnsi yes yes no 1175 0 LHCGAB+AdvTT382fe7bb.B+fb Type 1C Custom yes yes yes 1178 0 LHCGBB+AdvTTd027cc2c Type 1C WinAnsi yes yes no 1180 0 LHCGBC+AdvTTd027cc2c+fb Type 1C Custom yes yes yes 1183 0 LHCGBD+AdvTTd027cc2c+20 Type 1C WinAnsi yes yes no 1185 0 LHCGBE+AdvOT310e2d14 Type 1C WinAnsi yes yes no 1187 0 LHCGBF+AdvTT275472e6+22 Type 1C Custom yes yes yes 1190 0 LHCGBG+AdvTT052d8736+20 Type 1C WinAnsi yes yes no 1192 0 LHCGHF+AdvTT052d8736+fb Type 1C Custom yes yes yes 86 0 LHCHON+AdvTT382fe7bb.B+f1 Type 1C Custom yes yes yes 126 0 LHCHOO+AdvTT052d8736+f1 Type 1C Custom yes yes yes 132 0 LHDBOC+AdvOT310e2d14+22 Type 1C Custom yes yes yes 146 0 LHDDCL+AdvTT052d8736+01 Type 1C Custom yes yes yes 176 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2026-06-09 04:15:33 CEST RepresentationInformation: advlabmed_a2026m4v7n2p105-115.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2026-06-08 15:48:15 CEST Size: 1507388 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF, Tagged PDF PDFMetadata: Objects: 0 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: true NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Language: en-US Outlines: Item: Title: Determination of HE4 in pleural fluid and ratio: considerations and diagnostic performance for malignant pleural effusion Destination: flink1 Item: Title: Introduction Destination: flink2 Item: Title: Materials and methods Destination: flink3 Children: Item: Title: Study design and participants Destination: slink1 Item: Title: Pleural fluid and serum analysis Destination: slink2 Children: Item: Title: Sample collection Destination: tlink1 Item: Title: Cell counting and differentiation Destination: tlink2 Item: Title: Cytological study Destination: tlink3 Item: Title: Biochemical analysis Destination: tlink4 Item: Title: Statistical analysis Destination: slink3 Item: Title: Results Destination: flink4 Item: Title: Discussion Destination: flink5 Item: Title: Acknowledgments Destination: ackflink6 Item: Title: References Destination: flink7 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1697 ImageHeight: 2490 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode ColorSpace: ICCBased Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2005 ImageHeight: 677 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type0: Font: BaseFont: GlyphLessFont Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: LHCGBD+AdvTTd027cc2c+20 FontSubset: true FirstChar: 146 LastChar: 150 FontDescriptor: FontName: LHCGBD+AdvTTd027cc2c+20 Flags: Nonsymbolic FontBBox: -322, -218, 1437, 843 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LHCGBE+AdvOT310e2d14 FontSubset: true FirstChar: 43 LastChar: 177 FontDescriptor: FontName: LHCGBE+AdvOT310e2d14 Flags: Nonsymbolic FontBBox: -20, -427, 1541, 1062 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LHCHOO+AdvTT052d8736+f1 FontSubset: true FirstChar: 1 LastChar: 11 FontDescriptor: FontName: LHCHOO+AdvTT052d8736+f1 Flags: Symbolic FontBBox: 9, 0, 468, 687 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: LHCGBF+AdvTT275472e6+22 FontSubset: true FirstChar: 1 LastChar: 138 FontDescriptor: FontName: LHCGBF+AdvTT275472e6+22 Flags: Symbolic FontBBox: 9, -229, 1072, 770 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: LHCGBG+AdvTT052d8736+20 FontSubset: true FirstChar: 146 LastChar: 150 FontDescriptor: FontName: LHCGBG+AdvTT052d8736+20 Flags: Nonsymbolic FontBBox: -197, -229, 1302, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LHDDCL+AdvTT052d8736+01 FontSubset: true FirstChar: 1 LastChar: 153 FontDescriptor: FontName: LHDDCL+AdvTT052d8736+01 Flags: Symbolic FontBBox: -62, -229, 1052, 1000 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: LHCFPP+AdvTT052d8736 FontSubset: true FirstChar: 37 LastChar: 252 FontDescriptor: FontName: LHCFPP+AdvTT052d8736 Flags: Nonsymbolic FontBBox: -62, -218, 791, 989 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LHDBOC+AdvOT310e2d14+22 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: LHDBOC+AdvOT310e2d14+22 Flags: Symbolic FontBBox: -135, -385, 1333, 895 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: LHCGHF+AdvTT052d8736+fb FontSubset: true FirstChar: 1 LastChar: 4 FontDescriptor: FontName: LHCGHF+AdvTT052d8736+fb Flags: Symbolic FontBBox: 9, 0, 750, 718 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: LHCGAA+AdvTT382fe7bb.B FontSubset: true FirstChar: 37 LastChar: 242 FontDescriptor: FontName: LHCGAA+AdvTT382fe7bb.B Flags: Nonsymbolic FontBBox: -62, -218, 843, 1031 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LHCGAB+AdvTT382fe7bb.B+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: LHCGAB+AdvTT382fe7bb.B+fb Flags: Symbolic FontBBox: 9, 0, 875, 718 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: LHCGBB+AdvTTd027cc2c FontSubset: true FirstChar: 37 LastChar: 243 FontDescriptor: FontName: LHCGBB+AdvTTd027cc2c Flags: Serif, Nonsymbolic FontBBox: 0, -218, 906, 1052 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: LHCHON+AdvTT382fe7bb.B+f1 FontSubset: true FirstChar: 1 LastChar: 8 FontDescriptor: FontName: LHCHON+AdvTT382fe7bb.B+f1 Flags: Symbolic FontBBox: 9, 0, 489, 687 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: LHCGBC+AdvTTd027cc2c+fb FontSubset: true FirstChar: 1 LastChar: 5 FontDescriptor: FontName: LHCGBC+AdvTTd027cc2c+fb Flags: Symbolic FontBBox: 9, 0, 875, 729 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true CIDFontType2: Font: BaseFont: GlyphLessFont CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: GlyphLessFont Flags: FixedPitch, Symbolic FontBBox: 0, 0, 500, 1000 FontFile2: true XMP: 2026-05-08T15:07:46+05:30 2026-05-08T15:10:35+05:30 2026-05-08T15:10:35+05:30 application/pdf Determination of HE4 in pleural fluid and ratio: considerations and diagnostic performance for malignant pleural effusion © 2026 the author(s), published by De Gruyter, Berlin/Boston Elisa Nuez-Zaragoza HE4 pleural fluid HE4 ratio malignant pleural effusion journal Advances in Laboratory Medicine / Avances en Medicina de Laboratorio © 2026 the author(s), published by De Gruyter, Berlin/Boston 105-115 105 115 10.1515/almed-2025-0175 https://doi.org/10.1515/almed-2025-0175 10.1515/almed-2025-0175 https://doi.org/10.1515/almed-2025-0175 True https://www.degruyter.com/page/terms-conditions?language=en B 2 Print 1 Acrobat Distiller 8.1.0 (Windows) uuid:7c4fa09c-22f3-4b33-b945-5a4a663c64ea uuid:31d93ef8-0f7b-4eb9-a14c-fe27d97e2755 De Gruyter XMP Schema for WEB PDF http://www.degruyter.com/ns//web-pdf/ dg 10.1515/almed-2025-0175 Text external The Digital Object Identifier of document https://doi.org/10.1515/almed-2025-0175 text external The corresponding URL of the Digital Object Identifier. Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Contents: Link Annotation Rect: 51, 566, 179, 574 Annotation: Subtype: Link Contents: Link Annotation Rect: 96, 253, 185, 261 Annotation: Subtype: Link Contents: Link Annotation Rect: 189, 253, 281, 261 Annotation: Subtype: Link Contents: Link Annotation Rect: 51, 242, 82, 250 Annotation: Subtype: Link Contents: Link Annotation Rect: 187, 198, 280, 206 Annotation: Subtype: Link Contents: Link Annotation Rect: 51, 187, 84, 195 Annotation: Subtype: Link Contents: Link Annotation Rect: 150, 187, 275, 195 Annotation: Subtype: Link Contents: Link Annotation Rect: 122, 176, 247, 184 Annotation: Subtype: Link Contents: Link Annotation Rect: 174, 121, 281, 129 Annotation: Subtype: Link Contents: Link Annotation Rect: 51, 111, 66, 118 Annotation: Subtype: Link Contents: Link Annotation Rect: 255, 78, 279, 86 Annotation: Subtype: Link Contents: Link Annotation Rect: 51, 67, 151, 75 Annotation: Subtype: Link Contents: Link Annotation Rect: 351, 287, 466, 295 Annotation: Subtype: Link Contents: Link Annotation Rect: 502, 254, 525, 262 Annotation: Subtype: Link Contents: Link Annotation Rect: 297, 243, 397, 251 Annotation: Subtype: Link Contents: Link Annotation Rect: 319, 200, 443, 208 Annotation: Subtype: Link Contents: Link Annotation Rect: 505, 200, 528, 208 Annotation: Subtype: Link Contents: Link Annotation Rect: 297, 189, 396, 197 Annotation: Subtype: Link Contents: Link Annotation Rect: 502, 155, 525, 163 Annotation: Subtype: Link Contents: Link Annotation Rect: 297, 144, 398, 152 Annotation: Subtype: Link Contents: Link Annotation Rect: 450, 122, 523, 130 Annotation: Subtype: Link Contents: Link Annotation Rect: 297, 111, 346, 119 Annotation: Subtype: Link Contents: Link Annotation Rect: 450, 78, 523, 86 Annotation: Subtype: Link Contents: Link Annotation Rect: 297, 67, 348, 75 Thumb: true Page: Label: 2 Annotations: Annotation: Subtype: Link Contents: Link Annotation Rect: 62, 547, 72, 556 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 219, 534, 226, 544 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 233, 534, 240, 544 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 205, 508, 224, 518 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 131, 457, 138, 466 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 144, 457, 151, 466 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 62, 431, 72, 441 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 206, 393, 216, 402 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 96, 367, 106, 376 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 239, 328, 246, 338 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 251, 328, 258, 338 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 239, 289, 246, 299 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 250, 289, 255, 299 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 259, 289, 266, 299 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 212, 263, 219, 273 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 224, 263, 228, 273 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 233, 263, 237, 273 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 242, 263, 249, 273 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 97, 238, 110, 247 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 288, 225, 295, 234 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 62, 212, 66, 221 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 71, 212, 94, 221 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 240, 199, 247, 208 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 251, 199, 255, 208 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 260, 199, 264, 208 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 268, 199, 277, 208 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 281, 199, 291, 208 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 95, 84, 121, 93 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 368, 700, 382, 709 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 473, 687, 487, 696 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 462, 649, 469, 658 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 473, 649, 497, 658 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 410, 597, 418, 606 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 423, 597, 431, 606 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 436, 597, 447, 606 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 408, 571, 415, 580 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 420, 571, 444, 580 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 354, 519, 361, 529 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 366, 519, 378, 529 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 376, 480, 387, 490 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 406, 467, 420, 477 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 370, 110, 383, 119 Destination: 23 Thumb: true Page: Label: 3 Annotations: Annotation: Subtype: Link Contents: Link Annotation Rect: 405, 648, 419, 657 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 366, 557, 380, 567 Destination: 23 Thumb: true Page: Label: 4 Annotations: Annotation: Subtype: Link Contents: Link Annotation Rect: 203, 81, 235, 90 Destination: 5 Annotation: Subtype: Link Contents: Link Annotation Rect: 458, 293, 486, 302 Destination: 8 Annotation: Subtype: Link Contents: Link Annotation Rect: 348, 227, 377, 237 Destination: 10 Annotation: Subtype: Link Contents: Link Annotation Rect: 512, 122, 539, 132 Destination: 10 Thumb: true Page: Label: 5 Annotations: Annotation: Subtype: Link Contents: Link Annotation Rect: 138, 285, 230, 295 Destination: 28 Annotation: Subtype: Link Contents: Link Annotation Rect: 67, 169, 100, 178 Destination: 12 Annotation: Subtype: Link Contents: Link Annotation Rect: 67, 91, 95, 100 Destination: 15 Annotation: Subtype: Link Contents: Link Annotation Rect: 211, 78, 242, 87 Destination: 15 Annotation: Subtype: Link Contents: Link Annotation Rect: 411, 557, 442, 567 Destination: 15 Annotation: Subtype: Link Contents: Link Annotation Rect: 380, 479, 406, 489 Destination: 15 Annotation: Subtype: Link Contents: Link Annotation Rect: 486, 402, 514, 411 Destination: 15 Annotation: Subtype: Link Contents: Link Annotation Rect: 364, 220, 372, 230 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 376, 220, 384, 230 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 389, 220, 400, 230 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 502, 156, 513, 165 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 519, 156, 530, 165 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 404, 78, 415, 87 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 420, 78, 428, 87 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 434, 78, 442, 87 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 448, 78, 459, 87 Destination: 23 Thumb: true Page: Label: 6 Thumb: true Page: Label: 7 Thumb: true Page: Label: 8 Annotations: Annotation: Subtype: Link Contents: Link Annotation Rect: 125, 301, 139, 310 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 219, 301, 233, 310 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 203, 236, 213, 246 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 217, 236, 225, 246 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 229, 236, 253, 246 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 213, 210, 227, 220 Destination: 28 Annotation: Subtype: Link Contents: Link Annotation Rect: 284, 210, 297, 220 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 137, 197, 152, 207 Destination: 28 Annotation: Subtype: Link Contents: Link Annotation Rect: 220, 146, 233, 155 Destination: 28 Annotation: Subtype: Link Contents: Link Annotation Rect: 385, 340, 395, 349 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 466, 340, 480, 349 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 427, 262, 439, 272 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 443, 262, 454, 272 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 426, 249, 437, 259 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 442, 249, 453, 259 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 506, 249, 520, 259 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 461, 197, 472, 207 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 477, 197, 488, 207 Destination: 28 Annotation: Subtype: Link Contents: Link Annotation Rect: 353, 146, 364, 155 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 369, 146, 380, 155 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 517, 120, 530, 129 Destination: 28 Thumb: true Page: Label: 9 Annotations: Annotation: Subtype: Link Contents: Link Annotation Rect: 127, 583, 154, 592 Destination: 10 Annotation: Subtype: Link Contents: Link Annotation Rect: 197, 479, 211, 489 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 262, 402, 270, 411 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 274, 402, 281, 411 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 230, 363, 241, 372 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 502, 712, 512, 722 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 523, 648, 532, 657 Destination: 23 Annotation: Subtype: Link Contents: Link Annotation Rect: 297, 583, 307, 592 Destination: 23 Thumb: true Page: Label: 10 Thumb: true Page: Label: 11 Annotations: Annotation: Subtype: Link Contents: Link Annotation Rect: 299, 649, 428, 657 Thumb: true Checksum: 863e57ae Type: CRC32 Checksum: 163c6d1e1b999bce48ff9bef5ae56c1c Type: MD5 Checksum: 91cd5a99d6c819e874e1f15597a219c57c171ce2 Type: SHA-1 Checksum: 04b37e8f9f7212379fa872171f6ff4b4bb7e519d94fbc066befb60e003203c27 Type: SHA-256