a9497c86cdae0dd55c65bd16020dad3d s12979-026-00574-8_reference_2.pdf 343f844161a2087fe2d11fd311948d788ec83a0c s12979-026-00574-8_reference_2.pdf c932e0147f99f375c169f409309db7078061b581a6ea485e6a71470c0115992c s12979-026-00574-8_reference_2.pdf Creator: Adobe InDesign 18.3 (Windows) Producer: Adobe PDF Library 17.0 CreationDate: Tue Jun 2 05:46:56 2026 CEST ModDate: Tue Jun 2 05:46:57 2026 CEST Custom Metadata: yes Metadata Stream: yes Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 34 Encrypted: no Page size: 595.276 x 790.866 pts Page rot: 0 File size: 851715 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MyriadPro-BoldCond Type 1C WinAnsi yes no yes 424 0 MyriadPro-SemiboldSemiCn Type 1C Custom yes no yes 425 0 MyriadPro-SemiboldSemiCnIt Type 1C Custom yes no yes 426 0 MyriadPro-Regular Type 1C Custom yes no yes 427 0 MyriadPro-Semibold Type 1C WinAnsi yes no yes 428 0 MyriadPro-Bold Type 1C WinAnsi yes no yes 429 0 Verdana TrueType WinAnsi yes no yes 760 0 FAAAAI+DejaVuSans-Bold TrueType WinAnsi yes yes no 439 0 FAAABC+DejaVuSans TrueType WinAnsi yes yes no 440 0 FNBUMH+Verdana CID TrueType Identity-H yes yes yes 441 0 GCWKGR+Verdana CID TrueType Identity-H yes yes yes 442 0 FAAABI+DejaVuSans CID TrueType Identity-H yes yes yes 452 0 FAAACG+DejaVuSans,Italic TrueType WinAnsi yes yes no 462 0 FAAAFB+DejaVuSerif TrueType WinAnsi yes yes no 526 0 FAABCA+DejaVuSans-Bold CID TrueType Identity-H yes yes yes 725 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2026-06-09 04:15:22 CEST RepresentationInformation: s12979-026-00574-8_reference_2.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2026-06-08 18:28:48 CEST Size: 851715 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul InfoMessage: File header gives version as 1.4, but catalog dictionary gives version as 1.7 ID: PDF-HUL-87 MIMEtype: application/pdf Profile: Tagged PDF PDFMetadata: Objects: 931 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Language: en-US Info: Creator: Adobe InDesign 18.3 (Windows) Producer: Adobe PDF Library 17.0 CreationDate: Tue Jun 02 05:46:56 CEST 2026 ModDate: Tue Jun 02 05:46:57 CEST 2026 ID: 0xd242f2bed707f5b6635f40c3e0c2dccd, 0xd242f2bed707f5b6635f40c3e0c2dccd Filters: FilterPipeline: FlateDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1100 ImageHeight: 90 ColorSpace: black is zero BitsPerSample: 1 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric ImageMask: true Decode: 0, 1 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 204 ImageHeight: 18 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 116 ImageHeight: 17 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 125 ImageHeight: 19 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 400 ImageHeight: 29 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 125 ImageHeight: 45 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 291 ImageHeight: 37 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 731 ImageHeight: 429 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 109 ImageHeight: 24 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 31 ImageHeight: 134 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 593 ImageHeight: 433 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 59 ImageHeight: 41 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 47 ImageHeight: 17 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 571 ImageHeight: 429 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 105 ImageHeight: 24 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 45 ImageHeight: 20 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 544 ImageHeight: 437 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 39 ImageHeight: 24 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 70 ImageHeight: 21 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 87 ImageHeight: 13 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 153 ImageHeight: 25 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 571 ImageHeight: 429 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 109 ImageHeight: 24 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 47 ImageHeight: 21 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 31 ImageHeight: 134 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 51 ImageHeight: 18 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Fonts: Type0: Font: BaseFont: FAAABI+DejaVuSans Encoding: Identity-H ToUnicode: true Font: BaseFont: FAABCA+DejaVuSans-Bold Encoding: Identity-H ToUnicode: true Font: BaseFont: FNBUMH+Verdana Encoding: Identity-H ToUnicode: true Font: BaseFont: GCWKGR+Verdana Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: MyriadPro-BoldCond FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-BoldCond Flags: Nonsymbolic FontBBox: -150, -250, 970, 958 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MyriadPro-SemiboldSemiCn FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-SemiboldSemiCn Flags: Nonsymbolic FontBBox: -131, -250, 1115, 886 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-SemiboldSemiCnIt FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-SemiboldSemiCnIt Flags: Nonsymbolic, Italic FontBBox: -156, -250, 1096, 876 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-Regular FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Regular Flags: Nonsymbolic FontBBox: -157, -250, 1126, 952 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-Semibold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Semibold Flags: Nonsymbolic FontBBox: -161, -250, 1198, 972 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MyriadPro-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Bold Flags: Nonsymbolic FontBBox: -163, -250, 1256, 989 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true TrueType: Font: BaseFont: FAAAAI+DejaVuSans-Bold FontSubset: true FirstChar: 32 LastChar: 146 FontDescriptor: FontName: FAAAAI+DejaVuSans-Bold Flags: Nonsymbolic, ForceBold FontBBox: -1069, -415, 1975, 1175 FontFile2: true Encoding: WinAnsiEncoding Font: BaseFont: FAAABC+DejaVuSans FontSubset: true FirstChar: 32 LastChar: 252 FontDescriptor: FontName: FAAABC+DejaVuSans Flags: Nonsymbolic FontBBox: -1021, -463, 1793, 1232 FontFile2: true Encoding: WinAnsiEncoding Font: BaseFont: FAAACG+DejaVuSans,Italic FontSubset: true FirstChar: 32 LastChar: 252 FontDescriptor: FontName: FAAACG+DejaVuSans,Italic Flags: Nonsymbolic FontBBox: -1021, -463, 1793, 1232 FontFile2: true Encoding: WinAnsiEncoding Font: BaseFont: FAAAFB+DejaVuSerif FontSubset: true FirstChar: 32 LastChar: 65 FontDescriptor: FontName: FAAAFB+DejaVuSerif Flags: Nonsymbolic FontBBox: -770, -347, 2105, 1109 FontFile2: true Encoding: WinAnsiEncoding CIDFontType2: Font: BaseFont: FAAABI+DejaVuSans CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: FAAABI+DejaVuSans Flags: Nonsymbolic FontBBox: -1021, -463, 1793, 1232 FontFile2: true Font: BaseFont: FAABCA+DejaVuSans-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: FAABCA+DejaVuSans-Bold Flags: Nonsymbolic, ForceBold FontBBox: -1069, -415, 1975, 1175 FontFile2: true Font: BaseFont: Verdana CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: Verdana Flags: Nonsymbolic FontBBox: -559, -303, 1522, 1050 FontFile2: true Font: BaseFont: Verdana CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: Verdana Flags: Nonsymbolic FontBBox: -559, -303, 1522, 1050 FontFile2: true XMP: uuid:66db2a20-0654-4922-94ed-2a0cab0d0230 adobe:docid:indd:24bb93d9-bd1e-11dd-84db-a83b50d2aaad xmp.id:7485aec0-8afd-1948-8c9d-b195b5258194 proof:pdf xmp.iid:b0e7deb1-08b3-8948-83a1-dcfa9da6bc96 xmp.did:93bf005f-79bd-504e-9b5c-a0a4f94186c0 adobe:docid:indd:24bb93d9-bd1e-11dd-84db-a83b50d2aaad default converted from application/x-indesign to application/pdf Adobe InDesign 18.3 (Windows) / 2026-06-02T05:46:56+02:00 2026-06-02T05:46:56+02:00 2026-06-02T05:46:57+02:00 2026-06-02T05:46:57+02:00 Adobe InDesign 18.3 (Windows) journal 10.1186/s12979-026-00574-8 2010-04-23 true springer.com springerlink.com 2010-04-23 true 10.1186/s12979-026-00574-8 springer.com springerlink.com AM application/pdf Adobe PDF Library 17.0 False 0 3024036851 3024036851 Myriad Pro MyriadPro-SemiCn OpenType - PS Adobe Systems 0 1.003 0 3198020658 3198020658 Myriad Pro MyriadPro-Semibold OpenType - PS Adobe Systems 0 1.006 0 2496651361 2496651361 Myriad Pro MyriadPro-Regular OpenType - PS Adobe Systems 0 1.006 Springnew TimesNewRomanPSMT TimesNewRomanPS-BoldMT Arial-BoldMT Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 101, 410, 193, 399 Annotation: Subtype: Link Rect: 45, 398, 123, 387 Annotation: Subtype: Link Rect: 376, 741, 549, 730 Annotation: Subtype: Link Rect: 274, 118, 421, 108 Thumb: true Page: Sequence: 2 Page: Sequence: 3 Page: Sequence: 4 Page: Sequence: 5 Page: Sequence: 6 Page: Sequence: 7 Page: Sequence: 8 Page: Sequence: 9 Page: Sequence: 10 Page: Sequence: 11 Page: Sequence: 12 Page: Sequence: 13 Page: Sequence: 14 Page: Sequence: 15 Page: Sequence: 16 Page: Sequence: 17 Page: Sequence: 18 Page: Sequence: 19 Page: Sequence: 20 Page: Sequence: 21 Page: Sequence: 22 Page: Sequence: 23 Page: Sequence: 24 Page: Sequence: 25 Page: Sequence: 26 Page: Sequence: 27 Page: Sequence: 28 Page: Sequence: 29 Page: Sequence: 30 Page: Sequence: 31 Page: Sequence: 32 Page: Sequence: 33 Page: Sequence: 34 Checksum: 0efdbaa0 Type: CRC32 Checksum: a9497c86cdae0dd55c65bd16020dad3d Type: MD5 Checksum: 343f844161a2087fe2d11fd311948d788ec83a0c Type: SHA-1 Checksum: c932e0147f99f375c169f409309db7078061b581a6ea485e6a71470c0115992c Type: SHA-256