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PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: English Outlines: Item: Title: Comparative mortality of dominant Staphylococcus aureus lineages in human bacteremia and animal infection models Destination: mk:title Children: Item: Title: 1 Introduction Destination: mk:H1_1 Item: Title: 2 Material and methods Destination: mk:H1_2 Children: Item: Title: 2.1 Bacterial isolates Destination: mk:H2_1 Item: Title: 2.2 S. aureus phenotypic characterization Destination: mk:H2_2 Item: Title: 2.3 In vivo studies in the G. mellonella model Destination: mk:H2_3 Item: Title: 2.4 In vivo studies in the EE rabbit model Destination: mk:H2_4 Item: Title: 2.5 Transcriptomic analysis Destination: mk:H2_5 Item: Title: 2.6 S. aureus ST398 comparative genomics Destination: mk:H2_6 Item: Title: 2.7 Phylogenetic inference Destination: mk:H2_7 Item: Title: 2.8 Ethics statement Destination: mk:H2_8 Item: Title: 3 Results Destination: mk:H1_3 Children: Item: Title: 3.1 Genetic and clinical data associated with the S. aureus isolates under study Destination: mk:H2_9 Item: Title: 3.2 Growth rate, biofilm formation capacity and hemolytic activity of S. aureus isolates Destination: mk:H2_10 Item: Title: 3.3 G. mellonella larvae infection assays across S. aureus lineages Destination: mk:H2_11 Item: Title: 3.4 High lethality of ST398 isolates in the EE rabbit model Destination: mk:H2_12 Item: Title: 3.5 Comparative genomics and transcriptomics of CC30 and ST398 isolates Destination: mk:H2_13 Item: Title: 4 Discussion Destination: mk:H1_4 Children: Item: Title: 4.1 Divergent virulence patterns of S. aureus lineages in invertebrate and human hosts Destination: mk:H2_14 Item: Title: 4.2 Association of hemolysin production and agr system variants with virulence in G. mellonella Destination: mk:H2_15 Item: Title: 4.3 Model-dependent variation in S. aureus virulence across vertebrate and invertebrate hosts Destination: mk:H2_16 Item: Title: 4.4 Transcriptomic insights into S. aureus virulence and host-model discrepancies Destination: mk:H2_17 Item: Title: 5 Limitations of the study Destination: mk:H1_5 Item: Title: Funding Destination: mk:H1_6 Item: Title: CRediT authorship contribution statement Destination: mk:H1_7 Item: Title: Declaration of competing interest Destination: mk:HH1_3 Item: Title: Acknowledgments Destination: mk:HH1_4 Item: Title: Appendix A Supplementary data Destination: mk:H1_8 Item: Title: Data availability Destination: datalink5 Item: Title: References Destination: mk:HH2_1 Info: Title: Comparative mortality of dominant Staphylococcus aureus lineages in human bacteremia and animal infection models Author: Miquel Sánchez-Osuna Subject: Microbial Pathogenesis, 213 (2026) 108323. doi:10.1016/j.micpath.2026.108323 Keywords: Staphylococcus aureus,Bacteremia,Galleria mellonella,New Zealand white rabbits,Experimental endocarditis,Transcriptomics,Hemolysis,Biofilm Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Mon Feb 23 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Staphylococcus aureus Bacteremia Galleria mellonella New Zealand white rabbits Experimental endocarditis Transcriptomics Hemolysis Biofilm Comparative mortality of dominant Staphylococcus aureus lineages in human bacteremia and animal infection models Miquel Sánchez-Osuna Marc Bravo María-Alexandra Cañas Andrómeda-Celeste Gómez Inmaculada Gómez-Sánchez José M. Miró Isidre Gibert Oriol Gasch Cristina García-de-la-Mària Daniel Yero Oscar Q. Pich VoR 24th February 2026 Acrobat Distiller 8.1.0 (Windows) Staphylococcus aureus,Bacteremia,Galleria mellonella,New Zealand white rabbits,Experimental endocarditis,Transcriptomics,Hemolysis,Biofilm 24th February 2026 sciencedirect.com elsevier.com true 2010-04-23 10.1016/j.micpath.2026.108323 noindex journal © 2026 The Authors. 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