b364a0020998cdd1b249c0eb8bb6b81d mbi_a2026m5v17n5pe03665-25.pdf 48b513928d4b45c6b96159593be9d302bb7f5426 mbi_a2026m5v17n5pe03665-25.pdf f7e5c79ae05505fcf743d43a40368f7743b289dea2153ed55d2ff0c2bd3ab45d mbi_a2026m5v17n5pe03665-25.pdf Title: mGem: Population genomics of Staphylococcus aureus bacteremia and the impact of the COVID-19 pandemic Subject: mBio 2026.17:e03665-25 Keywords: Staphylococcus aureus, bacteremia, population genomics Author: Miquel Sánchez-Osuna, Ana Beatriz Garcez Buiatte, Rebecca Wang, Oriol Gasch, Isabella W. Martin, Cheryl P. Andam, Oscar Q. 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referenced object 'fig-caption-kriyadocs-F2_0' cannot be found ID: PDF-HUL-122 Offset: 1569971 MIMEtype: application/pdf Profile: Tagged PDF PDFMetadata: Objects: 0 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: true NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Language: EN Outlines: Item: Title: mGem: Population genomics of Staphylococcus aureus bacteremia and the impact of the COVID-19 pandemic Children: Item: Title: CLINICAL EPIDEMIOLOGY OF STAPHYLOCOCCUS AUREUS BACTEREMIA Item: Title: POPULATION STRUCTURE AND TEMPORAL DYNAMICS OF SAB LINEAGES Item: Title: GENETIC DETERMINANTS OF ANTIMICROBIAL RESISTANCE AND VIRULENCE Item: Title: CONCLUSIONS AND FUTURE DIRECTIONS Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 32 ImageHeight: 51 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 557 ImageHeight: 136 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 4246 ImageHeight: 2350 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2467 ImageHeight: 2238 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 33 ImageHeight: 32 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type1: Font: BaseFont: EBCCDV+MyriadPro-Regular FontSubset: true FirstChar: 32 LastChar: 150 FontDescriptor: FontName: EBCCDV+MyriadPro-Regular Flags: Nonsymbolic FontBBox: -157, -250, 1126, 952 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EBCCDV+MyriadPro-Light FontSubset: true FirstChar: 32 LastChar: 130 FontDescriptor: FontName: EBCCDV+MyriadPro-Light Flags: Nonsymbolic FontBBox: -153, -250, 1046, 935 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EBCCDV+MyriadPro-Semibold FontSubset: true FirstChar: 32 LastChar: 129 FontDescriptor: FontName: EBCCDV+MyriadPro-Semibold Flags: Nonsymbolic FontBBox: -161, -250, 1198, 973 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EBCCDV+MyriadPro-Light FontSubset: true FirstChar: 99 LastChar: 129 FontDescriptor: FontName: EBCCDV+MyriadPro-Light Flags: Nonsymbolic FontBBox: -153, -250, 1046, 935 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EBCCDV+MyriadPro-SemiboldIt FontSubset: true FirstChar: 32 LastChar: 121 FontDescriptor: FontName: EBCCDV+MyriadPro-SemiboldIt Flags: Nonsymbolic, Italic FontBBox: -193, -250, 1164, 972 FontFile3: true ToUnicode: true Font: BaseFont: EBCCDV+MyriadPro-It FontSubset: true FirstChar: 32 LastChar: 128 FontDescriptor: FontName: EBCCDV+MyriadPro-It Flags: Nonsymbolic, Italic FontBBox: -185, -250, 1090, 953 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: EBCCDV+MyriadPro-Bold FontSubset: true FirstChar: 49 LastChar: 56 FontDescriptor: FontName: EBCCDV+MyriadPro-Bold Flags: Nonsymbolic FontBBox: -163, -250, 1256, 989 FontFile3: true ToUnicode: true Font: BaseFont: Times-Roman Encoding: WinAnsiEncoding Font: BaseFont: EBCCDV+MyriadPro-Regular FontSubset: true FirstChar: 44 LastChar: 149 FontDescriptor: FontName: EBCCDV+MyriadPro-Regular Flags: Nonsymbolic FontBBox: -157, -250, 1126, 952 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true XMP: application/pdfmGem: Population genomics of Staphylococcus aureus bacteremia and the impact of the COVID-19 pandemicmBio03665-25Miquel Sánchez-OsunaAna Beatriz Garcez BuiatteRebecca WangOriol GaschIsabella W. MartinCheryl P. AndamOscar Q. PichMiquel Sánchez-OsunaAna Beatriz Garcez BuiatteRebecca WangOriol GaschIsabella W. MartinCheryl P. AndamOscar Q. PichAmerican Society for MicrobiologyCopyright © 2026 Sánchez-Osuna et al.This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.20262023The pressure of the coronavirus disease 2019 (COVID-19) pandemic on global healthcare systems and societies was unprecedented in the modern era. Social restrictions, containment measures, and disruptions in antimicrobial prescriptions and consumption during the pandemic have been reported to alter the epidemiology of bacterial diseases, although these effects likely differed markedly between locations. Here, we compare the clinical, clonal distribution, and genomic features of Staphylococcus aureus bloodstream isolates before, during, and after COVID-19 in two hospitals on different continents: Parc Taulí University Hospital (Spain) and Dartmouth-Hitchcock Medical Center (USA). We hypothesize that pandemic-related environmental perturbations, such as those due to infection control practices and antimicrobial exposure, may have contributed to shifts in the diversity of circulating bacterial lineages and genomic elements. Our findings revealed changes in the distribution of low-frequency clones, antimicrobial resistance genes, and virulence factors, potentially reflecting changes in selective pressures in clinical environments.20251205202603182150-7511uuid:c4574117-29d5-4e7f-9929-4b859017c8c8uuid:31851681-eabb-4aed-b9eb-a63f6466e59f Antenna House PDF Output Library 7.4.1901 Antenna House XSL Formatter V7.4 MR2 Linux : 7.4.3.63807 (2024-03-22T11:49+09) 2026-05-06T09:05:42+00:00 2026-05-06T09:05:42+00:00 2026-05-06T09:05:42+00:00 1a1a64cf-7d75-40c3-87cc-b826abdda709 1 Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Contents: CrossMarkLogoLink Rect: 505, 701, 544, 742 LastModified: D:20260506090542+00'00' Flags: Print Annotation: Subtype: Link Contents: 10.1128/mbio.03665-25 Rect: 462, 23, 534, 32 LastModified: D:20260506090542+00'00' Flags: Print Annotation: Subtype: Link Contents: ExternalLinking Rect: 391, 47, 536, 65 LastModified: D:20260506090542+00'00' Flags: Print Annotation: 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