29415ed291583568cdb07f8c3be55df7  s12864_025_12217_1.pdf
dba250ccb7d9b90d7eeb7c8a979042a44d5831b2  s12864_025_12217_1.pdf
3bd98e820d19a43545dcd8de0aeb38b92b7288cf21db2aa630dfa9d714717715  s12864_025_12217_1.pdf

Creator:         Adobe InDesign 18.0 (Windows)
Producer:        Adobe PDF Library 17.0; modified using iText® 5.5.13.4 ©2000-2024 iText Group NV (SPRINGER SBM; licensed version)
CreationDate:    Wed Dec 17 05:14:46 2025 CET
ModDate:         Wed Jan 21 12:24:43 2026 CET
Custom Metadata: yes
Metadata Stream: yes
Tagged:          yes
UserProperties:  no
Suspects:        no
Form:            none
JavaScript:      no
Pages:           10
Encrypted:       no
Page size:       595.276 x 793.701 pts
Page rot:        0
File size:       4522642 bytes
Optimized:       no
PDF version:     1.4


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
MyriadPro-Light                      Type 1C           Custom           yes no  yes     66  0
MyriadPro-Bold                       Type 1C           Custom           yes no  yes     41  0
MyriadPro-Regular                    Type 1C           Custom           yes no  yes     40  0
MyriadPro-It                         Type 1C           WinAnsi          yes no  yes    960  0
MyriadPro-Semibold                   Type 1C           Custom           yes no  yes     44  0
MyriadPro-LightIt                    Type 1C           WinAnsi          yes no  yes     67  0
MyriadPro-Bold                       Type 1C           WinAnsi          yes no  yes   1016  0
WarnockPro-Regular                   Type 1C           Custom           yes no  yes     42  0
WarnockPro-It                        Type 1C           Custom           yes no  yes     43  0
WarnockPro-Light                     Type 1C           Custom           yes no  yes     45  0
MyriadPro-Regular                    Type 1C           WinAnsi          yes no  yes     52  0
MyriadPro-It                         Type 1C           WinAnsi          yes no  yes     55  0
UZZQLK+TimesNewRomanPSMT             TrueType          WinAnsi          yes yes yes     68  0
MyriadPro-Regular                    Type 1C           WinAnsi          yes no  yes    240  0
MyriadPro-It                         Type 1C           WinAnsi          yes no  yes    243  0
FAMEJO+STIX-Regular                  Type 1C           Custom           yes yes yes    127  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2026-06-30 04:14:02 CEST
 RepresentationInformation: s12864_025_12217_1.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2026-06-29 13:59:34 CEST
  Size: 4522642
  Format: PDF
  Version: 1.4
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  Profile: Tagged PDF
  PDFMetadata: 
   Objects: 1056
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: false
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: en-US
    Outlines: 
     Item: 
      Title: Sex chromosome dosage compensation in a sex reversing skink is not influenced by sexual phenotype
      Children: 
       Item: 
        Title: Abstract
       Item: 
        Title: Introduction
       Item: 
        Title: Results
        Children: 
         Item: 
          Title: Genome assembly summary
         Item: 
          Title: Sex chromosome summary
         Item: 
          Title: Dosage compensation of the X chromosome
       Item: 
        Title: Discussion
       Item: 
        Title: Conclusions
       Item: 
        Title: Materials and methods
        Children: 
         Item: 
          Title: Sample collection and sexing
         Item: 
          Title: RNA extraction and sequencing
         Item: 
          Title: DNA extraction and sequencing for assembly
         Item: 
          Title: Genome assembly
         Item: 
          Title: Annotation
         Item: 
          Title: Read depth analysis
         Item: 
          Title: Bioinformatics analysis of RNA-seq
         Item: 
          Title: Gene ontology and gene function
       Item: 
        Title: References
   Info: 
    Creator: Adobe InDesign 18.0 (Windows)
    Producer: Adobe PDF Library 17.0; modified using iText® 5.5.13.4 ©2000-2024 iText Group NV (SPRINGER SBM; licensed version)
    CreationDate: Wed Dec 17 05:14:46 CET 2025
    ModDate: Wed Jan 21 12:24:43 CET 2026
   ID: 0xb8ee64fce7ac284691d919377aee36b0, 0xbb88c052ee2e29fd442c18bb5736c5b7
   Filters: 
    FilterPipeline: FlateDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1946
      ImageHeight: 2172
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1946
      ImageHeight: 1732
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1100
      ImageHeight: 90
      BitsPerSample: 1
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     ImageMask: true
     Decode: 0, 1
     Name: X
   Fonts: 
    Type1: 
     Font: 
      BaseFont: MyriadPro-It
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-It
       Flags: Nonsymbolic, Italic
       FontBBox: -185, -250, 1090, 953
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Light
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Light
       Flags: Nonsymbolic
       FontBBox: -49, -250, 1046, 883
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-LightIt
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-LightIt
       Flags: Nonsymbolic, Italic
       FontBBox: -121, -250, 1007, 863
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Regular
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Regular
       Flags: Nonsymbolic
       FontBBox: -157, -250, 1126, 952
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Bold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Bold
       Flags: Nonsymbolic
       FontBBox: -163, -250, 1256, 989
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: WarnockPro-Regular
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: WarnockPro-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -177, -533, 1474, 950
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: WarnockPro-It
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: WarnockPro-It
       Flags: Serif, Nonsymbolic, Italic
       FontBBox: -222, -533, 1474, 950
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Semibold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Semibold
       Flags: Nonsymbolic
       FontBBox: -161, -250, 1198, 972
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: WarnockPro-Light
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: WarnockPro-Light
       Flags: Serif, Nonsymbolic
       FontBBox: -176, -515, 1437, 929
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: FAMEJO+STIX-Regular
      FontSubset: true
      FirstChar: 31
      LastChar: 31
      FontDescriptor: 
       FontName: FAMEJO+STIX-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -970, -486, 2208, 1023
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
    TrueType: 
     Font: 
      BaseFont: UZZQLK+TimesNewRomanPSMT
      FontSubset: true
      FirstChar: 32
      LastChar: 32
      FontDescriptor: 
       FontName: UZZQLK+TimesNewRomanPSMT
       Flags: Serif, Nonsymbolic
       FontBBox: -568, -307, 2046, 1040
       FontFile2: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="Adobe XMP Core 5.1.0-jc003">
  <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
    <rdf:Description rdf:about=""
        xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/"
        xmlns:stRef="http://ns.adobe.com/xap/1.0/sType/ResourceRef#"
        xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#"
        xmlns:xmp="http://ns.adobe.com/xap/1.0/"
        xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/"
        xmlns:crossmark="http://crossref.org/crossmark/1.0/"
        xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/"
        xmlns:jav="http://www.niso.org/schemas/jav/1.0/"
        xmlns:dc="http://purl.org/dc/elements/1.1/"
        xmlns:pdf="http://ns.adobe.com/pdf/1.3/"
        xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/"
        xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/"
        xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#"
        xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#"
        xmlns:pdfaType="http://www.aiim.org/pdfa/ns/type#"
      xmpMM:InstanceID="uuid:12c5d6de-5acb-4971-aea0-3a5294d4fea4"
      xmpMM:OriginalDocumentID="adobe:docid:indd:aca9e6a3-b7bc-11dd-9b31-8d92eded7c31"
      xmpMM:DocumentID="xmp.id:bf35da42-b561-294a-ac7f-621601a266d7"
      xmpMM:RenditionClass="proof:pdf"
      xmpMM:VersionID="1"
      xmp:CreateDate="2025-12-17T05:14:46+01:00"
      xmp:ModifyDate="2026-01-21T12:24:43+01:00"
      xmp:MetadataDate="2026-01-21T12:24:43+01:00"
      xmp:CreatorTool="Adobe InDesign 18.0 (Windows)"
      prism:aggregationType="journal"
      crossmark:DOI="10.1186/s12864-025-12217-1"
      crossmark:MajorVersionDate="2010-04-23"
      crossmark:CrossmarkDomainExclusive="true"
      pdfx:CrossmarkMajorVersionDate="2010-04-23"
      pdfx:CrossmarkDomainExclusive="true"
      pdfx:doi="10.1186/s12864-025-12217-1"
      jav:journal_article_version="VoR"
      dc:format="application/pdf"
      pdf:Producer="Adobe PDF Library 17.0; modified using iText® 5.5.13.4 ©2000-2024 iText Group NV (SPRINGER SBM; licensed version)"
      pdf:Trapped="False"
      pdfaid:part="2"
      pdfaid:conformance="B">
      <xmpMM:DerivedFrom
        stRef:instanceID="xmp.iid:48d57dc8-b163-1840-8875-ebf7a5c91703"
        stRef:documentID="xmp.did:37b27164-ad68-264a-8f29-b2ee4324817c"
        stRef:renditionClass="default"/>
      <xmpMM:History>
        <rdf:Seq>
          <rdf:li
            stEvt:action="converted"
            stEvt:parameters="from application/x-indesign to application/pdf"
            stEvt:softwareAgent="Adobe InDesign 18.0 (Windows)"
            stEvt:when="2025-12-17T05:14:46+01:00"/>
          <rdf:li
            stEvt:action="converted"
            stEvt:instanceID="uuid:b60caee6-df39-48e9-be1c-0322fcba33ed"
            stEvt:parameters="converted to PDF/A-2b"
            stEvt:softwareAgent="pdfToolbox"
            stEvt:when="2025-12-17T07:50:04+01:00"/>
        </rdf:Seq>
      </xmpMM:History>
      <crossmark:CrossMarkDomains>
        <rdf:Seq>
          <rdf:li>springer.com</rdf:li>
          <rdf:li>springerlink.com</rdf:li>
        </rdf:Seq>
      </crossmark:CrossMarkDomains>
      <pdfx:CrossMarkDomains>
        <rdf:Seq>
          <rdf:li>springer.com</rdf:li>
          <rdf:li>springerlink.com</rdf:li>
        </rdf:Seq>
      </pdfx:CrossMarkDomains>
      <pdfaExtension:schemas>
        <rdf:Bag>
          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://ns.adobe.com/pdf/1.3/"
              pdfaSchema:prefix="pdf"
              pdfaSchema:schema="Adobe PDF">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="A name object indicating whether the document has been modified to include trapping information"
                  pdfaProperty:name="Trapped"
                  pdfaProperty:valueType="Text"/>
              </rdf:Seq>
            </pdfaSchema:property>
            </rdf:Description>
          </rdf:li>
          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://ns.adobe.com/xap/1.0/mm/"
              pdfaSchema:prefix="xmpMM"
              pdfaSchema:schema="XMP Media Management">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="UUID based identifier for specific incarnation of a document"
                  pdfaProperty:name="InstanceID"
                  pdfaProperty:valueType="URI"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="The common identifier for all versions and renditions of a document."
                  pdfaProperty:name="OriginalDocumentID"
                  pdfaProperty:valueType="URI"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original."
                  pdfaProperty:name="DerivedFrom"
                  pdfaProperty:valueType="ResourceRef"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="An unordered array of references to resources that were incorporated, by inclusion or reference, into this document."
                  pdfaProperty:name="Ingredients"
                  pdfaProperty:valueType="Bag ResourceRef"/>
              </rdf:Seq>
            </pdfaSchema:property>
            <pdfaSchema:valueType>
              <rdf:Seq>
                <rdf:li
                  pdfaType:description="Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced."
                  pdfaType:namespaceURI="http://ns.adobe.com/xap/1.0/sType/Part#"
                  pdfaType:prefix="stPart"
                  pdfaType:type="Part"/>
              </rdf:Seq>
            </pdfaSchema:valueType>
            </rdf:Description>
          </rdf:li>
          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://ns.adobe.com/xap/1.0/t/pg/"
              pdfaSchema:prefix="xmpTPg"
              pdfaSchema:schema="XMP Paged-Text">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="A structure containing the characteristics of a font used in a document"
                  pdfaProperty:name="Fonts"
                  pdfaProperty:valueType="Bag Font"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents)."
                  pdfaProperty:name="PlateNames"
                  pdfaProperty:valueType="Seq Text"/>
              </rdf:Seq>
            </pdfaSchema:property>
            <pdfaSchema:valueType>
              <rdf:Seq>
                <rdf:li
                  pdfaType:description="A structure containing the characteristics of a font used in a document."
                  pdfaType:namespaceURI="http://ns.adobe.com/xap/1.0/sType/Font#"
                  pdfaType:prefix="stFnt"
                  pdfaType:type="Font"/>
              </rdf:Seq>
            </pdfaSchema:valueType>
            </rdf:Description>
          </rdf:li>
          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://ns.adobe.com/pdfx/1.3/"
              pdfaSchema:prefix="pdfx"
              pdfaSchema:schema="pdfx">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="ID of PDF/X standard"
                  pdfaProperty:name="GTS_PDFXVersion"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Conformance level of PDF/X standard"
                  pdfaProperty:name="GTS_PDFXConformance"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Company creating the PDF"
                  pdfaProperty:name="Company"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Date when document was last modified"
                  pdfaProperty:name="SourceModified"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="Mirrors crossmark:CrosMarkDomains"
                  pdfaProperty:name="CrossMarkDomains"
                  pdfaProperty:valueType="Seq Text"/>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="Mirrors crossmark:CrossmarkDomainExclusive"
                  pdfaProperty:name="CrossmarkDomainExclusive"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="Mirrors crossmark:MajorVersionDate"
                  pdfaProperty:name="CrossmarkMajorVersionDate"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Mirrors crossmark:DOI"
                  pdfaProperty:name="doi"
                  pdfaProperty:valueType="Text"/>
              </rdf:Seq>
            </pdfaSchema:property>
            </rdf:Description>
          </rdf:li>
          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://www.aiim.org/pdfa/ns/id/"
              pdfaSchema:prefix="pdfaid"
              pdfaSchema:schema="PDF/A ID Schema">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Part of PDF/A standard"
                  pdfaProperty:name="part"
                  pdfaProperty:valueType="Integer"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Amendment of PDF/A standard"
                  pdfaProperty:name="amd"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Conformance level of PDF/A standard"
                  pdfaProperty:name="conformance"
                  pdfaProperty:valueType="Text"/>
              </rdf:Seq>
            </pdfaSchema:property>
            </rdf:Description>
          </rdf:li>
          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://crossref.org/crossmark/1.0/"
              pdfaSchema:prefix="crossmark"
              pdfaSchema:schema="crossmark">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="CrossMarkDomains"
                  pdfaProperty:name="CrossMarkDomains"
                  pdfaProperty:valueType="Seq Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="CrossmarkDomainExclusive"
                  pdfaProperty:name="CrossmarkDomainExclusive"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Usual same as prism:doi"
                  pdfaProperty:name="DOI"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="The date when a publication was published."
                  pdfaProperty:name="MajorVersionDate"
                  pdfaProperty:valueType="Text"/>
              </rdf:Seq>
            </pdfaSchema:property>
            </rdf:Description>
          </rdf:li>
          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://prismstandard.org/namespaces/basic/2.0/"
              pdfaSchema:prefix="prism"
              pdfaSchema:schema="Prism">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="The aggregation type specifies the unit of aggregation for a content collection. &#xA;Comment &#xA;PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. &#xA;Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. &#xA;&#xA;"
                  pdfaProperty:name="aggregationType"
                  pdfaProperty:valueType="Text"/>
              </rdf:Seq>
            </pdfaSchema:property>
            </rdf:Description>
          </rdf:li>
          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://www.niso.org/schemas/jav/1.0/"
              pdfaSchema:prefix="jav"
              pdfaSchema:schema="NISO">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="Values for Journal Article Version are one of the following:&#xA;AO = Author’s Original&#xA;SMUR = Submitted Manuscript Under Review&#xA;AM = Accepted Manuscript&#xA;P = Proof&#xA;VoR = Version of Record&#xA;CVoR = Corrected Version of Record&#xA;EVoR = Enhanced Version of Record"
                  pdfaProperty:name="journal_article_version"
                  pdfaProperty:valueType="Closed Choice of Text"/>
              </rdf:Seq>
            </pdfaSchema:property>
            </rdf:Description>
          </rdf:li>
        </rdf:Bag>
      </pdfaExtension:schemas>
    </rdf:Description>
  </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 418, 81, 530, 73
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 56, 750, 204, 740
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 508, 682, 540, 649
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 59, 611, 64, 598
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 128, 587, 133, 574
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 202, 551, 207, 538
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 212, 551, 217, 538
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 83, 491, 88, 478
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 193, 419, 198, 406
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 205, 419, 210, 406
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 256, 323, 261, 310
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 267, 323, 277, 310
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 132, 263, 141, 250
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 147, 263, 157, 250
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 175, 203, 185, 190
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 95, 191, 105, 178
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 87, 167, 97, 154
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 59, 119, 69, 106
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 108, 71, 118, 58
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 307, 695, 317, 682
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 401, 659, 411, 646
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 377, 647, 387, 634
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 520, 635, 525, 622
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 531, 635, 536, 622
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 304, 623, 314, 610
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 372, 587, 382, 574
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 387, 587, 397, 574
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 326, 251, 331, 238
       Flags: Print
       AppearanceDictionary: true
       Destination: 58
      Annotation: 
       Subtype: Link
       Rect: 371, 251, 376, 238
       Flags: Print
       AppearanceDictionary: true
       Destination: 72
      Annotation: 
       Subtype: Link
       Rect: 440, 227, 445, 214
       Flags: Print
       AppearanceDictionary: true
       Destination: 58
      Annotation: 
       Subtype: Link
       Rect: 429, 119, 434, 106
       Flags: Print
       AppearanceDictionary: true
       Destination: 72
     Thumb: true
    Page: 
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 501, 95, 506, 82
       Flags: Print
       AppearanceDictionary: true
       Destination: 58
      Annotation: 
       Subtype: Link
       Rect: 422, 178, 429, 168
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 148, 127, 156, 118
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
     Thumb: true
    Page: 
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 165, 467, 170, 454
       Flags: Print
       AppearanceDictionary: true
       Destination: 58
      Annotation: 
       Subtype: Link
       Rect: 159, 443, 164, 430
       Flags: Print
       AppearanceDictionary: true
       Destination: 58
      Annotation: 
       Subtype: Link
       Rect: 128, 407, 138, 394
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 119, 383, 129, 370
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 241, 347, 246, 334
       Flags: Print
       AppearanceDictionary: true
       Destination: 58
      Annotation: 
       Subtype: Link
       Rect: 523, 683, 533, 670
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 443, 563, 448, 550
       Flags: Print
       AppearanceDictionary: true
       Destination: 89
      Annotation: 
       Subtype: Link
       Rect: 479, 419, 484, 406
       Flags: Print
       AppearanceDictionary: true
       Destination: 89
      Annotation: 
       Subtype: Link
       Rect: 395, 359, 399, 346
       Flags: Print
       AppearanceDictionary: true
       Destination: 89
      Annotation: 
       Subtype: Link
       Rect: 455, 275, 460, 262
       Flags: Print
       AppearanceDictionary: true
       Destination: 89
      Annotation: 
       Subtype: Link
       Rect: 438, 191, 443, 178
       Flags: Print
       AppearanceDictionary: true
       Destination: 89
     Thumb: true
    Page: 
     Sequence: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 326, 155, 331, 142
       Flags: Print
       AppearanceDictionary: true
       Destination: 89
      Annotation: 
       Subtype: Link
       Rect: 385, 119, 390, 106
       Flags: Print
       AppearanceDictionary: true
       Destination: 89
     Thumb: true
    Page: 
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 123, 683, 128, 670
       Flags: Print
       AppearanceDictionary: true
       Destination: 89
      Annotation: 
       Subtype: Link
       Rect: 113, 647, 118, 634
       Flags: Print
       AppearanceDictionary: true
       Destination: 89
      Annotation: 
       Subtype: Link
       Rect: 203, 611, 208, 598
       Flags: Print
       AppearanceDictionary: true
       Destination: 89
      Annotation: 
       Subtype: Link
       Rect: 251, 467, 256, 454
       Flags: Print
       AppearanceDictionary: true
       Destination: 89
      Annotation: 
       Subtype: Link
       Rect: 156, 407, 161, 394
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 202, 395, 212, 382
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 59, 383, 69, 370
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 92, 347, 102, 334
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 109, 335, 119, 322
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 249, 335, 258, 322
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 334, 671, 343, 658
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 348, 671, 358, 658
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 339, 635, 344, 622
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 349, 635, 359, 622
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 505, 611, 515, 598
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 456, 587, 466, 574
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 471, 587, 481, 574
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 523, 515, 533, 502
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 386, 203, 391, 190
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 461, 143, 466, 130
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 376, 131, 386, 118
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 389, 119, 399, 106
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 371, 83, 381, 70
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 475, 71, 485, 58
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
     Thumb: true
    Page: 
     Sequence: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 133, 587, 143, 574
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 172, 71, 182, 58
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 482, 671, 492, 658
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 433, 635, 443, 622
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 327, 611, 337, 598
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 399, 575, 409, 562
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 448, 551, 457, 538
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 389, 479, 399, 466
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 375, 431, 384, 418
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 523, 431, 533, 418
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 472, 371, 482, 358
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 509, 359, 519, 346
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 369, 335, 530, 322
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 404, 323, 414, 310
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 307, 299, 317, 286
       Flags: Print
       AppearanceDictionary: true
       Destination: 174
      Annotation: 
       Subtype: Link
       Rect: 398, 95, 407, 82
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 389, 83, 399, 70
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
     Thumb: true
    Page: 
     Sequence: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 249, 707, 259, 694
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 260, 683, 269, 670
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 125, 587, 135, 574
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 124, 575, 134, 562
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 217, 551, 227, 538
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 237, 539, 247, 526
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 95, 467, 104, 454
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 59, 311, 69, 298
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 155, 263, 165, 250
       Flags: Print
       AppearanceDictionary: true
       Destination: 190
      Annotation: 
       Subtype: Link
       Rect: 248, 227, 287, 218
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 56, 218, 150, 209
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 325, 380, 445, 372
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 383, 308, 508, 300
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 141, 287, 247, 279
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 232, 188, 287, 180
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 71, 179, 122, 171
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 490, 638, 538, 630
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 319, 629, 383, 621
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 379, 566, 497, 558
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 336, 539, 442, 531
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 505, 134, 534, 126
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 319, 125, 375, 117
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 531, 116, 537, 108
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 319, 107, 448, 99
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 88, 701, 257, 693
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
  Checksum: 547ce78e
   Type: CRC32
  Checksum: 29415ed291583568cdb07f8c3be55df7
   Type: MD5
  Checksum: dba250ccb7d9b90d7eeb7c8a979042a44d5831b2
   Type: SHA-1
  Checksum: 3bd98e820d19a43545dcd8de0aeb38b92b7288cf21db2aa630dfa9d714717715
   Type: SHA-256