287f8dc28820676a14b7c3e0c9cbec42  s00384-026-05112-y.pdf
ff4904a44fa74d841df2f5aed5dd529e33e79417  s00384-026-05112-y.pdf
83fb576e41dfdf58c72a388e62a8a81d938d47ec48d9ffaa4a51e0262263c9c4  s00384-026-05112-y.pdf

Title:           Chemoradiotherapy and transanal endoscopic surgery versus transanal endoscopic surgery alone in T1N0M0 rectal cancer: a multicenter, randomized, controlled, phase III clinical trial (TAUTEM-T1 study)
Subject:         International Journal of Colorectal Disease, https://doi.org/10.1007/s00384-026-05112-y
Keywords:        Rectal cancer;Neoadjuvant treatment and rectal cancer;Local excision and rectal cancer;Transanal endoscopic microsurgery (TEM);Total mesorectal excision (TME)
Author:           Xavier Serra-Aracil 
Creator:         Adobe InDesign 15.1 (Windows)
Producer:        Adobe PDF Library 15.0; modified using iText® 5.5.13.4 ©2000-2024 iText Group NV (SPRINGER SBM; licensed version)
CreationDate:    Wed Apr 22 23:22:10 2026 CEST
ModDate:         Fri Jun  5 03:42:53 2026 CEST
Custom Metadata: yes
Metadata Stream: yes
Tagged:          no
UserProperties:  no
Suspects:        no
Form:            none
JavaScript:      no
Pages:           13
Encrypted:       no
Page size:       595.276 x 790.866 pts
Page rot:        0
File size:       1083542 bytes
Optimized:       no
PDF version:     1.4


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
MyriadPro-SemiCn                     Type 1C           WinAnsi          yes no  yes     76  0
MyriadPro-Semibold                   Type 1C           Custom           yes no  yes    437  0
MyriadPro-SemiboldSemiCn             Type 1C           Custom           yes no  yes    107  0
MyriadPro-Bold                       Type 1C           Custom           yes no  yes     77  0
VUOXFH+STIX-Regular                  Type 1C           Custom           yes yes yes     79  0
CQGTGO+MyriadPro-SemiCn2             Type 1C           WinAnsi          yes yes yes    527  0
MyriadPro-BoldSemiCn                 Type 1C           Custom           yes no  yes     78  0
EGBIWP+STIXMath-Regular              Type 1C           Custom           yes yes yes    108  0
STIX-Italic                          Type 1C           WinAnsi          yes no  yes    151  0
HPCIMJ+TimesNewRomanPSMT             CID TrueType      Identity-H       yes yes yes    161  0
AHQSSX+Code2000                      CID TrueType      Identity-H       yes yes yes    162  0
QLPCCM+Wingdings-Regular             Type 1C           WinAnsi          yes yes yes    438  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2026-07-21 03:56:34 CEST
 RepresentationInformation: s00384-026-05112-y.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2026-07-20 12:19:02 CEST
  Size: 1083542
  Format: PDF
  Version: 1.4
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 611
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: false
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: en-US
    Outlines: 
     Item: 
      Title: Chemoradiotherapy and transanal endoscopic surgery versus transanal endoscopic surgery alone in T1N0M0 rectal cancer: a multicenter, randomized, controlled, phase III clinical trial (TAUTEM-T1 study)
      Children: 
       Item: 
        Title: Abstract
        Children: 
         Item: 
          Title: Purpose 
         Item: 
          Title: Methods 
         Item: 
          Title: Results 
         Item: 
          Title: Conclusion 
         Item: 
          Title: Trial registration 
       Item: 
        Title: Introduction
       Item: 
        Title: Hypothesis and objectives
        Children: 
         Item: 
          Title: Hypothesis
       Item: 
        Title: Objectives
        Children: 
         Item: 
          Title: Primary objective
         Item: 
          Title: Secondary objectives
       Item: 
        Title: Methods
        Children: 
         Item: 
          Title: Study design
         Item: 
          Title: Patients – study population
         Item: 
          Title: Inclusion criteria
         Item: 
          Title: Exclusion criteria
         Item: 
          Title: Recruitment and study scope
         Item: 
          Title: Informed consent and legal considerations
         Item: 
          Title: Randomization
         Item: 
          Title: Study procedures (Fig. 1)
         Item: 
          Title: Chemoradiotherapy-TEM group (CRT-TEM)
          Children: 
           Item: 
            Title: Neoadjuvant treatment: preoperative CRT (long-course regimen)
           Item: 
            Title: Local excision by transanal endoscopic surgery
         Item: 
          Title: TEM group (TEM)
         Item: 
          Title: Pathological study
         Item: 
          Title: Definition of clinical and pathological response to preoperative chemoradiotherapy
         Item: 
          Title: Criteria for exiting the study protocol
         Item: 
          Title: Follow-up (Fig. 1)
         Item: 
          Title: Study variables
          Children: 
           Item: 
            Title: Primary variable (endpoint)
           Item: 
            Title: Secondary variables
         Item: 
          Title: Sample size
         Item: 
          Title: Interim analysis and stopping rules
         Item: 
          Title: Study monitoring
         Item: 
          Title: Statistical analysis
       Item: 
        Title: Discussion
       Item: 
        Title: Conclusion
       Item: 
        Title: Acknowledgements 
       Item: 
        Title: References
   Info: 
    Title: Chemoradiotherapy and transanal endoscopic surgery versus transanal endoscopic surgery alone in T1N0M0 rectal cancer: a multicenter, randomized, controlled, phase III clinical trial (TAUTEM-T1 study)
    Author:  Xavier Serra-Aracil 
    Subject: International Journal of Colorectal Disease, https://doi.org/10.1007/s00384-026-05112-y
    Keywords: Rectal cancer;Neoadjuvant treatment and rectal cancer;Local excision and rectal cancer;Transanal endoscopic microsurgery (TEM);Total mesorectal excision (TME)
    Creator: Adobe InDesign 15.1 (Windows)
    Producer: Adobe PDF Library 15.0; modified using iText® 5.5.13.4 ©2000-2024 iText Group NV (SPRINGER SBM; licensed version)
    CreationDate: Wed Apr 22 23:22:10 CEST 2026
    ModDate: Fri Jun 05 03:42:53 CEST 2026
   ID: 0x16abbeb5e97db848ade9ad6f93af68a0, 0x6f1744ec7d5fc156f6c1857076e31011
   Filters: 
    FilterPipeline: FlateDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1950
      ImageHeight: 2599
      ColorSpace: black is zero
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
     Intent: RelativeColorimetric
     Name: X
   Fonts: 
    Type0: 
     Font: 
      BaseFont: HPCIMJ+TimesNewRomanPSMT
      Encoding: Identity-H
      ToUnicode: true
     Font: 
      BaseFont: AHQSSX+Code2000
      Encoding: Identity-H
      ToUnicode: true
    Type1: 
     Font: 
      BaseFont: MyriadPro-Semibold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Semibold
       Flags: Nonsymbolic
       FontBBox: -161, -250, 1198, 972
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: QLPCCM+Wingdings-Regular
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: QLPCCM+Wingdings-Regular
       Flags: Nonsymbolic
       FontBBox: 0, -103, 1359, 439
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: STIX-Italic
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: STIX-Italic
       Flags: Serif, Nonsymbolic, Italic
       FontBBox: -970, -305, 1429, 1023
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-SemiboldSemiCn
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-SemiboldSemiCn
       Flags: Nonsymbolic
       FontBBox: -131, -250, 1115, 886
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-SemiCn
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-SemiCn
       Flags: Nonsymbolic
       FontBBox: -128, -250, 1059, 876
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: EGBIWP+STIXMath-Regular
      FontSubset: true
      FirstChar: 31
      LastChar: 32
      FontDescriptor: 
       FontName: EGBIWP+STIXMath-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -970, -524, 3238, 2566
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Bold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Bold
       Flags: Nonsymbolic
       FontBBox: -163, -250, 1256, 989
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-BoldSemiCn
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-BoldSemiCn
       Flags: Nonsymbolic
       FontBBox: -133, -250, 1161, 894
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: VUOXFH+STIX-Regular
      FontSubset: true
      FirstChar: 20
      LastChar: 252
      FontDescriptor: 
       FontName: VUOXFH+STIX-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -970, -486, 2208, 1023
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
    CIDFontType2: 
     Font: 
      BaseFont: HPCIMJ+TimesNewRomanPSMT
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: HPCIMJ+TimesNewRomanPSMT
       Flags: Serif, Symbolic
       FontBBox: -568, -307, 2046, 1040
       FontFile2: true
     Font: 
      BaseFont: AHQSSX+Code2000
      CIDSystemInfo: 
       Registry: Adobe
       Registry: Identity
       Supplement: 0
      FontDescriptor: 
       FontName: AHQSSX+Code2000
       Flags: Serif, Symbolic
       FontBBox: -1111, -295, 2107, 977
       FontFile2: true
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="Adobe XMP Core 5.1.0-jc003">
  <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
    <rdf:Description rdf:about=""
        xmlns:xmp="http://ns.adobe.com/xap/1.0/"
        xmlns:pdf="http://ns.adobe.com/pdf/1.3/"
        xmlns:dc="http://purl.org/dc/elements/1.1/"
        xmlns:crossmark="http://crossref.org/crossmark/1.0/"
        xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/"
        xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/"
        xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/"
        xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#"
        xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/"
        xmlns:sn="http://springernature.com/ns/xmpExtensions/2.0/"
        xmlns:author="http://springernature.com/ns/xmpExtensions/2.0/authorInfo/"
        xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/"
        xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#"
        xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#"
        xmlns:pdfaType="http://www.aiim.org/pdfa/ns/type#"
        xmlns:pdfaField="http://www.aiim.org/pdfa/ns/field#"
      xmp:CreateDate="2026-04-23T05:22:10+08:00"
      xmp:CreatorTool="Adobe InDesign 15.1 (Windows)"
      xmp:ModifyDate="2026-06-05T03:42:53+02:00"
      xmp:MetadataDate="2026-06-05T03:42:53+02:00"
      pdf:Producer="Adobe PDF Library 15.0; modified using iText® 5.5.13.4 ©2000-2024 iText Group NV (SPRINGER SBM; licensed version)"
      pdf:Keywords="Rectal cancer;Neoadjuvant treatment and rectal cancer;Local excision and rectal cancer;Transanal endoscopic microsurgery (TEM);Total mesorectal excision (TME)"
      pdf:Trapped="False"
      dc:format="application/pdf"
      dc:identifier="https://doi.org/10.1007/s00384-026-05112-y"
      crossmark:DOI="10.1007/s00384-026-05112-y"
      crossmark:MajorVersionDate="2010-04-23"
      crossmark:CrossmarkDomainExclusive="true"
      prism:url="https://doi.org/10.1007/s00384-026-05112-y"
      prism:doi="10.1007/s00384-026-05112-y"
      prism:issn="1432-1262"
      prism:aggregationType="journal"
      prism:publicationName="International Journal of Colorectal Disease"
      prism:copyright="The Author(s)"
      pdfx:CrossmarkMajorVersionDate="2010-04-23"
      pdfx:CrossmarkDomainExclusive="true"
      pdfx:doi="10.1007/s00384-026-05112-y"
      pdfx:robots="noindex"
      xmpMM:DocumentID="uuid:702b7d52-6945-44ac-b19c-cc3fedaf7ff9"
      xmpMM:InstanceID="uuid:2407ec47-dc1f-47f2-aa3d-1a3c7abf1070"
      xmpMM:RenditionClass="default"
      xmpMM:VersionID="1"
      pdfaid:part="2"
      pdfaid:conformance="B">
      <dc:publisher>
        <rdf:Bag>
          <rdf:li>Springer Berlin Heidelberg</rdf:li>
        </rdf:Bag>
      </dc:publisher>
      <dc:description>
        <rdf:Alt>
          <rdf:li xml:lang="x-default">International Journal of Colorectal Disease, https://doi.org/10.1007/s00384-026-05112-y</rdf:li>
        </rdf:Alt>
      </dc:description>
      <dc:subject>
        <rdf:Bag>
          <rdf:li>Rectal cancer</rdf:li>
          <rdf:li>Neoadjuvant treatment and rectal cancer</rdf:li>
          <rdf:li>Local excision and rectal cancer</rdf:li>
          <rdf:li>Transanal endoscopic microsurgery (TEM)</rdf:li>
          <rdf:li>Total mesorectal excision (TME)</rdf:li>
        </rdf:Bag>
      </dc:subject>
      <dc:title>
        <rdf:Alt>
          <rdf:li xml:lang="x-default">Chemoradiotherapy and transanal endoscopic surgery versus transanal endoscopic surgery alone in T1N0M0 rectal cancer: a multicenter, randomized, controlled, phase III clinical trial (TAUTEM-T1 study)</rdf:li>
        </rdf:Alt>
      </dc:title>
      <dc:creator>
        <rdf:Seq>
          <rdf:li> Xavier Serra-Aracil </rdf:li>
          <rdf:li> Anna Nonell </rdf:li>
          <rdf:li> Cristina Gener-Jorge </rdf:li>
          <rdf:li> Carles Pericay </rdf:li>
          <rdf:li> Thomas Golda </rdf:li>
          <rdf:li> Esther Kreisler </rdf:li>
          <rdf:li> Eloy Espin-Basany </rdf:li>
          <rdf:li> Anna Pallisera </rdf:li>
          <rdf:li> Jesus Badia-Closa </rdf:li>
          <rdf:li> Beatriz Espina </rdf:li>
          <rdf:li> Nerea Borda-Arrizabalaga </rdf:li>
          <rdf:li> Angel Reina </rdf:li>
          <rdf:li> Hector Guadalajara-Labajo </rdf:li>
          <rdf:li> Ana Otero </rdf:li>
          <rdf:li> Salvadora Delgado </rdf:li>
          <rdf:li> Miquel Kraft </rdf:li>
          <rdf:li> Rosa Querol </rdf:li>
          <rdf:li> Blas Flor </rdf:li>
          <rdf:li> Gianluca Pellino </rdf:li>
          <rdf:li> Sebastiano Biondo </rdf:li>
          <rdf:li> Aleidis Caro-Tarrago </rdf:li>
          <rdf:li> Anna Serracant </rdf:li>
          <rdf:li> Albert Garcia-Nalda </rdf:li>
          <rdf:li> Mariana Caraballo </rdf:li>
          <rdf:li> Ana Belén Moreno Garcia </rdf:li>
          <rdf:li> Joan Carles Ferreres </rdf:li>
          <rdf:li> Miquel A. Segi </rdf:li>
          <rdf:li> Eloy Espin </rdf:li>
          <rdf:li> Alejandro Solís Peña </rdf:li>
          <rdf:li> Carmen Martinez-Sanchez </rdf:li>
          <rdf:li> Francis Rubio </rdf:li>
          <rdf:li> Damián Garcia Olmo </rdf:li>
          <rdf:li> Hector Guadalajara </rdf:li>
          <rdf:li> Miguel Leon Arellano </rdf:li>
          <rdf:li> Miguel Pera </rdf:li>
        </rdf:Seq>
      </dc:creator>
      <crossmark:CrossMarkDomains>
        <rdf:Seq>
          <rdf:li>springer.com</rdf:li>
          <rdf:li>springerlink.com</rdf:li>
        </rdf:Seq>
      </crossmark:CrossMarkDomains>
      <pdfx:CrossMarkDomains>
        <rdf:Seq>
          <rdf:li>springer.com</rdf:li>
          <rdf:li>springerlink.com</rdf:li>
        </rdf:Seq>
      </pdfx:CrossMarkDomains>
      <xmpMM:History>
        <rdf:Seq>
          <rdf:li
            stEvt:action="converted"
            stEvt:instanceID="uuid:702b7d52-6945-44ac-b19c-cc3fedaf7ff9"
            stEvt:parameters="converted to PDF/A-2b"
            stEvt:softwareAgent="pdfToolbox"
            stEvt:when="2026-04-23T20:25:13Z"/>
        </rdf:Seq>
      </xmpMM:History>
      <sn:authorInfo>
        <rdf:Bag>
          <rdf:li
            author:name=" Xavier Serra-Aracil "
            author:orcid="http://orcid.org/0000-0003-0291-1900"/>
        </rdf:Bag>
      </sn:authorInfo>
      <pdfaExtension:schemas>
        <rdf:Bag>
          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://ns.adobe.com/pdfx/1.3/"
              pdfaSchema:prefix="pdfx"
              pdfaSchema:schema="Adobe Document Info PDF eXtension Schema">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="Mirrors crossmark:MajorVersionDate"
                  pdfaProperty:name="CrossmarkMajorVersionDate"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="Mirrors crossmark:CrossmarkDomainExclusive"
                  pdfaProperty:name="CrossmarkDomainExclusive"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Mirrors crossmark:DOI"
                  pdfaProperty:name="doi"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="Mirrors crossmark:CrosMarkDomains"
                  pdfaProperty:name="CrossMarkDomains"
                  pdfaProperty:valueType="seq Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="A name object indicating whether the document has been modified to include trapping information"
                  pdfaProperty:name="robots"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="ID of PDF/X standard"
                  pdfaProperty:name="GTS_PDFXVersion"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Conformance level of PDF/X standard"
                  pdfaProperty:name="GTS_PDFXConformance"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Company creating the PDF"
                  pdfaProperty:name="Company"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Date when document was last modified"
                  pdfaProperty:name="SourceModified"
                  pdfaProperty:valueType="Text"/>
              </rdf:Seq>
            </pdfaSchema:property>
            </rdf:Description>
          </rdf:li>
          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://crossref.org/crossmark/1.0/"
              pdfaSchema:prefix="crossmark"
              pdfaSchema:schema="Crossmark Schema">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Usual same as prism:doi"
                  pdfaProperty:name="DOI"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="The date when a publication was publishe."
                  pdfaProperty:name="MajorVersionDate"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="CrossmarkDomainExclusive"
                  pdfaProperty:name="CrossmarkDomainExclusive"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="CrossMarkDomains"
                  pdfaProperty:name="CrossMarkDomains"
                  pdfaProperty:valueType="seq Text"/>
              </rdf:Seq>
            </pdfaSchema:property>
            </rdf:Description>
          </rdf:li>
          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://prismstandard.org/namespaces/basic/2.0/"
              pdfaSchema:prefix="prism"
              pdfaSchema:schema="Prism Schema">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary."
                  pdfaProperty:name="url"
                  pdfaProperty:valueType="URI"/>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="The Digital Object Identifier for the article.&#xA;The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). "
                  pdfaProperty:name="doi"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version."
                  pdfaProperty:name="issn"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Volume number"
                  pdfaProperty:name="volume"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Issue number"
                  pdfaProperty:name="number"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Starting page"
                  pdfaProperty:name="startingPage"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Ending page"
                  pdfaProperty:name="endingPage"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. "
                  pdfaProperty:name="aggregationType"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.”"
                  pdfaProperty:name="publicationName"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="Copyright"
                  pdfaProperty:name="copyright"
                  pdfaProperty:valueType="Text"/>
              </rdf:Seq>
            </pdfaSchema:property>
            </rdf:Description>
          </rdf:li>
          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://ns.adobe.com/pdf/1.3/"
              pdfaSchema:prefix="pdf"
              pdfaSchema:schema="Adobe PDF Schema">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="A name object indicating whether the document has been modified to include trapping information"
                  pdfaProperty:name="Trapped"
                  pdfaProperty:valueType="Text"/>
              </rdf:Seq>
            </pdfaSchema:property>
            </rdf:Description>
          </rdf:li>
          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://ns.adobe.com/xap/1.0/mm/"
              pdfaSchema:prefix="xmpMM"
              pdfaSchema:schema="XMP Media Management Schema">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="UUID based identifier for specific incarnation of a document"
                  pdfaProperty:name="InstanceID"
                  pdfaProperty:valueType="URI"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="The common identifier for all versions and renditions of a document."
                  pdfaProperty:name="DocumentID"
                  pdfaProperty:valueType="URI"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="The common identifier for all versions and renditions of a document."
                  pdfaProperty:name="OriginalDocumentID"
                  pdfaProperty:valueType="URI"/>
              </rdf:Seq>
            </pdfaSchema:property>
            </rdf:Description>
          </rdf:li>
          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://www.aiim.org/pdfa/ns/id/"
              pdfaSchema:prefix="pdfaid"
              pdfaSchema:schema="PDF/A ID Schema">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Part of PDF/A standard"
                  pdfaProperty:name="part"
                  pdfaProperty:valueType="Integer"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Amendment of PDF/A standard"
                  pdfaProperty:name="amd"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Conformance level of PDF/A standard"
                  pdfaProperty:name="conformance"
                  pdfaProperty:valueType="Text"/>
              </rdf:Seq>
            </pdfaSchema:property>
            </rdf:Description>
          </rdf:li>
          <rdf:li>
            <rdf:Description
              pdfaSchema:schema="Springer Nature ORCID Schema"
              pdfaSchema:namespaceURI="http://springernature.com/ns/xmpExtensions/2.0/"
              pdfaSchema:prefix="sn">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:name="authorInfo"
                  pdfaProperty:valueType="Bag AuthorInformation"
                  pdfaProperty:category="external"
                  pdfaProperty:description="Author information: contains the name of each author and his/her ORCiD (ORCiD: Open Researcher and Contributor ID). An ORCiD is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors."/>
              </rdf:Seq>
            </pdfaSchema:property>
            <pdfaSchema:valueType>
              <rdf:Seq>
                <rdf:li>
                  <rdf:Description
                    pdfaType:type="AuthorInformation"
                    pdfaType:namespaceURI="http://springernature.com/ns/xmpExtensions/2.0/authorInfo/"
                    pdfaType:prefix="author"
                    pdfaType:description="Specifies the types of author information: name and ORCID of an author.">
                  <pdfaType:field>
                    <rdf:Seq>
                      <rdf:li
                        pdfaField:name="name"
                        pdfaField:valueType="Text"
                        pdfaField:description="Gives the name of an author."/>
                      <rdf:li
                        pdfaField:name="orcid"
                        pdfaField:valueType="URI"
                        pdfaField:description="Gives the ORCID of an author."/>
                    </rdf:Seq>
                  </pdfaType:field>
                  </rdf:Description>
                </rdf:li>
              </rdf:Seq>
            </pdfaSchema:valueType>
            </rdf:Description>
          </rdf:li>
        </rdf:Bag>
      </pdfaExtension:schemas>
    </rdf:Description>
  </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 513, 726, 546, 694
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 132, 598, 144, 586
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 205, 143, 210, 128
       Flags: Print
       AppearanceDictionary: true
       Destination: 197
      Annotation: 
       Subtype: Link
       Rect: 214, 143, 219, 128
       Flags: Print
       AppearanceDictionary: true
       Destination: 197
      Annotation: 
       Subtype: Link
       Rect: 375, 193, 380, 178
       Flags: Print
       AppearanceDictionary: true
       Destination: 197
      Annotation: 
       Subtype: Link
       Rect: 453, 168, 458, 153
       Flags: Print
       AppearanceDictionary: true
       Destination: 197
      Annotation: 
       Subtype: Link
       Rect: 481, 118, 486, 103
       Flags: Print
       AppearanceDictionary: true
       Destination: 197
      Annotation: 
       Subtype: Link
       Rect: 492, 118, 497, 103
       Flags: Print
       AppearanceDictionary: true
       Destination: 228
     Thumb: true
    Page: 
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 54, 723, 59, 708
       Flags: Print
       AppearanceDictionary: true
       Destination: 228
      Annotation: 
       Subtype: Link
       Rect: 64, 723, 69, 708
       Flags: Print
       AppearanceDictionary: true
       Destination: 228
      Annotation: 
       Subtype: Link
       Rect: 171, 698, 176, 683
       Flags: Print
       AppearanceDictionary: true
       Destination: 228
      Annotation: 
       Subtype: Link
       Rect: 164, 635, 174, 620
       Flags: Print
       AppearanceDictionary: true
       Destination: 228
      Annotation: 
       Subtype: Link
       Rect: 281, 573, 286, 558
       Flags: Print
       AppearanceDictionary: true
       Destination: 197
      Annotation: 
       Subtype: Link
       Rect: 51, 560, 55, 545
       Flags: Print
       AppearanceDictionary: true
       Destination: 228
      Annotation: 
       Subtype: Link
       Rect: 97, 548, 102, 533
       Flags: Print
       AppearanceDictionary: true
       Destination: 197
      Annotation: 
       Subtype: Link
       Rect: 109, 535, 114, 520
       Flags: Print
       AppearanceDictionary: true
       Destination: 197
      Annotation: 
       Subtype: Link
       Rect: 205, 523, 215, 508
       Flags: Print
       AppearanceDictionary: true
       Destination: 228
      Annotation: 
       Subtype: Link
       Rect: 165, 398, 175, 383
       Flags: Print
       AppearanceDictionary: true
       Destination: 228
      Annotation: 
       Subtype: Link
       Rect: 169, 335, 179, 320
       Flags: Print
       AppearanceDictionary: true
       Destination: 228
      Annotation: 
       Subtype: Link
       Rect: 75, 285, 85, 270
       Flags: Print
       AppearanceDictionary: true
       Destination: 228
      Annotation: 
       Subtype: Link
       Rect: 171, 148, 181, 133
       Flags: Print
       AppearanceDictionary: true
       Destination: 228
      Annotation: 
       Subtype: Link
       Rect: 213, 110, 223, 95
       Flags: Print
       AppearanceDictionary: true
       Destination: 228
      Annotation: 
       Subtype: Link
       Rect: 379, 735, 389, 720
       Flags: Print
       AppearanceDictionary: true
       Destination: 228
      Annotation: 
       Subtype: Link
       Rect: 359, 698, 369, 683
       Flags: Print
       AppearanceDictionary: true
       Destination: 228
      Annotation: 
       Subtype: Link
       Rect: 372, 635, 382, 620
       Flags: Print
       AppearanceDictionary: true
       Destination: 228
      Annotation: 
       Subtype: Link
       Rect: 387, 635, 397, 620
       Flags: Print
       AppearanceDictionary: true
       Destination: 228
      Annotation: 
       Subtype: Link
       Rect: 469, 598, 479, 583
       Flags: Print
       AppearanceDictionary: true
       Destination: 228
      Annotation: 
       Subtype: Link
       Rect: 455, 548, 466, 533
       Flags: Print
       AppearanceDictionary: true
       Destination: 228
      Annotation: 
       Subtype: Link
       Rect: 386, 335, 396, 320
       Flags: Print
       AppearanceDictionary: true
       Destination: 228
      Annotation: 
       Subtype: Link
       Rect: 401, 335, 412, 320
       Flags: Print
       AppearanceDictionary: true
       Destination: 228
      Annotation: 
       Subtype: Link
       Rect: 491, 298, 501, 283
       Flags: Print
       AppearanceDictionary: true
       Destination: 228
      Annotation: 
       Subtype: Link
       Rect: 506, 298, 515, 283
       Flags: Print
       AppearanceDictionary: true
       Destination: 228
      Annotation: 
       Subtype: Link
       Rect: 354, 260, 364, 245
       Flags: Print
       AppearanceDictionary: true
       Destination: 228
      Annotation: 
       Subtype: Link
       Rect: 502, 223, 512, 208
       Flags: Print
       AppearanceDictionary: true
       Destination: 228
      Annotation: 
       Subtype: Link
       Rect: 517, 223, 527, 208
       Flags: Print
       AppearanceDictionary: true
       Destination: 228
     Thumb: true
    Page: 
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 459, 736, 469, 721
       Flags: Print
       AppearanceDictionary: true
       Destination: 228
      Annotation: 
       Subtype: Link
       Rect: 514, 624, 519, 609
       Flags: Print
       AppearanceDictionary: true
       Destination: 197
      Annotation: 
       Subtype: Link
       Rect: 525, 624, 530, 609
       Flags: Print
       AppearanceDictionary: true
       Destination: 197
      Annotation: 
       Subtype: Link
       Rect: 528, 374, 538, 359
       Flags: Print
       AppearanceDictionary: true
       Destination: 228
      Annotation: 
       Subtype: Link
       Rect: 309, 336, 319, 321
       Flags: Print
       AppearanceDictionary: true
       Destination: 228
      Annotation: 
       Subtype: Link
       Rect: 325, 336, 335, 321
       Flags: Print
       AppearanceDictionary: true
       Destination: 228
      Annotation: 
       Subtype: Link
       Rect: 401, 211, 411, 196
       Flags: Print
       AppearanceDictionary: true
       Destination: 228
      Annotation: 
       Subtype: Link
       Rect: 476, 124, 486, 109
       Flags: Print
       AppearanceDictionary: true
       Destination: 228
     Thumb: true
    Page: 
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 266, 624, 276, 609
       Flags: Print
       AppearanceDictionary: true
       Destination: 228
      Annotation: 
       Subtype: Link
       Rect: 225, 349, 235, 334
       Flags: Print
       AppearanceDictionary: true
       Destination: 228
      Annotation: 
       Subtype: Link
       Rect: 191, 336, 201, 321
       Flags: Print
       AppearanceDictionary: true
       Destination: 336
      Annotation: 
       Subtype: Link
       Rect: 233, 324, 243, 309
       Flags: Print
       AppearanceDictionary: true
       Destination: 336
      Annotation: 
       Subtype: Link
       Rect: 173, 274, 183, 259
       Flags: Print
       AppearanceDictionary: true
       Destination: 336
      Annotation: 
       Subtype: Link
       Rect: 410, 735, 415, 722
       Flags: Print
       AppearanceDictionary: true
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 382, 673, 393, 658
       Flags: Print
       AppearanceDictionary: true
       Destination: 336
      Annotation: 
       Subtype: Link
       Rect: 530, 673, 540, 658
       Flags: Print
       AppearanceDictionary: true
       Destination: 336
      Annotation: 
       Subtype: Link
       Rect: 329, 648, 339, 633
       Flags: Print
       AppearanceDictionary: true
       Destination: 336
      Annotation: 
       Subtype: Link
       Rect: 377, 635, 382, 620
       Flags: Print
       AppearanceDictionary: true
       Destination: 228
      Annotation: 
       Subtype: Link
       Rect: 387, 635, 397, 620
       Flags: Print
       AppearanceDictionary: true
       Destination: 336
      Annotation: 
       Subtype: Link
       Rect: 366, 623, 376, 608
       Flags: Print
       AppearanceDictionary: true
       Destination: 336
      Annotation: 
       Subtype: Link
       Rect: 343, 273, 353, 258
       Flags: Print
       AppearanceDictionary: true
       Destination: 336
      Annotation: 
       Subtype: Link
       Rect: 490, 198, 500, 183
       Flags: Print
       AppearanceDictionary: true
       Destination: 336
      Annotation: 
       Subtype: Link
       Rect: 505, 198, 516, 183
       Flags: Print
       AppearanceDictionary: true
       Destination: 336
     Thumb: true
    Page: 
     Sequence: 5
     Thumb: true
    Page: 
     Sequence: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 77, 711, 87, 696
       Flags: Print
       AppearanceDictionary: true
       Destination: 336
      Annotation: 
       Subtype: Link
       Rect: 273, 599, 283, 584
       Flags: Print
       AppearanceDictionary: true
       Destination: 336
      Annotation: 
       Subtype: Link
       Rect: 76, 586, 86, 571
       Flags: Print
       AppearanceDictionary: true
       Destination: 336
      Annotation: 
       Subtype: Link
       Rect: 141, 586, 151, 571
       Flags: Print
       AppearanceDictionary: true
       Destination: 336
      Annotation: 
       Subtype: Link
       Rect: 158, 374, 163, 359
       Flags: Print
       AppearanceDictionary: true
       Destination: 228
      Annotation: 
       Subtype: Link
       Rect: 194, 186, 204, 171
       Flags: Print
       AppearanceDictionary: true
       Destination: 336
      Annotation: 
       Subtype: Link
       Rect: 77, 111, 87, 96
       Flags: Print
       AppearanceDictionary: true
       Destination: 336
      Annotation: 
       Subtype: Link
       Rect: 331, 649, 341, 634
       Flags: Print
       AppearanceDictionary: true
       Destination: 228
      Annotation: 
       Subtype: Link
       Rect: 309, 611, 319, 596
       Flags: Print
       AppearanceDictionary: true
       Destination: 228
      Annotation: 
       Subtype: Link
       Rect: 325, 611, 335, 596
       Flags: Print
       AppearanceDictionary: true
       Destination: 228
      Annotation: 
       Subtype: Link
       Rect: 404, 349, 414, 334
       Flags: Print
       AppearanceDictionary: true
       Destination: 336
     Thumb: true
    Page: 
     Sequence: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 116, 724, 126, 709
       Flags: Print
       AppearanceDictionary: true
       Destination: 336
      Annotation: 
       Subtype: Link
       Rect: 120, 411, 126, 398
       Flags: Print
       AppearanceDictionary: true
       Destination: 82
      Annotation: 
       Subtype: Link
       Rect: 467, 386, 477, 371
       Flags: Print
       AppearanceDictionary: true
       Destination: 336
     Thumb: true
    Page: 
     Sequence: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 272, 311, 283, 296
       Flags: Print
       AppearanceDictionary: true
       Destination: 228
      Annotation: 
       Subtype: Link
       Rect: 346, 112, 356, 97
       Flags: Print
       AppearanceDictionary: true
       Destination: 336
     Thumb: true
    Page: 
     Sequence: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 54, 674, 64, 659
       Flags: Print
       AppearanceDictionary: true
       Destination: 228
      Annotation: 
       Subtype: Link
       Rect: 179, 361, 189, 346
       Flags: Print
       AppearanceDictionary: true
       Destination: 336
      Annotation: 
       Subtype: Link
       Rect: 104, 124, 114, 109
       Flags: Print
       AppearanceDictionary: true
       Destination: 336
      Annotation: 
       Subtype: Link
       Rect: 119, 124, 129, 109
       Flags: Print
       AppearanceDictionary: true
       Destination: 336
      Annotation: 
       Subtype: Link
       Rect: 465, 574, 476, 559
       Flags: Print
       AppearanceDictionary: true
       Destination: 336
      Annotation: 
       Subtype: Link
       Rect: 335, 511, 345, 496
       Flags: Print
       AppearanceDictionary: true
       Destination: 228
      Annotation: 
       Subtype: Link
       Rect: 351, 511, 361, 496
       Flags: Print
       AppearanceDictionary: true
       Destination: 228
      Annotation: 
       Subtype: Link
       Rect: 472, 486, 482, 471
       Flags: Print
       AppearanceDictionary: true
       Destination: 415
      Annotation: 
       Subtype: Link
       Rect: 487, 486, 497, 471
       Flags: Print
       AppearanceDictionary: true
       Destination: 415
      Annotation: 
       Subtype: Link
       Rect: 309, 449, 319, 434
       Flags: Print
       AppearanceDictionary: true
       Destination: 415
      Annotation: 
       Subtype: Link
       Rect: 481, 149, 491, 134
       Flags: Print
       AppearanceDictionary: true
       Destination: 228
      Annotation: 
       Subtype: Link
       Rect: 496, 149, 506, 134
       Flags: Print
       AppearanceDictionary: true
       Destination: 228
     Thumb: true
    Page: 
     Sequence: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 392, 393, 542, 380
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 506, 257, 544, 244
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 247, 441, 234
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 499, 237, 544, 224
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 227, 503, 214
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 187, 487, 174
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 482, 157, 544, 144
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 147, 387, 134
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 494, 97, 544, 84
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 87, 438, 74
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 209, 706, 289, 693
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 696, 152, 683
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 93, 656, 239, 643
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 227, 606, 289, 593
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 596, 155, 583
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 123, 556, 258, 543
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 239, 536, 289, 523
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 526, 127, 513
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 208, 476, 289, 463
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 466, 140, 453
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 225, 406, 289, 393
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 396, 158, 383
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 96, 346, 249, 333
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 227, 306, 289, 293
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 296, 159, 283
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 200, 246, 289, 233
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 236, 140, 223
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 265, 186, 289, 173
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 176, 181, 163
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 207, 106, 289, 93
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 96, 152, 83
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 413, 696, 544, 683
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 686, 378, 673
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 616, 472, 603
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 438, 566, 544, 553
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 556, 366, 543
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 346, 496, 500, 483
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 463, 416, 544, 403
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 406, 393, 393
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 463, 376, 544, 363
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 366, 397, 353
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 461, 316, 544, 303
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 306, 390, 293
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 520, 286, 544, 273
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 276, 425, 263
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 387, 236, 544, 223
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 226, 344, 213
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 387, 176, 533, 163
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 390, 116, 541, 103
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 434, 96, 544, 83
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 86, 383, 73
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 12
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 155, 686, 289, 673
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 676, 138, 663
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 151, 576, 287, 563
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 179, 546, 289, 533
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 536, 110, 523
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 85, 476, 234, 463
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 416, 194, 403
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 137, 366, 286, 353
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 316, 231, 303
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 225, 296, 289, 283
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 286, 132, 273
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 153, 176, 283, 163
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 251, 136, 289, 123
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 126, 195, 113
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 368, 706, 529, 693
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 520, 656, 544, 643
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 646, 442, 633
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 461, 596, 544, 583
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 586, 419, 573
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 556, 471, 543
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 395, 486, 531, 473
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 334, 446, 544, 433
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 436, 405, 423
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 483, 386, 544, 373
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 376, 410, 363
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 454, 296, 544, 283
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 286, 393, 273
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 399, 226, 514, 213
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 415, 176, 530, 163
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
    Page: 
     Sequence: 13
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 174, 716, 289, 703
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 68, 706, 104, 693
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 126, 656, 240, 643
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 372, 696, 523, 683
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 442, 656, 544, 643
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 646, 366, 633
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 132, 544, 144, 532
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
  Checksum: c8eef58b
   Type: CRC32
  Checksum: 287f8dc28820676a14b7c3e0c9cbec42
   Type: MD5
  Checksum: ff4904a44fa74d841df2f5aed5dd529e33e79417
   Type: SHA-1
  Checksum: 83fb576e41dfdf58c72a388e62a8a81d938d47ec48d9ffaa4a51e0262263c9c4
   Type: SHA-256