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Title:           Perivascular adipose tissue modulates aortic reactivity in Marfan syndrome mice in a sex- and region-specific manner: Redox-dependent anticontractile effects in the female ascending aorta
Subject:         Biochemical Pharmacology, 250 (2026) 118095. doi:10.1016/j.bcp.2026.118095
Keywords:        Marfan syndrome,Thoracic aortic aneurysm,Perivascular adipose tissue,Inducible nitric oxide synthase,NOX4,Peroxynitrite
Author:          Jana Hua-Monclús
Creator:         Elsevier
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      Title: Perivascular adipose tissue modulates aortic reactivity in Marfan syndrome mice in a sex- and region-specific manner: Redox ...
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       Item: 
        Title: 1 Introduction
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        Title: 2 Materials and methods
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         Item: 
          Title: 2.1 Animals
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          Title: 2.2 Aortic tissue preparation
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          Title: 2.3 Aortic reactivity
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          Title: 2.4 Quantitative real-time PCR
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          Title: 2.5 NO levels
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          Title: 2.6 In situ oxidative stress
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          Title: 2.7 SR-μFTIR
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          Title: 2.8 Human tissue collection
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          Title: 2.9 Human aorta histology
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          Title: 2.10 Immunofluorescence
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          Title: 2.11 Statistics
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        Title: 3 Results
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         Item: 
          Title: 3.1 PVAT differentially modulates ascending and descending thoracic aorta contraction in male and female WT and MFS mice
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          Title: 3.2 Influence of aging on PVAT-induced anticontractile effect in female MFS ascending aortas
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          Title: 3.3 The anticontractile effect of PVAT is independent of the endothelium
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          Title: 3.4 NOS activity contributes to the PVAT-induced anticontractile effect
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          Title: 3.5 NOS expression and NO levels are not altered
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          Title: 3.6 Nox4 upregulation and oxidative stress in PVAT of MFS mice
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          Title: 3.7 SR-µFTIR does not reveal accumulation of structural lipid oxidation signatures or changes in protein secondary structur ...
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          Title: 3.8 Peroxynitrite-sensitive signaling mediates PVAT-dependent anticontractile effects in MFS
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        Title: CRediT authorship contribution statement
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        Title: Funding
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        Title: Declaration of competing interest
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        Title: Acknowledgements
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       Item: 
        Title: Data availability
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        Title: References
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       Rect: 389, 190, 535, 196
       Flags: Print
  Checksum: 100a143a
   Type: CRC32
  Checksum: b6d37fcd5db65fc7b50934190bec60bf
   Type: MD5
  Checksum: 80019ba4f4e18dede147bb04ffef7d8d1a4a40d4
   Type: SHA-1
  Checksum: 95c285d9842b63c13ac599ee286dd166f1bad78f200bcfcfb54595344a99b504
   Type: SHA-256