04acff8547d01e58e5c70991e6d899a6  FENDO_a2026m3d18.pdf
079f7ba2265798a6b5b379b6ca34515a984428a9  FENDO_a2026m3d18.pdf
7634de3dc4f0d5aa9b45a5f0d21e9429ef2b0f8e03f4d2c5eb9621f440fc62e3  FENDO_a2026m3d18.pdf

Title:           Immunoendocrine response to individual or combined exposure of polystyrene nanoplastics and elevated salinity on gilthead seabream
Subject:         Ruiz N, Blonç M, Tvarijonaviciute A, Teles M, Pastor J and Tort L (2026) Immunoendocrine response to individual or combined exposure of polystyrene nanoplastics and elevated salinity on gilthead seabream. Front. Endocrinol. 17:1759877. doi: 10.3389/fendo.2026.1759877
Keywords:        combined stressors; emergent pollutant; immune genes; PSNPs; Sparus aurata; stress response
Author:          Nuria Ruiz
CreationDate:    Tue Mar 17 05:12:58 2026 CET
ModDate:         Tue Mar 17 05:12:58 2026 CET
Custom Metadata: no
Metadata Stream: yes
Tagged:          no
UserProperties:  no
Suspects:        no
Form:            none
JavaScript:      no
Pages:           13
Encrypted:       no
Page size:       595.389 x 841.663 pts (A4)
Page rot:        0
File size:       2618975 bytes
Optimized:       no
PDF version:     1.4


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
OPALGH+AdvTTd3a5f740                 Type 1C           WinAnsi          yes yes no     235  0
OPALIA+AdvTT2c8ce45a                 Type 1C           WinAnsi          yes yes no     236  0
OPALIB+AdvTTc8b77491.I               Type 1C           WinAnsi          yes yes no     732  0
OPBAAG+AdvTT9b12cd41+01              Type 1C           MacRoman         yes yes no     733  0
OPALHI+AdvTTd3a5f740+20              Type 1C           WinAnsi          yes yes no     734  0
OPALHJ+AdvPSA18C                     Type 1C           WinAnsi          yes yes no     735  0
OPALHK+AdvTTd3a5f740+01              Type 1C           MacRoman         yes yes no     736  0
OPALHL+AdvTT9b12cd41                 Type 1C           WinAnsi          yes yes no     237  0
OPALHM+AdvPSA323                     Type 1C           WinAnsi          yes yes no     737  0
OPALHN+AdvTTd168d80a.I               Type 1C           WinAnsi          yes yes no     738  0
OPALHO+AdvTT9b12cd41+fb              Type 1C           Custom           yes yes yes    537  0
OPALHP+AdvTT9b12cd41+20              Type 1C           WinAnsi          yes yes no     739  0
OPBAEG+AdvOT1ef757c0                 Type 1C           WinAnsi          yes yes no     230  0
OPBAEH+AdvOT7d6df7ab.I               Type 1C           WinAnsi          yes yes no     233  0
OPBAFH+AdvOT1ef757c0+fb              Type 1C           Custom           yes yes yes    232  0
OPBAFI+AdvOT1ef757c0+20              Type 1C           WinAnsi          yes yes no     231  0
OPBAFJ+AdvOT2f02755f.I               Type 1C           WinAnsi          yes yes no     535  0
OPBAIJ+AdvOT1ef757c0+22              Type 1C           Custom           yes yes no     234  0
OPBDLH+AdvOTd877c31c                 Type 1C           WinAnsi          yes yes no     758  0
OPBDLI+AdvOTd877c31c+21              Type 1C           WinAnsi          yes yes no     759  0
OPBDLJ+AdvTT8b40f9c2.B+20            Type 1C           Custom           yes yes yes    760  0
OPBDOJ+AdvTT2c8ce45a+fb              Type 1C           Custom           yes yes yes    761  0
OPBPMB+AdvOT3f84ef53                 Type 1C           WinAnsi          yes yes no     536  0
OPDHJA+AdvOT1ef757c0+01              Type 1C           Custom           yes yes no     767  0
OPDHKA+AdvTT58d178b9+03              Type 1C           Custom           yes yes yes    768  0
OPDHKB+AdvTTd3a5f740+fb              Type 1C           Custom           yes yes yes    769  0
OPDHLC+AdvOT7d6df7ab.I+fb            Type 1C           Custom           yes yes yes    770  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2026-07-05 04:04:31 CEST
 RepresentationInformation: FENDO_a2026m3d18.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2026-07-04 06:51:36 CEST
  Size: 2618975
  Format: PDF
  Version: 1.4
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 850
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: true
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: en-US
    Outlines: 
     Item: 
      Title: Immunoendocrine response to individual or combined exposure of polystyrene nanoplastics and elevated salinity on gilthead seabream
      Destination: bmark_-523300065
      Children: 
       Item: 
        Title: 1 Introduction
        Destination: s1
       Item: 
        Title: 2 Materials and methodology
        Destination: s2
        Children: 
         Item: 
          Title: 2.1 Fish and husbandry, bioassay, and sampling
          Destination: s2_1
         Item: 
          Title: 2.2 Characterization of nanoplastics
          Destination: s2_2
         Item: 
          Title: 2.3 Hematological analyses
          Destination: s2_3
         Item: 
          Title: 2.4 Biochemical analyses
          Destination: s2_4
         Item: 
          Title: 2.5 RNA extraction and cDNA synthesis
          Destination: s2_5
         Item: 
          Title: 2.6 Real-time quantitative polymerase chain reaction
          Destination: s2_6
         Item: 
          Title: 2.7 Statistical analysis
          Destination: s2_7
       Item: 
        Title: 3 Results
        Destination: s3
        Children: 
         Item: 
          Title: 3.1 Characterization of nanoplastics
          Destination: s3_1
         Item: 
          Title: 3.2 Hematological analyses
          Destination: s3_2
         Item: 
          Title: 3.3 Biochemical analyses
          Destination: s3_3
         Item: 
          Title: 3.4 Gills gene expression
          Destination: s3_4
         Item: 
          Title: 3.5 Intestine gene expression
          Destination: s3_5
         Item: 
          Title: 3.6 Skin gene expression
          Destination: s3_6
       Item: 
        Title: 4 Discussion
        Destination: s4
        Children: 
         Item: 
          Title: 4.1 Impact of increased salinity
          Destination: s4_1
         Item: 
          Title: 4.2 Impact of waterborne PSNPs
          Destination: s4_2
         Item: 
          Title: 4.3 Combined impact of increased salinity and waterborne PSNPs
          Destination: s4_3
       Item: 
        Title: 5 Conclusion
        Destination: s5
       Item: 
        Title: Data availability statement
        Destination: bmark_-1258588262
       Item: 
        Title: Ethics statement
        Destination: bmark_1370551237
       Item: 
        Title: Author contributions
        Destination: bmark_-1208584890
       Item: 
        Title: Funding
        Destination: bmark_1865464027
       Item: 
        Title: Acknowledgments
        Destination: bmark_-366698314
       Item: 
        Title: Conflict of interest
        Destination: bmark_1089982005
       Item: 
        Title: Generative AI statement
        Destination: bmark_-1453097031
       Item: 
        Title: Publisher’s note
        Destination: bmark_-1256977648
       Item: 
        Title: References
        Destination: bmark_2090415954
   Info: 
    Title: Immunoendocrine response to individual or combined exposure of polystyrene nanoplastics and elevated salinity on gilthead seabream
    Author: Nuria Ruiz
    Subject: Ruiz N, Blonç M, Tvarijonaviciute A, Teles M, Pastor J and Tort L (2026) Immunoendocrine response to individual or combined exposure of polystyrene nanoplastics and elevated salinity on gilthead seabream. Front. Endocrinol. 17:1759877. doi: 10.3389/fendo.2026.1759877
    Keywords: combined stressors; emergent pollutant; immune genes; PSNPs; Sparus aurata; stress response
    CreationDate: Tue Mar 17 05:12:58 CET 2026
    ModDate: Tue Mar 17 05:12:58 CET 2026
   ID: 0xf24ac78e7645a714d72c76cdf9b111ee, 0xb5da564b0fdc5f8dcef181cb44421054
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 2919
      ImageHeight: 577
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1772
      ImageHeight: 943
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 2456
      ImageHeight: 2136
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 2440
      ImageHeight: 2128
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 2432
      ImageHeight: 2144
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
   Fonts: 
    Type1: 
     Font: 
      BaseFont: OPDHKA+AdvTT58d178b9+03
      FontSubset: true
      FirstChar: 0
      LastChar: 0
      FontDescriptor: 
       FontName: OPDHKA+AdvTT58d178b9+03
       Flags: Symbolic
       FontBBox: -645, -354, 916, 895
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: OPDHKB+AdvTTd3a5f740+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: OPDHKB+AdvTTd3a5f740+fb
       Flags: Symbolic
       FontBBox: 0, 0, 906, 708
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: OPDHLC+AdvOT7d6df7ab.I+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: OPDHLC+AdvOT7d6df7ab.I+fb
       Flags: Symbolic
       FontBBox: -156, -250, 802, 708
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: OPBAFJ+AdvOT2f02755f.I
      FontSubset: true
      FirstChar: 97
      LastChar: 103
      FontDescriptor: 
       FontName: OPBAFJ+AdvOT2f02755f.I
       Flags: Nonsymbolic
       FontBBox: -177, -291, 1281, 1000
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OPBPMB+AdvOT3f84ef53
      FontSubset: true
      FirstChar: 97
      LastChar: 98
      FontDescriptor: 
       FontName: OPBPMB+AdvOT3f84ef53
       Flags: Nonsymbolic
       FontBBox: -177, -291, 1083, 1000
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OPALHO+AdvTT9b12cd41+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: OPALHO+AdvTT9b12cd41+fb
       Flags: Symbolic
       FontBBox: 0, 0, 854, 697
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: OPALIB+AdvTTc8b77491.I
      FontSubset: true
      FirstChar: 83
      LastChar: 117
      FontDescriptor: 
       FontName: OPALIB+AdvTTc8b77491.I
       Flags: Nonsymbolic
       FontBBox: -145, -208, 1020, 895
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OPBAAG+AdvTT9b12cd41+01
      FontSubset: true
      FirstChar: 245
      LastChar: 245
      FontDescriptor: 
       FontName: OPBAAG+AdvTT9b12cd41+01
       Flags: Nonsymbolic
       FontBBox: -52, -208, 958, 875
       FontFile3: true
      Encoding: MacRomanEncoding
     Font: 
      BaseFont: OPALHI+AdvTTd3a5f740+20
      FontSubset: true
      FirstChar: 134
      LastChar: 146
      FontDescriptor: 
       FontName: OPALHI+AdvTTd3a5f740+20
       Flags: Nonsymbolic
       FontBBox: -114, -166, 1062, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OPALHJ+AdvPSA18C
      FontSubset: true
      FirstChar: 180
      LastChar: 184
      FontDescriptor: 
       FontName: OPALHJ+AdvPSA18C
       Flags: Nonsymbolic
       FontBBox: -156, -208, 1125, 802
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OPALHK+AdvTTd3a5f740+01
      FontSubset: true
      FirstChar: 245
      LastChar: 245
      FontDescriptor: 
       FontName: OPALHK+AdvTTd3a5f740+01
       Flags: Nonsymbolic
       FontBBox: -52, -208, 947, 885
       FontFile3: true
      Encoding: MacRomanEncoding
     Font: 
      BaseFont: OPALHM+AdvPSA323
      FontSubset: true
      FirstChar: 180
      LastChar: 184
      FontDescriptor: 
       FontName: OPALHM+AdvPSA323
       Flags: Nonsymbolic
       FontBBox: -156, -239, 1104, 770
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OPALHN+AdvTTd168d80a.I
      FontSubset: true
      FirstChar: 46
      LastChar: 117
      FontDescriptor: 
       FontName: OPALHN+AdvTTd168d80a.I
       Flags: Serif, Nonsymbolic
       FontBBox: -145, -208, 968, 875
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OPALHP+AdvTT9b12cd41+20
      FontSubset: true
      FirstChar: 134
      LastChar: 151
      FontDescriptor: 
       FontName: OPALHP+AdvTT9b12cd41+20
       Flags: Nonsymbolic
       FontBBox: -114, -166, 1010, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OPBAEG+AdvOT1ef757c0
      FontSubset: true
      FirstChar: 37
      LastChar: 227
      FontDescriptor: 
       FontName: OPBAEG+AdvOT1ef757c0
       Flags: Serif, Nonsymbolic
       FontBBox: -20, -250, 947, 854
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OPBAFI+AdvOT1ef757c0+20
      FontSubset: true
      FirstChar: 129
      LastChar: 150
      FontDescriptor: 
       FontName: OPBAFI+AdvOT1ef757c0+20
       Flags: Nonsymbolic
       FontBBox: -135, -187, 1010, 833
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OPBAFH+AdvOT1ef757c0+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: OPBAFH+AdvOT1ef757c0+fb
       Flags: Symbolic
       FontBBox: 0, -10, 781, 708
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: OPBAEH+AdvOT7d6df7ab.I
      FontSubset: true
      FirstChar: 44
      LastChar: 122
      FontDescriptor: 
       FontName: OPBAEH+AdvOT7d6df7ab.I
       Flags: Serif, Nonsymbolic
       FontBBox: -135, -250, 1000, 854
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OPBAIJ+AdvOT1ef757c0+22
      FontSubset: true
      FirstChar: 21
      LastChar: 21
      FontDescriptor: 
       FontName: OPBAIJ+AdvOT1ef757c0+22
       Flags: Nonsymbolic
       FontBBox: -135, -166, 697, 916
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
     Font: 
      BaseFont: OPALGH+AdvTTd3a5f740
      FontSubset: true
      FirstChar: 37
      LastChar: 122
      FontDescriptor: 
       FontName: OPALGH+AdvTTd3a5f740
       Flags: Serif, Nonsymbolic
       FontBBox: -52, -208, 916, 885
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OPALIA+AdvTT2c8ce45a
      FontSubset: true
      FirstChar: 40
      LastChar: 181
      FontDescriptor: 
       FontName: OPALIA+AdvTT2c8ce45a
       Flags: Serif, Nonsymbolic
       FontBBox: -52, -208, 947, 895
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OPALHL+AdvTT9b12cd41
      FontSubset: true
      FirstChar: 40
      LastChar: 242
      FontDescriptor: 
       FontName: OPALHL+AdvTT9b12cd41
       Flags: Serif, Nonsymbolic
       FontBBox: -52, -208, 906, 875
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OPBDLH+AdvOTd877c31c
      FontSubset: true
      FirstChar: 174
      LastChar: 174
      FontDescriptor: 
       FontName: OPBDLH+AdvOTd877c31c
       Flags: Nonsymbolic
       FontBBox: -62, -208, 927, 958
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OPBDLI+AdvOTd877c31c+21
      FontSubset: true
      FirstChar: 153
      LastChar: 153
      FontDescriptor: 
       FontName: OPBDLI+AdvOTd877c31c+21
       Flags: Nonsymbolic
       FontBBox: -10, -250, 1145, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: OPBDLJ+AdvTT8b40f9c2.B+20
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: OPBDLJ+AdvTT8b40f9c2.B+20
       Flags: Symbolic
       FontBBox: -177, -375, 2000, 1052
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: OPBDOJ+AdvTT2c8ce45a+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 1
      FontDescriptor: 
       FontName: OPBDOJ+AdvTT2c8ce45a+fb
       Flags: Symbolic
       FontBBox: 0, 0, 947, 708
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: OPDHJA+AdvOT1ef757c0+01
      FontSubset: true
      FirstChar: 20
      LastChar: 25
      FontDescriptor: 
       FontName: OPDHJA+AdvOT1ef757c0+01
       Flags: Serif, Nonsymbolic
       FontBBox: -20, -250, 947, 854
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="Adobe XMP Core 9.1-c001 79.2a0d8d9, 2023/03/14-11:19:46        ">
   <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
      <rdf:Description xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:pdf="http://ns.adobe.com/pdf/1.3/" xmlns:xmpRights="http://ns.adobe.com/xap/1.0/rights/" xmlns:xmp="http://ns.adobe.com/xap/1.0/" xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/" rdf:about="">
         <dc:format>application/pdf</dc:format>
         <dc:creator>
            <rdf:Seq>
               <rdf:li>Nuria Ruiz</rdf:li>
               <rdf:li>Manuel Blonç</rdf:li>
               <rdf:li>Asta Tvarijonaviciute</rdf:li>
               <rdf:li>Mariana Teles</rdf:li>
               <rdf:li>Josep Pastor</rdf:li>
               <rdf:li>Lluís Tort</rdf:li>
            </rdf:Seq>
         </dc:creator>
         <dc:description>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Ruiz N, Blonç M, Tvarijonaviciute A, Teles M, Pastor J and Tort L (2026) Immunoendocrine response to individual or combined exposure of polystyrene nanoplastics and elevated salinity on gilthead seabream. Front. Endocrinol. 17:1759877. doi: 10.3389/fendo.2026.1759877</rdf:li>
            </rdf:Alt>
         </dc:description>
         <dc:rights>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Copyright © 2026 Ruiz, Blonç, Tvarijonaviciute, Teles, Pastor and Tort.. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</rdf:li>
            </rdf:Alt>
         </dc:rights>
         <dc:subject>
            <rdf:Bag>
               <rdf:li>combined stressors</rdf:li>
               <rdf:li>emergent pollutant</rdf:li>
               <rdf:li>immune genes</rdf:li>
               <rdf:li>PSNPs</rdf:li>
               <rdf:li>Sparus aurata</rdf:li>
               <rdf:li>stress response</rdf:li>
            </rdf:Bag>
         </dc:subject>
         <dc:title>
            <rdf:Alt>
               <rdf:li xml:lang="x-default">Immunoendocrine response to individual or combined exposure of polystyrene nanoplastics and elevated salinity on gilthead seabream</rdf:li>
            </rdf:Alt>
         </dc:title>
         <pdf:Keywords>combined stressors; emergent pollutant; immune genes; PSNPs; Sparus aurata; stress response</pdf:Keywords>
         <xmpRights:Marked>True</xmpRights:Marked>
         <xmpRights:WebStatement>https://www.frontiersin.org/legal/copyright-statement</xmpRights:WebStatement>
         <xmp:ModifyDate>2026-03-17T12:12:58+08:00</xmp:ModifyDate>
         <xmp:CreateDate>2026-03-17T12:12:58+08:00</xmp:CreateDate>
         <xmp:MetadataDate>2026-03-17T12:12:58+08:00</xmp:MetadataDate>
         <xmpMM:DocumentID>uuid:2accc607-345e-4b32-b194-ab8c03903112</xmpMM:DocumentID>
         <xmpMM:InstanceID>uuid:58e45d8f-3f42-4d53-8cf3-312f9203c25a</xmpMM:InstanceID>
      </rdf:Description>
   </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 219, 683, 499, 704
      Annotation: 
       Subtype: Link
       Rect: 219, 658, 468, 679
      Annotation: 
       Subtype: Link
       Rect: 219, 633, 452, 654
      Annotation: 
       Subtype: Link
       Rect: 219, 608, 476, 629
      Annotation: 
       Subtype: Link
       Rect: 219, 583, 501, 604
      Annotation: 
       Subtype: Link
       Rect: 49, 33, 134, 40
      Annotation: 
       Subtype: Link
       Rect: 499, 33, 545, 40
      Annotation: 
       Subtype: Link
       Rect: 49, 688, 125, 703
      Annotation: 
       Subtype: Link
       Rect: 57, 542, 115, 549
      Annotation: 
       Subtype: Link
       Rect: 49, 395, 155, 402
      Annotation: 
       Subtype: Link
       Rect: 69, 344, 162, 351
      Annotation: 
       Subtype: Link
       Rect: 49, 335, 99, 342
      Annotation: 
       Subtype: Link
       Rect: 453, 784, 509, 791
      Annotation: 
       Subtype: Link
       Rect: 470, 774, 518, 781
      Annotation: 
       Subtype: Link
       Rect: 450, 765, 540, 772
      Annotation: 
       Subtype: Link
       Rect: 49, 753, 248, 802
    Page: 
     Label: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 132, 692, 137, 701
       Destination: 36
      Annotation: 
       Subtype: Link
       Rect: 282, 680, 287, 689
       Destination: 36
      Annotation: 
       Subtype: Link
       Rect: 146, 667, 150, 676
       Destination: 36
      Annotation: 
       Subtype: Link
       Rect: 219, 630, 223, 639
       Destination: 36
      Annotation: 
       Subtype: Link
       Rect: 280, 467, 285, 476
       Destination: 36
      Annotation: 
       Subtype: Link
       Rect: 175, 442, 179, 451
       Destination: 36
      Annotation: 
       Subtype: Link
       Rect: 87, 430, 91, 439
       Destination: 36
      Annotation: 
       Subtype: Link
       Rect: 155, 405, 159, 414
       Destination: 36
      Annotation: 
       Subtype: Link
       Rect: 118, 367, 123, 376
       Destination: 36
      Annotation: 
       Subtype: Link
       Rect: 127, 367, 135, 376
       Destination: 36
      Annotation: 
       Subtype: Link
       Rect: 181, 342, 185, 351
       Destination: 36
      Annotation: 
       Subtype: Link
       Rect: 271, 342, 275, 351
       Destination: 36
      Annotation: 
       Subtype: Link
       Rect: 279, 342, 288, 351
       Destination: 36
      Annotation: 
       Subtype: Link
       Rect: 49, 330, 58, 339
       Destination: 36
      Annotation: 
       Subtype: Link
       Rect: 191, 305, 200, 314
       Destination: 36
      Annotation: 
       Subtype: Link
       Rect: 204, 305, 212, 314
       Destination: 36
      Annotation: 
       Subtype: Link
       Rect: 169, 230, 173, 239
       Destination: 36
      Annotation: 
       Subtype: Link
       Rect: 179, 230, 188, 239
       Destination: 36
      Annotation: 
       Subtype: Link
       Rect: 193, 230, 202, 239
       Destination: 36
      Annotation: 
       Subtype: Link
       Rect: 208, 230, 216, 239
       Destination: 36
      Annotation: 
       Subtype: Link
       Rect: 160, 180, 168, 189
       Destination: 36
      Annotation: 
       Subtype: Link
       Rect: 87, 130, 95, 139
       Destination: 36
      Annotation: 
       Subtype: Link
       Rect: 70, 117, 75, 126
       Destination: 36
      Annotation: 
       Subtype: Link
       Rect: 352, 746, 360, 755
       Destination: 36
      Annotation: 
       Subtype: Link
       Rect: 365, 746, 373, 755
       Destination: 36
      Annotation: 
       Subtype: Link
       Rect: 417, 558, 426, 567
       Destination: 36
      Annotation: 
       Subtype: Link
       Rect: 431, 558, 439, 567
       Destination: 36
      Annotation: 
       Subtype: Link
       Rect: 448, 521, 457, 530
       Destination: 36
      Annotation: 
       Subtype: Link
       Rect: 451, 799, 545, 806
      Annotation: 
       Subtype: Link
       Rect: 49, 33, 134, 40
      Annotation: 
       Subtype: Link
       Rect: 499, 33, 545, 40
    Page: 
     Label: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 70, 708, 99, 717
       Destination: 27
      Annotation: 
       Subtype: Link
       Rect: 451, 799, 545, 806
      Annotation: 
       Subtype: Link
       Rect: 49, 33, 134, 40
      Annotation: 
       Subtype: Link
       Rect: 499, 33, 545, 40
    Page: 
     Label: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 307, 682, 315, 691
       Destination: 37
      Annotation: 
       Subtype: Link
       Rect: 484, 544, 492, 553
       Destination: 37
      Annotation: 
       Subtype: Link
       Rect: 497, 544, 505, 553
       Destination: 37
      Annotation: 
       Subtype: Link
       Rect: 516, 532, 543, 541
       Destination: 28
      Annotation: 
       Subtype: Link
       Rect: 348, 507, 375, 516
       Destination: 29
      Annotation: 
       Subtype: Link
       Rect: 492, 407, 498, 414
       Destination: 37
      Annotation: 
       Subtype: Link
       Rect: 492, 377, 498, 384
       Destination: 37
      Annotation: 
       Subtype: Link
       Rect: 492, 348, 498, 355
       Destination: 37
      Annotation: 
       Subtype: Link
       Rect: 492, 319, 498, 326
       Destination: 37
      Annotation: 
       Subtype: Link
       Rect: 492, 290, 498, 297
       Destination: 37
      Annotation: 
       Subtype: Link
       Rect: 492, 261, 498, 268
       Destination: 37
      Annotation: 
       Subtype: Link
       Rect: 492, 231, 498, 238
       Destination: 37
      Annotation: 
       Subtype: Link
       Rect: 492, 202, 498, 209
       Destination: 37
      Annotation: 
       Subtype: Link
       Rect: 492, 173, 498, 180
       Destination: 37
      Annotation: 
       Subtype: Link
       Rect: 492, 144, 498, 151
       Destination: 37
      Annotation: 
       Subtype: Link
       Rect: 492, 115, 498, 122
       Destination: 37
      Annotation: 
       Subtype: Link
       Rect: 492, 86, 498, 93
       Destination: 37
      Annotation: 
       Subtype: Link
       Rect: 451, 799, 545, 806
      Annotation: 
       Subtype: Link
       Rect: 49, 33, 134, 40
      Annotation: 
       Subtype: Link
       Rect: 499, 33, 545, 40
    Page: 
     Label: 5
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 81, 369, 89, 378
       Destination: 37
      Annotation: 
       Subtype: Link
       Rect: 237, 321, 290, 330
      Annotation: 
       Subtype: Link
       Rect: 49, 309, 87, 318
      Annotation: 
       Subtype: Link
       Rect: 307, 695, 339, 704
       Destination: 29
      Annotation: 
       Subtype: Link
       Rect: 509, 547, 540, 556
       Destination: 30
      Annotation: 
       Subtype: Link
       Rect: 412, 436, 439, 445
       Destination: 30
      Annotation: 
       Subtype: Link
       Rect: 447, 288, 485, 297
       Destination: 31
      Annotation: 
       Subtype: Link
       Rect: 502, 213, 540, 222
       Destination: 31
      Annotation: 
       Subtype: Link
       Rect: 451, 799, 545, 806
      Annotation: 
       Subtype: Link
       Rect: 49, 34, 134, 41
      Annotation: 
       Subtype: Link
       Rect: 499, 34, 545, 41
    Page: 
     Label: 6
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 128, 469, 164, 478
       Destination: 31
      Annotation: 
       Subtype: Link
       Rect: 181, 419, 230, 428
       Destination: 31
      Annotation: 
       Subtype: Link
       Rect: 120, 381, 159, 391
       Destination: 31
      Annotation: 
       Subtype: Link
       Rect: 248, 307, 285, 316
       Destination: 31
      Annotation: 
       Subtype: Link
       Rect: 181, 269, 215, 278
       Destination: 31
      Annotation: 
       Subtype: Link
       Rect: 307, 519, 345, 528
       Destination: 31
      Annotation: 
       Subtype: Link
       Rect: 406, 444, 443, 453
       Destination: 31
      Annotation: 
       Subtype: Link
       Rect: 451, 432, 484, 441
       Destination: 31
      Annotation: 
       Subtype: Link
       Rect: 395, 358, 454, 367
       Destination: 32
      Annotation: 
       Subtype: Link
       Rect: 467, 333, 502, 342
       Destination: 32
      Annotation: 
       Subtype: Link
       Rect: 345, 295, 397, 304
       Destination: 32
      Annotation: 
       Subtype: Link
       Rect: 307, 270, 350, 279
       Destination: 32
      Annotation: 
       Subtype: Link
       Rect: 437, 245, 471, 254
       Destination: 32
      Annotation: 
       Subtype: Link
       Rect: 451, 799, 545, 806
      Annotation: 
       Subtype: Link
       Rect: 49, 33, 134, 40
      Annotation: 
       Subtype: Link
       Rect: 499, 33, 545, 40
    Page: 
     Label: 7
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 122, 268, 172, 277
       Destination: 32
      Annotation: 
       Subtype: Link
       Rect: 86, 193, 119, 202
       Destination: 32
      Annotation: 
       Subtype: Link
       Rect: 52, 68, 103, 77
       Destination: 33
      Annotation: 
       Subtype: Link
       Rect: 425, 193, 464, 202
       Destination: 33
      Annotation: 
       Subtype: Link
       Rect: 336, 118, 372, 127
       Destination: 33
      Annotation: 
       Subtype: Link
       Rect: 373, 68, 407, 77
       Destination: 33
      Annotation: 
       Subtype: Link
       Rect: 451, 799, 545, 806
      Annotation: 
       Subtype: Link
       Rect: 49, 33, 134, 40
      Annotation: 
       Subtype: Link
       Rect: 499, 33, 545, 40
    Page: 
     Label: 8
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 106, 242, 143, 251
       Destination: 33
      Annotation: 
       Subtype: Link
       Rect: 220, 204, 256, 213
       Destination: 33
      Annotation: 
       Subtype: Link
       Rect: 198, 192, 230, 201
       Destination: 33
      Annotation: 
       Subtype: Link
       Rect: 333, 217, 341, 226
       Destination: 37
      Annotation: 
       Subtype: Link
       Rect: 346, 217, 354, 226
       Destination: 37
      Annotation: 
       Subtype: Link
       Rect: 405, 217, 413, 226
       Destination: 37
      Annotation: 
       Subtype: Link
       Rect: 418, 217, 426, 226
       Destination: 37
      Annotation: 
       Subtype: Link
       Rect: 307, 119, 316, 128
       Destination: 37
      Annotation: 
       Subtype: Link
       Rect: 320, 119, 328, 128
       Destination: 37
      Annotation: 
       Subtype: Link
       Rect: 451, 799, 545, 806
      Annotation: 
       Subtype: Link
       Rect: 49, 33, 134, 40
      Annotation: 
       Subtype: Link
       Rect: 499, 33, 545, 40
    Page: 
     Label: 9
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 175, 187, 183, 196
       Destination: 37
      Annotation: 
       Subtype: Link
       Rect: 206, 125, 214, 134
       Destination: 37
      Annotation: 
       Subtype: Link
       Rect: 506, 200, 514, 209
       Destination: 36
      Annotation: 
       Subtype: Link
       Rect: 520, 200, 528, 209
       Destination: 37
      Annotation: 
       Subtype: Link
       Rect: 447, 187, 456, 196
       Destination: 37
      Annotation: 
       Subtype: Link
       Rect: 328, 150, 337, 159
       Destination: 36
      Annotation: 
       Subtype: Link
       Rect: 451, 799, 545, 806
      Annotation: 
       Subtype: Link
       Rect: 49, 33, 134, 40
      Annotation: 
       Subtype: Link
       Rect: 499, 33, 545, 40
    Page: 
     Label: 10
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 276, 746, 285, 755
       Destination: 37
      Annotation: 
       Subtype: Link
       Rect: 99, 708, 107, 717
       Destination: 37
      Annotation: 
       Subtype: Link
       Rect: 52, 608, 60, 617
       Destination: 37
      Annotation: 
       Subtype: Link
       Rect: 65, 608, 73, 617
       Destination: 37
      Annotation: 
       Subtype: Link
       Rect: 234, 583, 243, 592
       Destination: 37
      Annotation: 
       Subtype: Link
       Rect: 249, 583, 258, 592
       Destination: 37
      Annotation: 
       Subtype: Link
       Rect: 264, 583, 272, 592
       Destination: 37
      Annotation: 
       Subtype: Link
       Rect: 196, 458, 204, 467
       Destination: 37
      Annotation: 
       Subtype: Link
       Rect: 261, 408, 271, 417
       Destination: 37
      Annotation: 
       Subtype: Link
       Rect: 136, 345, 145, 355
       Destination: 37
      Annotation: 
       Subtype: Link
       Rect: 279, 233, 288, 242
       Destination: 37
      Annotation: 
       Subtype: Link
       Rect: 49, 221, 57, 230
       Destination: 37
      Annotation: 
       Subtype: Link
       Rect: 218, 196, 226, 205
       Destination: 37
      Annotation: 
       Subtype: Link
       Rect: 236, 146, 244, 154
       Destination: 37
      Annotation: 
       Subtype: Link
       Rect: 535, 758, 543, 767
       Destination: 36
      Annotation: 
       Subtype: Link
       Rect: 304, 746, 312, 755
       Destination: 37
      Annotation: 
       Subtype: Link
       Rect: 500, 746, 508, 755
       Destination: 36
      Annotation: 
       Subtype: Link
       Rect: 307, 683, 315, 692
       Destination: 37
      Annotation: 
       Subtype: Link
       Rect: 322, 683, 330, 692
       Destination: 37
      Annotation: 
       Subtype: Link
       Rect: 508, 583, 517, 592
       Destination: 36
      Annotation: 
       Subtype: Link
       Rect: 521, 583, 529, 592
       Destination: 37
      Annotation: 
       Subtype: Link
       Rect: 337, 471, 346, 480
       Destination: 37
      Annotation: 
       Subtype: Link
       Rect: 371, 446, 380, 455
       Destination: 37
      Annotation: 
       Subtype: Link
       Rect: 392, 433, 401, 442
       Destination: 37
      Annotation: 
       Subtype: Link
       Rect: 534, 370, 543, 380
       Destination: 37
      Annotation: 
       Subtype: Link
       Rect: 304, 358, 312, 367
       Destination: 37
      Annotation: 
       Subtype: Link
       Rect: 406, 333, 414, 342
       Destination: 37
      Annotation: 
       Subtype: Link
       Rect: 457, 173, 465, 182
       Destination: 37
      Annotation: 
       Subtype: Link
       Rect: 470, 173, 478, 182
       Destination: 37
      Annotation: 
       Subtype: Link
       Rect: 451, 799, 545, 806
      Annotation: 
       Subtype: Link
       Rect: 49, 33, 134, 40
      Annotation: 
       Subtype: Link
       Rect: 499, 33, 545, 40
    Page: 
     Label: 11
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 277, 546, 285, 555
       Destination: 37
      Annotation: 
       Subtype: Link
       Rect: 51, 496, 60, 505
       Destination: 37
      Annotation: 
       Subtype: Link
       Rect: 64, 496, 72, 505
       Destination: 37
      Annotation: 
       Subtype: Link
       Rect: 87, 446, 95, 455
       Destination: 36
      Annotation: 
       Subtype: Link
       Rect: 237, 396, 246, 405
       Destination: 37
      Annotation: 
       Subtype: Link
       Rect: 438, 396, 510, 405
      Annotation: 
       Subtype: Link
       Rect: 451, 799, 545, 806
      Annotation: 
       Subtype: Link
       Rect: 49, 33, 134, 40
      Annotation: 
       Subtype: Link
       Rect: 499, 33, 545, 40
    Page: 
     Label: 12
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 107, 372, 173, 379
      Annotation: 
       Subtype: Link
       Rect: 61, 335, 136, 342
      Annotation: 
       Subtype: Link
       Rect: 117, 299, 192, 306
      Annotation: 
       Subtype: Link
       Rect: 61, 250, 128, 257
      Annotation: 
       Subtype: Link
       Rect: 61, 221, 142, 228
      Annotation: 
       Subtype: Link
       Rect: 266, 201, 290, 208
      Annotation: 
       Subtype: Link
       Rect: 49, 193, 105, 200
      Annotation: 
       Subtype: Link
       Rect: 266, 172, 290, 179
      Annotation: 
       Subtype: Link
       Rect: 49, 164, 91, 171
      Annotation: 
       Subtype: Link
       Rect: 218, 144, 290, 151
      Annotation: 
       Subtype: Link
       Rect: 261, 115, 290, 122
      Annotation: 
       Subtype: Link
       Rect: 49, 107, 111, 114
      Annotation: 
       Subtype: Link
       Rect: 144, 79, 230, 86
      Annotation: 
       Subtype: Link
       Rect: 521, 380, 545, 387
      Annotation: 
       Subtype: Link
       Rect: 304, 372, 348, 379
      Annotation: 
       Subtype: Link
       Rect: 482, 343, 536, 350
      Annotation: 
       Subtype: Link
       Rect: 316, 306, 379, 313
      Annotation: 
       Subtype: Link
       Rect: 518, 285, 545, 292
      Annotation: 
       Subtype: Link
       Rect: 304, 277, 355, 284
      Annotation: 
       Subtype: Link
       Rect: 485, 248, 545, 255
      Annotation: 
       Subtype: Link
       Rect: 372, 211, 458, 218
      Annotation: 
       Subtype: Link
       Rect: 521, 182, 545, 189
      Annotation: 
       Subtype: Link
       Rect: 304, 174, 339, 181
      Annotation: 
       Subtype: Link
       Rect: 521, 153, 545, 160
      Annotation: 
       Subtype: Link
       Rect: 304, 145, 343, 152
      Annotation: 
       Subtype: Link
       Rect: 345, 116, 425, 123
      Annotation: 
       Subtype: Link
       Rect: 327, 79, 441, 86
      Annotation: 
       Subtype: Link
       Rect: 451, 799, 545, 806
      Annotation: 
       Subtype: Link
       Rect: 49, 33, 134, 40
      Annotation: 
       Subtype: Link
       Rect: 499, 33, 545, 40
    Page: 
     Label: 13
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 203, 716, 290, 723
      Annotation: 
       Subtype: Link
       Rect: 97, 679, 189, 686
      Annotation: 
       Subtype: Link
       Rect: 179, 643, 265, 649
      Annotation: 
       Subtype: Link
       Rect: 209, 606, 285, 613
      Annotation: 
       Subtype: Link
       Rect: 175, 585, 233, 593
      Annotation: 
       Subtype: Link
       Rect: 151, 549, 232, 556
      Annotation: 
       Subtype: Link
       Rect: 114, 513, 189, 519
      Annotation: 
       Subtype: Link
       Rect: 148, 484, 226, 491
      Annotation: 
       Subtype: Link
       Rect: 174, 447, 259, 455
      Annotation: 
       Subtype: Link
       Rect: 227, 411, 290, 418
      Annotation: 
       Subtype: Link
       Rect: 61, 375, 138, 381
      Annotation: 
       Subtype: Link
       Rect: 207, 346, 258, 353
      Annotation: 
       Subtype: Link
       Rect: 185, 309, 269, 317
      Annotation: 
       Subtype: Link
       Rect: 136, 281, 212, 288
      Annotation: 
       Subtype: Link
       Rect: 169, 245, 244, 252
      Annotation: 
       Subtype: Link
       Rect: 146, 216, 215, 223
      Annotation: 
       Subtype: Link
       Rect: 61, 195, 129, 203
      Annotation: 
       Subtype: Link
       Rect: 231, 167, 290, 174
      Annotation: 
       Subtype: Link
       Rect: 49, 159, 71, 166
      Annotation: 
       Subtype: Link
       Rect: 93, 139, 199, 145
      Annotation: 
       Subtype: Link
       Rect: 262, 110, 290, 117
      Annotation: 
       Subtype: Link
       Rect: 49, 102, 104, 109
      Annotation: 
       Subtype: Link
       Rect: 521, 744, 545, 751
      Annotation: 
       Subtype: Link
       Rect: 304, 736, 359, 743
      Annotation: 
       Subtype: Link
       Rect: 439, 707, 510, 715
      Annotation: 
       Subtype: Link
       Rect: 518, 679, 545, 686
      Annotation: 
       Subtype: Link
       Rect: 304, 671, 377, 678
      Annotation: 
       Subtype: Link
       Rect: 345, 651, 434, 657
      Annotation: 
       Subtype: Link
       Rect: 316, 622, 408, 629
      Annotation: 
       Subtype: Link
       Rect: 352, 594, 441, 601
      Annotation: 
       Subtype: Link
       Rect: 316, 565, 411, 572
      Annotation: 
       Subtype: Link
       Rect: 425, 529, 503, 536
      Annotation: 
       Subtype: Link
       Rect: 521, 508, 545, 515
      Annotation: 
       Subtype: Link
       Rect: 304, 500, 373, 507
      Annotation: 
       Subtype: Link
       Rect: 521, 480, 545, 486
      Annotation: 
       Subtype: Link
       Rect: 304, 472, 351, 478
      Annotation: 
       Subtype: Link
       Rect: 434, 443, 507, 450
      Annotation: 
       Subtype: Link
       Rect: 434, 406, 521, 414
      Annotation: 
       Subtype: Link
       Rect: 521, 378, 545, 385
      Annotation: 
       Subtype: Link
       Rect: 304, 370, 358, 377
      Annotation: 
       Subtype: Link
       Rect: 517, 333, 545, 341
      Annotation: 
       Subtype: Link
       Rect: 304, 325, 379, 333
      Annotation: 
       Subtype: Link
       Rect: 429, 297, 506, 304
      Annotation: 
       Subtype: Link
       Rect: 403, 269, 481, 275
      Annotation: 
       Subtype: Link
       Rect: 443, 232, 493, 239
      Annotation: 
       Subtype: Link
       Rect: 521, 203, 545, 211
      Annotation: 
       Subtype: Link
       Rect: 304, 195, 366, 203
      Annotation: 
       Subtype: Link
       Rect: 443, 167, 523, 174
      Annotation: 
       Subtype: Link
       Rect: 521, 139, 545, 145
      Annotation: 
       Subtype: Link
       Rect: 304, 131, 369, 137
      Annotation: 
       Subtype: Link
       Rect: 452, 102, 525, 109
      Annotation: 
       Subtype: Link
       Rect: 451, 799, 545, 806
      Annotation: 
       Subtype: Link
       Rect: 49, 33, 134, 40
      Annotation: 
       Subtype: Link
       Rect: 499, 33, 545, 40
  Checksum: 0a40280b
   Type: CRC32
  Checksum: 04acff8547d01e58e5c70991e6d899a6
   Type: MD5
  Checksum: 079f7ba2265798a6b5b379b6ca34515a984428a9
   Type: SHA-1
  Checksum: 7634de3dc4f0d5aa9b45a5f0d21e9429ef2b0f8e03f4d2c5eb9621f440fc62e3
   Type: SHA-256