9e3020b22f71656a0ebc1c2475304e82  12308_2026_Article_704.pdf
896b3fd697c4f3c9d5daed83904aa785ffd393a2  12308_2026_Article_704.pdf
d2a66a5e206afc28c2b61704f1ff556eda45a05adc7fc0530e456c6de162f2f3  12308_2026_Article_704.pdf

Title:           When pseudo–Richter transformation hits the spleen: a case report and literature review
Subject:         Journal of Hematopathology, https://doi.org/10.1007/s12308-026-00704-7
Keywords:        Chronic lymphocytic leukemia;Pseudo-Richter;Splenic rupture;Ibrutinib
Author:           Ricard Onieva 
Creator:         Adobe InDesign 15.1 (Windows)
Producer:        Adobe PDF Library 15.0; modified using iText® 5.5.13.4 ©2000-2024 iText Group NV (SPRINGER SBM; licensed version)
CreationDate:    Tue Jun  2 20:36:04 2026 CEST
ModDate:         Tue Jun  2 23:55:30 2026 CEST
Custom Metadata: yes
Metadata Stream: yes
Tagged:          no
UserProperties:  no
Suspects:        no
Form:            none
JavaScript:      no
Pages:           4
Encrypted:       no
Page size:       595.276 x 790.866 pts
Page rot:        0
File size:       937738 bytes
Optimized:       no
PDF version:     1.4


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
MyriadPro-SemiCn                     Type 1C           WinAnsi          yes no  yes     17  0
MyriadPro-Semibold                   Type 1C           Custom           yes no  yes    157  0
MyriadPro-SemiboldSemiCn             Type 1C           Custom           yes no  yes     48  0
MyriadPro-Bold                       Type 1C           Custom           yes no  yes     19  0
KRJLGE+STIX-Regular                  Type 1C           Custom           yes yes yes     18  0
STIX-Italic                          Type 1C           WinAnsi          yes no  yes     20  0
VTJFSW+Wingdings-Regular             Type 1C           WinAnsi          yes yes yes    158  0
NEAOAJ+MyriadPro-SemiCn2             Type 1C           WinAnsi          yes yes yes    198  0
STIX-Bold                            Type 1C           WinAnsi          yes no  yes     49  0
MyriadPro-BoldSemiCn                 Type 1C           WinAnsi          yes no  yes    113  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2026-08-01 05:18:08 CEST
 RepresentationInformation: 12308_2026_Article_704.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2026-07-31 14:40:37 CEST
  Size: 937738
  Format: PDF
  Version: 1.4
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 219
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    ViewerPreferences: 
     HideToolbar: false
     HideMenubar: false
     HideWindowUI: false
     FitWindow: false
     CenterWindow: false
     DisplayDocTitle: false
     NonFullScreenPageMode: UseNone
     Direction: L2R
     ViewArea: CropBox
     ViewClip: CropBox
     PrintArea: CropBox
     PageClip: CropBox
    PageLayout: SinglePage
    PageMode: UseOutlines
    Language: en-US
    Outlines: 
     Item: 
      Title: When pseudo–Richter transformation hits the spleen: a case report and literature review
      Children: 
       Item: 
        Title: Abstract
       Item: 
        Title: Introduction
       Item: 
        Title: Clinical history
       Item: 
        Title: Materials and methods
       Item: 
        Title: Results
       Item: 
        Title: Discussion
       Item: 
        Title: Conclusions
       Item: 
        Title: References
   Info: 
    Title: When pseudo Richter transformation hits the spleen: a case report and literature review
    Author:  Ricard Onieva 
    Subject: Journal of Hematopathology, https://doi.org/10.1007/s12308-026-00704-7
    Keywords: Chronic lymphocytic leukemia;Pseudo-Richter;Splenic rupture;Ibrutinib
    Creator: Adobe InDesign 15.1 (Windows)
    Producer: Adobe PDF Library 15.0; modified using iText® 5.5.13.4 ©2000-2024 iText Group NV (SPRINGER SBM; licensed version)
    CreationDate: Tue Jun 02 20:36:04 CEST 2026
    ModDate: Tue Jun 02 23:55:30 CEST 2026
   ID: 0x504fd99249beb745bcde8034ac037009, 0x807e628c4f7619d0927dab043790f178
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1500
      ImageHeight: 907
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Intent: RelativeColorimetric
     Name: X
   Fonts: 
    Type1: 
     Font: 
      BaseFont: MyriadPro-SemiboldSemiCn
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-SemiboldSemiCn
       Flags: Nonsymbolic
       FontBBox: -131, -250, 1115, 886
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-SemiCn
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-SemiCn
       Flags: Nonsymbolic
       FontBBox: -128, -250, 1059, 876
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: STIX-Bold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: STIX-Bold
       Flags: Serif, Nonsymbolic
       FontBBox: -998, -552, 2000, 1055
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-BoldSemiCn
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-BoldSemiCn
       Flags: Nonsymbolic
       FontBBox: -133, -250, 1161, 894
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: KRJLGE+STIX-Regular
      FontSubset: true
      FirstChar: 27
      LastChar: 243
      FontDescriptor: 
       FontName: KRJLGE+STIX-Regular
       Flags: Serif, Nonsymbolic
       FontBBox: -970, -486, 2208, 1023
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Bold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Bold
       Flags: Nonsymbolic
       FontBBox: -163, -250, 1256, 989
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: STIX-Italic
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: STIX-Italic
       Flags: Serif, Nonsymbolic, Italic
       FontBBox: -970, -305, 1429, 1023
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
     Font: 
      BaseFont: MyriadPro-Semibold
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: MyriadPro-Semibold
       Flags: Nonsymbolic
       FontBBox: -161, -250, 1198, 972
       FontFile3: true
      EncodingDictionary: 
       BaseEncoding: WinAnsiEncoding
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: VTJFSW+Wingdings-Regular
      FontSubset: true
      FirstChar: 0
      LastChar: 255
      FontDescriptor: 
       FontName: VTJFSW+Wingdings-Regular
       Flags: Nonsymbolic
       FontBBox: 0, -103, 1359, 439
       FontFile3: true
      Encoding: WinAnsiEncoding
      ToUnicode: true
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/" x:xmptk="Adobe XMP Core 5.1.0-jc003">
  <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
    <rdf:Description rdf:about=""
        xmlns:xmp="http://ns.adobe.com/xap/1.0/"
        xmlns:pdf="http://ns.adobe.com/pdf/1.3/"
        xmlns:dc="http://purl.org/dc/elements/1.1/"
        xmlns:crossmark="http://crossref.org/crossmark/1.0/"
        xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/"
        xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/"
        xmlns:xmpMM="http://ns.adobe.com/xap/1.0/mm/"
        xmlns:stEvt="http://ns.adobe.com/xap/1.0/sType/ResourceEvent#"
        xmlns:pdfaid="http://www.aiim.org/pdfa/ns/id/"
        xmlns:pdfaExtension="http://www.aiim.org/pdfa/ns/extension/"
        xmlns:pdfaSchema="http://www.aiim.org/pdfa/ns/schema#"
        xmlns:pdfaProperty="http://www.aiim.org/pdfa/ns/property#"
        xmlns:pdfaType="http://www.aiim.org/pdfa/ns/type#"
        xmlns:pdfaField="http://www.aiim.org/pdfa/ns/field#"
      xmp:CreateDate="2026-06-03T02:36:04+08:00"
      xmp:CreatorTool="Adobe InDesign 15.1 (Windows)"
      xmp:ModifyDate="2026-06-02T23:55:30+02:00"
      xmp:MetadataDate="2026-06-02T23:55:30+02:00"
      pdf:Producer="Adobe PDF Library 15.0; modified using iText® 5.5.13.4 ©2000-2024 iText Group NV (SPRINGER SBM; licensed version)"
      pdf:Keywords="Chronic lymphocytic leukemia;Pseudo-Richter;Splenic rupture;Ibrutinib"
      pdf:Trapped="False"
      dc:format="application/pdf"
      dc:identifier="https://doi.org/10.1007/s12308-026-00704-7"
      crossmark:DOI="10.1007/s12308-026-00704-7"
      crossmark:MajorVersionDate="2010-04-23"
      crossmark:CrossmarkDomainExclusive="true"
      prism:url="https://doi.org/10.1007/s12308-026-00704-7"
      prism:doi="10.1007/s12308-026-00704-7"
      prism:issn="1865-5785"
      prism:aggregationType="journal"
      prism:publicationName="Journal of Hematopathology"
      prism:copyright="The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature"
      pdfx:CrossmarkMajorVersionDate="2010-04-23"
      pdfx:CrossmarkDomainExclusive="true"
      pdfx:doi="10.1007/s12308-026-00704-7"
      pdfx:robots="noindex"
      xmpMM:DocumentID="uuid:0fab9895-4a1a-462b-aed4-c519f7d08cac"
      xmpMM:InstanceID="uuid:550d8552-90fa-40d2-b1ca-89cf53eb568d"
      xmpMM:RenditionClass="default"
      xmpMM:VersionID="1"
      pdfaid:part="2"
      pdfaid:conformance="B">
      <dc:publisher>
        <rdf:Bag>
          <rdf:li>Springer Berlin Heidelberg</rdf:li>
        </rdf:Bag>
      </dc:publisher>
      <dc:description>
        <rdf:Alt>
          <rdf:li xml:lang="x-default">Journal of Hematopathology, https://doi.org/10.1007/s12308-026-00704-7</rdf:li>
        </rdf:Alt>
      </dc:description>
      <dc:subject>
        <rdf:Bag>
          <rdf:li>Chronic lymphocytic leukemia</rdf:li>
          <rdf:li>Pseudo-Richter</rdf:li>
          <rdf:li>Splenic rupture</rdf:li>
          <rdf:li>Ibrutinib</rdf:li>
        </rdf:Bag>
      </dc:subject>
      <dc:title>
        <rdf:Alt>
          <rdf:li xml:lang="x-default">When pseudo–Richter transformation hits the spleen: a case report and literature review</rdf:li>
        </rdf:Alt>
      </dc:title>
      <dc:creator>
        <rdf:Seq>
          <rdf:li> Ricard Onieva </rdf:li>
          <rdf:li> Laura Rama </rdf:li>
          <rdf:li> Carmen Blázquez </rdf:li>
          <rdf:li> Rut Astorga </rdf:li>
          <rdf:li> Laura Escudero </rdf:li>
          <rdf:li> Maria Elena Ramila </rdf:li>
          <rdf:li> M. Carmen Ramos </rdf:li>
          <rdf:li> Natalia Papaleo </rdf:li>
        </rdf:Seq>
      </dc:creator>
      <crossmark:CrossMarkDomains>
        <rdf:Seq>
          <rdf:li>springer.com</rdf:li>
          <rdf:li>springerlink.com</rdf:li>
        </rdf:Seq>
      </crossmark:CrossMarkDomains>
      <pdfx:CrossMarkDomains>
        <rdf:Seq>
          <rdf:li>springer.com</rdf:li>
          <rdf:li>springerlink.com</rdf:li>
        </rdf:Seq>
      </pdfx:CrossMarkDomains>
      <xmpMM:History>
        <rdf:Seq>
          <rdf:li
            stEvt:action="converted"
            stEvt:instanceID="uuid:0fab9895-4a1a-462b-aed4-c519f7d08cac"
            stEvt:parameters="converted to PDF/A-2b"
            stEvt:softwareAgent="pdfToolbox"
            stEvt:when="2026-06-02T21:19:11Z"/>
        </rdf:Seq>
      </xmpMM:History>
      <pdfaExtension:schemas>
        <rdf:Bag>
          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://ns.adobe.com/pdfx/1.3/"
              pdfaSchema:prefix="pdfx"
              pdfaSchema:schema="Adobe Document Info PDF eXtension Schema">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="Mirrors crossmark:MajorVersionDate"
                  pdfaProperty:name="CrossmarkMajorVersionDate"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="Mirrors crossmark:CrossmarkDomainExclusive"
                  pdfaProperty:name="CrossmarkDomainExclusive"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Mirrors crossmark:DOI"
                  pdfaProperty:name="doi"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="Mirrors crossmark:CrosMarkDomains"
                  pdfaProperty:name="CrossMarkDomains"
                  pdfaProperty:valueType="seq Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="A name object indicating whether the document has been modified to include trapping information"
                  pdfaProperty:name="robots"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="ID of PDF/X standard"
                  pdfaProperty:name="GTS_PDFXVersion"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Conformance level of PDF/X standard"
                  pdfaProperty:name="GTS_PDFXConformance"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Company creating the PDF"
                  pdfaProperty:name="Company"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Date when document was last modified"
                  pdfaProperty:name="SourceModified"
                  pdfaProperty:valueType="Text"/>
              </rdf:Seq>
            </pdfaSchema:property>
            </rdf:Description>
          </rdf:li>
          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://crossref.org/crossmark/1.0/"
              pdfaSchema:prefix="crossmark"
              pdfaSchema:schema="Crossmark Schema">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Usual same as prism:doi"
                  pdfaProperty:name="DOI"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="The date when a publication was publishe."
                  pdfaProperty:name="MajorVersionDate"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="CrossmarkDomainExclusive"
                  pdfaProperty:name="CrossmarkDomainExclusive"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="CrossMarkDomains"
                  pdfaProperty:name="CrossMarkDomains"
                  pdfaProperty:valueType="seq Text"/>
              </rdf:Seq>
            </pdfaSchema:property>
            </rdf:Description>
          </rdf:li>
          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://prismstandard.org/namespaces/basic/2.0/"
              pdfaSchema:prefix="prism"
              pdfaSchema:schema="Prism Schema">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary."
                  pdfaProperty:name="url"
                  pdfaProperty:valueType="URI"/>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="The Digital Object Identifier for the article.&#xA;The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). "
                  pdfaProperty:name="doi"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version."
                  pdfaProperty:name="issn"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Volume number"
                  pdfaProperty:name="volume"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Issue number"
                  pdfaProperty:name="number"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Starting page"
                  pdfaProperty:name="startingPage"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Ending page"
                  pdfaProperty:name="endingPage"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. "
                  pdfaProperty:name="aggregationType"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.”"
                  pdfaProperty:name="publicationName"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="external"
                  pdfaProperty:description="Copyright"
                  pdfaProperty:name="copyright"
                  pdfaProperty:valueType="Text"/>
              </rdf:Seq>
            </pdfaSchema:property>
            </rdf:Description>
          </rdf:li>
          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://ns.adobe.com/pdf/1.3/"
              pdfaSchema:prefix="pdf"
              pdfaSchema:schema="Adobe PDF Schema">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="A name object indicating whether the document has been modified to include trapping information"
                  pdfaProperty:name="Trapped"
                  pdfaProperty:valueType="Text"/>
              </rdf:Seq>
            </pdfaSchema:property>
            </rdf:Description>
          </rdf:li>
          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://ns.adobe.com/xap/1.0/mm/"
              pdfaSchema:prefix="xmpMM"
              pdfaSchema:schema="XMP Media Management Schema">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="UUID based identifier for specific incarnation of a document"
                  pdfaProperty:name="InstanceID"
                  pdfaProperty:valueType="URI"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="The common identifier for all versions and renditions of a document."
                  pdfaProperty:name="DocumentID"
                  pdfaProperty:valueType="URI"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="The common identifier for all versions and renditions of a document."
                  pdfaProperty:name="OriginalDocumentID"
                  pdfaProperty:valueType="URI"/>
              </rdf:Seq>
            </pdfaSchema:property>
            </rdf:Description>
          </rdf:li>
          <rdf:li>
            <rdf:Description
              pdfaSchema:namespaceURI="http://www.aiim.org/pdfa/ns/id/"
              pdfaSchema:prefix="pdfaid"
              pdfaSchema:schema="PDF/A ID Schema">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Part of PDF/A standard"
                  pdfaProperty:name="part"
                  pdfaProperty:valueType="Integer"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Amendment of PDF/A standard"
                  pdfaProperty:name="amd"
                  pdfaProperty:valueType="Text"/>
                <rdf:li
                  pdfaProperty:category="internal"
                  pdfaProperty:description="Conformance level of PDF/A standard"
                  pdfaProperty:name="conformance"
                  pdfaProperty:valueType="Text"/>
              </rdf:Seq>
            </pdfaSchema:property>
            </rdf:Description>
          </rdf:li>
          <rdf:li>
            <rdf:Description
              pdfaSchema:schema="Springer Nature ORCID Schema"
              pdfaSchema:namespaceURI="http://springernature.com/ns/xmpExtensions/2.0/"
              pdfaSchema:prefix="sn">
            <pdfaSchema:property>
              <rdf:Seq>
                <rdf:li
                  pdfaProperty:name="authorInfo"
                  pdfaProperty:valueType="Bag AuthorInformation"
                  pdfaProperty:category="external"
                  pdfaProperty:description="Author information: contains the name of each author and his/her ORCiD (ORCiD: Open Researcher and Contributor ID). An ORCiD is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors."/>
              </rdf:Seq>
            </pdfaSchema:property>
            <pdfaSchema:valueType>
              <rdf:Seq>
                <rdf:li>
                  <rdf:Description
                    pdfaType:type="AuthorInformation"
                    pdfaType:namespaceURI="http://springernature.com/ns/xmpExtensions/2.0/authorInfo/"
                    pdfaType:prefix="author"
                    pdfaType:description="Specifies the types of author information: name and ORCID of an author.">
                  <pdfaType:field>
                    <rdf:Seq>
                      <rdf:li
                        pdfaField:name="name"
                        pdfaField:valueType="Text"
                        pdfaField:description="Gives the name of an author."/>
                      <rdf:li
                        pdfaField:name="orcid"
                        pdfaField:valueType="URI"
                        pdfaField:description="Gives the ORCID of an author."/>
                    </rdf:Seq>
                  </pdfaType:field>
                  </rdf:Description>
                </rdf:li>
              </rdf:Seq>
            </pdfaSchema:valueType>
            </rdf:Description>
          </rdf:li>
        </rdf:Bag>
      </pdfaExtension:schemas>
    </rdf:Description>
  </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 513, 726, 546, 694
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 268, 266, 273, 251
       Flags: Print
       AppearanceDictionary: true
       Destination: 57
      Annotation: 
       Subtype: Link
       Rect: 278, 266, 283, 251
       Flags: Print
       AppearanceDictionary: true
       Destination: 57
      Annotation: 
       Subtype: Link
       Rect: 269, 216, 274, 201
       Flags: Print
       AppearanceDictionary: true
       Destination: 57
      Annotation: 
       Subtype: Link
       Rect: 278, 216, 283, 201
       Flags: Print
       AppearanceDictionary: true
       Destination: 57
      Annotation: 
       Subtype: Link
       Rect: 331, 329, 336, 314
       Flags: Print
       AppearanceDictionary: true
       Destination: 57
      Annotation: 
       Subtype: Link
       Rect: 331, 241, 336, 226
       Flags: Print
       AppearanceDictionary: true
       Destination: 57
      Annotation: 
       Subtype: Link
       Rect: 341, 241, 346, 226
       Flags: Print
       AppearanceDictionary: true
       Destination: 57
      Annotation: 
       Subtype: Link
       Rect: 408, 179, 413, 164
       Flags: Print
       AppearanceDictionary: true
       Destination: 57
      Annotation: 
       Subtype: Link
       Rect: 371, 91, 376, 76
       Flags: Print
       AppearanceDictionary: true
       Destination: 57
     Thumb: true
    Page: 
     Sequence: 2
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 514, 535, 519, 520
       Flags: Print
       AppearanceDictionary: true
       Destination: 23
      Annotation: 
       Subtype: Link
       Rect: 415, 235, 420, 220
       Flags: Print
       AppearanceDictionary: true
       Destination: 57
      Annotation: 
       Subtype: Link
       Rect: 353, 185, 358, 170
       Flags: Print
       AppearanceDictionary: true
       Destination: 57
      Annotation: 
       Subtype: Link
       Rect: 354, 135, 359, 120
       Flags: Print
       AppearanceDictionary: true
       Destination: 23
     Thumb: true
    Page: 
     Sequence: 3
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 188, 199, 193, 184
       Flags: Print
       AppearanceDictionary: true
       Destination: 57
      Annotation: 
       Subtype: Link
       Rect: 230, 186, 235, 171
       Flags: Print
       AppearanceDictionary: true
       Destination: 57
      Annotation: 
       Subtype: Link
       Rect: 241, 186, 246, 171
       Flags: Print
       AppearanceDictionary: true
       Destination: 57
      Annotation: 
       Subtype: Link
       Rect: 484, 199, 494, 184
       Flags: Print
       AppearanceDictionary: true
       Destination: 57
      Annotation: 
       Subtype: Link
       Rect: 409, 149, 414, 134
       Flags: Print
       AppearanceDictionary: true
       Destination: 57
      Annotation: 
       Subtype: Link
       Rect: 67, 429, 71, 416
       Flags: Print
       AppearanceDictionary: true
       Destination: 57
      Annotation: 
       Subtype: Link
       Rect: 82, 417, 87, 404
       Flags: Print
       AppearanceDictionary: true
       Destination: 57
      Annotation: 
       Subtype: Link
       Rect: 82, 394, 87, 381
       Flags: Print
       AppearanceDictionary: true
       Destination: 57
      Annotation: 
       Subtype: Link
       Rect: 82, 372, 87, 359
       Flags: Print
       AppearanceDictionary: true
       Destination: 57
      Annotation: 
       Subtype: Link
       Rect: 80, 349, 84, 336
       Flags: Print
       AppearanceDictionary: true
       Destination: 57
      Annotation: 
       Subtype: Link
       Rect: 80, 327, 84, 314
       Flags: Print
       AppearanceDictionary: true
       Destination: 57
      Annotation: 
       Subtype: Link
       Rect: 80, 304, 84, 291
       Flags: Print
       AppearanceDictionary: true
       Destination: 57
      Annotation: 
       Subtype: Link
       Rect: 80, 292, 84, 279
       Flags: Print
       AppearanceDictionary: true
       Destination: 57
      Annotation: 
       Subtype: Link
       Rect: 80, 279, 84, 266
       Flags: Print
       AppearanceDictionary: true
       Destination: 57
     Thumb: true
    Page: 
     Sequence: 4
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 178, 686, 188, 671
       Flags: Print
       AppearanceDictionary: true
       Destination: 57
      Annotation: 
       Subtype: Link
       Rect: 193, 686, 203, 671
       Flags: Print
       AppearanceDictionary: true
       Destination: 57
      Annotation: 
       Subtype: Link
       Rect: 392, 716, 542, 703
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 507, 616, 544, 603
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 606, 445, 593
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 340, 566, 493, 553
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 460, 526, 544, 513
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 516, 409, 503
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 368, 476, 514, 463
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 377, 436, 540, 423
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 414, 396, 525, 383
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 463, 356, 544, 343
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 346, 419, 333
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 306, 480, 293
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 495, 266, 544, 253
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 256, 425, 243
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 378, 206, 531, 193
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 424, 176, 539, 163
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 460, 126, 544, 113
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 323, 116, 395, 103
       Flags: Print
       AppearanceDictionary: true
     Thumb: true
  Checksum: 950a7074
   Type: CRC32
  Checksum: 9e3020b22f71656a0ebc1c2475304e82
   Type: MD5
  Checksum: 896b3fd697c4f3c9d5daed83904aa785ffd393a2
   Type: SHA-1
  Checksum: d2a66a5e206afc28c2b61704f1ff556eda45a05adc7fc0530e456c6de162f2f3
   Type: SHA-256