93160dc07f6c7feface791bc73cede1e eurjoupai_a2026v30n6e70321iENG.pdf 1adfa21a0e41dda760994d64d986e0be76868fb7 eurjoupai_a2026v30n6e70321iENG.pdf 42b8a692a1b0d35e9a7d5573de666aef53ef96e05770a5ac1346187561e7b803 eurjoupai_a2026v30n6e70321iENG.pdf Title: Efficacy of Low‐Dose Naltrexone in Women With Fibromyalgia Syndrome: A 12‐Month Randomised, Double‐Blind, Placebo‐Controlled Single‐Centre Clinical Trial (INNOVA Study) Subject: European Journal of Pain 2026.30:e70321 Author: Carla Rodríguez-Freire, Jaime Navarrete, Antoni Rozadilla-Sacanell, Juan P. Sanabria-Mazo, Beatriz del Pino-Gaya, Xavier Borràs, Albert Feliu-Soler, Juan V. Luciano Creator: Adobe InDesign 19.5 (Windows) Producer: Adobe PDF Library 17.0; modified using iText 4.2.0 by 1T3XT CreationDate: Fri Jun 26 09:14:46 2026 CEST ModDate: Wed Jul 8 19:40:06 2026 CEST Custom Metadata: yes Metadata Stream: yes Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 15 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 407339 bytes Optimized: no PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- FVBJTY+STIXTwoText Type 1C Custom yes yes yes 54 0 ZMZZNK+STIXTwoText-BoldItalic Type 1C WinAnsi yes yes yes 155 0 BPYLPG+STIXTwoText-Italic Type 1C Custom yes yes yes 56 0 XJANLO+ArialRoundedMTBold Type 1C WinAnsi yes yes no 2784 0 ZMZZNK+STIXTwoText-Bold Type 1C Custom yes yes yes 55 0 XJANLO+STIX-Regular Type 1C Custom yes yes yes 92 0 Times-Roman Type 1 WinAnsi no no no 5 0 QWOXRC+TimesNewRomanPSMT Type 1C WinAnsi yes yes no 118 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2026-07-10 04:39:11 CEST RepresentationInformation: eurjoupai_a2026v30n6e70321iENG.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2026-07-09 05:33:43 CEST Size: 407339 Format: PDF Version: 1.7 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Tagged PDF PDFMetadata: Objects: 0 FreeObjects: 2 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: true NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Language: en-US Outlines: Item: Title: Efficacy of Low-Dose Naltrexone in Women With Fibromyalgia Syndrome: A 12-Month Randomised, Double-Blind, Placebo-Controlled Single-Centre Clinical Trial (INNOVA Study) Children: Item: Title: ABSTRACT Item: Title: 1   |   Introduction Item: Title: 2   |   Methods Children: Item: Title: 2.1   |   Study Design Item: Title: 2.2   |   Participants Item: Title: 2.3   |   Randomisation and Masking Item: Title: 2.4   |   Procedures Item: Title: 2.5   |   Outcomes Item: Title: 2.6   |   Data Analysis Item: Title: 3   |   Results Children: Item: Title: 3.1   |   Participant Flow and Baseline Characteristics Item: Title: 3.2   |   Retention and Adherence Item: Title: 3.3   |   Primary and Secondary Outcomes (ITT Population) Item: Title: 3.4   |   Responder Analyses and Baseline Predictors Item: Title: 3.5   |   Per-Protocol Analyses (80% Adherence and Completers) Item: Title: 3.6   |   Safety and Adverse Events Item: Title: 3.7   |   Perceived Treatment Allocation Item: Title: 4   |   Discussion Item: Title: 5   |   Conclusion Item: Title: Author Contributions Item: Title: Acknowledgements Item: Title: Funding Item: Title: Conflicts of Interest Item: Title: Data Availability Statement Item: Title: 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