7e51948b3d5e65b703da1c0ceb3f9418 antageche_a2026m8v70n8pe1064425.pdf e8fd3cedd4be9d4c68775bb6272c0255811bd21f antageche_a2026m8v70n8pe1064425.pdf 0b3f5c54c9557957da22965e7de645570275e98688a126971be0d2694166ec2d antageche_a2026m8v70n8pe1064425.pdf Title: A newly identified homologous SxtPR efflux system contributes to sulfamethoxazole/trimethoprim susceptibility and pathogenesis in Klebsiella pneumoniae Subject: Antimicrob Agents Chemother 2026.70:e01644-25 Keywords: Klebsiella pneumoniae, MFS efflux pump, LysR−type transcriptional regulator Author: Jordi Corral, María Pérez-Varela, Marc Gaona, Susana Campoy, Jordi Barbé, Jesús Aranda Creator: Antenna House XSL Formatter V7.4 MR2 Linux : 7.4.3.63807 (2024-03-22T11:49+09) Producer: Antenna House PDF Output Library 7.4.1901 CreationDate: Wed Jul 29 12:14:36 2026 CEST ModDate: Wed Jul 29 12:14:36 2026 CEST Custom Metadata: yes Metadata Stream: yes Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 6 Encrypted: no 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indirect destination - referenced object 'fig-caption-kriyadocs-F1_0' cannot be found ID: PDF-HUL-122 Offset: 750999 MIMEtype: application/pdf Profile: Tagged PDF PDFMetadata: Objects: 0 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: true NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseNone Language: EN Outlines: Item: Title: A newly identified homologous SxtPR efflux system contributes to sulfamethoxazole/trimethoprim susceptibility and pathogenesis in Klebsiella pneumoniae Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 32 ImageHeight: 51 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: 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ZBPFTU+MyriadPro-Regular FontSubset: true FirstChar: 44 LastChar: 139 FontDescriptor: FontName: ZBPFTU+MyriadPro-Regular Flags: Nonsymbolic FontBBox: -157, -250, 1126, 952 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true XMP: application/pdfA newly identified homologous SxtPR efflux system contributes to sulfamethoxazole/trimethoprim susceptibility and pathogenesis in Klebsiella pneumoniaeAAC01644-25Jordi CorralMaría Pérez-VarelaMarc GaonaSusana CampoyJordi BarbéJesús ArandaJordi CorralMaría Pérez-VarelaMarc GaonaSusana CampoyJordi BarbéJesús ArandaASMCopyright © 2026 Corral et al.This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.20262023Klebsiella pneumoniae is an opportunistic pathogen responsible for a wide range of healthcare-associated infections. In a recent work, we identified a novel Major Facilitator Superfamily efflux system in Acinetobacter baumannii, designated SxtPR, which mediates antimicrobial resistance and pathogenicity (M. Gaona, J. Corral, S. Campoy, J. Barbé, et al, Antimicrob Agents Chemother e0071224, 2024, https://doi.org/10.1128/aac.00712-24). Here, we report the identification and characterization of a homologous system in Klebsiella pneumoniae that plays a similar dual role in antimicrobial resistance and virulence.20251029202605060066-4804uuid:0e420e5e-e139-447a-b4ca-3b332d8d3b94uuid:feaf3825-8907-4e8e-a6d1-6cf424bfe386 Antenna House PDF Output Library 7.4.1901 Antenna House XSL Formatter V7.4 MR2 Linux : 7.4.3.63807 (2024-03-22T11:49+09) 2026-07-29T10:14:36+00:00 2026-07-29T10:14:36+00:00 2026-07-29T10:14:36+00:00 aaf3d0e9-07f8-44b8-b943-7ff0d9ce9779 1 Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Contents: ExternalLinking Rect: 41, 447, 376, 470 LastModified: D:20260729101436+00'00' Flags: Print Annotation: Subtype: Link Contents: ExternalLinking Rect: 200, 123, 247, 134 LastModified: D:20260729101436+00'00' Flags: Print Annotation: Subtype: Link Contents: ExternalLinking Rect: 231, 111, 278, 122 LastModified: D:20260729101436+00'00' Flags: Print Annotation: Subtype: Link Contents: ExternalLinking 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