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Title:           Resorufin-derived esters as fluorescent probes to test for the esterase activity and active-site topology of aldehyde dehydrogenase
Subject:         Chemico-Biological Interactions, 436 (2026) 112209. doi:10.1016/j.cbi.2026.112209
Keywords:        Esterase,Fluorescence,Kinetic properties,Oxidoreductases,Structure-function relationships
Author:          Raquel Pequerul
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      Title: Resorufin-derived esters as fluorescent probes to test for the esterase activity and active-site topology of aldehyde dehyd ...
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        Title: 1 Introduction
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        Title: 2 Materials and methods
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          Title: 2.1 ALDH substrates and inhibitors
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          Title: 2.2 Chemistry
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           Item: 
            Title: 2.2.1 Resorufin propionate (2)
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             Item: 
              Title: 2.2.1.1 Formula: C15H11NO4
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            Title: 2.2.2 Resorufin hexanoate (3)
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             Item: 
              Title: 2.2.2.1 Formula: C18H17NO4
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            Title: 2.2.3 Resorufin octanoate (4)
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              Title: 2.2.3.1 Formula: C20H21N04
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            Title: 2.2.4 Resorufin benzoate (5)
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              Title: 2.2.4.1 Formula: C19H11NO4
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            Title: 2.2.5 Resorufin retinoate (6)
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              Title: 2.2.5.1 Formula: C31H33NO4
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          Title: 2.3 Protein expression and purification
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          Title: 2.4 Fluorescence assay for the determination of the kinetic constants
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         Item: 
          Title: 2.5 Molecular docking analysis
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          Title: 2.6 Cell culture and ALDH activity and inhibition assays in cell extracts
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        Title: 3 Results and discussion
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          Title: 3.1 Kinetic characterization of ALDH1A isoforms using resorufin derivatives as substrates
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          Title: 3.2 Molecular docking of resorufin esters into ALDH1A active sites
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            Title: 3.2.1 Resorufin hexanoate
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            Title: 3.2.3 Resorufin benzoate
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            Title: 3.2.4 Resorufin retinoate
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          Title: 3.3 Comparative analysis of ALDH activity in lung cancer A549 and glioblastoma A172 cell extracts
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          Title: 3.4 Contribution of ALDH to esterase activity in glioblastoma A172 cell extracts
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        Title: 4 Conclusions
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       Item: 
        Title: CRediT authorship contribution statement
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       Item: 
        Title: Declaration of competing interest
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        Title: Acknowledgements
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        Title: Appendix A. Supplementary data
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       Item: 
        Title: Data availability
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        Title: References
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    Author: Raquel Pequerul
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    Keywords: Esterase,Fluorescence,Kinetic properties,Oxidoreductases,Structure-function relationships
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