c05929352647a5eb2fb65c9956448357 s40291-026-00860-7.pdf 22d53c1579700a03bd70c96163e9ade61c43b116 s40291-026-00860-7.pdf 69570d4875a6928198f9c7feb83393b1d49e35bb1ae068b58c5ad50ca8e6bf5b s40291-026-00860-7.pdf Title: Cost-Effectiveness of a Host-Response Point-of-Care Assay for Early Sepsis Diagnosis in UK Emergency Departments Subject: Molecular Diagnosis & Therapy, https://doi.org/10.1007/s40291-026-00860-7 Author: Erika P. Plata-Menchaca Creator: Springer Producer: Adobe PDF Library 17.0; modified using iTextSharp™ 5.5.14-SNAPSHOT ©2000-2020 iText Group NV (AGPL-version) CreationDate: Mon Aug 10 18:05:38 2026 CEST ModDate: Mon Aug 10 18:07:42 2026 CEST Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 14 Encrypted: no Page size: 595.276 x 790.866 pts Page rot: 0 File size: 1528143 bytes Optimized: yes PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MyriadPro-SemiCn Type 1C Custom yes no yes 803 0 MyriadPro-Semibold Type 1C Custom yes no yes 804 0 MyriadPro-SemiboldSemiCn Type 1C Custom yes no yes 810 0 MyriadPro-Bold Type 1C Custom yes no yes 815 0 EAGNCP+STIX-Regular Type 1C Custom yes yes yes 816 0 CCKNAR+MyriadPro-SemiCn2 Type 1C WinAnsi yes yes yes 848 0 MyriadPro-BoldSemiCn Type 1C Custom yes no yes 538 0 MyriadPro-SemiCn3 Type 1C Custom yes no yes 545 0 XQHCID+Calibri Type 1C WinAnsi yes yes no 553 0 WRSWUF+Calibri-Bold Type 1C WinAnsi yes yes no 557 0 Calibri2 Type 1C WinAnsi yes no no 556 0 STIX-Italic Type 1C WinAnsi yes no yes 559 0 Calibri3 Type 1C WinAnsi yes no no 587 0 CRLTVT+Verdana Type 1C WinAnsi yes yes no 583 0 Calibri-Bold2 Type 1C WinAnsi yes no no 581 0 Calibri4 Type 1C WinAnsi yes no no 577 0 Calibri5 Type 1C Custom yes no no 582 0 Calibri6 Type 1C WinAnsi yes no no 620 0 Verdana2 Type 1C WinAnsi yes no no 622 0 Calibri7 Type 1C WinAnsi yes no no 618 0 Calibri8 Type 1C Custom yes no no 621 0 Calibri9 Type 1C WinAnsi yes no no 624 0 Calibri10 Type 1C WinAnsi yes no no 625 0 BIWFPR+Wingdings-Regular Type 1C WinAnsi yes yes yes 753 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2026-09-11 04:19:53 CEST RepresentationInformation: s40291-026-00860-7.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2026-09-10 19:03:34 CEST Size: 1528143 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 898 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Cost-Effectiveness of a Host-Response Point-of-Care Assay for Early Sepsis Diagnosis in UK Emergency Departments Children: Item: Title: Abstract Children: Item: Title: Background Item: Title: Objective Item: Title: Methods Item: Title: Results Item: Title: Conclusions Item: Title: 1 Introduction Item: Title: 2 Methods Children: Item: Title: 2.1 Model Structure Item: Title: 2.2 Time Horizon and Perspective Item: Title: 2.3 LPS-induced TNF-α Release Assay description Item: Title: 2.4 Input Parameters Item: Title: 2.5 Analytical Approach Item: Title: 2.6 Ethics approval and consent to participate Item: Title: 3 Results Item: Title: 4 Discussion Item: Title: 5 Limitations and future directions Item: Title: 6 Conclusions Item: Title: References Info: Title: Cost-Effectiveness of a Host-Response Point-of-Care Assay for Early Sepsis Diagnosis in UK Emergency Departments Author: Erika P. Plata-Menchaca Subject: Molecular Diagnosis & Therapy, https://doi.org/10.1007/s40291-026-00860-7 Creator: Springer Producer: Adobe PDF Library 17.0; modified using iTextSharp™ 5.5.14-SNAPSHOT ©2000-2020 iText Group NV (AGPL-version) CreationDate: Mon Aug 10 18:35:38 CEST 2026 ModDate: Mon Aug 10 18:37:42 CEST 2026 ID: 0x591d64941ab4ac4ba9e3d59acaaa4bda, 0x1ae4b297ff80024fa3a7cf1f2aaf59a7 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 31 ImageHeight: 167 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 49 ImageHeight: 32 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 79 ImageHeight: 32 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 27 ImageHeight: 26 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 14 ImageHeight: 17 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 14 ImageHeight: 32 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 21 ImageHeight: 32 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 15 ImageHeight: 28 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 59 ImageHeight: 31 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 57 ImageHeight: 31 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 18 ImageHeight: 32 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 14 ImageHeight: 32 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 25 ImageHeight: 25 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 18 ImageHeight: 32 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 15 ImageHeight: 16 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 21 ImageHeight: 31 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 23 ImageHeight: 26 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 14 ImageHeight: 31 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 59 ImageHeight: 31 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 68 ImageHeight: 31 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 24 ImageHeight: 26 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 14 ImageHeight: 22 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 17 ImageHeight: 31 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 76 ImageHeight: 32 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 35 ImageHeight: 772 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 266 ImageHeight: 15 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 39 ImageHeight: 31 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 47 ImageHeight: 31 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 88 ImageHeight: 31 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 27 ImageHeight: 24 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 29 ImageHeight: 22 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 26 ImageHeight: 23 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 15 ImageHeight: 27 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 14 ImageHeight: 14 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 11 ImageHeight: 12 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 42 ImageHeight: 32 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 21 ImageHeight: 27 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 14 ImageHeight: 24 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 20 ImageHeight: 31 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 46 ImageHeight: 32 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 24 ImageHeight: 27 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 15 ImageHeight: 24 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 20 ImageHeight: 32 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 14 ImageHeight: 32 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 25 ImageHeight: 26 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 15 ImageHeight: 28 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 55 ImageHeight: 32 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 15 ImageHeight: 23 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 21 ImageHeight: 32 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 50 ImageHeight: 31 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 13 ImageHeight: 27 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 43 ImageHeight: 32 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 12 ImageHeight: 18 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 21 ImageHeight: 24 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 39 ImageHeight: 32 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 50 ImageHeight: 32 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 76 ImageHeight: 31 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 12 ImageHeight: 27 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 11 ImageHeight: 15 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 50 ImageHeight: 32 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 27 ImageHeight: 22 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 14 ImageHeight: 26 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 764 ImageHeight: 78 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 13 ImageHeight: 27 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 14 ImageHeight: 31 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 11 ImageHeight: 15 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 772 ImageHeight: 33 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 35 ImageHeight: 32 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 67 ImageHeight: 31 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 21 ImageHeight: 32 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 26 ImageHeight: 27 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 50 ImageHeight: 31 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 31 ImageHeight: 164 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 17 ImageHeight: 26 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 89 ImageHeight: 32 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 50 ImageHeight: 31 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 26 ImageHeight: 26 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 80 ImageHeight: 31 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 18 ImageHeight: 31 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 31 ImageHeight: 208 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 31 ImageHeight: 270 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 47 ImageHeight: 31 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 31 ImageHeight: 828 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 14 ImageHeight: 17 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 27 ImageHeight: 27 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 11 ImageHeight: 26 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 22 ImageHeight: 32 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 13 ImageHeight: 26 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 56 ImageHeight: 32 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 15 ImageHeight: 14 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 27 ImageHeight: 26 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1163 ImageHeight: 77 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Intent: RelativeColorimetric Decode: 0, 255 Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1805 ImageHeight: 735 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1778 ImageHeight: 724 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Fonts: Type1: Font: BaseFont: Calibri4 FirstChar: 32 LastChar: 163 FontDescriptor: FontName: Calibri4 Flags: Nonsymbolic FontBBox: -503, -312, 1240, 1026 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: MyriadPro-SemiCn FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-SemiCn Flags: Nonsymbolic FontBBox: -128, -250, 1059, 876 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: MyriadPro-Semibold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Semibold Flags: Nonsymbolic FontBBox: -161, -250, 1198, 972 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: Calibri-Bold2 FirstChar: 32 LastChar: 120 FontDescriptor: FontName: Calibri-Bold2 Flags: Nonsymbolic FontBBox: -519, -349, 1263, 1039 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: Calibri5 FirstChar: 31 LastChar: 163 FontDescriptor: FontName: Calibri5 Flags: Nonsymbolic FontBBox: -503, -312, 1240, 1026 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: CRLTVT+Verdana FontSubset: true FirstChar: 32 LastChar: 118 FontDescriptor: FontName: CRLTVT+Verdana Flags: Nonsymbolic FontBBox: -560, -303, 1523, 1051 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: XQHCID+Calibri FontSubset: true FirstChar: 32 LastChar: 119 FontDescriptor: FontName: XQHCID+Calibri Flags: Nonsymbolic FontBBox: -503, -312, 1240, 1026 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: MyriadPro-SemiboldSemiCn FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-SemiboldSemiCn Flags: Nonsymbolic FontBBox: -131, -250, 1115, 886 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: Calibri7 FirstChar: 32 LastChar: 163 FontDescriptor: FontName: Calibri7 Flags: Nonsymbolic FontBBox: -503, -312, 1240, 1026 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: Calibri3 FirstChar: 32 LastChar: 163 FontDescriptor: FontName: Calibri3 Flags: Nonsymbolic FontBBox: -503, -312, 1240, 1026 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: Calibri2 FirstChar: 32 LastChar: 121 FontDescriptor: FontName: Calibri2 Flags: Nonsymbolic FontBBox: -503, -312, 1240, 1026 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: Calibri6 FirstChar: 32 LastChar: 163 FontDescriptor: FontName: Calibri6 Flags: Nonsymbolic FontBBox: -503, -312, 1240, 1026 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: WRSWUF+Calibri-Bold FontSubset: true FirstChar: 32 LastChar: 66 FontDescriptor: FontName: WRSWUF+Calibri-Bold Flags: Nonsymbolic FontBBox: -519, -349, 1263, 1039 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: Calibri8 FirstChar: 31 LastChar: 163 FontDescriptor: FontName: Calibri8 Flags: Nonsymbolic FontBBox: -503, -312, 1240, 1026 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true Font: BaseFont: Verdana2 FirstChar: 32 LastChar: 118 FontDescriptor: FontName: Verdana2 Flags: Nonsymbolic FontBBox: -560, -303, 1523, 1051 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: MyriadPro-Bold FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-Bold Flags: Nonsymbolic FontBBox: -163, -250, 1256, 989 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: STIX-Italic FirstChar: 0 LastChar: 255 FontDescriptor: FontName: STIX-Italic Flags: Serif, Nonsymbolic, Italic FontBBox: -970, -305, 1429, 1023 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: EAGNCP+STIX-Regular FontSubset: true FirstChar: 24 LastChar: 248 FontDescriptor: FontName: EAGNCP+STIX-Regular Flags: Serif, Nonsymbolic FontBBox: -970, -486, 2208, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: Calibri9 FirstChar: 32 LastChar: 163 FontDescriptor: FontName: Calibri9 Flags: Nonsymbolic FontBBox: -503, -312, 1240, 1026 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: Calibri10 FirstChar: 32 LastChar: 163 FontDescriptor: FontName: Calibri10 Flags: Nonsymbolic FontBBox: -503, -312, 1240, 1026 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: BIWFPR+Wingdings-Regular FontSubset: true FirstChar: 0 LastChar: 255 FontDescriptor: FontName: BIWFPR+Wingdings-Regular Flags: Nonsymbolic FontBBox: 0, -103, 1359, 439 FontFile3: true Encoding: WinAnsiEncoding ToUnicode: true Font: BaseFont: MyriadPro-BoldSemiCn FirstChar: 0 LastChar: 255 FontDescriptor: FontName: MyriadPro-BoldSemiCn Flags: Nonsymbolic FontBBox: -133, -250, 1161, 894 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true XMP: 2026-08-10T21:35:38+05:30 Springer 2026-08-10T21:37:42+05:30 2026-08-10T21:37:42+05:30 application/pdf https://doi.org/10.1007/s40291-026-00860-7 Springer International Publishing Molecular Diagnosis & Therapy, https://doi.org/10.1007/s40291-026-00860-7 Cost-Effectiveness of a Host-Response Point-of-Care Assay for Early Sepsis Diagnosis in UK Emergency Departments Erika P. Plata-Menchaca Enrique Hernández-Jiménez Queralt Caus-Capdevila Judit Cubedo Eduard Guerrero Ignasi Azagra Joan Vieyra Francisco Eduardo Dardón-Fierro Jia Louise Kate Zhang Cheryl McDade Christopher Knight David Price Bob Jarman Ricard Ferrer 10.1007/s40291-026-00860-7 2010-04-23 true springer.com springerlink.com https://doi.org/10.1007/s40291-026-00860-7 10.1007/s40291-026-00860-7 1179-2000 journal Molecular Diagnosis & Therapy The Author(s) 2010-04-23 true 10.1007/s40291-026-00860-7 noindex springer.com springerlink.com VoR Adobe PDF Library 17.0; modified using iTextSharp™ 5.5.14-SNAPSHOT ©2000-2020 iText Group NV (AGPL-version) False uuid:8c985fba-ec14-4777-a2c2-22bec96d6122 uuid:9fefdcb4-134f-413c-9210-73f71a19cc0e default 1 converted uuid:8c985fba-ec14-4777-a2c2-22bec96d6122 converted to PDF/A-2b pdfToolbox 2026-08-10T21:36:21+05:30 converted uuid:16b8e394-3d9b-4ac6-906f-e9599ee9856b converted to PDF/A-2b pdfToolbox 2026-08-10T21:37:41+05:30 2 B Ricard Ferrer http://orcid.org/0000-0002-4859-4747 http://ns.adobe.com/pdfx/1.3/ pdfx Adobe Document Info PDF eXtension Schema external Mirrors crossmark:MajorVersionDate CrossmarkMajorVersionDate Text external Mirrors crossmark:CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal Mirrors crossmark:DOI doi Text external Mirrors crossmark:CrosMarkDomains CrossMarkDomains seq Text internal A name object indicating whether the document has been modified to include trapping information robots Text internal ID of PDF/X standard GTS_PDFXVersion Text internal Conformance level of PDF/X standard GTS_PDFXConformance Text internal Company creating the PDF Company Text internal Date when document was last modified SourceModified Text http://crossref.org/crossmark/1.0/ crossmark Crossmark Schema internal Usual same as prism:doi DOI Text external The date when a publication was publishe. MajorVersionDate Text internal CrossmarkDomainExclusive CrossmarkDomainExclusive Text internal CrossMarkDomains CrossMarkDomains seq Text http://prismstandard.org/namespaces/basic/2.0/ prism Prism Schema external This element provides the url for an article or unit of content. The attribute platform is optionally allowed for situations in which multiple URLs must be specified. PRISM recommends that a subset of the PCV platform values, namely “mobile” and “web”, be used in conjunction with this element. NOTE: PRISM recommends against the use of the #other value allowed in the PRISM Platform controlled vocabulary. In lieu of using #other please reach out to the PRISM group at prism-wg@yahoogroups.com to request addition of your term to the Platform Controlled Vocabulary. url URI external The Digital Object Identifier for the article. The DOI may also be used as the dc:identifier. If used as a dc:identifier, the URI form should be captured, and the bare identifier should also be captured using prism:doi. If an alternate unique identifier is used as the required dc:identifier, then the DOI should be specified as a bare identifier within prism:doi only. If the URL associated with a DOI is to be specified, then prism:url may be used in conjunction with prism:doi in order to provide the service endpoint (i.e. the URL). doi Text external ISSN for an electronic version of the issue in which the resource occurs. Permits publishers to include a second ISSN, identifying an electronic version of the issue in which the resource occurs (therefore e(lectronic)Issn. If used, prism:eIssn MUST contain the ISSN of the electronic version. issn Text internal Volume number volume Text internal Issue number number Text internal Starting page startingPage Text internal Ending page endingPage Text external The aggregation type specifies the unit of aggregation for a content collection. Comment PRISM recommends that the PRISM Aggregation Type Controlled Vocabulary be used to provide values for this element. Note: PRISM recommends against the use of the #other value currently allowed in this controlled vocabulary. In lieu of using #other please reach out to the PRISM group at info@prismstandard.org to request addition of your term to the Aggregation Type Controlled Vocabulary. aggregationType Text external Title of the magazine, or other publication, in which a resource was/will be published. Typically this will be used to provide the name of the magazine an article appeared in as metadata for the article, along with information such as the article title, the publisher, volume, number, and cover date. Note: Publication name can be used to differentiate between a print magazine and the online version if the names are different such as “magazine” and “magazine.com.” publicationName Text external Copyright copyright Text http://ns.adobe.com/pdf/1.3/ pdf Adobe PDF Schema internal A name object indicating whether the document has been modified to include trapping information Trapped Text http://ns.adobe.com/xap/1.0/mm/ xmpMM XMP Media Management Schema internal UUID based identifier for specific incarnation of a document InstanceID URI internal The common identifier for all versions and renditions of a document. DocumentID URI internal The common identifier for all versions and renditions of a document. OriginalDocumentID URI internal A reference to the original document from which this one is derived. It is a minimal reference; missing components can be assumed to be unchanged. For example, a new version might only need to specify the instance ID and version number of the previous version, or a rendition might only need to specify the instance ID and rendition class of the original. DerivedFrom ResourceRef Identifies a portion of a document. This can be a position at which the document has been changed since the most recent event history (stEvt:changed). For a resource within an xmpMM:Ingredients list, the ResourceRef uses this type to identify both the portion of the containing document that refers to the resource, and the portion of the referenced resource that is referenced. http://ns.adobe.com/xap/1.0/sType/Part# stPart Part http://www.aiim.org/pdfa/ns/id/ pdfaid PDF/A ID Schema internal Part of PDF/A standard part Integer internal Amendment of PDF/A standard amd Text internal Conformance level of PDF/A standard conformance Text Springer Nature ORCID Schema http://springernature.com/ns/xmpExtensions/2.0/ sn authorInfo Bag AuthorInformation external Author information: contains the name of each author and his/her ORCiD (ORCiD: Open Researcher and Contributor ID). An ORCiD is a persistent identifier (a non-proprietary alphanumeric code) to uniquely identify scientific and other academic authors. AuthorInformation http://springernature.com/ns/xmpExtensions/2.0/authorInfo/ author Specifies the types of author information: name and ORCID of an author. name Text Gives the name of an author. orcid URI Gives the ORCID of an author. http://ns.adobe.com/xap/1.0/t/pg/ xmpTPg XMP Paged-Text internal XMP08 Spec: An ordered array of plate names that are needed to print the document (including any in contained documents). PlateNames Seq Text internal A structure containing the characteristics of a font used in a document Fonts Bag Font A structure containing the characteristics of a font used in a document. http://ns.adobe.com/xap/1.0/sType/Font# stFnt Font http://www.niso.org/schemas/jav/1.0/ jav NISO external Values for Journal Article Version are one of the following: AO = Author’s Original SMUR = Submitted Manuscript Under Review AM = Accepted Manuscript P = Proof VoR = Version of Record CVoR = Corrected Version of Record EVoR = Enhanced Version of Record journal_article_version Closed Choice of Text Pages: Page: Sequence: 1 Annotations: Annotation: Subtype: Link Rect: 513, 726, 546, 694 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 402, 609, 414, 597 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 135, 139, 140, 124 Flags: Print AppearanceDictionary: true Destination: 375 Annotation: Subtype: Link Rect: 446, 165, 451, 150 Flags: Print AppearanceDictionary: true Destination: 375 Thumb: true Page: Sequence: 2 Annotations: Annotation: Subtype: Link Rect: 95, 337, 100, 322 Flags: Print AppearanceDictionary: true Destination: 375 Annotation: Subtype: Link Rect: 185, 237, 191, 222 Flags: Print AppearanceDictionary: true Destination: 375 Annotation: Subtype: Link Rect: 192, 175, 197, 159 Flags: Print AppearanceDictionary: true Destination: 375 Annotation: Subtype: Link Rect: 210, 150, 215, 134 Flags: Print AppearanceDictionary: true Destination: 375 Annotation: Subtype: Link Rect: 220, 150, 225, 134 Flags: Print AppearanceDictionary: true Destination: 375 Annotation: Subtype: Link Rect: 309, 723, 314, 708 Flags: Print AppearanceDictionary: true Destination: 375 Annotation: Subtype: Link Rect: 501, 685, 507, 670 Flags: Print AppearanceDictionary: true Destination: 375 Annotation: Subtype: Link Rect: 512, 685, 522, 670 Flags: Print AppearanceDictionary: true Destination: 375 Annotation: Subtype: Link Rect: 432, 610, 442, 595 Flags: Print AppearanceDictionary: true Destination: 375 Annotation: Subtype: Link Rect: 497, 260, 507, 245 Flags: Print AppearanceDictionary: true Destination: 375 Annotation: Subtype: Link Rect: 512, 260, 523, 245 Flags: Print AppearanceDictionary: true Destination: 418 Thumb: true Page: Sequence: 3 Annotations: Annotation: Subtype: Link Rect: 73, 372, 78, 357 Flags: Print AppearanceDictionary: true Destination: 30 Annotation: Subtype: Link Rect: 209, 335, 214, 320 Flags: Print AppearanceDictionary: true Destination: 299 Annotation: Subtype: Link Rect: 203, 322, 208, 307 Flags: Print AppearanceDictionary: true Destination: 299 Annotation: Subtype: Link Rect: 201, 297, 211, 282 Flags: Print AppearanceDictionary: true Destination: 418 Annotation: Subtype: Link Rect: 221, 197, 232, 182 Flags: Print AppearanceDictionary: true Destination: 418 Annotation: Subtype: Link Rect: 237, 197, 248, 182 Flags: Print AppearanceDictionary: true Destination: 418 Annotation: Subtype: Link Rect: 499, 161, 504, 146 Flags: Print AppearanceDictionary: true Destination: 302 Annotation: Subtype: Link Rect: 388, 149, 398, 134 Flags: Print AppearanceDictionary: true Destination: 375 Annotation: Subtype: Link Rect: 403, 149, 413, 134 Flags: Print AppearanceDictionary: true Destination: 418 Annotation: Subtype: Link Rect: 418, 149, 428, 134 Flags: Print AppearanceDictionary: true Destination: 418 Thumb: true Page: Sequence: 4 Annotations: Annotation: Subtype: Link Rect: 175, 136, 185, 121 Flags: Print AppearanceDictionary: true Destination: 418 Annotation: Subtype: Link Rect: 190, 136, 200, 121 Flags: Print AppearanceDictionary: true Destination: 418 Thumb: true Page: Sequence: 5 Thumb: true Page: Sequence: 6 Annotations: Annotation: Subtype: Link Rect: 86, 135, 91, 120 Flags: Print AppearanceDictionary: true Destination: 302 Annotation: Subtype: Link Rect: 364, 236, 369, 221 Flags: Print AppearanceDictionary: true Destination: 302 Annotation: Subtype: Link Rect: 356, 696, 365, 683 Flags: Print AppearanceDictionary: true Destination: 418 Annotation: Subtype: Link Rect: 353, 661, 362, 648 Flags: Print AppearanceDictionary: true Destination: 418 Thumb: true Page: Sequence: 7 Annotations: Annotation: Subtype: Link Rect: 103, 249, 108, 234 Flags: Print AppearanceDictionary: true Destination: 310 Annotation: Subtype: Link Rect: 129, 249, 134, 234 Flags: Print AppearanceDictionary: true Destination: 346 Annotation: Subtype: Link Rect: 88, 211, 93, 196 Flags: Print AppearanceDictionary: true Destination: 346 Annotation: Subtype: Link Rect: 413, 236, 418, 221 Flags: Print AppearanceDictionary: true Destination: 358 Annotation: Subtype: Link Rect: 430, 236, 435, 221 Flags: Print AppearanceDictionary: true Destination: 365 Thumb: true Page: Sequence: 8 Annotations: Annotation: Subtype: Link Rect: 272, 335, 283, 320 Flags: Print AppearanceDictionary: true Destination: 418 Annotation: Subtype: Link Rect: 239, 297, 244, 282 Flags: Print AppearanceDictionary: true Destination: 375 Annotation: Subtype: Link Rect: 229, 247, 234, 232 Flags: Print AppearanceDictionary: true Destination: 375 Annotation: Subtype: Link Rect: 239, 247, 244, 232 Flags: Print AppearanceDictionary: true Destination: 375 Annotation: Subtype: Link Rect: 249, 247, 259, 232 Flags: Print AppearanceDictionary: true Destination: 375 Annotation: Subtype: Link Rect: 171, 210, 181, 195 Flags: Print AppearanceDictionary: true Destination: 418 Annotation: Subtype: Link Rect: 76, 185, 86, 170 Flags: Print AppearanceDictionary: true Destination: 418 Annotation: Subtype: Link Rect: 91, 185, 101, 170 Flags: Print AppearanceDictionary: true Destination: 418 Annotation: Subtype: Link Rect: 96, 122, 106, 107 Flags: Print AppearanceDictionary: true Destination: 418 Annotation: Subtype: Link Rect: 101, 97, 111, 82 Flags: Print AppearanceDictionary: true Destination: 418 Annotation: Subtype: Link Rect: 342, 436, 352, 421 Flags: Print AppearanceDictionary: true Destination: 418 Annotation: Subtype: Link Rect: 455, 299, 465, 284 Flags: Print AppearanceDictionary: true Destination: 418 Annotation: Subtype: Link Rect: 470, 299, 481, 284 Flags: Print AppearanceDictionary: true Destination: 418 Annotation: Subtype: Link Rect: 309, 124, 320, 109 Flags: Print AppearanceDictionary: true Destination: 418 Thumb: true Page: Sequence: 9 Thumb: true Page: Sequence: 10 Thumb: true Page: Sequence: 11 Annotations: Annotation: Subtype: Link Rect: 391, 128, 542, 115 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 12 Annotations: Annotation: Subtype: Link Rect: 306, 706, 467, 693 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 407, 633, 544, 620 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 323, 623, 373, 610 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 440, 583, 544, 570 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 323, 573, 380, 560 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 442, 533, 544, 520 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 323, 523, 391, 510 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 344, 483, 468, 470 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 493, 453, 544, 440 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 323, 443, 409, 430 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 404, 403, 542, 390 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 427, 373, 544, 360 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 323, 363, 340, 350 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 459, 323, 544, 310 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 323, 313, 406, 300 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 414, 273, 544, 260 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 323, 263, 347, 250 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 431, 243, 544, 230 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 323, 233, 345, 220 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 456, 183, 544, 170 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 323, 173, 390, 160 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 441, 133, 544, 120 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 323, 123, 372, 110 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 481, 103, 544, 90 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 323, 93, 442, 80 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 13 Annotations: Annotation: Subtype: Link Rect: 252, 726, 289, 713 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 68, 716, 212, 703 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 138, 686, 282, 673 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 118, 666, 253, 653 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 172, 606, 289, 593 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 68, 596, 95, 583 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 228, 566, 289, 553 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 68, 556, 156, 543 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 203, 516, 289, 503 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 68, 506, 126, 493 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 219, 486, 289, 473 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 68, 476, 289, 463 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 68, 466, 119, 453 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 68, 416, 219, 403 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 85, 376, 250, 363 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 68, 336, 242, 323 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 164, 296, 289, 283 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 68, 286, 127, 273 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 226, 246, 289, 233 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 68, 236, 159, 223 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 323, 696, 477, 683 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 434, 676, 544, 663 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 323, 666, 360, 653 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 520, 636, 544, 623 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 323, 626, 467, 613 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 413, 596, 544, 583 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 323, 586, 353, 573 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 389, 556, 533, 543 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 323, 506, 452, 493 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 402, 466, 544, 453 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 323, 456, 348, 443 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 344, 396, 457, 383 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 481, 376, 544, 363 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 323, 366, 427, 353 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 460, 326, 544, 313 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 323, 316, 379, 303 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 379, 266, 525, 253 Flags: Print AppearanceDictionary: true Annotation: Subtype: Link Rect: 402, 163, 414, 151 Flags: Print AppearanceDictionary: true Thumb: true Page: Sequence: 14 Thumb: true Checksum: a601e521 Type: CRC32 Checksum: c05929352647a5eb2fb65c9956448357 Type: MD5 Checksum: 22d53c1579700a03bd70c96163e9ade61c43b116 Type: SHA-1 Checksum: 69570d4875a6928198f9c7feb83393b1d49e35bb1ae068b58c5ad50ca8e6bf5b Type: SHA-256