fa07098a7140db9ae675518fde55391b The_Journal_of_Physiology_-_2026_-_Bolivar_-_Peripheral.pdf 9c20d5752f6b26a3704202a76df7eb5fa985d88e The_Journal_of_Physiology_-_2026_-_Bolivar_-_Peripheral.pdf dccd6bfbcc95ec6fe9b01fba0d1e688c50a0b0d099a7c60d6fd255a4648749c4 The_Journal_of_Physiology_-_2026_-_Bolivar_-_Peripheral.pdf Title: Peripheral regeneration of Aβ low‐threshold mechanoreceptors is limited despite activation of regenerative transcriptional pathways Subject: The Journal of Physiology 0.0 Keywords: Author: Creator: LaTeX with hyperref package Producer: Acrobat Distiller 11.0 (Windows); modified using iText 4.2.0 by 1T3XT CreationDate: Fri Jul 17 12:16:40 2026 CEST ModDate: Mon Sep 14 18:44:38 2026 CEST Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 22 Encrypted: no Page size: 595.276 x 782.362 pts Page rot: 0 File size: 4614848 bytes Optimized: no PDF version: 1.6 name type encoding emb sub uni object ID 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PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'tjp70725-bib-0049' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'tjp70725-bib-0042' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'tjp70725-bib-0052' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'tjp70725-bib-0059' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'tjp70725-bib-0058' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'tjp70725-bib-0001' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'tjp70725-bib-0044' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'tjp70725-bib-0063' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 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indirect destination - referenced object 'tjp70725-bib-0016' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'tjp70725-supinfo-0001' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'tjp70725-bib-0023' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'tjp70725-bib-0071' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'tjp70725-bib-0002' cannot be found ID: PDF-HUL-149 ErrorMessage: Invalid indirect destination - referenced object 'tjp70725-bib-0009' cannot be found ID: PDF-HUL-149 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0047' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0009' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0028' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0066' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0037' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0065' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0056' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0018' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0027' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0010' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0055' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0048' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0045' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0017' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0038' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0059' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0054' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0020' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0068' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0011' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0025' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0006' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0067' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0039' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0046' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0053' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0005' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0040' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0060' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0033' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0026' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0019' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0012' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0023' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0070' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0014' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0042' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0061' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0032' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0013' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0004' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0051' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0062' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0041' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0034' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0003' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0069' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0052' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0024' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0031' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0035' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0007' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0030' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0016' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0021' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0002' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0072' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-supinfo-0001' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0001' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0049' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0058' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0063' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0044' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0015' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0008' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0071' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0022' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0057' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0029' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0064' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0036' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0043' cannot be found ID: PDF-HUL-122 Offset: 4090012 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'tjp70725-bib-0050' cannot be found ID: PDF-HUL-122 Offset: 4090012 MIMEtype: application/pdf PDFMetadata: Objects: 0 FreeObjects: 2 IncrementalUpdates: 0 DocumentCatalog: PageLayout: SinglePage PageMode: UseOutlines Outlines: Item: Title: Peripheral regeneration of A83² low-threshold mechanoreceptors is limited despite activation of regenerative transcriptional pathways Destination: chapter..1 Children: Item: Title: Introduction Destination: section..1.1 Item: Title: Methods Destination: section..1.2 Children: Item: Title: Animals Destination: subsection..1.2.1 Item: Title: Immunofluorescence Destination: subsection..1.2.2 Item: Title: Femoral nerve transection and retrograde tracing Destination: subsection..1.2.3 Item: Title: Sciatic nerve crush Destination: subsection..1.2.4 Item: Title: Translating ribosome affinity purification Destination: subsection..1.2.5 Item: Title: Library preparation and RNA-sequencing Destination: subsection..1.2.6 Item: Title: Statistical analysis Destination: subsection..1.2.7 Item: Title: Results Destination: section..1.3 Children: Item: Title: Calb1-Cre/tdT mice preferentially label low-threshold mechanoreceptors Destination: subsection..1.3.1 Item: Title: A83²-LTMRs preferentially regenerate toward cutaneous targets Destination: subsection..1.3.2 Item: Title: Calb1 + neurons have limited regeneration after nerve injury Destination: subsection..1.3.3 Item: Title: Regenerative transcriptional programme activated by A83²-LTMRs Destination: subsection..1.3.4 Item: Title: Distinct transcriptional responses in peripheral neuronal subtypes Destination: subsection..1.3.5 Item: Title: Discussion Destination: section..1.4 Item: Title: Appendix Destination: section..1.5 Item: Title: References Destination: section..1.6 Item: Title: Additional information Destination: section..1.7 Children: Item: Title: Data availability statement Destination: subsection..1.7.1 Item: Title: Competing interests Destination: subsection..1.7.2 Item: Title: Author contributions Destination: subsection..1.7.3 Item: Title: Funding Destination: subsection..1.7.4 Item: Title: Acknowledgements Destination: subsection..1.7.5 Item: Title: Generative AI statement Destination: subsection..1.7.6 Item: Title: Supporting information Destination: section..1.8 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/png ImageWidth: 228 ImageHeight: 45 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1500 ImageHeight: 1229 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 228 ImageHeight: 45 ColorSpace: black is zero BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: 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