aee053eb57643297a45033395c947dae s10495-026-02398-9.pdf d56491ca076f3b965c96c6635ab5f69bb20c515b s10495-026-02398-9.pdf 6302f7e105826f92fff21f01682dc22d11c9022e0d1eee8d60dda710d3ef84d5 s10495-026-02398-9.pdf Creator: Adobe InDesign 18.3 (Windows) Producer: Adobe PDF Library 17.0 CreationDate: Mon Aug 17 09:24:22 2026 CEST ModDate: Mon Aug 17 09:24:22 2026 CEST Custom Metadata: yes Metadata Stream: yes Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 16 Encrypted: no Page size: 595.276 x 790.866 pts Page rot: 0 File size: 1699188 bytes Optimized: yes PDF version: 1.5 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- UPFMHP+TimesNewRomanPSMT CID TrueType Identity-H yes yes yes 1232 0 MyriadPro-SemiCn Type 1C WinAnsi yes no yes 1234 0 MyriadPro-Bold Type 1C WinAnsi yes no yes 1236 0 MyriadPro-SemiboldSemiCn Type 1C Custom yes no yes 1239 0 MyriadPro-Semibold Type 1C Custom yes no yes 1242 0 PSQIPZ+TimesNewRomanPSMT TrueType WinAnsi yes yes yes 1244 0 MyriadPro-BoldSemiCn Type 1C Custom yes no yes 261 0 Springnew TrueType WinAnsi yes no yes 262 0 PQKYPZ+TimesNewRomanPS-ItalicMT TrueType WinAnsi yes yes yes 269 0 Springnew TrueType WinAnsi yes no yes 273 0 ZSIGZF+TimesNewRomanPS-BoldMT TrueType WinAnsi yes yes yes 282 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2026-09-17 03:57:32 CEST RepresentationInformation: s10495-026-02398-9.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2026-09-16 11:11:56 CEST Size: 1699188 Format: PDF Version: 1.5 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF, Tagged PDF PDFMetadata: Objects: 0 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en-US Outlines: Item: Title: The autoimmune regulator (AIRE) is a target of the E3-Ubiquitin ligase Seven-in-absentia homolog 1 (SIAH1). Children: Item: Title: Abstract Item: Title: Introduction Item: Title: Materials and methods Children: Item: Title: Antibodies Item: Title: DNA constructs Item: Title: Thymus samples, cell culture, and transfection Item: Title: Flow cytometry Item: Title: Western blot Item: Title: Immunofluorescence Item: Title: Co-immunoprecipitation assay Item: Title: Modeling of SIAH1 interactions with CACYBP and AIRE motifs Item: Title: Apoptosis assays Item: Title: Ubiquitination assays Item: Title: AIRE degradation assays Item: Title: Statistical analysis Item: Title: Results Children: Item: Title: CACYBP/SIP levels are upregulated in AIRE-expressing cells Item: Title: AIRE and SIP do not interact in transfected HEK-293 cells Item: Title: AIRE interacts with SIAH1 and SIAH2 in transfected HEK-293 cells and in the thymus Item: Title: AIRE interacts with SIAH proteins via its N-terminal SIAH-binding motif Item: Title: Structural modeling predicts that SIAH1 selectively interacts with the AIRE119-125 motif Item: Title: The CARD domain and the SIAH1-interacting motif are essential for AIRE-mediated apoptosis Item: Title: SIAH1-mediated ubiquitination and proteasomal degradation of AIRE Item: Title: Discussion Item: Title: Conclusion Item: Title: References Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1524 ImageHeight: 2015 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1524 ImageHeight: 667 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1524 ImageHeight: 1902 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Intent: RelativeColorimetric Name: X Image: NisoImageMetadata: FormatName: 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