69b8d04a2ef6869aa214d76ad4b59d9e PIIS1353802026006838.pdf 05070441b911f131548f7d97fb3223920c8eeafc PIIS1353802026006838.pdf cb539e5b01ab010be5e92726f220bdd36484e77832963172e5074a8a529398a3 PIIS1353802026006838.pdf Title: Association of α-synuclein seed-amplification kinetics with cognitive decline in idiopathic Parkinson's disease Subject: Parkinsonism and Related Disorders, 150 (2026) 108856. doi:10.1016/j.parkreldis.2026.108856 Keywords: Parkinson's disease,CSF,Seed-amplification assay,α-synuclein,Cognitive decline Author: Jon Rodriguez-Antiguedad Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Fri Aug 21 01:35:16 2026 CEST ModDate: Fri Aug 21 13:26:15 2026 CEST Custom Metadata: yes Metadata Stream: yes Tagged: yes UserProperties: no Suspects: no Form: none JavaScript: no Pages: 7 Encrypted: no Page size: 595.276 x 793.701 pts Page rot: 0 File size: 746138 bytes Optimized: yes PDF version: 1.7 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- VFMBIU+Univers Type 1C Builtin yes yes yes 1067 0 NNLAUQ+TeX_CM_Roman Type 1C Builtin yes yes yes 1071 0 KBIMCC+CharisSIL CID TrueType Identity-H yes yes yes 1075 0 AAAEJD+CharisSIL CID TrueType Identity-H yes yes yes 1080 0 AMTKUR+CharisSIL-Bold CID TrueType Identity-H yes yes yes 1088 0 IDGTKA+STIX-Regular Type 1C Custom yes yes yes 1093 0 PVZLBA+CharisSIL-Italic CID TrueType Identity-H yes yes yes 1098 0 RGQXUC+CharisSIL CID TrueType Identity-H yes yes yes 1103 0 BVKPIG+TeX_CM_Maths_Symbols Type 1C Builtin yes yes yes 1109 0 NTMBZO+TeX_CM_Maths_Italic Type 1C Builtin yes yes yes 149 0 AAAAAD+CharisSIL CID TrueType Identity-H yes yes yes 153 0 BFYOPN+TimesNewRomanPSMT CID TrueType Identity-H yes yes yes 160 0 WLEURM+CharisSIL-Italic CID TrueType Identity-H yes yes yes 165 0 ZCIUIM+STIX-Italic Type 1C Custom yes yes yes 171 0 AAAALE+CharisSIL-Italic CID TrueType Identity-H yes yes yes 176 0 JCPMQC+STIX-Bold Type 1C Custom yes yes yes 42 0 NYBEHZ+TeX_CM_Bold_Maths_Symbols Type 1C Builtin yes yes yes 47 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2026-09-17 03:57:14 CEST RepresentationInformation: PIIS1353802026006838.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2026-09-16 12:12:31 CEST Size: 746138 Format: PDF Version: 1.7 Status: Well-Formed, but not valid SignatureMatches: PDF-hul ErrorMessage: Invalid indirect destination - referenced object 'sec16' cannot be found ID: PDF-HUL-149 ErrorMessage: edu.harvard.hul.ois.jhove.module.pdf.PdfInvalidException: Invalid indirect destination - referenced object 'sec16' cannot be found ID: PDF-HUL-122 Offset: 651286 MIMEtype: application/pdf Profile: Linearized PDF, Tagged PDF PDFMetadata: Objects: 1219 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: true NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: English Outlines: Item: Title: Association of α-synuclein seed-amplification kinetics with cognitive decline in idiopathic Parkinson's disease Destination: mk:title Children: Item: Title: 1 Introduction Destination: mk:H1_1 Item: Title: 2 Methods Destination: mk:H1_2 Children: Item: Title: 2.1 Study design and selection of participants Destination: mk:H2_1 Item: Title: 2.2 Clinical assessments Destination: mk:H2_2 Item: Title: 2.3 CSF α-syn SAA Destination: mk:H2_3 Item: Title: 2.4 Statistical analysis Destination: mk:H2_4 Item: Title: 3 Results Destination: mk:H1_3 Children: Item: Title: 3.1 Baseline characteristics Destination: mk:H2_5 Item: Title: 3.2 Baseline kinetic parameters and clinical progression Destination: mk:H2_6 Item: Title: 3.3 Baseline kinetic parameters and progression in cognitive domains Destination: mk:H2_7 Item: Title: 3.4 Sensitivity analysis Destination: mk:H2_8 Item: Title: 4 Discussion Destination: mk:H1_4 Item: Title: Data availability Destination: mk:H1_5 Item: Title: Funding sources Destination: mk:H1_6 Item: Title: CRediT authorship contribution statement Destination: mk:H1_7 Item: Title: Declaration of competing interest Destination: mk:HH1_2 Item: Title: Acknowledgements Destination: mk:HH1_3 Item: Title: Appendix A Supplementary data Destination: mk:H1_8 Item: Title: References Destination: mk:HH2_1 Info: Title: Association of α-synuclein seed-amplification kinetics with cognitive decline in idiopathic Parkinson's disease Author: Jon Rodriguez-Antiguedad Subject: Parkinsonism and Related Disorders, 150 (2026) 108856. doi:10.1016/j.parkreldis.2026.108856 Keywords: Parkinson's disease,CSF,Seed-amplification assay,α-synuclein,Cognitive decline Creator: Elsevier Producer: Acrobat Distiller 8.1.0 (Windows) CreationDate: Fri Aug 21 01:35:16 CEST 2026 ModDate: Fri Aug 21 13:26:15 CEST 2026 ID: 0x986c14495008ed262350f14b54128f08, 0xde7fd6c6a12c6a22a4f519718a51a1fd Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 236 ImageHeight: 298 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 33 ImageHeight: 33 BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 248 ImageHeight: 271 BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type0: Font: BaseFont: AMTKUR+CharisSIL-Bold Encoding: Identity-H ToUnicode: true Font: BaseFont: BFYOPN+TimesNewRomanPSMT Encoding: Identity-H ToUnicode: true Font: BaseFont: AAAALE+CharisSIL-Italic Encoding: Identity-H ToUnicode: true Font: BaseFont: KBIMCC+CharisSIL Encoding: Identity-H ToUnicode: true Font: BaseFont: WLEURM+CharisSIL-Italic Encoding: Identity-H ToUnicode: true Font: BaseFont: AAAEJD+CharisSIL Encoding: Identity-H ToUnicode: true Font: BaseFont: AAAAAD+CharisSIL Encoding: Identity-H ToUnicode: true Font: BaseFont: PVZLBA+CharisSIL-Italic Encoding: Identity-H ToUnicode: true Font: BaseFont: RGQXUC+CharisSIL Encoding: Identity-H ToUnicode: true Type1: Font: BaseFont: BVKPIG+TeX_CM_Maths_Symbols FontSubset: true FirstChar: 1 LastChar: 138 FontDescriptor: FontName: BVKPIG+TeX_CM_Maths_Symbols Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: IDGTKA+STIX-Regular FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: IDGTKA+STIX-Regular Flags: Nonsymbolic FontBBox: -970, -486, 2208, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: NTMBZO+TeX_CM_Maths_Italic FontSubset: true FirstChar: 1 LastChar: 127 FontDescriptor: FontName: NTMBZO+TeX_CM_Maths_Italic Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: JCPMQC+STIX-Bold FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: JCPMQC+STIX-Bold Flags: Nonsymbolic, ForceBold FontBBox: -998, -552, 2000, 1055 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: VFMBIU+Univers FontSubset: true FirstChar: 32 LastChar: 251 FontDescriptor: FontName: VFMBIU+Univers Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: ZCIUIM+STIX-Italic FontSubset: true FirstChar: 1 LastChar: 6 FontDescriptor: FontName: ZCIUIM+STIX-Italic Flags: Nonsymbolic, Italic FontBBox: -970, -305, 1429, 1023 FontFile3: true EncodingDictionary: BaseEncoding: WinAnsiEncoding Differences: true ToUnicode: true Font: BaseFont: NNLAUQ+TeX_CM_Roman FontSubset: true FirstChar: 1 LastChar: 128 FontDescriptor: FontName: NNLAUQ+TeX_CM_Roman Flags: Symbolic FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true Font: BaseFont: NYBEHZ+TeX_CM_Bold_Maths_Symbols FontSubset: true FirstChar: 1 LastChar: 255 FontDescriptor: FontName: NYBEHZ+TeX_CM_Bold_Maths_Symbols Flags: Symbolic, ForceBold FontBBox: -50, -180, 1000, 720 FontFile3: true ToUnicode: true CIDFontType2: Font: BaseFont: RGQXUC+CharisSIL CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: RGQXUC+CharisSIL Flags: Serif, Symbolic FontBBox: -692, -533, 1623, 1319 FontFile2: true Font: BaseFont: AMTKUR+CharisSIL-Bold CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: AMTKUR+CharisSIL-Bold Flags: Nonsymbolic, ForceBold FontBBox: -720, -533, 1759, 1320 FontFile2: true Font: BaseFont: BFYOPN+TimesNewRomanPSMT CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: BFYOPN+TimesNewRomanPSMT Flags: Nonsymbolic FontBBox: -568, -307, 2000, 1007 FontFile2: true Font: BaseFont: AAAALE+CharisSIL-Italic CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: AAAALE+CharisSIL-Italic Flags: Symbolic, Italic FontBBox: -716, -533, 1626, 1317 FontFile2: true Font: BaseFont: KBIMCC+CharisSIL CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: KBIMCC+CharisSIL Flags: Nonsymbolic FontBBox: -692, -533, 1623, 1319 FontFile2: true Font: BaseFont: WLEURM+CharisSIL-Italic CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: WLEURM+CharisSIL-Italic Flags: Serif, Symbolic, Italic FontBBox: -716, -533, 1627, 1318 FontFile2: true Font: BaseFont: AAAEJD+CharisSIL CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: AAAEJD+CharisSIL Flags: Symbolic FontBBox: -692, -533, 1623, 1318 FontFile2: true Font: BaseFont: AAAAAD+CharisSIL CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: AAAAAD+CharisSIL Flags: Symbolic FontBBox: -692, -533, 1623, 1318 FontFile2: true Font: BaseFont: PVZLBA+CharisSIL-Italic CIDSystemInfo: Registry: Adobe Registry: Identity Supplement: 0 FontDescriptor: FontName: PVZLBA+CharisSIL-Italic Flags: Nonsymbolic, Italic FontBBox: -716, -533, 1627, 1318 FontFile2: true XMP: http://creativecommons.org/licenses/by-nc-nd/4.0/ elsevier.com sciencedirect.com true 10.1016/j.parkreldis.2026.108856 2010-04-23 application/pdf 10.1016/j.parkreldis.2026.108856 Elsevier Ltd Parkinsonism and Related Disorders, 150 (2026) 108856. doi:10.1016/j.parkreldis.2026.108856 Parkinson's disease CSF Seed-amplification assay α-synuclein Cognitive decline Association of α-synuclein seed-amplification kinetics with cognitive decline in idiopathic Parkinson's disease Jon Rodriguez-Antiguedad Arnau Puig-Davi Iñigo Ruiz-Barrio David Campo-Caballero Elena Vacchi Giorgia Melli Lidia Bojtos Carla Franch-Marti Gonzalo Olmedo-Saura Anna Vazquez-Oliver Saül Martinez-Horta Jaime Kulisevsky Javier Pagonabarraga VoR 21st August 2026 Acrobat Distiller 8.1.0 (Windows) Parkinson's disease,CSF,Seed-amplification assay,α-synuclein,Cognitive decline 21st August 2026 sciencedirect.com elsevier.com true 2010-04-23 7.0.1 10.1016/j.parkreldis.2026.108856 noindex journal 2026-09-01 1 September 2026 10.1016/j.parkreldis.2026.108856 1353-8020 108856 Parkinsonism and Related Disorders 108856 https://doi.org/10.1016/j.parkreldis.2026.108856 150 https://www.elsevier.com/tdm/tdmrep-policy.json 1 2026-08-20T23:35:16 Elsevier 2026-08-21T11:26:15 2026-08-21T11:26:15 uuid:1b499bed-4ce8-4c0c-b682-0d58baae1cbe uuid:b6ed5266-03cb-4855-90c0-636283357f42 True Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 164, 576, 168, 587 Flags: Print Destination: 1057 Annotation: Subtype: Link Rect: 171, 576, 175, 587 Flags: Print Destination: 1057 Annotation: Subtype: Link Rect: 178, 576, 181, 587 Flags: Print Destination: 1057 Annotation: Subtype: Link Rect: 184, 576, 188, 587 Flags: Print Destination: 1057 Annotation: Subtype: Link Rect: 189, 574, 197, 582 Flags: Print Annotation: Subtype: Link Rect: 189, 571, 197, 582 Flags: Print Annotation: Subtype: Link Rect: 283, 576, 287, 587 Flags: Print Destination: 1057 Annotation: Subtype: Link Rect: 290, 576, 294, 587 Flags: Print Destination: 1057 Annotation: Subtype: Link Rect: 297, 576, 300, 587 Flags: Print Destination: 1057 Annotation: Subtype: Link Rect: 303, 576, 307, 587 Flags: Print Destination: 1057 Annotation: Subtype: Link Rect: 397, 576, 401, 587 Flags: Print Destination: 1057 Annotation: Subtype: Link Rect: 403, 576, 408, 587 Flags: Print Destination: 1057 Annotation: Subtype: Link Rect: 410, 576, 414, 587 Flags: Print Destination: 1057 Annotation: Subtype: Link Rect: 417, 576, 421, 587 Flags: Print Destination: 1057 Annotation: Subtype: Link Rect: 150, 563, 154, 574 Flags: Print Destination: 1057 Annotation: Subtype: Link Rect: 157, 563, 159, 574 Flags: Print Destination: 1057 Annotation: Subtype: Link Rect: 160, 561, 168, 569 Flags: Print Annotation: Subtype: Link Rect: 160, 558, 168, 569 Flags: Print Annotation: Subtype: Link Rect: 237, 563, 242, 574 Flags: Print Destination: 1057 Annotation: Subtype: Link Rect: 244, 563, 249, 574 Flags: Print Destination: 1057 Annotation: Subtype: Link Rect: 249, 561, 258, 569 Flags: Print Annotation: Subtype: Link Rect: 249, 558, 258, 569 Flags: Print Annotation: Subtype: Link Rect: 328, 563, 332, 574 Flags: Print Destination: 1057 Annotation: Subtype: Link Rect: 334, 563, 339, 574 Flags: Print Destination: 1057 Annotation: Subtype: Link Rect: 342, 563, 344, 574 Flags: Print Destination: 1057 Annotation: Subtype: Link Rect: 408, 563, 412, 574 Flags: Print Destination: 1057 Annotation: Subtype: Link Rect: 415, 563, 419, 574 Flags: Print Destination: 1057 Annotation: Subtype: Link Rect: 422, 563, 425, 574 Flags: Print Destination: 1057 Annotation: Subtype: Link Rect: 428, 563, 432, 574 Flags: Print Destination: 1057 Annotation: Subtype: Link Rect: 128, 550, 133, 561 Flags: Print Destination: 1057 Annotation: Subtype: Link Rect: 135, 550, 139, 561 Flags: Print Destination: 1057 Annotation: Subtype: Link Rect: 256, 550, 260, 561 Flags: Print Destination: 1057 Annotation: Subtype: Link Rect: 262, 550, 266, 561 Flags: Print Destination: 1057 Annotation: Subtype: Link Rect: 269, 550, 273, 561 Flags: Print Destination: 1057 Annotation: Subtype: Link Rect: 275, 550, 280, 561 Flags: Print Destination: 1057 Annotation: Subtype: Link Rect: 388, 550, 392, 561 Flags: Print Destination: 1057 Annotation: Subtype: Link Rect: 395, 550, 398, 561 Flags: Print Destination: 1057 Annotation: Subtype: Link Rect: 401, 550, 405, 561 Flags: Print Destination: 1057 Annotation: Subtype: Link Rect: 134, 537, 138, 548 Flags: Print Destination: 1057 Annotation: Subtype: Link Rect: 141, 537, 145, 548 Flags: Print Destination: 1057 Annotation: Subtype: Link Rect: 148, 537, 151, 548 Flags: Print Destination: 1057 Annotation: Subtype: Link Rect: 154, 537, 158, 548 Flags: Print Destination: 1057 Annotation: Subtype: Link Rect: 248, 537, 252, 548 Flags: Print Destination: 1057 Annotation: Subtype: Link Rect: 254, 537, 259, 548 Flags: Print Destination: 1057 Annotation: Subtype: Link Rect: 261, 537, 265, 548 Flags: Print Destination: 1057 Annotation: Subtype: Link Rect: 267, 537, 272, 548 Flags: Print Destination: 1057 Annotation: Subtype: Link Rect: 274, 537, 278, 548 Flags: Print Destination: 1057 Annotation: Subtype: Link Rect: 389, 537, 393, 548 Flags: Print Destination: 1057 Annotation: Subtype: Link Rect: 396, 537, 400, 548 Flags: Print Destination: 1057 Annotation: Subtype: Link Rect: 402, 537, 406, 548 Flags: Print Destination: 1057 Annotation: Subtype: Link Rect: 409, 537, 413, 548 Flags: Print Destination: 1057 Annotation: Subtype: Link Rect: 413, 535, 422, 543 Flags: Print Annotation: Subtype: Link Rect: 413, 532, 422, 543 Flags: Print Annotation: Subtype: Link Rect: 217, 172, 221, 180 Flags: Print Destination: 76 Annotation: Subtype: Link Rect: 309, 203, 314, 211 Flags: Print Destination: 76 Annotation: Subtype: Link Rect: 342, 172, 347, 180 Flags: Print Destination: 76 Annotation: Subtype: Link Rect: 363, 151, 367, 159 Flags: Print Destination: 76 Annotation: Subtype: Link Rect: 98, 104, 180, 111 Flags: Print Annotation: Subtype: Link Rect: 321, 722, 369, 730 Flags: Print Annotation: Subtype: Link Rect: 269, 667, 402, 675 Flags: Print Annotation: Subtype: Link Rect: 37, 87, 198, 94 Flags: Print Annotation: Subtype: Link Rect: 207, 748, 386, 760 Annotation: Subtype: Link Rect: 501, 616, 529, 644 Annotation: Subtype: Link Rect: 425, 57, 557, 69 Annotation: Subtype: Link Rect: 37, 48, 72, 59 Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 106, 709, 111, 717 Flags: Print Destination: 76 Annotation: Subtype: Link Rect: 144, 678, 149, 686 Flags: Print Destination: 76 Annotation: Subtype: Link Rect: 176, 647, 181, 655 Flags: Print Destination: 76 Annotation: Subtype: Link Rect: 206, 584, 223, 592 Flags: Print Destination: 76 Annotation: Subtype: Link Rect: 229, 532, 233, 540 Flags: Print Destination: 76 Annotation: Subtype: Link Rect: 235, 532, 257, 540 Flags: Print Destination: 76 Annotation: Subtype: Link Rect: 69, 458, 86, 466 Flags: Print Destination: 76 Annotation: Subtype: Link Rect: 207, 437, 216, 445 Flags: Print Destination: 76 Annotation: Subtype: Link Rect: 131, 322, 135, 330 Flags: Print Destination: 76 Annotation: Subtype: Link Rect: 138, 322, 147, 330 Flags: Print Destination: 76 Annotation: Subtype: Link Rect: 193, 249, 288, 257 Flags: Print Annotation: Subtype: Link Rect: 37, 239, 148, 247 Flags: Print Annotation: Subtype: Link Rect: 230, 176, 288, 184 Flags: Print Annotation: Subtype: Link Rect: 37, 165, 49, 173 Flags: Print Annotation: Subtype: Link Rect: 338, 552, 436, 560 Flags: Print Annotation: Subtype: Link Rect: 346, 521, 351, 529 Flags: Print Destination: 76 Annotation: Subtype: Link Rect: 424, 374, 500, 382 Flags: Print Destination: null Annotation: Subtype: Link Rect: 463, 154, 555, 162 Flags: Print Destination: null Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 206, 469, 283, 477 Flags: Print Destination: null Annotation: Subtype: Link Rect: 158, 417, 185, 425 Flags: Print Destination: 24 Annotation: Subtype: Link Rect: 164, 406, 246, 414 Flags: Print Destination: null Annotation: Subtype: Link Rect: 309, 657, 418, 665 Flags: Print Destination: null Annotation: Subtype: Link Rect: 344, 479, 436, 487 Flags: Print Destination: null Annotation: Subtype: Link Rect: 503, 437, 530, 445 Flags: Print Destination: 38 Annotation: Subtype: Link Rect: 504, 353, 557, 361 Flags: Print Destination: null Annotation: Subtype: Link Rect: 306, 343, 345, 351 Flags: Print Destination: null Annotation: Subtype: Link Rect: 309, 270, 393, 278 Flags: Print Destination: null Annotation: Subtype: Link Rect: 419, 144, 439, 152 Flags: Print Destination: 38 Annotation: Subtype: Link Rect: 526, 81, 552, 89 Flags: Print Destination: 38 Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 172, 92, 255, 100 Flags: Print Destination: null Annotation: Subtype: Link Rect: 504, 293, 557, 301 Flags: Print Destination: null Annotation: Subtype: Link Rect: 306, 282, 337, 290 Flags: Print Destination: null Annotation: Subtype: Link Rect: 309, 167, 396, 175 Flags: Print Destination: null Annotation: Subtype: Link Rect: 347, 104, 434, 112 Flags: Print Destination: null Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 105, 626, 110, 634 Flags: Print Destination: 76 Annotation: Subtype: Link Rect: 194, 553, 216, 561 Flags: Print Destination: 76 Annotation: Subtype: Link Rect: 82, 437, 91, 445 Flags: Print Destination: 76 Annotation: Subtype: Link Rect: 94, 437, 103, 445 Flags: Print Destination: 76 Annotation: Subtype: Link Rect: 165, 312, 169, 320 Flags: Print Destination: 76 Annotation: Subtype: Link Rect: 171, 312, 180, 320 Flags: Print Destination: 76 Annotation: Subtype: Link Rect: 183, 312, 192, 320 Flags: Print Destination: 137 Annotation: Subtype: Link Rect: 112, 249, 121, 257 Flags: Print Destination: 137 Annotation: Subtype: Link Rect: 94, 197, 103, 205 Flags: Print Destination: 76 Annotation: Subtype: Link Rect: 105, 197, 114, 205 Flags: Print Destination: 137 Annotation: Subtype: Link Rect: 127, 124, 136, 132 Flags: Print Destination: 137 Annotation: Subtype: Link Rect: 72, 92, 81, 100 Flags: Print Destination: 76 Annotation: Subtype: Link Rect: 309, 720, 318, 728 Flags: Print Destination: 137 Annotation: Subtype: Link Rect: 546, 689, 551, 696 Flags: Print Destination: 76 Annotation: Subtype: Link Rect: 417, 364, 426, 372 Flags: Print Destination: 137 Annotation: Subtype: Link Rect: 429, 228, 557, 236 Flags: Print Annotation: Subtype: Link Rect: 306, 218, 383, 226 Flags: Print Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 247, 388, 288, 396 Flags: Print Annotation: Subtype: Link Rect: 37, 377, 175, 385 Flags: Print Annotation: Subtype: Link Rect: 89, 329, 231, 336 Flags: Print Annotation: Subtype: Link Rect: 82, 273, 227, 280 Flags: Print Annotation: Subtype: Link Rect: 147, 257, 222, 264 Flags: Print Annotation: Subtype: Link Rect: 53, 249, 121, 256 Flags: Print Annotation: Subtype: Link Rect: 212, 218, 283, 224 Flags: Print Annotation: Subtype: Link Rect: 53, 210, 89, 216 Flags: Print Annotation: Subtype: Link Rect: 213, 186, 285, 192 Flags: Print Annotation: Subtype: Link Rect: 53, 178, 112, 184 Flags: Print Annotation: Subtype: Link Rect: 86, 138, 217, 144 Flags: Print Annotation: Subtype: Link Rect: 82, 66, 224, 73 Flags: Print Annotation: Subtype: Link Rect: 351, 724, 454, 730 Flags: Print Annotation: Subtype: Link Rect: 436, 692, 544, 698 Flags: Print Annotation: Subtype: Link Rect: 322, 684, 346, 690 Flags: Print Annotation: Subtype: Link Rect: 388, 652, 521, 658 Flags: Print Annotation: Subtype: Link Rect: 410, 620, 546, 627 Flags: Print Annotation: Subtype: Link Rect: 385, 572, 501, 579 Flags: Print Annotation: Subtype: Link Rect: 421, 525, 524, 531 Flags: Print Annotation: Subtype: Link Rect: 516, 485, 549, 491 Flags: Print Annotation: Subtype: Link Rect: 323, 477, 395, 483 Flags: Print Annotation: Subtype: Link Rect: 323, 445, 426, 451 Flags: Print Annotation: Subtype: Link Rect: 483, 413, 554, 419 Flags: Print Annotation: Subtype: Link Rect: 323, 405, 356, 411 Flags: Print Annotation: Subtype: Link Rect: 358, 365, 474, 372 Flags: Print Annotation: Subtype: Link Rect: 533, 333, 555, 340 Flags: Print Annotation: Subtype: Link Rect: 323, 325, 433, 332 Flags: Print Annotation: Subtype: Link Rect: 449, 262, 555, 268 Flags: Print Annotation: Subtype: Link Rect: 323, 254, 358, 260 Flags: Print Annotation: Subtype: Link Rect: 499, 230, 544, 236 Flags: Print Annotation: Subtype: Link Rect: 323, 222, 408, 228 Flags: Print Annotation: Subtype: Link Rect: 433, 198, 522, 204 Flags: Print Annotation: Subtype: Link Rect: 405, 150, 523, 156 Flags: Print Annotation: Subtype: Link Rect: 454, 118, 548, 125 Flags: Print Annotation: Subtype: Link Rect: 323, 110, 355, 117 Flags: Print Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 251, 732, 284, 738 Flags: Print Annotation: Subtype: Link Rect: 54, 724, 151, 730 Flags: Print Annotation: Subtype: Link Rect: 264, 700, 286, 706 Flags: Print Annotation: Subtype: Link Rect: 54, 692, 139, 698 Flags: Print Annotation: Subtype: Link Rect: 423, 676, 553, 682 Flags: Print Checksum: 060a1f26 Type: CRC32 Checksum: 69b8d04a2ef6869aa214d76ad4b59d9e Type: MD5 Checksum: 05070441b911f131548f7d97fb3223920c8eeafc Type: SHA-1 Checksum: cb539e5b01ab010be5e92726f220bdd36484e77832963172e5074a8a529398a3 Type: SHA-256