70ccc22fa997e7dd47284a4c3758ca09  d5an01327e.pdf
f067ffb1fbba4039374eef0f3744e48392225f18  d5an01327e.pdf
e37a7ca69e5beb29ba6d6e8f44c4ef0097bd529b2945e91836076112d30c4f72  d5an01327e.pdf

Title:           d5an01327e 4424..4442 ++
Creator:         Aspose Ltd.
Producer:        Aspose.PDF for .NET 22.3.0
CreationDate:    Tue Jul 21 12:00:59 2026 CEST
ModDate:         Mon Jul 27 19:47:53 2026 CEST
Custom Metadata: no
Metadata Stream: yes
Tagged:          no
UserProperties:  no
Suspects:        no
Form:            AcroForm
JavaScript:      no
Pages:           19
Encrypted:       no
Page size:       595.276 x 779.528 pts
Page rot:        0
File size:       5388563 bytes
Optimized:       no
PDF version:     1.3


name                                 type              encoding         emb sub uni object ID
------------------------------------ ----------------- ---------------- --- --- --- ---------
PHLKEE+AdvOTa2a4c9ce                 Type 1C           WinAnsi          yes yes no      14  0
PHLLIF+AdvOT999035f4                 Type 1C           WinAnsi          yes yes no      15  0
PHLLJG+AdvOTce71c481.I               Type 1C           WinAnsi          yes yes no      16  0
PHLLKH+AdvOT76a2e33b                 Type 1C           WinAnsi          yes yes no      17  0
PHLLKI+AdvOTedaa8737.I               Type 1C           WinAnsi          yes yes no      18  0
PHLLLI+AdvOT76a2e33b+20              Type 1C           WinAnsi          yes yes no      19  0
PHLKPB+AdvOT2c8ce45a                 Type 1C           WinAnsi          yes yes no      30  0
PHLLDA+AdvOTd168d80a.I               Type 1C           WinAnsi          yes yes no     166  0
PHLLEB+AdvOT9b12cd41                 Type 1C           WinAnsi          yes yes no     167  0
PHLLEC+AdvOTd3a5f740                 Type 1C           WinAnsi          yes yes no      24  0
PHLLGC+AdvOT9b12cd41+fb              Type 1C           Custom           yes yes yes    168  0
PHLLGD+AdvOT9b12cd41+20              Type 1C           WinAnsi          yes yes no     169  0
PHLLHE+AdvOT8608a8d1+22              Type 1C           Custom           yes yes yes     33  0
PHLLIE+AdvOT8608a8d1+03              Type 1C           Custom           yes yes yes     25  0
MKRNLK+LiberationSansRegular         CID TrueType      Identity-H       yes yes yes    220  0
Helvetica                            Type 1            WinAnsi          no  no  no       2  0
PHLMAH+AdvOT999035f4+fb              Type 1C           Custom           yes yes yes     20  0
PHLMBI+AdvOT999035f4+20              Type 1C           WinAnsi          yes yes no      21  0
PHLMGH+AdvOTaa6301a5.B               Type 1C           WinAnsi          yes yes no      22  0
PHLMHI+AdvOT8608a8d1+21              Type 1C           WinAnsi          yes yes no      23  0
PHLPIG+AdvOTd3a5f740+fb              Type 1C           Custom           yes yes yes     29  0
PHMBKK+AdvOTd3a5f740+20              Type 1C           WinAnsi          yes yes no      31  0
PHMBKL+AdvOTdd3b7348.I+03            Type 1C           Custom           yes yes yes     32  0
PHMCAK+AdvPS483E12                   Type 1C           WinAnsi          yes yes no      39  0
PHMCEJ+AdvOT749c1f5a.I               Type 1C           WinAnsi          yes yes no      40  0
PIFFHC+AdvOT999035f4+01              Type 1C           Custom           yes yes yes    101  0


Jhove (Rel. 1.28.0, 2023-05-18)
 Date: 2026-10-15 04:03:21 CEST
 RepresentationInformation: d5an01327e.pdf
  ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16)
  LastModified: 2026-10-14 13:36:49 CEST
  Size: 5388563
  Format: PDF
  Version: 1.3
  Status: Well-Formed and valid
  SignatureMatches:
   PDF-hul
  MIMEtype: application/pdf
  PDFMetadata: 
   Objects: 243
   FreeObjects: 1
   IncrementalUpdates: 0
   DocumentCatalog: 
    PageLayout: SinglePage
    PageMode: UseNone
   Info: 
    Title: d5an01327e 4424..4442 ++
    Creator: Aspose Ltd.
    Producer: Aspose.PDF for .NET 22.3.0
    CreationDate: Tue Jul 21 12:30:59 CEST 2026
    ModDate: Mon Jul 27 19:47:53 CEST 2026
   ID: 0xbc336a71da4c02b1450c62230b834862, 0x34322d37362d32312d33382d36302d44
   Filters: 
    FilterPipeline: FlateDecode
    FilterPipeline: DCTDecode
   Images: 
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 408
      ImageHeight: 78
      ColorSpace: CMYK
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 43
      ImageHeight: 43
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 981
      ImageHeight: 377
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 981
      ImageHeight: 464
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 982
      ImageHeight: 1049
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 2045
      ImageHeight: 2032
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 2044
      ImageHeight: 781
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1760
      ImageHeight: 1189
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 2046
      ImageHeight: 2028
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1322
      ImageHeight: 1236
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/png
      ImageWidth: 1652
      ImageHeight: 1414
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
     Filter: FlateDecode
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1762
      ImageHeight: 1679
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
    Image: 
     NisoImageMetadata: 
      FormatName: image/jpg
      CompressionScheme: JPEG
      ImageWidth: 1865
      ImageHeight: 2405
      ColorSpace: RGB
      BitsPerSample: 8
      BitsPerSampleUnit: integer
   Fonts: 
    Type1: 
     Font: 
      BaseFont: PHMBKL+AdvOTdd3b7348.I+03
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: PHMBKL+AdvOTdd3b7348.I+03
       Flags: Symbolic
       FontBBox: -104, -208, 864, 854
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: PHLLHE+AdvOT8608a8d1+22
      FontSubset: true
      FirstChar: 2
      LastChar: 21
      FontDescriptor: 
       FontName: PHLLHE+AdvOT8608a8d1+22
       Flags: Symbolic
       FontBBox: 0, -322, 1218, 968
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: PIFFHC+AdvOT999035f4+01
      FontSubset: true
      FirstChar: 1
      LastChar: 4
      FontDescriptor: 
       FontName: PIFFHC+AdvOT999035f4+01
       Flags: Symbolic
       FontBBox: -72, -250, 989, 947
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: PHLLDA+AdvOTd168d80a.I
      FontSubset: true
      FirstChar: 46
      LastChar: 121
      FontDescriptor: 
       FontName: PHLLDA+AdvOTd168d80a.I
       Flags: Nonsymbolic
       FontBBox: -145, -208, 968, 875
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: PHLLEB+AdvOT9b12cd41
      FontSubset: true
      FirstChar: 40
      LastChar: 237
      FontDescriptor: 
       FontName: PHLLEB+AdvOT9b12cd41
       Flags: Nonsymbolic
       FontBBox: -52, -208, 906, 875
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: PHMCAK+AdvPS483E12
      FontSubset: true
      FirstChar: 118
      LastChar: 118
      FontDescriptor: 
       FontName: PHMCAK+AdvPS483E12
       Flags: Nonsymbolic
       FontBBox: 9, -125, 1250, 812
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: PHLLGC+AdvOT9b12cd41+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: PHLLGC+AdvOT9b12cd41+fb
       Flags: Symbolic
       FontBBox: 0, 0, 854, 697
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: PHMCEJ+AdvOT749c1f5a.I
      FontSubset: true
      FirstChar: 46
      LastChar: 112
      FontDescriptor: 
       FontName: PHMCEJ+AdvOT749c1f5a.I
       Flags: Nonsymbolic
       FontBBox: -145, -208, 989, 885
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: PHLLGD+AdvOT9b12cd41+20
      FontSubset: true
      FirstChar: 150
      LastChar: 150
      FontDescriptor: 
       FontName: PHLLGD+AdvOT9b12cd41+20
       Flags: Nonsymbolic
       FontBBox: -114, -166, 1010, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: PHLKEE+AdvOTa2a4c9ce
      FontSubset: true
      FirstChar: 48
      LastChar: 121
      FontDescriptor: 
       FontName: PHLKEE+AdvOTa2a4c9ce
       Flags: Nonsymbolic
       FontBBox: -20, -197, 1072, 906
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: PHLLIF+AdvOT999035f4
      FontSubset: true
      FirstChar: 37
      LastChar: 252
      FontDescriptor: 
       FontName: PHLLIF+AdvOT999035f4
       Flags: Serif, Nonsymbolic
       FontBBox: -72, -260, 947, 906
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: PHLLJG+AdvOTce71c481.I
      FontSubset: true
      FirstChar: 40
      LastChar: 243
      FontDescriptor: 
       FontName: PHLLJG+AdvOTce71c481.I
       Flags: Serif, Nonsymbolic
       FontBBox: -197, -260, 947, 875
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: PHLLKH+AdvOT76a2e33b
      FontSubset: true
      FirstChar: 44
      LastChar: 169
      FontDescriptor: 
       FontName: PHLLKH+AdvOT76a2e33b
       Flags: Nonsymbolic
       FontBBox: -10, -197, 1041, 885
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: PHLLKI+AdvOTedaa8737.I
      FontSubset: true
      FirstChar: 65
      LastChar: 121
      FontDescriptor: 
       FontName: PHLLKI+AdvOTedaa8737.I
       Flags: Nonsymbolic
       FontBBox: -114, -197, 1145, 885
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: PHLLLI+AdvOT76a2e33b+20
      FontSubset: true
      FirstChar: 150
      LastChar: 150
      FontDescriptor: 
       FontName: PHLLLI+AdvOT76a2e33b+20
       Flags: Nonsymbolic
       FontBBox: -31, -197, 1135, 791
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: PHLMAH+AdvOT999035f4+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 3
      FontDescriptor: 
       FontName: PHLMAH+AdvOT999035f4+fb
       Flags: Symbolic
       FontBBox: 0, 0, 885, 697
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: PHLMBI+AdvOT999035f4+20
      FontSubset: true
      FirstChar: 129
      LastChar: 150
      FontDescriptor: 
       FontName: PHLMBI+AdvOT999035f4+20
       Flags: Nonsymbolic
       FontBBox: -197, -239, 1250, 812
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: PHLMGH+AdvOTaa6301a5.B
      FontSubset: true
      FirstChar: 45
      LastChar: 121
      FontDescriptor: 
       FontName: PHLMGH+AdvOTaa6301a5.B
       Flags: Serif, Nonsymbolic
       FontBBox: -93, -260, 947, 885
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: PHLMHI+AdvOT8608a8d1+21
      FontSubset: true
      FirstChar: 153
      LastChar: 153
      FontDescriptor: 
       FontName: PHLMHI+AdvOT8608a8d1+21
       Flags: Nonsymbolic
       FontBBox: -10, -250, 1145, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: PHLLEC+AdvOTd3a5f740
      FontSubset: true
      FirstChar: 40
      LastChar: 177
      FontDescriptor: 
       FontName: PHLLEC+AdvOTd3a5f740
       Flags: Nonsymbolic
       FontBBox: -52, -208, 916, 885
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: PHLLIE+AdvOT8608a8d1+03
      FontSubset: true
      FirstChar: 1
      LastChar: 4
      FontDescriptor: 
       FontName: PHLLIE+AdvOT8608a8d1+03
       Flags: Symbolic
       FontBBox: -479, -364, 854, 927
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: PHLPIG+AdvOTd3a5f740+fb
      FontSubset: true
      FirstChar: 1
      LastChar: 4
      FontDescriptor: 
       FontName: PHLPIG+AdvOTd3a5f740+fb
       Flags: Symbolic
       FontBBox: 0, 0, 906, 708
       FontFile3: true
      EncodingDictionary: 
       Differences: true
      ToUnicode: true
     Font: 
      BaseFont: PHLKPB+AdvOT2c8ce45a
      FontSubset: true
      FirstChar: 44
      LastChar: 121
      FontDescriptor: 
       FontName: PHLKPB+AdvOT2c8ce45a
       Flags: Nonsymbolic
       FontBBox: -52, -208, 947, 895
       FontFile3: true
      Encoding: WinAnsiEncoding
     Font: 
      BaseFont: PHMBKK+AdvOTd3a5f740+20
      FontSubset: true
      FirstChar: 150
      LastChar: 150
      FontDescriptor: 
       FontName: PHMBKK+AdvOTd3a5f740+20
       Flags: Nonsymbolic
       FontBBox: -114, -166, 1062, 864
       FontFile3: true
      Encoding: WinAnsiEncoding
   XMP: <x:xmpmeta xmlns:x="adobe:ns:meta/">
 <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#">
  <rdf:Description rdf:about="" xmlns:dc="http://purl.org/dc/elements/1.1/">
   <dc:format>application/pdf</dc:format>
   <dc:identifier>doi:10.1039/d5an01327e</dc:identifier>
   <dc:creator>
    <rdf:Seq>
     <rdf:li>R. González-Vegas, O. Seksek, S. Chiblak, S. Brons, A. Abdollahi, Y. Prezado, I. Yousef, I. Martínez-Rovira</rdf:li>
    </rdf:Seq>
   </dc:creator>
   <dc:description>
    <rdf:Alt>
     <rdf:li xml:lang="x-default">Analyst (2026), 151, 4424-4442, doi:10.1039/d5an01327e</rdf:li>
    </rdf:Alt>
   </dc:description>
   <dc:publisher>
    <rdf:Bag>
     <rdf:li>Royal Society of Chemistry</rdf:li>
    </rdf:Bag>
   </dc:publisher>
   <dc:rights>
    <rdf:Alt>
     <rdf:li xml:lang="x-default">This journal is © The Royal Society of Chemistry 2026</rdf:li>
    </rdf:Alt>
   </dc:rights>
   <dc:title>
    <rdf:Alt>
     <rdf:li xml:lang="x-default">Revealing the biomolecular response of glioma cells to helium, carbon and oxygen minibeam radiation therapy using synchrotron-based infrared microspectroscopy</rdf:li>
    </rdf:Alt>
   </dc:title>
  </rdf:Description>
  <rdf:Description rdf:about="" xmlns:prism="http://prismstandard.org/namespaces/basic/2.0/">
   <prism:copyright>This journal is © The Royal Society of Chemistry 2026</prism:copyright>
   <prism:versionIdentifier>Issue</prism:versionIdentifier>
   <prism:doi>10.1039/d5an01327e</prism:doi>
   <prism:eIssn>1364-5528</prism:eIssn>
   <prism:endingPage>4442</prism:endingPage>
   <prism:issn>0003-2654</prism:issn>
   <prism:publicationName>Analyst</prism:publicationName>
   <prism:rightsAgent>contracts-copyright@rsc.org</prism:rightsAgent>
   <prism:startingPage>4424</prism:startingPage>
   <prism:volume>151</prism:volume>
   <prism:publicationDate>2026-07-21</prism:publicationDate>
   <prism:url rdf:resource="http://dx.doi.org/10.1039/d5an01327e" />
  </rdf:Description>
  <rdf:Description rdf:about="" xmlns:crossmark="http://crossref.org/crossmark/2.0/">
   <crossmark:MajorVersionDate>2026-07-21</crossmark:MajorVersionDate>
   <crossmark:CrossmarkDomainExclusive>false</crossmark:CrossmarkDomainExclusive>
   <crossmark:DOI>10.1039/d5an01327e</crossmark:DOI>
   <crossmark:CrossMarkDomains>
    <rdf:Seq>
     <rdf:li>rsc.org</rdf:li>
    </rdf:Seq>
   </crossmark:CrossMarkDomains>
  </rdf:Description>
  <rdf:Description rdf:about="" xmlns:pdfx="http://ns.adobe.com/pdfx/1.3/">
   <pdfx:doi>10.1039/d5an01327e</pdfx:doi>
   <pdfx:CrossmarkMajorVersionDate>2026-07-21</pdfx:CrossmarkMajorVersionDate>
   <pdfx:CrossmarkDomainExclusive>false</pdfx:CrossmarkDomainExclusive>
   <pdfx:CrossMarkDomains>
    <rdf:Seq>
     <rdf:li>rsc.org</rdf:li>
    </rdf:Seq>
   </pdfx:CrossMarkDomains>
  </rdf:Description>
  <rdf:Description rdf:about="" xmlns:pdf="http://ns.adobe.com/pdf/1.3/">
   <pdf:Producer>Acrobat Distiller 10.0.0 (Windows); modified using iTextSharp™ 5.5.1 ©2000-2014 iText Group NV (AGPL-version)</pdf:Producer>
  </rdf:Description>
  <rdf:Description rdf:about="" xmlns:xmp="http://ns.adobe.com/xap/1.0/">
   <xmp:ModifyDate>2026-07-21T15:31:46+05:30</xmp:ModifyDate>
   <xmp:MetadataDate>2026-07-21T15:31:46+05:30</xmp:MetadataDate>
  </rdf:Description>
 </rdf:RDF>
</x:xmpmeta>
   Pages: 
    Page: 
     Label: 4424
     Sequence: 1
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 42, 252, 79, 259
      Annotation: 
       Subtype: Link
       Rect: 262, 553, 272, 564
      Annotation: 
       Subtype: Link
       Rect: 289, 541, 299, 552
      Annotation: 
       Subtype: Link
       Rect: 406, 541, 416, 552
      Annotation: 
       Subtype: Widget
       Rect: 42, 621, 141, 640
       Flags: Print
       AppearanceDictionary: true
      Annotation: 
       Subtype: Link
       Rect: 428, 666, 547, 676
       Flags: Print
    Page: 
     Label: 4425
     Sequence: 2
    Page: 
     Label: 4426
     Sequence: 3
    Page: 
     Label: 4427
     Sequence: 4
    Page: 
     Label: 4428
     Sequence: 5
    Page: 
     Label: 4429
     Sequence: 6
    Page: 
     Label: 4430
     Sequence: 7
    Page: 
     Label: 4431
     Sequence: 8
    Page: 
     Label: 4432
     Sequence: 9
    Page: 
     Label: 4433
     Sequence: 10
    Page: 
     Label: 4434
     Sequence: 11
    Page: 
     Label: 4435
     Sequence: 12
    Page: 
     Label: 4436
     Sequence: 13
    Page: 
     Label: 4437
     Sequence: 14
    Page: 
     Label: 4438
     Sequence: 15
    Page: 
     Label: 4439
     Sequence: 16
    Page: 
     Label: 4440
     Sequence: 17
     Annotations: 
      Annotation: 
       Subtype: Link
       Rect: 264, 684, 289, 693
      Annotation: 
       Subtype: Link
       Rect: 264, 684, 291, 693
      Annotation: 
       Subtype: Link
       Rect: 42, 672, 112, 681
      Annotation: 
       Subtype: Link
       Rect: 200, 636, 225, 645
      Annotation: 
       Subtype: Link
       Rect: 200, 636, 291, 645
      Annotation: 
       Subtype: Link
       Rect: 42, 624, 90, 633
    Page: 
     Label: 4441
     Sequence: 18
    Page: 
     Label: 4442
     Sequence: 19
  Checksum: b9e8a8c2
   Type: CRC32
  Checksum: 70ccc22fa997e7dd47284a4c3758ca09
   Type: MD5
  Checksum: f067ffb1fbba4039374eef0f3744e48392225f18
   Type: SHA-1
  Checksum: e37a7ca69e5beb29ba6d6e8f44c4ef0097bd529b2945e91836076112d30c4f72
   Type: SHA-256