cfddcc1deb2e29ea52b92923d79e1412 fimmu-17-1846423.pdf d6b8a1821d15faed0c89cf1d8b023acd62b76721 fimmu-17-1846423.pdf 358e1f9319eb67e7ae84c0d5d57ed8a7d504e85a715345e5a93a810aee83be5c fimmu-17-1846423.pdf Title: Prolonged SARS-CoV-2 infection in hematologic malignancies: clinical impact, risk factors and intra-host viral evolution Subject: Jiménez M, Andrés C, González-Sánchez A, Navarro V, Medina I, Prats-Méndez I, Antón A, Martinez-Gallo M, Albasanz A, Arenas P, Pérez A, Novoa S, Serna Á, Pumarola T, Hernández M, Ruiz-Camps I, Valcárcel D, Crespo M, Esperalba J, Bosch F and Abrisqueta P (2026) Prolonged SARS-CoV-2 infection in hematologic malignancies: clinical impact, risk factors and intra-host viral evolution. Front. Immunol. 17:1846423. doi: 10.3389/fimmu.2026.1846423 Keywords: hematologic malignancies & chemotherapy; immunodeficiencies; prolonged COVID-19 pneumonia; prolonged SARS-CoV-2 infections; SARS - CoV – 2 Author: Moraima Jiménez CreationDate: Tue Aug 4 04:45:59 2026 CEST ModDate: Tue Aug 4 04:45:59 2026 CEST Custom Metadata: no Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 14 Encrypted: no Page size: 595.389 x 841.663 pts (A4) Page rot: 0 File size: 2694359 bytes Optimized: no PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- COCCDH+AdvTTd3a5f740 Type 1C WinAnsi yes yes no 225 0 COCHEB+AdvTTd168d80a.I Type 1C WinAnsi yes yes no 569 0 COCCDI+AdvPSA18C Type 1C WinAnsi yes yes no 701 0 COCCDJ+AdvTTd3a5f740+20 Type 1C WinAnsi yes yes no 702 0 COCCDK+AdvTTd3a5f740+01 Type 1C MacRoman yes yes no 703 0 COCCDL+AdvTT9b12cd41 Type 1C WinAnsi yes yes no 227 0 COCCDM+AdvTT9b12cd41+20 Type 1C WinAnsi yes yes no 228 0 COCCEN+AdvTT2c8ce45a Type 1C WinAnsi yes yes no 226 0 COCCEO+AdvTT9b12cd41+fb Type 1C Custom yes yes yes 505 0 COCHBB+AdvPSA323 Type 1C WinAnsi yes yes no 229 0 COCHIB+AdvTT2c8ce45a+fb Type 1C Custom yes yes yes 713 0 COCHIC+AdvTT2c8ce45a+20 Type 1C WinAnsi yes yes no 714 0 COCHID+AdvOT1ef757c0 Type 1C WinAnsi yes yes no 222 0 COCHIE+AdvOT1ef757c0+20 Type 1C WinAnsi yes yes no 223 0 COCHIF+AdvOT1ef757c0+fb Type 1C Custom yes yes yes 224 0 COCHJF+AdvOT1ef757c0+22 Type 1C Custom yes yes yes 504 0 COCHJG+AdvTTd3a5f740+fb Type 1C Custom yes yes yes 715 0 COCHJH+AdvOT7d6df7ab.I Type 1C WinAnsi yes yes no 503 0 COFLGK+AdvTT58d178b9+03 Type 1C Custom yes yes yes 735 0 COFLIK+AdvOT1ef757c0+01 Type 1C MacRoman yes yes no 736 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2026-10-14 04:05:57 CEST RepresentationInformation: fimmu-17-1846423.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2026-10-13 18:47:39 CEST Size: 2694359 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf PDFMetadata: Objects: 793 FreeObjects: 1 IncrementalUpdates: 0 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: true NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: en-US Outlines: Item: Title: Prolonged SARS-CoV-2 infection in hematologic malignancies: clinical impact, risk factors and intra-host viral evolution Destination: bmark_-889278719 Children: Item: Title: Introduction Destination: s1 Item: Title: Methods Destination: s2 Children: Item: Title: Study design and patient cohort Destination: s2_1 Item: Title: Definition of prolonged COVID-19 Destination: s2_2 Item: Title: SARS-CoV-2 diagnosis and whole genome sequencing Destination: s2_3 Item: Title: Statistical analysis Destination: s2_4 Item: Title: Ethical approval Destination: s2_5 Item: Title: Results Destination: s3 Children: Item: Title: Incidence and risk factors of prolonged SARS-CoV-2 infection Destination: s3_1 Item: Title: Prolonged SARS-CoV-2 Omicron infection in vaccinated patients with HM Destination: s3_2 Item: Title: Intra-host viral evolution in prolonged COVID-19 Destination: s3_3 Item: Title: Clinical impact of prolonged COVID-19 Destination: s3_4 Item: Title: Discussion Destination: s4 Item: Title: Data availability statement Destination: bmark_-1258588262 Item: Title: Ethics statement Destination: bmark_1370551237 Item: Title: Author contributions Destination: bmark_-1208584890 Item: Title: Funding Destination: bmark_1865464027 Item: Title: Acknowledgments Destination: bmark_-366698314 Item: Title: Conflict of interest Destination: bmark_1089982005 Item: Title: Generative AI statement Destination: bmark_-1453097031 Item: Title: Publisher’s note Destination: bmark_-1256977648 Item: Title: Supplementary material Destination: bmark_632582120 Item: Title: References Destination: bmark_2090415954 Info: Title: Prolonged SARS-CoV-2 infection in hematologic malignancies: clinical impact, risk factors and intra-host viral evolution Author: Moraima Jiménez Subject: Jiménez M, Andrés C, González-Sánchez A, Navarro V, Medina I, Prats-Méndez I, Antón A, Martinez-Gallo M, Albasanz A, Arenas P, Pérez A, Novoa S, Serna Á, Pumarola T, Hernández M, Ruiz-Camps I, Valcárcel D, Crespo M, Esperalba J, Bosch F and Abrisqueta P (2026) Prolonged SARS-CoV-2 infection in hematologic malignancies: clinical impact, risk factors and intra-host viral evolution. Front. Immunol. 17:1846423. doi: 10.3389/fimmu.2026.1846423 Keywords: hematologic malignancies & chemotherapy; immunodeficiencies; prolonged COVID-19 pneumonia; prolonged SARS-CoV-2 infections; SARS - CoV   2 CreationDate: Tue Aug 04 04:45:59 CEST 2026 ModDate: Tue Aug 04 04:45:59 CEST 2026 ID: 0xd9e682b65922d5e50f2e4047d9a6501a, 0xa25b81293a8ed53deb67a23639a7b2c2 Filters: FilterPipeline: FlateDecode FilterPipeline: DCTDecode Images: Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 2919 ImageHeight: 577 ColorSpace: CMYK BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1772 ImageHeight: 1210 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1588 ImageHeight: 1860 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1670 ImageHeight: 1822 BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 1629 ImageHeight: 2310 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/png ImageWidth: 2180 ImageHeight: 2892 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Filter: FlateDecode Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1654 ImageHeight: 1274 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Image: NisoImageMetadata: FormatName: image/jpg CompressionScheme: JPEG ImageWidth: 1577 ImageHeight: 1204 ColorSpace: RGB BitsPerSample: 8 BitsPerSampleUnit: integer Fonts: Type1: Font: BaseFont: COCHIF+AdvOT1ef757c0+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: COCHIF+AdvOT1ef757c0+fb Flags: Symbolic FontBBox: 0, -10, 781, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: COFLIK+AdvOT1ef757c0+01 FontSubset: true FirstChar: 245 LastChar: 245 FontDescriptor: FontName: COFLIK+AdvOT1ef757c0+01 Flags: Serif, Nonsymbolic FontBBox: -20, -250, 947, 854 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: COCCDH+AdvTTd3a5f740 FontSubset: true FirstChar: 37 LastChar: 176 FontDescriptor: FontName: COCCDH+AdvTTd3a5f740 Flags: Serif, Nonsymbolic FontBBox: -52, -208, 916, 885 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: COCCEN+AdvTT2c8ce45a FontSubset: true FirstChar: 38 LastChar: 121 FontDescriptor: FontName: COCCEN+AdvTT2c8ce45a Flags: Serif, Nonsymbolic FontBBox: -52, -208, 947, 895 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: COCCDL+AdvTT9b12cd41 FontSubset: true FirstChar: 37 LastChar: 242 FontDescriptor: FontName: COCCDL+AdvTT9b12cd41 Flags: Serif, Nonsymbolic FontBBox: -52, -208, 906, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: COCCDM+AdvTT9b12cd41+20 FontSubset: true FirstChar: 134 LastChar: 146 FontDescriptor: FontName: COCCDM+AdvTT9b12cd41+20 Flags: Nonsymbolic FontBBox: -114, -166, 1010, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: COCHBB+AdvPSA323 FontSubset: true FirstChar: 180 LastChar: 180 FontDescriptor: FontName: COCHBB+AdvPSA323 Flags: Nonsymbolic FontBBox: -156, -239, 1104, 770 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: COCHIB+AdvTT2c8ce45a+fb FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: COCHIB+AdvTT2c8ce45a+fb Flags: Symbolic FontBBox: 0, 0, 947, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: COCHIC+AdvTT2c8ce45a+20 FontSubset: true FirstChar: 150 LastChar: 150 FontDescriptor: FontName: COCHIC+AdvTT2c8ce45a+20 Flags: Nonsymbolic FontBBox: -125, -166, 1125, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: COCHJG+AdvTTd3a5f740+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: COCHJG+AdvTTd3a5f740+fb Flags: Symbolic FontBBox: 0, 0, 906, 708 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: COCHJH+AdvOT7d6df7ab.I FontSubset: true FirstChar: 40 LastChar: 119 FontDescriptor: FontName: COCHJH+AdvOT7d6df7ab.I Flags: Nonsymbolic FontBBox: -135, -250, 1000, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: COCHJF+AdvOT1ef757c0+22 FontSubset: true FirstChar: 1 LastChar: 1 FontDescriptor: FontName: COCHJF+AdvOT1ef757c0+22 Flags: Symbolic FontBBox: -135, -166, 697, 916 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: COCCEO+AdvTT9b12cd41+fb FontSubset: true FirstChar: 1 LastChar: 3 FontDescriptor: FontName: COCCEO+AdvTT9b12cd41+fb Flags: Symbolic FontBBox: 0, 0, 854, 697 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true Font: BaseFont: COCHEB+AdvTTd168d80a.I FontSubset: true FirstChar: 46 LastChar: 118 FontDescriptor: FontName: COCHEB+AdvTTd168d80a.I Flags: Serif, Nonsymbolic FontBBox: -145, -208, 968, 875 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: COCCDI+AdvPSA18C FontSubset: true FirstChar: 180 LastChar: 180 FontDescriptor: FontName: COCCDI+AdvPSA18C Flags: Nonsymbolic FontBBox: -156, -208, 1125, 802 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: COCCDJ+AdvTTd3a5f740+20 FontSubset: true FirstChar: 134 LastChar: 146 FontDescriptor: FontName: COCCDJ+AdvTTd3a5f740+20 Flags: Nonsymbolic FontBBox: -114, -166, 1062, 864 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: COCHID+AdvOT1ef757c0 FontSubset: true FirstChar: 35 LastChar: 252 FontDescriptor: FontName: COCHID+AdvOT1ef757c0 Flags: Serif, Nonsymbolic FontBBox: -20, -250, 947, 854 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: COCCDK+AdvTTd3a5f740+01 FontSubset: true FirstChar: 245 LastChar: 245 FontDescriptor: FontName: COCCDK+AdvTTd3a5f740+01 Flags: Nonsymbolic FontBBox: -52, -208, 947, 885 FontFile3: true Encoding: MacRomanEncoding Font: BaseFont: COCHIE+AdvOT1ef757c0+20 FontSubset: true FirstChar: 146 LastChar: 150 FontDescriptor: FontName: COCHIE+AdvOT1ef757c0+20 Flags: Nonsymbolic FontBBox: -135, -187, 1010, 833 FontFile3: true Encoding: WinAnsiEncoding Font: BaseFont: COFLGK+AdvTT58d178b9+03 FontSubset: true FirstChar: 0 LastChar: 0 FontDescriptor: FontName: COFLGK+AdvTT58d178b9+03 Flags: Symbolic FontBBox: -645, -354, 916, 895 FontFile3: true EncodingDictionary: Differences: true ToUnicode: true XMP: application/pdf Moraima Jiménez Cristina Andrés Alejandra González-Sánchez Víctor Navarro Irene Medina Ignasi Prats-Méndez Andrés Antón Mónica Martinez-Gallo Adaia Albasanz Pamela Arenas Ana Pérez Sandra Novoa Ángel Serna Tomás Pumarola Manuel Hernández Isabel Ruiz-Camps David Valcárcel Marta Crespo Juliana Esperalba Francesc Bosch Pau Abrisqueta Jiménez M, Andrés C, González-Sánchez A, Navarro V, Medina I, Prats-Méndez I, Antón A, Martinez-Gallo M, Albasanz A, Arenas P, Pérez A, Novoa S, Serna Á, Pumarola T, Hernández M, Ruiz-Camps I, Valcárcel D, Crespo M, Esperalba J, Bosch F and Abrisqueta P (2026) Prolonged SARS-CoV-2 infection in hematologic malignancies: clinical impact, risk factors and intra-host viral evolution. Front. Immunol. 17:1846423. doi: 10.3389/fimmu.2026.1846423 Copyright © 2026 Jiménez, Andrés, González-Sánchez, Navarro, Medina, Prats-Méndez, Antón, Martinez-Gallo, Albasanz, Arenas, Pérez, Novoa, Serna, Pumarola, Hernández, Ruiz-Camps, Valcárcel, Crespo, Esperalba, Bosch and Abrisqueta. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. hematologic malignancies & chemotherapy immunodeficiencies prolonged COVID-19 pneumonia prolonged SARS-CoV-2 infections SARS - CoV – 2 Prolonged SARS-CoV-2 infection in hematologic malignancies: clinical impact, risk factors and intra-host viral evolution hematologic malignancies & chemotherapy; immunodeficiencies; prolonged COVID-19 pneumonia; prolonged SARS-CoV-2 infections; SARS - CoV – 2 2026-08-04T10:45:59+08:00 2026-08-04T10:45:59+08:00 2026-08-04T10:45:59+08:00 True https://www.frontiersin.org/legal/copyright-statement uuid:9e82e5e4-8ee9-453e-9bfe-f952ec4695bf uuid:e21bc2e5-b001-4e95-a1be-2cc239085a50 Pages: Page: Label: 1 Annotations: Annotation: Subtype: Link Rect: 219, 683, 539, 704 Annotation: Subtype: Link Rect: 219, 658, 503, 679 Annotation: Subtype: Link Rect: 219, 633, 519, 654 Annotation: Subtype: Link Rect: 219, 608, 458, 629 Annotation: Subtype: Link Rect: 49, 33, 128, 40 Annotation: Subtype: Link Rect: 499, 33, 545, 40 Annotation: Subtype: Link Rect: 49, 688, 125, 703 Annotation: Subtype: Link Rect: 57, 533, 123, 540 Annotation: Subtype: Link Rect: 57, 523, 146, 530 Annotation: Subtype: Link Rect: 49, 331, 159, 338 Annotation: Subtype: Link Rect: 120, 245, 145, 252 Annotation: Subtype: Link Rect: 49, 236, 167, 243 Annotation: Subtype: Link Rect: 449, 784, 505, 791 Annotation: Subtype: Link Rect: 466, 774, 516, 781 Annotation: Subtype: Link Rect: 446, 765, 540, 772 Annotation: Subtype: Link Rect: 49, 753, 248, 802 Page: Label: 2 Annotations: Annotation: Subtype: Link Rect: 215, 550, 219, 559 Destination: 40 Annotation: Subtype: Link Rect: 224, 550, 228, 559 Destination: 40 Annotation: Subtype: Link Rect: 243, 500, 247, 509 Destination: 40 Annotation: Subtype: Link Rect: 251, 500, 255, 509 Destination: 40 Annotation: Subtype: Link Rect: 266, 475, 270, 484 Destination: 40 Annotation: Subtype: Link Rect: 215, 450, 219, 459 Destination: 40 Annotation: Subtype: Link Rect: 225, 450, 229, 459 Destination: 40 Annotation: Subtype: Link Rect: 235, 412, 239, 421 Destination: 40 Annotation: Subtype: Link Rect: 243, 412, 251, 421 Destination: 40 Annotation: Subtype: Link Rect: 251, 362, 259, 371 Destination: 40 Annotation: Subtype: Link Rect: 263, 362, 271, 371 Destination: 40 Annotation: Subtype: Link Rect: 264, 337, 272, 346 Destination: 40 Annotation: Subtype: Link Rect: 277, 337, 285, 346 Destination: 40 Annotation: Subtype: Link Rect: 338, 528, 346, 537 Destination: 40 Annotation: Subtype: Link Rect: 469, 503, 499, 512 Destination: 30 Annotation: Subtype: Link Rect: 480, 465, 488, 474 Destination: 40 Annotation: Subtype: Link Rect: 512, 440, 540, 449 Destination: 30 Annotation: Subtype: Link Rect: 400, 367, 409, 376 Destination: 40 Annotation: Subtype: Link Rect: 415, 367, 424, 376 Destination: 40 Annotation: Subtype: Link Rect: 366, 305, 374, 314 Destination: 40 Annotation: Subtype: Link Rect: 379, 305, 388, 314 Destination: 40 Annotation: Subtype: Link Rect: 448, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 128, 40 Annotation: Subtype: Link Rect: 499, 33, 545, 40 Page: Label: 3 Annotations: Annotation: Subtype: Link Rect: 121, 399, 204, 408 Destination: 40 Annotation: Subtype: Link Rect: 139, 374, 287, 383 Annotation: Subtype: Link Rect: 207, 361, 215, 370 Destination: 40 Annotation: Subtype: Link Rect: 236, 349, 245, 358 Destination: 40 Annotation: Subtype: Link Rect: 278, 311, 287, 320 Destination: 41 Annotation: Subtype: Link Rect: 176, 274, 184, 283 Destination: 41 Annotation: Subtype: Link Rect: 276, 236, 285, 245 Destination: 41 Annotation: Subtype: Link Rect: 52, 211, 61, 220 Destination: 41 Annotation: Subtype: Link Rect: 448, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 34, 128, 41 Annotation: Subtype: Link Rect: 499, 34, 545, 41 Page: Label: 4 Annotations: Annotation: Subtype: Link Rect: 448, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 128, 40 Annotation: Subtype: Link Rect: 499, 33, 545, 40 Page: Label: 5 Annotations: Annotation: Subtype: Link Rect: 335, 318, 419, 327 Destination: 40 Annotation: Subtype: Link Rect: 434, 218, 461, 227 Destination: 31 Annotation: Subtype: Link Rect: 448, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 128, 40 Annotation: Subtype: Link Rect: 499, 33, 545, 40 Page: Label: 6 Annotations: Annotation: Subtype: Link Rect: 199, 71, 230, 80 Destination: 33 Annotation: Subtype: Link Rect: 448, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 128, 40 Annotation: Subtype: Link Rect: 499, 33, 545, 40 Page: Label: 7 Annotations: Annotation: Subtype: Link Rect: 136, 164, 166, 173 Destination: 34 Annotation: Subtype: Link Rect: 503, 264, 533, 273 Destination: 35 Annotation: Subtype: Link Rect: 450, 239, 540, 248 Destination: 40 Annotation: Subtype: Link Rect: 490, 114, 520, 123 Destination: 36 Annotation: Subtype: Link Rect: 362, 64, 447, 73 Destination: 40 Annotation: Subtype: Link Rect: 448, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 128, 40 Annotation: Subtype: Link Rect: 499, 33, 545, 40 Page: Label: 8 Annotations: Annotation: Subtype: Link Rect: 169, 196, 257, 205 Destination: 40 Annotation: Subtype: Link Rect: 143, 121, 174, 130 Destination: 37 Annotation: Subtype: Link Rect: 331, 233, 361, 242 Destination: 38 Annotation: Subtype: Link Rect: 448, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 128, 40 Annotation: Subtype: Link Rect: 499, 33, 545, 40 Page: Label: 9 Annotations: Annotation: Subtype: Link Rect: 448, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 128, 40 Annotation: Subtype: Link Rect: 499, 33, 545, 40 Page: Label: 10 Annotations: Annotation: Subtype: Link Rect: 160, 183, 169, 192 Destination: 40 Annotation: Subtype: Link Rect: 174, 183, 182, 192 Destination: 40 Annotation: Subtype: Link Rect: 188, 183, 196, 192 Destination: 41 Annotation: Subtype: Link Rect: 202, 183, 210, 192 Destination: 41 Annotation: Subtype: Link Rect: 278, 133, 287, 142 Destination: 41 Annotation: Subtype: Link Rect: 276, 121, 285, 130 Destination: 40 Annotation: Subtype: Link Rect: 258, 71, 267, 80 Destination: 41 Annotation: Subtype: Link Rect: 389, 383, 398, 392 Destination: 40 Annotation: Subtype: Link Rect: 501, 271, 509, 280 Destination: 40 Annotation: Subtype: Link Rect: 514, 271, 523, 280 Destination: 40 Annotation: Subtype: Link Rect: 533, 271, 542, 280 Destination: 41 Annotation: Subtype: Link Rect: 360, 258, 369, 267 Destination: 40 Annotation: Subtype: Link Rect: 374, 258, 383, 267 Destination: 40 Annotation: Subtype: Link Rect: 389, 258, 397, 267 Destination: 41 Annotation: Subtype: Link Rect: 502, 258, 511, 267 Destination: 40 Annotation: Subtype: Link Rect: 435, 246, 444, 255 Destination: 41 Annotation: Subtype: Link Rect: 328, 233, 337, 242 Destination: 41 Annotation: Subtype: Link Rect: 456, 221, 465, 230 Destination: 40 Annotation: Subtype: Link Rect: 364, 171, 373, 180 Destination: 41 Annotation: Subtype: Link Rect: 402, 96, 411, 105 Destination: 41 Annotation: Subtype: Link Rect: 448, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 128, 40 Annotation: Subtype: Link Rect: 499, 33, 545, 40 Page: Label: 11 Annotations: Annotation: Subtype: Link Rect: 175, 385, 184, 394 Destination: 41 Annotation: Subtype: Link Rect: 52, 298, 60, 307 Destination: 41 Annotation: Subtype: Link Rect: 274, 248, 282, 257 Destination: 41 Annotation: Subtype: Link Rect: 149, 210, 158, 219 Destination: 41 Annotation: Subtype: Link Rect: 89, 198, 97, 207 Destination: 41 Annotation: Subtype: Link Rect: 168, 198, 177, 207 Destination: 41 Annotation: Subtype: Link Rect: 70, 98, 79, 107 Destination: 41 Annotation: Subtype: Link Rect: 419, 385, 428, 394 Destination: 41 Annotation: Subtype: Link Rect: 432, 385, 441, 394 Destination: 41 Annotation: Subtype: Link Rect: 485, 273, 494, 282 Destination: 41 Annotation: Subtype: Link Rect: 498, 273, 507, 282 Destination: 41 Annotation: Subtype: Link Rect: 474, 235, 483, 244 Destination: 41 Annotation: Subtype: Link Rect: 487, 235, 496, 244 Destination: 41 Annotation: Subtype: Link Rect: 369, 173, 377, 182 Destination: 41 Annotation: Subtype: Link Rect: 382, 173, 391, 182 Destination: 41 Annotation: Subtype: Link Rect: 448, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 33, 128, 40 Annotation: Subtype: Link Rect: 499, 33, 545, 40 Page: Label: 12 Annotations: Annotation: Subtype: Link Rect: 278, 646, 287, 655 Destination: 40 Annotation: Subtype: Link Rect: 165, 583, 173, 592 Destination: 41 Annotation: Subtype: Link Rect: 178, 583, 187, 592 Destination: 41 Annotation: Subtype: Link Rect: 108, 496, 116, 505 Destination: 41 Annotation: Subtype: Link Rect: 127, 421, 136, 430 Destination: 41 Annotation: Subtype: Link Rect: 448, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 34, 128, 41 Annotation: Subtype: Link Rect: 499, 34, 545, 41 Page: Label: 13 Annotations: Annotation: Subtype: Link Rect: 304, 484, 545, 493 Annotation: Subtype: Link Rect: 304, 472, 401, 481 Annotation: Subtype: Link Rect: 212, 406, 287, 413 Annotation: Subtype: Link Rect: 145, 369, 219, 376 Annotation: Subtype: Link Rect: 145, 333, 195, 340 Annotation: Subtype: Link Rect: 266, 304, 290, 311 Annotation: Subtype: Link Rect: 49, 296, 101, 303 Annotation: Subtype: Link Rect: 61, 260, 112, 267 Annotation: Subtype: Link Rect: 263, 231, 290, 238 Annotation: Subtype: Link Rect: 49, 223, 101, 230 Annotation: Subtype: Link Rect: 61, 187, 136, 194 Annotation: Subtype: Link Rect: 97, 158, 165, 165 Annotation: Subtype: Link Rect: 133, 130, 201, 137 Annotation: Subtype: Link Rect: 266, 93, 290, 100 Annotation: Subtype: Link Rect: 49, 85, 85, 92 Annotation: Subtype: Link Rect: 387, 414, 467, 421 Annotation: Subtype: Link Rect: 516, 385, 545, 392 Annotation: Subtype: Link Rect: 304, 377, 366, 384 Annotation: Subtype: Link Rect: 345, 349, 435, 356 Annotation: Subtype: Link Rect: 448, 320, 529, 327 Annotation: Subtype: Link Rect: 316, 292, 372, 299 Annotation: Subtype: Link Rect: 408, 263, 459, 270 Annotation: Subtype: Link Rect: 372, 227, 453, 234 Annotation: Subtype: Link Rect: 316, 190, 435, 197 Annotation: Subtype: Link Rect: 436, 160, 501, 167 Annotation: Subtype: Link Rect: 461, 131, 530, 138 Annotation: Subtype: Link Rect: 345, 87, 418, 94 Annotation: Subtype: Link Rect: 459, 65, 545, 72 Annotation: Subtype: Link Rect: 448, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 34, 128, 41 Annotation: Subtype: Link Rect: 499, 34, 545, 41 Page: Label: 14 Annotations: Annotation: Subtype: Link Rect: 120, 752, 206, 759 Annotation: Subtype: Link Rect: 103, 716, 158, 723 Annotation: Subtype: Link Rect: 212, 695, 286, 702 Annotation: Subtype: Link Rect: 110, 675, 290, 682 Annotation: Subtype: Link Rect: 72, 630, 162, 637 Annotation: Subtype: Link Rect: 93, 594, 172, 601 Annotation: Subtype: Link Rect: 230, 565, 284, 572 Annotation: Subtype: Link Rect: 265, 537, 290, 544 Annotation: Subtype: Link Rect: 49, 529, 96, 536 Annotation: Subtype: Link Rect: 266, 500, 290, 507 Annotation: Subtype: Link Rect: 49, 492, 97, 499 Annotation: Subtype: Link Rect: 61, 456, 161, 463 Annotation: Subtype: Link Rect: 184, 427, 258, 434 Annotation: Subtype: Link Rect: 266, 399, 290, 406 Annotation: Subtype: Link Rect: 49, 391, 107, 398 Annotation: Subtype: Link Rect: 93, 354, 166, 361 Annotation: Subtype: Link Rect: 178, 326, 239, 333 Annotation: Subtype: Link Rect: 316, 736, 397, 743 Annotation: Subtype: Link Rect: 419, 708, 485, 715 Annotation: Subtype: Link Rect: 392, 679, 463, 686 Annotation: Subtype: Link Rect: 316, 643, 370, 650 Annotation: Subtype: Link Rect: 471, 614, 544, 621 Annotation: Subtype: Link Rect: 352, 578, 423, 585 Annotation: Subtype: Link Rect: 316, 541, 372, 548 Annotation: Subtype: Link Rect: 372, 505, 444, 512 Annotation: Subtype: Link Rect: 316, 476, 388, 483 Annotation: Subtype: Link Rect: 464, 440, 520, 447 Annotation: Subtype: Link Rect: 510, 410, 545, 417 Annotation: Subtype: Link Rect: 304, 402, 325, 409 Annotation: Subtype: Link Rect: 424, 364, 501, 371 Annotation: Subtype: Link Rect: 346, 326, 424, 333 Annotation: Subtype: Link Rect: 448, 799, 545, 806 Annotation: Subtype: Link Rect: 49, 34, 128, 41 Annotation: Subtype: Link Rect: 499, 34, 545, 41 Checksum: 3edb28f9 Type: CRC32 Checksum: cfddcc1deb2e29ea52b92923d79e1412 Type: MD5 Checksum: d6b8a1821d15faed0c89cf1d8b023acd62b76721 Type: SHA-1 Checksum: 358e1f9319eb67e7ae84c0d5d57ed8a7d504e85a715345e5a93a810aee83be5c Type: SHA-256