d992f24ce3b44249ccc95917be9327cf s40259-026-00806-9.pdf 64bdb883a4be95e893e07b87a72fba47905027a9 s40259-026-00806-9.pdf 9630176d1c58009b4ca679dd4328fca0d85adcbca62bbdc83a39eebed5a6dfe4 s40259-026-00806-9.pdf Title: Biosimilars: A Virtuous Cycle of Sustainability and Innovation Subject: BioDrugs, https://doi.org/10.1007/s40259-026-00806-9 Author: Fernando de Mora Creator: Springer Producer: Adobe PDF Library 17.0; modified using iTextSharp™ 5.5.14-SNAPSHOT ©2000-2020 iText Group NV (AGPL-version) CreationDate: Mon Sep 7 08:54:45 2026 CEST ModDate: Mon Sep 7 08:56:57 2026 CEST Custom Metadata: yes Metadata Stream: yes Tagged: no UserProperties: no Suspects: no Form: none JavaScript: no Pages: 11 Encrypted: no Page size: 595.276 x 790.866 pts Page rot: 0 File size: 639852 bytes Optimized: yes PDF version: 1.4 name type encoding emb sub uni object ID ------------------------------------ ----------------- ---------------- --- --- --- --------- MyriadPro-SemiCn Type 1C Custom yes no yes 930 0 MyriadPro-Semibold Type 1C Custom yes no yes 931 0 MyriadPro-SemiboldSemiCn Type 1C Custom yes no yes 941 0 MyriadPro-Bold Type 1C Custom yes no yes 942 0 MREBSA+STIX-Regular Type 1C Custom yes yes yes 943 0 WPOXKJ+Wingdings-Regular Type 1C WinAnsi yes yes yes 955 0 CAQHXG+MyriadPro-SemiCn2 Type 1C WinAnsi yes yes yes 984 0 MyriadPro-BoldSemiCn Type 1C WinAnsi yes no yes 397 0 MyriadPro-SemiCn3 Type 1C WinAnsi yes no yes 405 0 Jhove (Rel. 1.28.0, 2023-05-18) Date: 2026-10-27 03:55:50 CET RepresentationInformation: s40259-026-00806-9.pdf ReportingModule: PDF-hul, Rel. 1.12.4 (2023-03-16) LastModified: 2026-10-26 18:44:22 CET Size: 639852 Format: PDF Version: 1.4 Status: Well-Formed and valid SignatureMatches: PDF-hul MIMEtype: application/pdf Profile: Linearized PDF PDFMetadata: Objects: 1030 FreeObjects: 1 IncrementalUpdates: 1 DocumentCatalog: ViewerPreferences: HideToolbar: false HideMenubar: false HideWindowUI: false FitWindow: false CenterWindow: false DisplayDocTitle: false NonFullScreenPageMode: UseNone Direction: L2R ViewArea: CropBox ViewClip: CropBox PrintArea: CropBox PageClip: CropBox PageLayout: SinglePage PageMode: UseOutlines Language: EN Outlines: Item: Title: Biosimilars: A Virtuous Cycle of Sustainability and Innovation Children: Item: Title: Abstract Item: Title: 1 Background Item: Title: 2 Classification of Biosimilar-Driven Innovation Children: Item: Title: 2.1 Pharmaceutical Innovation Children: Item: Title: 2.1.1 Disruptive innovation: drug repurposing (repositioning) and target optimization Item: Title: 2.1.2 Incremental innovation: evolution of marketed reference biological medicines Item: Title: 2.1.3 Innovative developments within the biosimilar Item: Title: 2.2 Technological Innovation Children: Item: Title: 2.2.1 Innovation in healthcare technologies and methodologies Item: Title: 2.2.2 Innovation in pharmaceutical (galenic) technology Item: Title: 2.2.3 Methodological and process engineering innovation Item: Title: 2.3 Therapeutic Innovation Children: Item: Title: 2.3.1 Therapeutic innovation incorporated into the biosimilar Item: Title: 2.3.2 Therapeutic innovation fostered by biosimilars Item: Title: 2.3.3 Therapeutic paradigm shift Item: Title: 3 Conclusions Item: Title: References Info: Title: Biosimilars: A Virtuous Cycle of Sustainability and Innovation Author: Fernando de Mora Subject: BioDrugs, https://doi.org/10.1007/s40259-026-00806-9 Creator: Springer Producer: Adobe PDF Library 17.0; 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