In the substantia nigra of the brain of Parkinsonian patients, the Lewy body is an inclusion body measuring 5-25 µm in diameter. Its morphology is spherical, cosinophilic, with a dense core surrounded by a weakly staining halo, and found generally in the cytoplasm of monoaminergic pigmented cells and medium and large-sized cholinergic neurons. The Lewy body is surrounded by neuromelanin in the substantia nigra.