In patients with normal erythroid turnover, this short interruption of red cell production does not lead to anemia, but in patients with high red cell turnover, due to hemolysis, blood loss, or other causes, the temporary failure of erythropoiesis can precipitate an 'aplastic crisis'. The crisis resolves as the immune response develops. In patients who are immunocompromised, infection may persist and produce chronic pure red cell aplasia.