APC regulates the rates of proliferation and apoptosis by several different mechanisms. Wild-type APC is important for cytoskeletal integrity, cellular adhesion, and Wnt signaling. APC plays a role in the G1/S transition of the cell cycle by modulating expression levels of c-myc and cyclin D1. Wildtype, full length APC is also important in maintaining intestinal cell migration up the crypt and inducing apoptosis.