Psychostimulant medications are sympathomimetic amines and have been shown to function as direct and indirect agonists at adrenergic receptor sites. They can act directly at the postsynaptic receptor mimicking the effects of norepinephrine or dopamine, can block the reuptake of norepinephrine and dopamine into the presynaptic neuron, and can increase the release of these monoamines into the extraneuronal space.