are intracellular proteins of human origin and, as such, they are expected to display reduced immunogenicity in human recipients, thus overcoming the major obstacle involved in the use of bacterial and plant-based chimeric proteins. These apoptosis inducing protein-based chimeras are sufficient to induce apoptosis in the target cells in the absence of any additional death stimuli. Despite the fact that these chimeric proteins are delivered from the exterior of the cell, we showed that they are allocated to the same compartments as their endogenous counterpart proteins and induce apoptosis in a way similar to the normal triggering of apoptosis.