Dr. Fisman and colleagues developed a model to simulate the initial management, clinical course, and later complications of an infected hipprosthesis to evaluate the cost-effectiveness of these two strategies—two-stage exchange arthroplasty or open debridement of the hip prosthesis followed by 6 weeks of antibiotic therapy for managing infected THRs in hypothetical groups of 65-year-old men and women and frail 80-year-old men and women.