Nematodes account for an estimated four of every five animals in the world. Parasitic nematodes are major challenges to human health and agriculture. Parasitic nematodes, including whipworm, Ascaris, hookworm, and filarial worms, currently infect about 3 billion people. Plant parasitic nematodes, such as root knot nematode, cause an estimated 80 billion dollars in crop damage annually.