The neuro-image processing section is part of a larger multi- disciplinary neuroimaging team, involving neurologists, neur-radiologists, neuropsychologists, MR physicists , biologists, and computer scientists. Our neuroimage processing applications are triggered by the clinical research of the neuroimaging group. We are mainly involved in clinical studies on normal aging, several types of dementia, and migraine. We develop robust algorithms and implement them in user friendly software tools that are daily used by clinical researchers in Leiden and at external partner institutions. An overview of the different projects will be presented.