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Title:           La protonterapia en el tratamiento del cáncer
Subject:         La protonterapia en el tratamiento del cáncer. Evaluación de la seguridad, eficacia y efectividad clínicas, y eficiencia
Author:          Ministerio de Sanidad - Agència de Qualitat i Avaluació Sanitàries de Catalunya - Departament de Salut
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    Outlines: 
     Item: 
      Title: Información preliminar
      Children: 
       Item: 
        Title: Autoría
       Item: 
        Title: Otros participantes 
       Item: 
        Title: Coordinación
       Item: 
        Title: Declaración de conflictos de interés
     Item: 
      Title: Índice 
     Item: 
      Title: Índice de figuras 
     Item: 
      Title: Índice de tablas 
     Item: 
      Title: Abreviaturas y acrónimos 
     Item: 
      Title: Resumen
      Children: 
       Item: 
        Title: Introducción: 
       Item: 
        Title: Objetivos: 
       Item: 
        Title: Material y métodos: 
       Item: 
        Title: Resultados: 
        Children: 
         Item: 
          Title: Seguridad y eficacia/efectividad clínicas: 
       Item: 
        Title: Eficiencia: 
       Item: 
        Title: Conclusiones: 
     Item: 
      Title: English abstract
      Children: 
       Item: 
        Title: Introduction: 
       Item: 
        Title: Objectives: 
       Item: 
        Title: Material and methods: 
       Item: 
        Title: Results: 
        Children: 
         Item: 
          Title: Safety and clinical efficacy/effectiveness: 
       Item: 
        Title: Efficiency:  
       Item: 
        Title: Conclusions: 
     Item: 
      Title: Resum en català
      Children: 
       Item: 
        Title: Introducció:  
       Item: 
        Title: Material i mètodes: 
       Item: 
        Title: Resultats:
        Children: 
         Item: 
          Title: Seguretat i eficàcia/efectivitat clíniques: 
       Item: 
        Title: Eficiència: 
       Item: 
        Title: Conclusions: 
     Item: 
      Title: I. Antecedentes y justificación
     Item: 
      Title: II. Introducción
      Children: 
       Item: 
        Title: II.1 Descripción del problema de salud
        Children: 
         Item: 
          Title: II.1.1. Problema de salud diana
         Item: 
          Title: II.1.2. Manejo actual del problema de salud
         Item: 
          Title: II.1.3. Población diana
       Item: 
        Title: II.2 Descripción y características técnicas de la tecnología a estudio
        Children: 
         Item: 
          Title: II.2.1. Características de la tecnología
         Item: 
          Title: II.2.2. Regulación: licencias y autorizaciones
         Item: 
          Title: II.2.3. Utilización
          Children: 
           Item: 
            Title: Difusión de la PT 
           Item: 
            Title: La PT en España
         Item: 
          Title: II.2.4. Requerimientos de la técnica
          Children: 
           Item: 
            Title: Características técnicas del acelerador
           Item: 
            Title: Edificio y obra civil
           Item: 
            Title: Requisitos de protección radiológica de la instalación
           Item: 
            Title: Instalaciones y equipamientos clínicos
           Item: 
            Title: Plantilla y plan de formación
         Item: 
          Title: II.2.5. Financiación de la tecnología
     Item: 
      Title: III. Objetivos y pregunta de investigación
      Children: 
       Item: 
        Title: III.1 Objetivos
        Children: 
         Item: 
          Title: III.1.1. Objetivo General
         Item: 
          Title: III.1.2. Objetivos Específicos
         Item: 
          Title: III.1.3. Preguntas de investigación
     Item: 
      Title: IV.. Metodología
      Children: 
       Item: 
        Title: IV.1 Metodología de la revisión narrativa sobre la descripción del problema de salud y la tecnologí
        Children: 
         Item: 
          Title: VI.1.1. Fuentes de información y estrategia de búsqueda
         Item: 
          Title: IV.1.2 Criterios de inclusión y exclusión
         Item: 
          Title: IV.1.3 Proceso de selección de los estudios
         Item: 
          Title: IV.1.4 Evaluación de calidad 
         Item: 
          Title: IV.1.5 Extracción de datos
         Item: 
          Title: IV.1.6 Síntesis de los datos
       Item: 
        Title: IV.2 Metodología de la RS de la seguridad y eficacia/efectividad clínicas
        Children: 
         Item: 
          Title: IV.2.1 Fuentes de información y estrategia de búsqueda
         Item: 
          Title: IV.2.2 Criterios de inclusión y exclusión
         Item: 
          Title: IV.2.3 Proceso de selección de los estudios
          Children: 
           Item: 
            Title: Cabeza y cuello
           Item: 
            Title: Sistema nervioso central (SNC)
           Item: 
            Title: Tórax
           Item: 
            Title: Sistema digestivo
           Item: 
            Title: Sistema genitourinario
           Item: 
            Title: Mama y sistema reproductor femenino
         Item: 
          Title: IV.2.4 Extracción de características de los estudios
         Item: 
          Title: IV.2.5 Extracción de los resultados de los estudios
         Item: 
          Title: IV.2.6. Evaluación del riesgo de sesgo de los desenlaces primarios 
         Item: 
          Title: IV.2.7. Análisis y síntesis de los resultados
          Children: 
           Item: 
            Title: Efectos relativos y absolutos
           Item: 
            Title: Definición de las DMI
         Item: 
          Title: IV.2.8 Estudios en marcha
       Item: 
        Title: IV.3 Metodología de la RS sobre aspectos económicos
        Children: 
         Item: 
          Title: IV.3.1 Fuentes de información y estrategia de búsqueda
         Item: 
          Title: IV.3.2 Criterios de inclusión y exclusión
         Item: 
          Title: IV.3.3 Proceso de selección de los estudios
         Item: 
          Title: IV.3.4 Extracción de datos
         Item: 
          Title: IV.3.5 Evaluación de la calidad 
         Item: 
          Title: IV.3.6 Síntesis de los resultados
         Item: 
          Title: IV.3.7 Estudios en marcha
       Item: 
        Title: IV.4 Participación de grupos de interés
        Children: 
         Item: 
          Title: IV.4.1. Participación de los profesionales sanitarios
     Item: 
      Title: V. Resultados
      Children: 
       Item: 
        Title: V.1 Resultados de la RS de seguridad y eficacia/efectividad clínicas
        Children: 
         Item: 
          Title: V.1.1 Resultados de la búsqueda bibliográfica y proceso de cribado de referencias
         Item: 
          Title: V.1.2 Resultados de seguridad y eficacia/efectividad clínicas por cáncer
          Children: 
           Item: 
            Title: V.1.2.1 Cabeza y cuello
            Children: 
             Item: 
              Title: Cáncer de cavidad oral y faríngeo - Población pediátrica
             Item: 
              Title: Cáncer de cavidad oral y faríngeo - Población adulta
             Item: 
              Title: Cáncer de cavidad nasal y senos paranasales - Población adulta
           Item: 
            Title: V.1.2.2 Sistema nervioso central
            Children: 
             Item: 
              Title: Gliomas, glioblastomas y gliosarcomas - Población adulta
             Item: 
              Title: Meduloblastoma - Población adulta
             Item: 
              Title: Neuroma acústico o schwannoma vestibular - Población adulta
             Item: 
              Title: Metástasis leptomeníngea cerebral - Población adulta
           Item: 
            Title: V.1.2.3 Tórax
            Children: 
             Item: 
              Title: Cáncer de pulmón - Población adulta
           Item: 
            Title: V.1.2.4 Sistema digestivo
            Children: 
             Item: 
              Title: Cáncer esofágico - Población adulta
             Item: 
              Title: Cáncer pancreático - Población adulta
             Item: 
              Title: Hepatocarcinoma - Población adulta
             Item: 
              Title: Cáncer anal - Población adulta
           Item: 
            Title: V.1.2.5 Sistema genitourinario
            Children: 
             Item: 
              Title: Cáncer de próstata - Población adulta
             Item: 
              Title: Cáncer testicular - Población adulta
           Item: 
            Title: V.1.2.6 Mama y sistema reproductor femenino
            Children: 
             Item: 
              Title: Cáncer de mama - Población adulta
             Item: 
              Title: Cáncer uterino - Población adulta
         Item: 
          Title: V.1.3 Estudios en marcha
       Item: 
        Title: V.2 Resultados de la RS sobre aspectos económicos
        Children: 
         Item: 
          Title: V.2.1. Resultados de la búsqueda bibliográfica y proceso de cribado de referencias
         Item: 
          Title: V.2.2 Resultados de coste-efectividad por cáncer
          Children: 
           Item: 
            Title: V.2.2.1 Cabeza y cuello
            Children: 
             Item: 
              Title: Cáncer de cavidad oral y faríngeo - Población adulta
             Item: 
              Title: Cáncer de cavidad nasal y senos paranasales 
           Item: 
            Title: V.2.2.2. Tórax
            Children: 
             Item: 
              Title: Cáncer de pulmón - Población adulta
           Item: 
            Title: V.2.2.3 Sistema digestivo
            Children: 
             Item: 
              Title: Cáncer pancreático - Población adulta
           Item: 
            Title: V.2.2.4 Sistema genitourinario
            Children: 
             Item: 
              Title: Cáncer de próstata - Población adulta
           Item: 
            Title: V.2.2.5 Mama y sistema reproductor femenino
            Children: 
             Item: 
              Title: Cáncer de mama - Población adulta
         Item: 
          Title: V.2.3 Estudios en marcha
     Item: 
      Title: VI. Discusión
      Children: 
       Item: 
        Title: VI.1 Cuestiones metodológicas
       Item: 
        Title: VI.2 Discusión de los resultados de la RS de seguridad y eficacia/efectividad clínicas
        Children: 
         Item: 
          Title: VI.2.1 Síntesis de la evidencia según indicación
          Children: 
           Item: 
            Title: Cáncer de cavidad oral y faríngeo - Población pediátrica
           Item: 
            Title: Cáncer de cavidad oral y faríngeo - Población adulta
           Item: 
            Title: Cáncer de cavidad nasal y senos paranasales - Población adulta
           Item: 
            Title: Gliomas, glioblastomas y gliosarcomas - Población adulta
           Item: 
            Title: Meduloblastoma - Población adulta
           Item: 
            Title: Neuroma acústico o schwannoma vestibular - Población adulta
           Item: 
            Title: Metástasis leptomeníngea cerebral - Población adulta
           Item: 
            Title: Cáncer de pulmón - Población adulta
           Item: 
            Title: Cáncer esofágico - Población adulta
           Item: 
            Title: Cáncer pancreático - Población adulta
           Item: 
            Title: Hepatocarcinoma - Población adulta
           Item: 
            Title: Cáncer anal - Población adulta
           Item: 
            Title: Cáncer de próstata - Población adulta
           Item: 
            Title: Cáncer testicular - Población adulta
           Item: 
            Title: Cáncer de mama - Población adulta
           Item: 
            Title: Cáncer uterino - Población adulta
         Item: 
          Title: VI.2.2 Recomendaciones de investigación futura
          Children: 
           Item: 
            Title: En población pediátrica
           Item: 
            Title: En población adulta
       Item: 
        Title: VI.3 Discusión de los resultados de la RS de la eficiencia
        Children: 
         Item: 
          Title: Cáncer de cavidad oral y faríngeo - Población adulta
         Item: 
          Title: Cáncer de cavidad nasal y senos paranasales - población adulta
         Item: 
          Title: Cáncer de pulmón - población adulta
         Item: 
          Title: Cáncer pancreático - población adulta
         Item: 
          Title: Hepatocarcinoma - población adulta
         Item: 
          Title: Cáncer de próstata - población adulta
         Item: 
          Title: Cáncer de mama - población adulta 
       Item: 
        Title: VI.4. Aplicabilidad
     Item: 
      Title: VII. Conclusiones
     Item: 
      Title: VIII. Referencias
     Item: 
      Title: IX. Anexos
      Children: 
       Item: 
        Title: ANEXO 1. Estrategias de búsqueda en las bases de datos
        Children: 
         Item: 
          Title: Seguridad y eficacia/efectividad clínicas
         Item: 
          Title: Aspectos económicos
       Item: 
        Title: ANEXO 2. Referencias excluidas de la evaluación de la seguridad y eficacia/efectividad clínicas
       Item: 
        Title: ANEXO 3. Referencias excluidas de la evaluación del coste-efectividad
       Item: 
        Title: ANEXO 4. Tabla de características de los estudios incluidos en los dominios de seguridad y eficacia/
        Children: 
         Item: 
          Title: 1. Cabeza y cuello
          Children: 
           Item: 
            Title: Cáncer de cavidad oral y faríngeo población pediátrica
           Item: 
            Title: Cáncer de cavidad oral y faríngeo población adulta
           Item: 
            Title: Cáncer de cavidad nasal y senos paranasales población adulta
         Item: 
          Title: 2. Sistema nervioso central
          Children: 
           Item: 
            Title: Gliomas, glioblastomas y gliosarcomas población adulta
           Item: 
            Title: Meduloblastoma población adulta
           Item: 
            Title: Neuroma acústico o schwannoma vestibular población adulta
           Item: 
            Title: Metástasis leptomeníngea cerebral población adulta
         Item: 
          Title: 3. Tórax
          Children: 
           Item: 
            Title: Cáncer de pulmón población adulta
         Item: 
          Title: 4. Sistema digestivo
          Children: 
           Item: 
            Title: Cáncer esofágico población adulta
           Item: 
            Title: Cáncer pancreático población adulta
           Item: 
            Title: Hepatocarcinoma población adulta
           Item: 
            Title: Cáncer anal población adulta
         Item: 
          Title: 5. Sistema genitourinario
          Children: 
           Item: 
            Title: Cáncer de próstata población adulta
           Item: 
            Title: Cáncer testicular población adulta
         Item: 
          Title: 6. Mama y sistema reproductor femenino
          Children: 
           Item: 
            Title: Cáncer de mama población adulta
           Item: 
            Title: Cáncer uterino población adulta
       Item: 
        Title: ANEXO 5. Riesgo de sesgo de los estudios incluidos en el dominio de seguridad y eficacia/efectividad
        Children: 
         Item: 
          Title: 1. Cabeza y cuello
          Children: 
           Item: 
            Title: Cáncer de cavidad oral y faríngeo población pediátrica
           Item: 
            Title: Cáncer de cavidad oral y faríngeo población adulta
           Item: 
            Title: Cáncer de cavidad nasal y senos paranasales población adulta
         Item: 
          Title: 2. Sistema nervioso central
          Children: 
           Item: 
            Title: Gliomas, glioblastomas y gliosarcomas población adulta
           Item: 
            Title: Meduloblastoma población adulta
           Item: 
            Title: Neuroma acústico o schwannoma vestibular población adulta
           Item: 
            Title: Metástasis leptomeníngea población adulta
         Item: 
          Title: 3. Tórax
          Children: 
           Item: 
            Title: Cáncer de pulmón población adulta
         Item: 
          Title: 4. Sistema digestivo
          Children: 
           Item: 
            Title: Cáncer esofágico población adulta
           Item: 
            Title: Cáncer pancreático población adulta
           Item: 
            Title: Hepatocarcinoma población adulta
           Item: 
            Title: Cáncer anal población adulta
         Item: 
          Title: 5. Sistema genitourinario
          Children: 
           Item: 
            Title: Cáncer de próstata población adulta
         Item: 
          Title: 6. Mama y sistema reproductor femenino
          Children: 
           Item: 
            Title: Cáncer de mama población adulta
           Item: 
            Title: Cáncer uterino población adulta
       Item: 
        Title: ANEXO 6. Tablas de extracción de resultados de los estudios incluidos en los dominios de seguridad y
        Children: 
         Item: 
          Title: 1. Cabeza y cuello
          Children: 
           Item: 
            Title: Cáncer de cavidad oral y faríngeo población pediátrica
           Item: 
            Title: Cáncer de cavidad oral y faríngeo población adulta
           Item: 
            Title: Cáncer de cavidad nasal y senos paranasales población adulta
         Item: 
          Title: 2. Sistema nervioso central
          Children: 
           Item: 
            Title: Gliomas, glioblastomas y gliosarcomas población adulta
           Item: 
            Title: Meduloblastoma población adulta
           Item: 
            Title: Neuroma acústico o schwannoma vestibular población adulta
           Item: 
            Title: Metástasis leptomeníngea cerebral población adulta
         Item: 
          Title: 3. Tórax
          Children: 
           Item: 
            Title: Cáncer de pulmón población adulta
         Item: 
          Title: 4. Sistema digestivo
          Children: 
           Item: 
            Title: Cáncer esofágico población adulta
           Item: 
            Title: Cáncer pancreático población adulta
           Item: 
            Title: Hepatocarcinoma población adulta
           Item: 
            Title: Cáncer anal población adulta
         Item: 
          Title: 5. Sistema genitourinario
          Children: 
           Item: 
            Title: Cáncer de próstata población adulta
           Item: 
            Title: Cáncer testicular población adulta
         Item: 
          Title: 6. Mama y sistema reproductor femenino
          Children: 
           Item: 
            Title: Cáncer de mama población adulta
           Item: 
            Title: Cáncer uterino población adulta
       Item: 
        Title: ANEXO 7. Tabla de extracción de características y resultados de los estudios incluidos en el dominio
        Children: 
         Item: 
          Title: 1. Cabeza y cuello
         Item: 
          Title: 2. Tórax
         Item: 
          Title: 3. Sistema digestivo
         Item: 
          Title: 4. Sistema genitourinario
         Item: 
          Title: 5. Mama y sistema reproductor femenino
       Item: 
        Title: ANEXO 8. Evaluación de la calidad de los estudios de coste-efectividad incluidos en el informe
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  Checksum: 59fe6db6079f2e99863bed6524138fc4
   Type: MD5
  Checksum: 0276d76e4d25e494e120fa501f317b9e630e4862
   Type: SHA-1
  Checksum: a4af1272a6eb6600db56e04b03002b95c0887d031ddceba3c4ba411931cd4ee6
   Type: SHA-256