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2021-01-30T11:58:10+01:00 Adobe Photoshop CC 2017 (Windows) / saved xmp.iid:1c4ba2d0-466f-1f43-b3f6-9ab8ebaf9d95 2021-01-31T13:29:29+01:00 Adobe Photoshop CC 2017 (Windows) / converted from application/vnd.adobe.photoshop to application/pdf derived converted from application/vnd.adobe.photoshop to application/pdf saved xmp.iid:5c72b169-d525-2d4f-b691-6e49c0e5221c 2021-01-31T13:29:29+01:00 Adobe Photoshop CC 2017 (Windows) / xmp.iid:1c4ba2d0-466f-1f43-b3f6-9ab8ebaf9d95 adobe:docid:photoshop:d606ced1-62ea-11eb-81a9-b141ce473a7c xmp.did:72bdf3d8-3b58-504c-a0c0-a1904947287e 3 Capa 14 Capa 3 Capa 10 If a wine with a dose of cardioprotective effect was to be If a wine with a dose of cardioprotective effect was to be created, it would be interesting to evaluate its organoleptic properties and get the legislation to consider it as a functional wine to avoid possible rejection by the consumer. It would be very appropriate forfurtherstudies to research on h It would be very appropriate forfurtherstudies to research on how to increase the bioavailability of resveratrol in humans, as it is primarily responsible for this polyphenol having such a high therapeutic dose. Achieving greater bioavailability could greatly help the biotechnological techniques used in wine to achieve their goals. Capa 13 There are several stimuli involved in the accumulation of resve There are several stimuli involved in the accumulation of resveratrol. UV-C irradiation has been shown to increase resveratrol synthesis in grapes, but unfortunately the maximum levels achieved are still far from the minimum dose with cardioprotective effect. Considering as shown the minimum dose 30 mg/day and a moderate wine consumption (200mL/day), we can conclude that a wine with cardioprotective effect should contain a minimum concentration of 150 mg/L of resveratrol. When observing the concentrations in which the wine is found, w When observing the concentrations in which the wine is found, we can see that it is not possible to absorb the effective dose through moderate consumption, so the interpretations drawn on the French paradox which identified wine as a cardioprotective element would be wrong. Capa 8 Wine Variety Total Wine Variety Total Capa 9 PIN MER CAS TEM GAR AVG PIN MER CAS TEM GAR AVG 9.39 9.19 3.23 3.43 6.37 5.65 9.39 9.19 3.23 3.43 6.37 5.65 The terminal enzyme involved in the biosynthesis of resveratro The terminal enzyme involved in the biosynthesis of resveratrol is stilbene synthase, which isactivated by exogenous stressors, ultraviolet light and chemical signals defined from pathogenic fungi. In addition, several factors during the winemaking processsupport the increase of transresveratrol levels such as increased temperature, higher SO2 levels and/or decreased pH. Capa 7 Although other studies suggest that resveratrol has high intest Although other studies suggest that resveratrol has high intestinal absorption (Walle et al., 2004), its bioavailability is very low. Research that used 25 mg oral doses showed peak concentrations of <10 ng/ml at 0.5–2 h in plasma after ingestion and most of the oral dose was recovered in the urine. Capa 4 Through human subject research it has been observed that diff Through human subject research it has been observed that different doses of resveratrol by vasodilation have cardioprotective effects. Wong et al. (2011) is the study that identified the smallest effective dose, which is 30 mg/day. Capa 6 RESVERATROL CONCENTRATION IN RED WINES RESVERATROL CONCENTRATION IN RED WINES ORGANOLEPTIC PROPERTIES OF A WINE WITH A HIGH RESVERATROL CONTE ORGANOLEPTIC PROPERTIES OF A WINE WITH A HIGH RESVERATROL CONTENT Gaudette and Pickering (2011) evaluated the sensory properties Gaudette and Pickering (2011) evaluated the sensory properties of a Cabernet Sauvignon fortified with 20 and 200 mg/L resveratrol. Even though the high concentration of resveratrol did not alter the taste or aromatic profile of Cabernet Sauvignon, a change in the colour of the wine was detected. BIOAVAILABILITY OF RESVERATROL BIOAVAILABILITY OF RESVERATROL STIMULI THAT INTERVENE ON THE ACCUMULATION OF RESVERATROL IN G STIMULI THAT INTERVENE ON THE ACCUMULATION OF RESVERATROL IN GRAPES INTRODUCTION & OBJECTIVES INTRODUCTION & OBJECTIVES INDUCTION OF RESVERATROL BY UV-C IRRADIATION INDUCTION OF RESVERATROL BY UV-C IRRADIATION CONCLUSIONS CONCLUSIONS The term French paradox arose from an epidemiological observati The term French paradox arose from an epidemiological observation, where it was possible to observe a relatively low incidence of cardiovascular disease in the French population, even when it had a sufficiently high dietary intake of saturated fat . For this reason, resveratrol and its vasculoprotective properties were thought to be linked to the possible health benefits attributed to moderate wine consumption. The objectives of this review are to investigate whether it makes sense to state that the levels of resveratrol found in wine may actually play a cardioprotective role. We will identify what its effective dose is through literature review, and whether it is found in wine in these concentrations. We will also try to study which stimuli can intervene on the accumulation of resveratrol in grapes and to what extent the amount of this compound can be increased using biotechnological practices. Lastly, conclude whether the wine would be organoleptically suitable under these certain conditions. Note. Tempranillo, TEM; Cabernet Sauvignon, CAS; Merlot, MER; Note. Tempranillo, TEM; Cabernet Sauvignon, CAS; Merlot, MER; Syrah, SYR; Monastrell, MON; Garnatxa, GAR and Carinyena, CAR .Values are expressed as mg/1Kg fresh weight of total grape berry. This datat refers to the set formed by resveratrol, piceid, piceatannol and viniferins. Note. Cabernet Sauvignon, CAS; Merlot, MER; Pinot noir PIN; Te Note. Cabernet Sauvignon, CAS; Merlot, MER; Pinot noir PIN; Tempranillo, TEM; i Garnatxa, GAR. Values are expressed as mg/L of wine. The data refers to the set formed by resveratrol and piceid. Capa 5 TEM CAS MER SYR MON GAR CAR TEM CAS MER SYR MON GAR CAR 4.76 1.97 15.43 4.28 11.18 2.37 2.37 4.76 1.97 15.43 4.28 11.18 2.37 2.37 Variety Control UV Variety Control UV 22.45 19.28 35.51 14.30 11.64 12.05 26.21 22.45 19.28 35.51 14.30 11.64 12.05 26.21 CARDIOPROTECTIVE RESERVERATROL DOSE CARDIOPROTECTIVE RESERVERATROL DOSE RESVERATROL IN WINE AND THE FRENCH PARADOX : MYTH OR REALITY? RESVERATROL IN WINE AND THE FRENCH PARADOX : MYTH OR REALITY? Jan Amills Pérez Jan Amills Pérez Capa 11 Gaudette, N. J. i Pickering, G. J. (2011) «Sensory and chemica Gaudette, N. J. i Pickering, G. J. (2011) «Sensory and chemical characteristics of trans-resveratrol-fortified wine», Australian Journal of Grape and Wine Research, 17(2), p. 249-257. Capa 12 Wong, R. H. X., Howe, P. R.C., Buckley, J. D., Coates, A. M., K Wong, R. H. X., Howe, P. R.C., Buckley, J. D., Coates, A. M., Kunz, I. i Berry, N. M. (2011) «Acute resveratrol supplementation improves flow-mediated dilatation in overweight/obese individuals with mildly elevated blood pressure», Nutrition, Metabolism and Cardiovascular Diseases, 21(11), p. 851-856. adobe:docid:photoshop:45ffac0f-4b72-11eb-aaaf-9de488d6adf4 adobe:docid:photoshop:8c0e9e53-61a2-11eb-bef5-f885ccf58be9 Adobe Photoshop for Windows -- Image Conversion Plug-in Pages: Page: Sequence: 1 Checksum: 549122a9 Type: CRC32 Checksum: 76f1fdce2f7af9807ea42399751d77c7 Type: MD5 Checksum: 5aff99d4d87bf0f157e4be54462129bf76b8b7b4 Type: SHA-1